| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOR323C | 12.30 | 7.41E-35 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
| YJR043C | 7.94 | 1.01E-15 | POL32 | Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p |
| YDR126W | 7.47 | 3.91E-14 | SWF1 | Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion |
| YKL126W | 6.77 | 6.40E-12 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
| YOL012C | 5.93 | 1.53E-9 | HTZ1 | Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin |
| YER162C | 5.34 | 4.61E-8 | RAD4 | Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins |
| YDR099W | 4.57 | 2.41E-6 | BMH2 | 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress |
| YNL121C | 4.50 | 3.46E-6 | TOM70 | Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication |
| YKL135C | 4.44 | 4.44E-6 | APL2 | Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress |
| YMR158W | 4.37 | 6.11E-6 | MRPS8 | Mitochondrial ribosomal protein of the small subunit |
| YOR233W | 4.02 | 2.96E-5 | KIN4 | Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication |
| YDR393W | 4.01 | 3.05E-5 | SHE9 | Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex |
| YKL054C | 3.99 | 3.26E-5 | DEF1 | RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis |
| YGL236C | 3.94 | 4.07E-5 | MTO1 | Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants |
| YOR228C | 3.90 | 4.88E-5 | YOR228C | Protein of unknown function, localized to the mitochondrial outer membrane |
