Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR316C-B_d | 8.20 | 1.16E-16 | YMR316C-B_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YML123C | 6.85 | 3.73E-12 | PHO84 | High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity |
YDL160C | 5.81 | 3.04E-9 | DHH1 | Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress |
YMR215W | 5.12 | 1.57E-7 | GAS3 | Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation |
YPR054W | 4.98 | 3.20E-7 | SMK1 | Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p |
YMR316W | 4.96 | 3.45E-7 | DIA1 | Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
YBL042C | 4.81 | 7.54E-7 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
YPR072W | 4.69 | 1.39E-6 | NOT5 | Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation |
YGL208W | 4.39 | 5.69E-6 | SIP2 | One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane |
YKR019C | 4.37 | 6.09E-6 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
YKL063C_p | 4.18 | 1.47E-5 | YKL063C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi |
YDL011C_d | 4.04 | 2.68E-5 | YDL011C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W |
YGR154C | 4.03 | 2.76E-5 | GTO1 | Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization |
YLR286C | 4.00 | 3.18E-5 | CTS1 | Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p |
YGR207C | 3.98 | 3.49E-5 | CIR1 | Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response |