Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR010C_d | 9.44 | 1.81E-21 | YDR010C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YBR058C-A | 7.33 | 1.17E-13 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YLR131C | 6.96 | 1.67E-12 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YGL026C | 6.95 | 1.88E-12 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
YCR092C | 6.34 | 1.13E-10 | MSH3 | Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability |
YDR500C | 6.03 | 8.09E-10 | RPL37B | Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication |
YDR354W | 5.96 | 1.23E-9 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YDR126W | 5.73 | 5.02E-9 | SWF1 | Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion |
YLR435W | 5.63 | 9.07E-9 | TSR2 | Protein with a potential role in pre-rRNA processing |
YDL089W | 5.56 | 1.36E-8 | NUR1 | Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate |
YOR323C | 5.50 | 1.88E-8 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
YGR037C | 5.44 | 2.61E-8 | ACB1 | Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress |
YDR207C | 5.34 | 4.63E-8 | UME6 | Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p |
YOL065C | 5.31 | 5.45E-8 | INP54 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins |
YER090W | 5.19 | 1.03E-7 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |