Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL143W | 5.75 | 4.49E-9 | 0.53 | CCT4 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YLR197W | 5.30 | 5.80E-8 | 0.53 | NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
YDL016C_d | 5.21 | 9.21E-8 | 0.53 | YDL016C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication |
YGL092W | 4.89 | 5.05E-7 | 0.53 | NUP145 | Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 |
YGR073C_d | 4.82 | 7.05E-7 | 0.53 | YGR073C_d | Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein |
YMR301C | 4.69 | 1.35E-6 | 0.53 | ATM1 | Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol |
YGL225W | 4.33 | 7.37E-6 | 0.53 | VRG4 | Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi |
YOR210W | 4.00 | 3.20E-5 | 0.53 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YDR243C | 3.80 | 7.37E-5 | 0.53 | PRP28 | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
YPL012W | 3.74 | 9.36E-5 | 0.53 | RRP12 | Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats |
YDR302W | 3.61 | 1.53E-4 | 0.53 | GPI11 | ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog |
YPR016C | 3.59 | 1.66E-4 | 0.53 | TIF6 | Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits |
YKL111C_d | 3.06 | 0.00112 | 0.11 | YKL111C_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 |
YDL208W | 2.95 | 0.00161 | 0.09 | NHP2 | Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing |
YPL143W | 2.86 | 0.00215 | 0.00 | RPL33A | Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication |