1896-0090

(Z)-3-[3-bromo-4-(dimethylamino)phenyl]-2-cyanoprop-2-enamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_752
Screen concentration 130.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 772567
SMILES CN(C)C1=C(C=C(C=C1)C=C(C#N)C(=O)N)Br
Standardized SMILES CN(C)c1ccc(C=C(C#N)C(=O)N)cc1Br
Molecular weight 294.1472
ALogP 2.05
H-bond donor count 1
H-bond acceptor count 3
Response signature TSC3-RPN4

Pool Growth Kinetics
% growth inhibition (Het. pool) 18.73
% growth inhibition (Hom. pool) 12.47


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 772567
Download HIP data (tab-delimited text)  (excel)
Gene:CDC25(YLR310C)|FD-Score:3.14|P-value:8.40E-4|Clearance:0.12||SGD DESC:Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 Gene:DBP10(YDL031W)|FD-Score:3.45|P-value:2.76E-4|Clearance:0.2||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis Gene:GUS1(YGL245W)|FD-Score:3.19|P-value:7.05E-4|Clearance:0.05||SGD DESC:Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:KAR1(YNL188W)|FD-Score:5.44|P-value:2.67E-8|Clearance:1.22||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:NUT2(YPR168W)|FD-Score:-3.49|P-value:2.41E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress Gene:PBN1(YCL052C)|FD-Score:3.8|P-value:7.12E-5|Clearance:0.06||SGD DESC:Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X Gene:PSA1(YDL055C)|FD-Score:3.25|P-value:5.78E-4|Clearance:0.06||SGD DESC:GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure Gene:RCL1(YOL010W)|FD-Score:3.73|P-value:9.63E-5|Clearance:0.19||SGD DESC:Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected Gene:RNT1(YMR239C)|FD-Score:4.08|P-value:2.30E-5|Clearance:0.1||SGD DESC:Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes Gene:RPO31(YOR116C)|FD-Score:4.22|P-value:1.22E-5|Clearance:0.15||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:SUI2(YJR007W)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.08||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:TFC3(YAL001C)|FD-Score:3.98|P-value:3.45E-5|Clearance:0.06||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TIF34(YMR146C)|FD-Score:3.92|P-value:4.48E-5|Clearance:0.11||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:YAE1(YJR067C)|FD-Score:3.75|P-value:8.89E-5|Clearance:0.02||SGD DESC:Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species Gene:CDC25(YLR310C)|FD-Score:3.14|P-value:8.40E-4|Clearance:0.12||SGD DESC:Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 Gene:DBP10(YDL031W)|FD-Score:3.45|P-value:2.76E-4|Clearance:0.2||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis Gene:GUS1(YGL245W)|FD-Score:3.19|P-value:7.05E-4|Clearance:0.05||SGD DESC:Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:KAR1(YNL188W)|FD-Score:5.44|P-value:2.67E-8|Clearance:1.22||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:NUT2(YPR168W)|FD-Score:-3.49|P-value:2.41E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress Gene:PBN1(YCL052C)|FD-Score:3.8|P-value:7.12E-5|Clearance:0.06||SGD DESC:Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X Gene:PSA1(YDL055C)|FD-Score:3.25|P-value:5.78E-4|Clearance:0.06||SGD DESC:GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure Gene:RCL1(YOL010W)|FD-Score:3.73|P-value:9.63E-5|Clearance:0.19||SGD DESC:Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected Gene:RNT1(YMR239C)|FD-Score:4.08|P-value:2.30E-5|Clearance:0.1||SGD DESC:Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes Gene:RPO31(YOR116C)|FD-Score:4.22|P-value:1.22E-5|Clearance:0.15||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:SUI2(YJR007W)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.08||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:TFC3(YAL001C)|FD-Score:3.98|P-value:3.45E-5|Clearance:0.06||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TIF34(YMR146C)|FD-Score:3.92|P-value:4.48E-5|Clearance:0.11||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:YAE1(YJR067C)|FD-Score:3.75|P-value:8.89E-5|Clearance:0.02||SGD DESC:Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 772567
Download HOP data (tab-delimited text)  (excel)
Gene:ACE2(YLR131C)|FD-Score:6.12|P-value:4.73E-10||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:ACO1(YLR304C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ARG4(YHR018C)|FD-Score:-3.16|P-value:7.80E-4||SGD DESC:Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway Gene:ART5(YGR068C)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:ATG19(YOL082W)|FD-Score:-5.35|P-value:4.37E-8||SGD DESC:Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles Gene:AXL2(YIL140W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate Gene:BAT2(YJR148W)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase Gene:BLI1(YKL061W_p)|FD-Score:4.68|P-value:1.46E-6||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome Gene:BSD2(YBR290W)|FD-Score:6.15|P-value:3.89E-10||SGD DESC:Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification Gene:CIN1(YOR349W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Gene:CTF3(YLR381W)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 Gene:EIS1(YMR031C)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:EMP46(YLR080W)|FD-Score:-3.15|P-value:8.24E-4||SGD DESC:Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport Gene:ERV41(YML067C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:FIT1(YDR534C)|FD-Score:-3.3|P-value:4.82E-4||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:GIP4(YAL031C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate Gene:GZF3(YJL110C)|FD-Score:4.5|P-value:3.35E-6||SGD DESC:GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication Gene:HEK2(YBL032W)|FD-Score:4.02|P-value:2.88E-5||SGD DESC:RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K Gene:HIT1(YJR055W)|FD-Score:4.47|P-value:4.00E-6||SGD DESC:Protein of unknown function, required for growth at high temperature Gene:HMS1(YOR032C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant Gene:LSM6(YDR378C)|FD-Score:4.1|P-value:2.07E-5||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA Gene:LYS12(YIL094C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate Gene:MKC7(YDR144C)|FD-Score:-3.46|P-value:2.72E-4||SGD DESC:GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p Gene:MPT5(YGL178W)|FD-Score:-3.11|P-value:9.37E-4||SGD DESC:mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity Gene:MUD1(YBR119W)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing Gene:NOP13(YNL175C)|FD-Score:-3.17|P-value:7.65E-4||SGD DESC:Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress Gene:OMA1(YKR087C)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:PAC10(YGR078C)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PEX21(YGR239C)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:PMT5(YDL093W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:POL32(YJR043C)|FD-Score:4.01|P-value:3.09E-5||SGD DESC:Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p Gene:PPQ1(YPL179W)|FD-Score:3.78|P-value:7.72E-5||SGD DESC:Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors Gene:RFM1(YOR279C)|FD-Score:5.24|P-value:7.96E-8||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:RPS28B(YLR264W)|FD-Score:3.89|P-value:5.05E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication Gene:SLM3(YDL033C)|FD-Score:4.41|P-value:5.15E-6||SGD DESC:tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) Gene:SOH1(YGL127C)|FD-Score:3.27|P-value:5.35E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:SPS100(YHR139C)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SSE1(YPL106C)|FD-Score:-3.14|P-value:8.51E-4||SGD DESC:ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication Gene:STB5(YHR178W)|FD-Score:4.84|P-value:6.61E-7||SGD DESC:Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gene:THI72(YOR192C)|FD-Score:3.78|P-value:7.78E-5||SGD DESC:Transporter of thiamine or related compound; shares sequence similarity with Thi7p Gene:TSC3(YBR058C-A)|FD-Score:11.5|P-value:6.59E-31||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBX5(YDR330W)|FD-Score:-4.09|P-value:2.19E-5||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p Gene:YBL062W(YBL062W_d)|FD-Score:3.16|P-value:7.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR049C(YCR049C_d)|FD-Score:5.41|P-value:3.16E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR220C(YDR220C_d)|FD-Score:-3.82|P-value:6.75E-5||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YGL149W(YGL149W_d)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Gene:YGL199C(YGL199C_d)|FD-Score:-3.74|P-value:9.11E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W Gene:YGR153W(YGR153W_p)|FD-Score:-5.92|P-value:1.56E-9||SGD DESC:Putative protein of unknown function Gene:YHR130C(YHR130C_d)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL077W-B(YJL077W-B_p)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YJL120W(YJL120W_d)|FD-Score:3.13|P-value:8.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Gene:YKE2(YLR200W)|FD-Score:4.32|P-value:7.80E-6||SGD DESC:Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin Gene:YLR296W(YLR296W_d)|FD-Score:4.26|P-value:1.04E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR122C(YMR122C_d)|FD-Score:3.22|P-value:6.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR277C(YOR277C_d)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPK3(YBR028C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner Gene:YPR195C(YPR195C_d)|FD-Score:-4.16|P-value:1.57E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YVC1(YOR087W)|FD-Score:-3.2|P-value:6.91E-4||SGD DESC:Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock Gene:ACE2(YLR131C)|FD-Score:6.12|P-value:4.73E-10||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:ACO1(YLR304C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ARG4(YHR018C)|FD-Score:-3.16|P-value:7.80E-4||SGD DESC:Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway Gene:ART5(YGR068C)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:ATG19(YOL082W)|FD-Score:-5.35|P-value:4.37E-8||SGD DESC:Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles Gene:AXL2(YIL140W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate Gene:BAT2(YJR148W)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase Gene:BLI1(YKL061W_p)|FD-Score:4.68|P-value:1.46E-6||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome Gene:BSD2(YBR290W)|FD-Score:6.15|P-value:3.89E-10||SGD DESC:Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification Gene:CIN1(YOR349W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Gene:CTF3(YLR381W)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 Gene:EIS1(YMR031C)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:EMP46(YLR080W)|FD-Score:-3.15|P-value:8.24E-4||SGD DESC:Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport Gene:ERV41(YML067C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:FIT1(YDR534C)|FD-Score:-3.3|P-value:4.82E-4||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:GIP4(YAL031C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate Gene:GZF3(YJL110C)|FD-Score:4.5|P-value:3.35E-6||SGD DESC:GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication Gene:HEK2(YBL032W)|FD-Score:4.02|P-value:2.88E-5||SGD DESC:RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K Gene:HIT1(YJR055W)|FD-Score:4.47|P-value:4.00E-6||SGD DESC:Protein of unknown function, required for growth at high temperature Gene:HMS1(YOR032C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant Gene:LSM6(YDR378C)|FD-Score:4.1|P-value:2.07E-5||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA Gene:LYS12(YIL094C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate Gene:MKC7(YDR144C)|FD-Score:-3.46|P-value:2.72E-4||SGD DESC:GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p Gene:MPT5(YGL178W)|FD-Score:-3.11|P-value:9.37E-4||SGD DESC:mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity Gene:MUD1(YBR119W)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing Gene:NOP13(YNL175C)|FD-Score:-3.17|P-value:7.65E-4||SGD DESC:Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress Gene:OMA1(YKR087C)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:PAC10(YGR078C)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PEX21(YGR239C)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:PMT5(YDL093W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:POL32(YJR043C)|FD-Score:4.01|P-value:3.09E-5||SGD DESC:Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p Gene:PPQ1(YPL179W)|FD-Score:3.78|P-value:7.72E-5||SGD DESC:Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors Gene:RFM1(YOR279C)|FD-Score:5.24|P-value:7.96E-8||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:RPS28B(YLR264W)|FD-Score:3.89|P-value:5.05E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication Gene:SLM3(YDL033C)|FD-Score:4.41|P-value:5.15E-6||SGD DESC:tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) Gene:SOH1(YGL127C)|FD-Score:3.27|P-value:5.35E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:SPS100(YHR139C)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SSE1(YPL106C)|FD-Score:-3.14|P-value:8.51E-4||SGD DESC:ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication Gene:STB5(YHR178W)|FD-Score:4.84|P-value:6.61E-7||SGD DESC:Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gene:THI72(YOR192C)|FD-Score:3.78|P-value:7.78E-5||SGD DESC:Transporter of thiamine or related compound; shares sequence similarity with Thi7p Gene:TSC3(YBR058C-A)|FD-Score:11.5|P-value:6.59E-31||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBX5(YDR330W)|FD-Score:-4.09|P-value:2.19E-5||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p Gene:YBL062W(YBL062W_d)|FD-Score:3.16|P-value:7.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR049C(YCR049C_d)|FD-Score:5.41|P-value:3.16E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR220C(YDR220C_d)|FD-Score:-3.82|P-value:6.75E-5||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YGL149W(YGL149W_d)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Gene:YGL199C(YGL199C_d)|FD-Score:-3.74|P-value:9.11E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W Gene:YGR153W(YGR153W_p)|FD-Score:-5.92|P-value:1.56E-9||SGD DESC:Putative protein of unknown function Gene:YHR130C(YHR130C_d)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL077W-B(YJL077W-B_p)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YJL120W(YJL120W_d)|FD-Score:3.13|P-value:8.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Gene:YKE2(YLR200W)|FD-Score:4.32|P-value:7.80E-6||SGD DESC:Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin Gene:YLR296W(YLR296W_d)|FD-Score:4.26|P-value:1.04E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR122C(YMR122C_d)|FD-Score:3.22|P-value:6.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR277C(YOR277C_d)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPK3(YBR028C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner Gene:YPR195C(YPR195C_d)|FD-Score:-4.16|P-value:1.57E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YVC1(YOR087W)|FD-Score:-3.2|P-value:6.91E-4||SGD DESC:Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL188W5.442.67E-81.22KAR1Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YOR116C4.221.22E-50.14RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YMR239C4.082.30E-50.10RNT1Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
YAL001C3.983.45E-50.06TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YMR146C3.924.48E-50.11TIF34eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation
YCL052C3.807.12E-50.06PBN1Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
YJR067C3.758.89E-50.02YAE1Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
YOL010W3.739.63E-50.19RCL1Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
YJR007W3.542.00E-40.09SUI2Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
YDL031W3.452.76E-40.20DBP10Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YDL055C3.255.78E-40.06PSA1GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YGL245W3.197.05E-40.05GUS1Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
YLR310C3.148.40E-40.12CDC25Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
YKL172W3.020.001260.01EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YJL111W3.010.001300.01CCT7Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR058C-A11.506.59E-31TSC3Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YBR290W6.153.89E-10BSD2Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
YLR131C6.124.73E-10ACE2Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
YCR049C_d5.413.16E-8YCR049C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR279C5.247.96E-8RFM1DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YHR178W4.846.61E-7STB5Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
YKL061W_p4.681.46E-6BLI1_pPutative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
YJL110C4.503.35E-6GZF3GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
YJR055W4.474.00E-6HIT1Protein of unknown function, required for growth at high temperature
YDL033C4.415.15E-6SLM3tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
YLR200W4.327.80E-6YKE2Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
YLR296W_d4.261.04E-5YLR296W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL031C4.251.09E-5GIP4Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate
YGR078C4.171.54E-5PAC10Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YDR378C4.102.07E-5LSM6Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA

GO enrichment analysis for SGTC_752
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2732.95E-101SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.103896TSC3-RPN4
0.2691.59E-98SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.0967742TSC3-RPN4
0.2603.80E-92SGTC_8850865-0106 16.8 μMChemDiv (Drug-like library)27933800.0819672TSC3-RPN4
0.2607.34E-92SGTC_18584-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 μMTimTec (Natural product derivative library)7563770.0985916TSC3-RPN4
0.2505.70E-85SGTC_520329-0193 875.0 nMChemDiv (Drug-like library)37392920.106061TSC3-RPN4
0.2495.01E-84SGTC_1604st002052 72.4 μMTimTec (Natural product derivative library)62548340.147541TSC3-RPN4
0.2398.22E-78SGTC_12991079-1439 3.7 μMChemDiv (Drug-like library)3231610.0704225TSC3-RPN4
0.2361.30E-75SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.129032TSC3-RPN4
0.2358.42E-75SGTC_1662st014054 52.0 μMTimTec (Natural product derivative library)28387770.113924TSC3-RPN4
0.2331.37E-73SGTC_8971000-0139 31.4 μMChemDiv (Drug-like library)61510200.169492
0.2225.97E-67SGTC_320928-0142 34.1 μMChemDiv (Drug-like library)22442420.117647TSC3-RPN4
0.2112.81E-60SGTC_1919st067113 52.3 μMTimTec (Natural product derivative library)12682430.1TSC3-RPN4
0.2072.00E-58SGTC_33179138495 8.8 μMChembridge (Drug-like library)170201390.106667
0.2061.60E-57SGTC_22186965428 193.0 μMChembridge (Fragment library)6756840.112903TSC3-RPN4
0.2056.92E-57SGTC_20905301565 104.4 μMChembridge (Fragment library)20563440.131148TSC3-RPN4

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1651st01192886.1 μM0.358491720198TimTec (Natural product derivative library)232.258421.77414RSC complex & mRNA processing
SGTC_1652st01193278 μM0.3448281551076TimTec (Natural product derivative library)245.230742.10905RSC complex & mRNA processing
SGTC_510ag-490170 μM0.3220345328779ICCB bioactive library294.304662.44434
SGTC_462ag-879158 μM0.3148156809654ICCB bioactive library316.460963.88224
SGTC_8710574-0004149 μM0.3050859551173ChemDiv (Drug-like library)306.315363.83514
SGTC_6710560-0003407 μM0.2586213238678ChemDiv (Drug-like library)267.328981.50115
SGTC_503tyrphostin 8294 μM0.25531992970ICCB bioactive library170.167441.77313TSC3-RPN4
SGTC_1985st07138265.5 μM0.2459026123237TimTec (Natural product derivative library)305.325762.66906
SGTC_20965468907200 μM0.241379759785Chembridge (Fragment library)236.293480.44925
SGTC_2042p-Dimethylaminoacetophenone200 μM0.21276675037Chembridge (Fragment library)163.216321.73202