0568-0725

2,4-dichloro-N-(2,4-dichloro-6-nitrophenyl)benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_760
Screen concentration 82.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 3916171
SMILES C1=CC(=C(C=C1Cl)Cl)C(=O)NC2=C(C=C(C=C2[N+](=O)[O-])Cl)Cl
Standardized SMILES [O-][N+](=O)c1cc(Cl)cc(Cl)c1NC(=O)c2ccc(Cl)cc2Cl
Molecular weight 380.0103
ALogP 5.17
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.41
% growth inhibition (Hom. pool) 3.33


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3916171
Download HIP data (tab-delimited text)  (excel)
Gene:GPI10(YGL142C)|FD-Score:-3.2|P-value:6.95E-4|Clearance:0||SGD DESC:Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog Gene:KAR1(YNL188W)|FD-Score:3.37|P-value:3.70E-4|Clearance:0.18||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:MCD4(YKL165C)|FD-Score:-4.06|P-value:2.48E-5|Clearance:0||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:NOC2(YOR206W)|FD-Score:3.5|P-value:2.32E-4|Clearance:0.18||SGD DESC:Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Gene:PRE6(YOL038W)|FD-Score:-3.72|P-value:1.01E-4|Clearance:0||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:PTA1(YAL043C)|FD-Score:-3.93|P-value:4.28E-5|Clearance:0||SGD DESC:Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII Gene:RPL17A(YKL180W)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.18||SGD DESC:Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RRB1(YMR131C)|FD-Score:3.27|P-value:5.35E-4|Clearance:0.18||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:RRN7(YJL025W)|FD-Score:-3.12|P-value:9.11E-4|Clearance:0||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:SCM3(YDL139C)|FD-Score:3.83|P-value:6.45E-5|Clearance:0.18||SGD DESC:Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP Gene:SUA5(YGL169W)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.18||SGD DESC:Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family Gene:TCP1(YDR212W)|FD-Score:3.59|P-value:1.67E-4|Clearance:0.18||SGD DESC:Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein Gene:YIF1(YNL263C)|FD-Score:-3.24|P-value:5.95E-4|Clearance:0||SGD DESC:Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 Gene:GPI10(YGL142C)|FD-Score:-3.2|P-value:6.95E-4|Clearance:0||SGD DESC:Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog Gene:KAR1(YNL188W)|FD-Score:3.37|P-value:3.70E-4|Clearance:0.18||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:MCD4(YKL165C)|FD-Score:-4.06|P-value:2.48E-5|Clearance:0||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:NOC2(YOR206W)|FD-Score:3.5|P-value:2.32E-4|Clearance:0.18||SGD DESC:Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Gene:PRE6(YOL038W)|FD-Score:-3.72|P-value:1.01E-4|Clearance:0||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:PTA1(YAL043C)|FD-Score:-3.93|P-value:4.28E-5|Clearance:0||SGD DESC:Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII Gene:RPL17A(YKL180W)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.18||SGD DESC:Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RRB1(YMR131C)|FD-Score:3.27|P-value:5.35E-4|Clearance:0.18||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:RRN7(YJL025W)|FD-Score:-3.12|P-value:9.11E-4|Clearance:0||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:SCM3(YDL139C)|FD-Score:3.83|P-value:6.45E-5|Clearance:0.18||SGD DESC:Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP Gene:SUA5(YGL169W)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.18||SGD DESC:Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family Gene:TCP1(YDR212W)|FD-Score:3.59|P-value:1.67E-4|Clearance:0.18||SGD DESC:Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein Gene:YIF1(YNL263C)|FD-Score:-3.24|P-value:5.95E-4|Clearance:0||SGD DESC:Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3916171
Download HOP data (tab-delimited text)  (excel)
Gene:ADE8(YDR408C)|FD-Score:3.88|P-value:5.18E-5||SGD DESC:Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:AIM46(YHR199C)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APD1(YBR151W)|FD-Score:-3.1|P-value:9.67E-4||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ATP14(YLR295C)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress Gene:CMC4(YMR194C-B)|FD-Score:-3.19|P-value:7.13E-4||SGD DESC:Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs Gene:CTF4(YPR135W)|FD-Score:-4.71|P-value:1.26E-6||SGD DESC:Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Gene:CUR1(YPR158W)|FD-Score:-4.27|P-value:9.88E-6||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DOS2(YDR068W)|FD-Score:3.16|P-value:7.80E-4||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:DPH6(YLR143W_p)|FD-Score:4.73|P-value:1.12E-6||SGD DESC:Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene Gene:ECM33(YBR078W)|FD-Score:-5.06|P-value:2.07E-7||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ERF2(YLR246W)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole Gene:FKS1(YLR342W)|FD-Score:3.19|P-value:7.20E-4||SGD DESC:Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling Gene:FLO10(YKR102W)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth Gene:GYP1(YOR070C)|FD-Score:3.73|P-value:9.42E-5||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HOR2(YER062C)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication Gene:HTB2(YBL002W)|FD-Score:4.6|P-value:2.16E-6||SGD DESC:Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation Gene:HXT1(YHR094C)|FD-Score:-3.91|P-value:4.57E-5||SGD DESC:Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication Gene:KAP123(YER110C)|FD-Score:5.16|P-value:1.21E-7||SGD DESC:Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 Gene:MDV1(YJL112W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MGM101(YJR144W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MRPL37(YBR268W)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NQM1(YGR043C)|FD-Score:4.23|P-value:1.19E-5||SGD DESC:Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift Gene:PCK1(YKR097W)|FD-Score:4.36|P-value:6.36E-6||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PHM6(YDR281C)|FD-Score:3.09|P-value:9.98E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PHO87(YCR037C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:POP2(YNR052C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRM10(YJL108C)|FD-Score:4.09|P-value:2.19E-5||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:ROD1(YOR018W)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RPS6A(YPL090C)|FD-Score:-3.17|P-value:7.57E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:RRG7(YOR305W)|FD-Score:-3.21|P-value:6.64E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene Gene:SNU66(YOR308C)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 Gene:SPE2(YOL052C)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically Gene:SRO77(YBL106C)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SSP120(YLR250W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:STO1(YMR125W)|FD-Score:3.27|P-value:5.41E-4||SGD DESC:Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 Gene:UBA3(YPR066W)|FD-Score:3.92|P-value:4.39E-5||SGD DESC:Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:UBC12(YLR306W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Gene:VPS65(YLR322W_d)|FD-Score:3.35|P-value:4.07E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Gene:YAF9(YNL107W)|FD-Score:-4.07|P-value:2.40E-5||SGD DESC:Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain Gene:YBL039W-B(YBL039W-B_p)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:Putative protein of unknown function Gene:YBR138C(YBR138C_p)|FD-Score:-3.97|P-value:3.58E-5||SGD DESC:Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene Gene:YDR042C(YDR042C_p)|FD-Score:4.09|P-value:2.15E-5||SGD DESC:Putative protein of unknown function; expression is increased in ssu72-ts69 mutant Gene:YDR222W(YDR222W_p)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YHL008C(YHL008C_p)|FD-Score:-3.9|P-value:4.80E-5||SGD DESC:Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YLR285C-A(YLR285C-A_p)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR342W-A(YLR342W-A_p)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Putative protein of unknown function Gene:YLR366W(YLR366W_d)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Gene:YLR428C(YLR428C_d)|FD-Score:4.33|P-value:7.47E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YMR252C(YMR252C_p)|FD-Score:3.81|P-value:6.86E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene Gene:YNL109W(YNL109W_d)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C Gene:YNL228W(YNL228W_d)|FD-Score:4.75|P-value:1.04E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YNR029C(YNR029C_p)|FD-Score:-3.53|P-value:2.09E-4||SGD DESC:Putative protein of unknown function, deletion confers reduced fitness in saline Gene:YPT31(YER031C)|FD-Score:-3.61|P-value:1.53E-4||SGD DESC:Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication Gene:ADE8(YDR408C)|FD-Score:3.88|P-value:5.18E-5||SGD DESC:Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:AIM46(YHR199C)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APD1(YBR151W)|FD-Score:-3.1|P-value:9.67E-4||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ATP14(YLR295C)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress Gene:CMC4(YMR194C-B)|FD-Score:-3.19|P-value:7.13E-4||SGD DESC:Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs Gene:CTF4(YPR135W)|FD-Score:-4.71|P-value:1.26E-6||SGD DESC:Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Gene:CUR1(YPR158W)|FD-Score:-4.27|P-value:9.88E-6||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DOS2(YDR068W)|FD-Score:3.16|P-value:7.80E-4||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:DPH6(YLR143W_p)|FD-Score:4.73|P-value:1.12E-6||SGD DESC:Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene Gene:ECM33(YBR078W)|FD-Score:-5.06|P-value:2.07E-7||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ERF2(YLR246W)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole Gene:FKS1(YLR342W)|FD-Score:3.19|P-value:7.20E-4||SGD DESC:Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling Gene:FLO10(YKR102W)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth Gene:GYP1(YOR070C)|FD-Score:3.73|P-value:9.42E-5||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HOR2(YER062C)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication Gene:HTB2(YBL002W)|FD-Score:4.6|P-value:2.16E-6||SGD DESC:Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation Gene:HXT1(YHR094C)|FD-Score:-3.91|P-value:4.57E-5||SGD DESC:Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication Gene:KAP123(YER110C)|FD-Score:5.16|P-value:1.21E-7||SGD DESC:Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 Gene:MDV1(YJL112W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MGM101(YJR144W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MRPL37(YBR268W)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NQM1(YGR043C)|FD-Score:4.23|P-value:1.19E-5||SGD DESC:Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift Gene:PCK1(YKR097W)|FD-Score:4.36|P-value:6.36E-6||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PHM6(YDR281C)|FD-Score:3.09|P-value:9.98E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PHO87(YCR037C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:POP2(YNR052C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRM10(YJL108C)|FD-Score:4.09|P-value:2.19E-5||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:ROD1(YOR018W)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RPS6A(YPL090C)|FD-Score:-3.17|P-value:7.57E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:RRG7(YOR305W)|FD-Score:-3.21|P-value:6.64E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene Gene:SNU66(YOR308C)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 Gene:SPE2(YOL052C)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically Gene:SRO77(YBL106C)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SSP120(YLR250W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:STO1(YMR125W)|FD-Score:3.27|P-value:5.41E-4||SGD DESC:Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 Gene:UBA3(YPR066W)|FD-Score:3.92|P-value:4.39E-5||SGD DESC:Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:UBC12(YLR306W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Gene:VPS65(YLR322W_d)|FD-Score:3.35|P-value:4.07E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Gene:YAF9(YNL107W)|FD-Score:-4.07|P-value:2.40E-5||SGD DESC:Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain Gene:YBL039W-B(YBL039W-B_p)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:Putative protein of unknown function Gene:YBR138C(YBR138C_p)|FD-Score:-3.97|P-value:3.58E-5||SGD DESC:Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene Gene:YDR042C(YDR042C_p)|FD-Score:4.09|P-value:2.15E-5||SGD DESC:Putative protein of unknown function; expression is increased in ssu72-ts69 mutant Gene:YDR222W(YDR222W_p)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YHL008C(YHL008C_p)|FD-Score:-3.9|P-value:4.80E-5||SGD DESC:Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YLR285C-A(YLR285C-A_p)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR342W-A(YLR342W-A_p)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Putative protein of unknown function Gene:YLR366W(YLR366W_d)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Gene:YLR428C(YLR428C_d)|FD-Score:4.33|P-value:7.47E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YMR252C(YMR252C_p)|FD-Score:3.81|P-value:6.86E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene Gene:YNL109W(YNL109W_d)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C Gene:YNL228W(YNL228W_d)|FD-Score:4.75|P-value:1.04E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YNR029C(YNR029C_p)|FD-Score:-3.53|P-value:2.09E-4||SGD DESC:Putative protein of unknown function, deletion confers reduced fitness in saline Gene:YPT31(YER031C)|FD-Score:-3.61|P-value:1.53E-4||SGD DESC:Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL139C3.836.45E-50.18SCM3Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP
YGL169W3.711.02E-40.18SUA5Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
YDR212W3.591.67E-40.18TCP1Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
YOR206W3.502.32E-40.18NOC2Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YNL188W3.373.70E-40.18KAR1Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YKL180W3.324.53E-40.18RPL17ARibosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YMR131C3.275.35E-40.18RRB1Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YOL135C3.090.001010.04MED7Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YLR075W3.050.001150.14RPL10Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
YKR004C2.910.001830.11ECM9Non-essential protein of unknown function
YGL201C2.800.002570.02MCM6Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
YDL004W2.780.002710.02ATP16Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YER022W2.760.002870.07SRB4Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
YGL102C_d2.690.003590.01YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YNL126W2.680.003650.02SPC98Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER110C5.161.21E-7KAP123Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YNL228W_d4.751.04E-6YNL228W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
YLR143W_p4.731.12E-6DPH6_pDiphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
YBL002W4.602.16E-6HTB2Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YKR097W4.366.36E-6PCK1Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YLR428C_d4.337.47E-6YLR428C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
YGR043C4.231.19E-5NQM1Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
YDR042C_p4.092.15E-5YDR042C_pPutative protein of unknown function; expression is increased in ssu72-ts69 mutant
YJL108C4.092.19E-5PRM10Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPR066W3.924.39E-5UBA3Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YDR408C3.885.18E-5ADE8Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YLR295C3.875.37E-5ATP14Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress
YMR252C_p3.816.86E-5YMR252C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
YOR070C3.739.42E-5GYP1Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YJR144W3.711.02E-4MGM101Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage

GO enrichment analysis for SGTC_760
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0855.22E-11SGTC_7543474-0146 171.0 μMChemDiv (Drug-like library)247620780.0909091copper-dependent oxidative stress
0.0723.77E-8SGTC_1469k284-2957 126.0 μMChemDiv (Drug-like library)238848410.0779221
0.0706.54E-8SGTC_24655809242 33.2 μMMiscellaneous27317480.0933333
0.0691.30E-7SGTC_30829117008 49.5 μMChembridge (Drug-like library)414485290.125
0.0612.53E-6SGTC_510ag-490 170.0 μMICCB bioactive library53287790.115942
0.0595.51E-6SGTC_5294076-0302 30.3 μMChemDiv (Drug-like library)58165220.0625mitochondrial processes
0.0543.01E-5SGTC_11981612-1005 86.7 μMChemDiv (Drug-like library)69985090.104651
0.0543.73E-5SGTC_700141-0289 43.3 μMChemDiv (Drug-like library)3524080.296296mitochondrial stress
0.0525.97E-5SGTC_761k216-0224 480.0 μMChemDiv (Drug-like library)13404040.114754
0.0501.14E-4SGTC_9093448-9333 149.0 μMChemDiv (Drug-like library)33440740.0666667
0.0491.50E-4SGTC_6751309-0189 238.0 μMChemDiv (Drug-like library)42465300.162162
0.0491.71E-4SGTC_7144296-0578 26.1 μMChemDiv (Drug-like library)15897750.10989
0.0491.90E-4SGTC_508roscovitine 141.0 μMICCB bioactive library1603550.0487805
0.0472.68E-4SGTC_1074carmofur 3.8 μMNIH Clinical Collection25770.0882353exosome
0.0472.76E-4SGTC_23769072922 81.3 μMChembridge (Fragment library)170879680.193548

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3650121-005213.6 μM0.5416673101739ChemDiv (Drug-like library)361.564684.2624mitochondrial response to ROS
SGTC_2872904403725.97 μM0.4255326465195Chembridge (Drug-like library)284.1131234.14912
SGTC_7251497-096319 μM0.423549977ChemDiv (Drug-like library)356.117783.73215copper-dependent oxidative stress
SGTC_2942905277762.25 μM0.46469503Chembridge (Drug-like library)284.1131234.14912
SGTC_2866903424558.44 μM0.3928576462273Chembridge (Drug-like library)331.195984.41212
SGTC_6260214-000933 μM0.3921573437874ChemDiv (Drug-like library)332.225222.29717copper-dependent oxidative stress
SGTC_7051124-0212310 μM0.3921579554485ChemDiv (Drug-like library)293.1484.01212
SGTC_1240136-02177.12 μM0.3833333976905ChemDiv (Drug-like library)476.223245.16417mitochondrial stress
SGTC_21065357045167.29 μM0.377358668842Chembridge (Fragment library)281.13733.01412
SGTC_12510490-5699265 μM0.3653853883818ChemDiv (Drug-like library)301.555783.66612