0250-0039

N-[(1E)-3,4,4-trichloro-2-nitro-1-phenylsulfanylbuta-1,3-dienyl]aniline

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_771
Screen concentration 27.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 3005115
SMILES C1=CC=C(C=C1)NC(=C(C(=C(Cl)Cl)Cl)[N+](=O)[O-])SC2=CC=CC=C2
Standardized SMILES [O-][N+](=O)C(=C(Nc1ccccc1)Sc2ccccc2)C(=C(Cl)Cl)Cl
Molecular weight 401.6947
ALogP 5.84
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 15.12
% growth inhibition (Hom. pool) 7.48


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3005115
Download HIP data (tab-delimited text)  (excel)
Gene:ARP2(YDL029W)|FD-Score:3.46|P-value:2.74E-4|Clearance:0.06||SGD DESC:Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Gene:CDC123(YLR215C)|FD-Score:3.88|P-value:5.21E-5|Clearance:0.17||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:GRS1(YBR121C)|FD-Score:3.86|P-value:5.76E-5|Clearance:0.17||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:HEM15(YOR176W)|FD-Score:3.77|P-value:8.05E-5|Clearance:0.17||SGD DESC:Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway Gene:IRR1(YIL026C)|FD-Score:3.23|P-value:6.12E-4|Clearance:0.13||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:NUP159(YIL115C)|FD-Score:-3.71|P-value:1.05E-4|Clearance:0||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) Gene:OST2(YOR103C)|FD-Score:3.26|P-value:5.53E-4|Clearance:0.03||SGD DESC:Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PRP2(YNR011C)|FD-Score:3.11|P-value:9.49E-4|Clearance:0.02||SGD DESC:RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 Gene:SEC23(YPR181C)|FD-Score:-3.58|P-value:1.70E-4|Clearance:0||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:UBA2(YDR390C)|FD-Score:3.39|P-value:3.43E-4|Clearance:0.13||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:YTM1(YOR272W)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.14||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats Gene:ARP2(YDL029W)|FD-Score:3.46|P-value:2.74E-4|Clearance:0.06||SGD DESC:Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Gene:CDC123(YLR215C)|FD-Score:3.88|P-value:5.21E-5|Clearance:0.17||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:GRS1(YBR121C)|FD-Score:3.86|P-value:5.76E-5|Clearance:0.17||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:HEM15(YOR176W)|FD-Score:3.77|P-value:8.05E-5|Clearance:0.17||SGD DESC:Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway Gene:IRR1(YIL026C)|FD-Score:3.23|P-value:6.12E-4|Clearance:0.13||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:NUP159(YIL115C)|FD-Score:-3.71|P-value:1.05E-4|Clearance:0||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) Gene:OST2(YOR103C)|FD-Score:3.26|P-value:5.53E-4|Clearance:0.03||SGD DESC:Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PRP2(YNR011C)|FD-Score:3.11|P-value:9.49E-4|Clearance:0.02||SGD DESC:RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 Gene:SEC23(YPR181C)|FD-Score:-3.58|P-value:1.70E-4|Clearance:0||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:UBA2(YDR390C)|FD-Score:3.39|P-value:3.43E-4|Clearance:0.13||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:YTM1(YOR272W)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.14||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3005115
Download HOP data (tab-delimited text)  (excel)
Gene:APD1(YBR151W)|FD-Score:3.79|P-value:7.63E-5||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:APL2(YKL135C)|FD-Score:4.44|P-value:4.44E-6||SGD DESC:Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Gene:BMH2(YDR099W)|FD-Score:4.57|P-value:2.41E-6||SGD DESC:14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:CKA1(YIL035C)|FD-Score:3.38|P-value:3.65E-4||SGD DESC:Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching Gene:DAL81(YIR023W)|FD-Score:-3.2|P-value:6.93E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DEF1(YKL054C)|FD-Score:3.99|P-value:3.26E-5||SGD DESC:RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis Gene:DPL1(YDR294C)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate Gene:ECM22(YLR228C)|FD-Score:-3.23|P-value:6.24E-4||SGD DESC:Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication Gene:FRE1(YLR214W)|FD-Score:-4.45|P-value:4.30E-6||SGD DESC:Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels Gene:HTZ1(YOL012C)|FD-Score:5.93|P-value:1.53E-9||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:HUL5(YGL141W)|FD-Score:-3.34|P-value:4.20E-4||SGD DESC:Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD Gene:ICE2(YIL090W)|FD-Score:3.16|P-value:7.97E-4||SGD DESC:Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells Gene:ICL2(YPR006C)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:IME2(YJL106W)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Gene:INM2(YDR287W)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy Gene:JJJ3(YJR097W)|FD-Score:-4.63|P-value:1.87E-6||SGD DESC:Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 Gene:KIN4(YOR233W)|FD-Score:4.02|P-value:2.96E-5||SGD DESC:Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication Gene:MRPL37(YBR268W)|FD-Score:3.82|P-value:6.58E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS8(YMR158W)|FD-Score:4.37|P-value:6.11E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTO1(YGL236C)|FD-Score:3.94|P-value:4.07E-5||SGD DESC:Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants Gene:NQM1(YGR043C)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift Gene:NUP2(YLR335W)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PBA1(YLR199C)|FD-Score:-3.44|P-value:2.86E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PET117(YER058W)|FD-Score:-3.8|P-value:7.10E-5||SGD DESC:Protein required for assembly of cytochrome c oxidase Gene:PMT5(YDL093W)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:POL32(YJR043C)|FD-Score:7.94|P-value:1.01E-15||SGD DESC:Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p Gene:PPN1(YDR452W)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PRO2(YOR323C)|FD-Score:12.3|P-value:7.41E-35||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RAD4(YER162C)|FD-Score:5.34|P-value:4.61E-8||SGD DESC:Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins Gene:RPN4(YDL020C)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RPS4A(YJR145C)|FD-Score:-3.28|P-value:5.12E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication Gene:SEC22(YLR268W)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SHE9(YDR393W)|FD-Score:4.01|P-value:3.05E-5||SGD DESC:Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex Gene:SPG1(YGR236C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SWF1(YDR126W)|FD-Score:7.47|P-value:3.91E-14||SGD DESC:Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion Gene:TAT1(YBR069C)|FD-Score:-5.11|P-value:1.58E-7||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TOM70(YNL121C)|FD-Score:4.5|P-value:3.46E-6||SGD DESC:Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication Gene:TSC3(YBR058C-A)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBX2(YML013W)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:VMA9(YCL005W-A)|FD-Score:-3.17|P-value:7.66E-4||SGD DESC:Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis Gene:YDR034W-B(YDR034W-B_p)|FD-Score:-4.59|P-value:2.27E-6||SGD DESC:Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YDR169C-A(YDR169C-A_p)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR199W(YDR199W_d)|FD-Score:3.12|P-value:9.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.85|P-value:5.99E-5||SGD DESC:Putative protein of unknown function Gene:YGR054W(YGR054W)|FD-Score:-3.12|P-value:9.13E-4||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-4.12|P-value:1.93E-5||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YHR050W-A(YHR050W-A_p)|FD-Score:3.1|P-value:9.56E-4||SGD DESC:Protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR012C(YLR012C_p)|FD-Score:-3.69|P-value:1.10E-4||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YML094C-A(YML094C-A_d)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Gene:YMR141C(YMR141C_d)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR014W(YNR014W_p)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication Gene:YNR048W(YNR048W)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication Gene:YOR228C(YOR228C)|FD-Score:3.9|P-value:4.88E-5||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPK1(YKL126W)|FD-Score:6.77|P-value:6.40E-12||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR150W(YPR150W_d)|FD-Score:-3.21|P-value:6.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Gene:YPR174C(YPR174C_p)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication Gene:APD1(YBR151W)|FD-Score:3.79|P-value:7.63E-5||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:APL2(YKL135C)|FD-Score:4.44|P-value:4.44E-6||SGD DESC:Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Gene:BMH2(YDR099W)|FD-Score:4.57|P-value:2.41E-6||SGD DESC:14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:CKA1(YIL035C)|FD-Score:3.38|P-value:3.65E-4||SGD DESC:Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching Gene:DAL81(YIR023W)|FD-Score:-3.2|P-value:6.93E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DEF1(YKL054C)|FD-Score:3.99|P-value:3.26E-5||SGD DESC:RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis Gene:DPL1(YDR294C)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate Gene:ECM22(YLR228C)|FD-Score:-3.23|P-value:6.24E-4||SGD DESC:Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication Gene:FRE1(YLR214W)|FD-Score:-4.45|P-value:4.30E-6||SGD DESC:Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels Gene:HTZ1(YOL012C)|FD-Score:5.93|P-value:1.53E-9||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:HUL5(YGL141W)|FD-Score:-3.34|P-value:4.20E-4||SGD DESC:Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD Gene:ICE2(YIL090W)|FD-Score:3.16|P-value:7.97E-4||SGD DESC:Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells Gene:ICL2(YPR006C)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:IME2(YJL106W)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Gene:INM2(YDR287W)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy Gene:JJJ3(YJR097W)|FD-Score:-4.63|P-value:1.87E-6||SGD DESC:Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 Gene:KIN4(YOR233W)|FD-Score:4.02|P-value:2.96E-5||SGD DESC:Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication Gene:MRPL37(YBR268W)|FD-Score:3.82|P-value:6.58E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS8(YMR158W)|FD-Score:4.37|P-value:6.11E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTO1(YGL236C)|FD-Score:3.94|P-value:4.07E-5||SGD DESC:Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants Gene:NQM1(YGR043C)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift Gene:NUP2(YLR335W)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PBA1(YLR199C)|FD-Score:-3.44|P-value:2.86E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PET117(YER058W)|FD-Score:-3.8|P-value:7.10E-5||SGD DESC:Protein required for assembly of cytochrome c oxidase Gene:PMT5(YDL093W)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:POL32(YJR043C)|FD-Score:7.94|P-value:1.01E-15||SGD DESC:Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p Gene:PPN1(YDR452W)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PRO2(YOR323C)|FD-Score:12.3|P-value:7.41E-35||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RAD4(YER162C)|FD-Score:5.34|P-value:4.61E-8||SGD DESC:Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins Gene:RPN4(YDL020C)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RPS4A(YJR145C)|FD-Score:-3.28|P-value:5.12E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication Gene:SEC22(YLR268W)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SHE9(YDR393W)|FD-Score:4.01|P-value:3.05E-5||SGD DESC:Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex Gene:SPG1(YGR236C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SWF1(YDR126W)|FD-Score:7.47|P-value:3.91E-14||SGD DESC:Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion Gene:TAT1(YBR069C)|FD-Score:-5.11|P-value:1.58E-7||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TOM70(YNL121C)|FD-Score:4.5|P-value:3.46E-6||SGD DESC:Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication Gene:TSC3(YBR058C-A)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBX2(YML013W)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:VMA9(YCL005W-A)|FD-Score:-3.17|P-value:7.66E-4||SGD DESC:Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis Gene:YDR034W-B(YDR034W-B_p)|FD-Score:-4.59|P-value:2.27E-6||SGD DESC:Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YDR169C-A(YDR169C-A_p)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR199W(YDR199W_d)|FD-Score:3.12|P-value:9.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.85|P-value:5.99E-5||SGD DESC:Putative protein of unknown function Gene:YGR054W(YGR054W)|FD-Score:-3.12|P-value:9.13E-4||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-4.12|P-value:1.93E-5||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YHR050W-A(YHR050W-A_p)|FD-Score:3.1|P-value:9.56E-4||SGD DESC:Protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR012C(YLR012C_p)|FD-Score:-3.69|P-value:1.10E-4||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YML094C-A(YML094C-A_d)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Gene:YMR141C(YMR141C_d)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR014W(YNR014W_p)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication Gene:YNR048W(YNR048W)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication Gene:YOR228C(YOR228C)|FD-Score:3.9|P-value:4.88E-5||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPK1(YKL126W)|FD-Score:6.77|P-value:6.40E-12||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR150W(YPR150W_d)|FD-Score:-3.21|P-value:6.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Gene:YPR174C(YPR174C_p)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR215C3.885.21E-50.17CDC123Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YBR121C3.865.76E-50.17GRS1Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
YOR176W3.778.05E-50.17HEM15Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YOR272W3.601.60E-40.14YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YDL029W3.462.74E-40.06ARP2Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YDR390C3.393.43E-40.13UBA2Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YOR103C3.265.53E-40.03OST2Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YIL026C3.236.12E-40.13IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YNR011C3.119.49E-40.02PRP2RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
YGL102C_d3.080.001030.07YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YBR154C3.020.001280.03RPB5RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YNL062C2.980.001420.11GCD10Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YHR019C2.880.002010.03DED81Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YLR026C2.850.002190.10SED5cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YGR246C2.750.003020.11BRF1TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR323C12.307.41E-35PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YJR043C7.941.01E-15POL32Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YDR126W7.473.91E-14SWF1Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
YKL126W6.776.40E-12YPK1Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
YOL012C5.931.53E-9HTZ1Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YER162C5.344.61E-8RAD4Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
YDR099W4.572.41E-6BMH214-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
YNL121C4.503.46E-6TOM70Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication
YKL135C4.444.44E-6APL2Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
YMR158W4.376.11E-6MRPS8Mitochondrial ribosomal protein of the small subunit
YOR233W4.022.96E-5KIN4Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
YDR393W4.013.05E-5SHE9Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
YKL054C3.993.26E-5DEF1RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
YGL236C3.944.07E-5MTO1Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YOR228C3.904.88E-5YOR228CProtein of unknown function, localized to the mitochondrial outer membrane

GO enrichment analysis for SGTC_771
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1734.70E-41SGTC_2405ticlatone 3.5 μMMiscellaneous62580.0892857
0.1701.91E-39SGTC_20345197015 53.1 μMChembridge (Fragment library)7806760.142857SWF1 & branched chain AA biosynthesis
0.1673.37E-38SGTC_20435101342 149.0 μMChembridge (Fragment library)6784510.0461538SWF1 & branched chain AA biosynthesis
0.1653.22E-37SGTC_575k072-0246 11.9 μMChemDiv (Drug-like library)67967790.106667
0.1653.94E-37SGTC_1696st025591 34.8 μMTimTec (Natural product derivative library)27871470.206349SWF1 & branched chain AA biosynthesis
0.1627.22E-36SGTC_772k072-0172 35.3 μMChemDiv (Drug-like library)58619800.0857143
0.1561.73E-33SGTC_31059121040 49.5 μMChembridge (Drug-like library)414489070.153846
0.1441.46E-28SGTC_8420271-0008 11.1 μMChemDiv (Drug-like library)12217090.125heme biosynthesis & mitochondrial translocase
0.1426.61E-28SGTC_1973st070275 50.2 μMTimTec (Natural product derivative library)171183340.0869565
0.1411.03E-27SGTC_14224031-0024 15.5 μMChemDiv (Drug-like library)7824270.15625iron homeostasis
0.1345.04E-25SGTC_1464k208-0027 110.0 μMChemDiv (Drug-like library)X14640.108434
0.1301.15E-23SGTC_21125488546 200.0 μMChembridge (Fragment library)6007570.0163934TSC3-RPN4
0.1271.37E-22SGTC_23447990960 77.0 μMChembridge (Fragment library)1408130.137255
0.1271.57E-22SGTC_340469-0683 81.8 μMChemDiv (Drug-like library)36909230.16129SWF1 & branched chain AA biosynthesis
0.1223.68E-21SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.0307692TSC3-RPN4

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_850868-0259160.06 μM0.30769283173ChemDiv (Drug-like library)256.256682.5431360S ribosome export
SGTC_1764st04450293.5 μM0.2978728407TimTec (Natural product derivative library)214.223.27413
SGTC_13281441-002569.2 μM0.2807024562601ChemDiv (Drug-like library)287.270722.2724
SGTC_230213-001140 μM0.28627608ChemDiv (Drug-like library)304.215123.06317copper-dependent oxidative stress
SGTC_12971068-011114.1 μM0.272727767057ChemDiv (Drug-like library)312.214244.33712
SGTC_12650819-100168.8 μM0.2678573106768ChemDiv (Drug-like library)351.53013.17326
SGTC_410478-063282.64 μM0.2641513750424ChemDiv (Drug-like library)229.234642.52724
SGTC_13621611-0397101 μM0.25490227816ChemDiv (Drug-like library)227.258523.65612
SGTC_23175986382200 μM0.254902877883Chembridge (Fragment library)229.27442.07913
SGTC_6260214-000933 μM0.2456143437874ChemDiv (Drug-like library)332.225222.29717copper-dependent oxidative stress