0083-0095

2-[(3-bromo-4-hydroxy-5-methylphenyl)-(3-bromo-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzenesulfonate

An indicator and reagent.

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_782
Screen concentration 30.5 μM
Source ChemDiv (Drug-like library)
PubChem CID 3591729
SMILES CC1=CC(=C(C2=CC=CC=C2S(=O)(=O)[O-])C3=CC(=C(C(=C3)Br)O)C)C=C(C1=O)Br
Standardized SMILES CC1=CC(=C(c2cc(C)c(O)c(Br)c2)c3ccccc3S(=O)(=O)[O-])C=C(Br)C1=O
Molecular weight 539.2138
ALogP 3.22
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.56
% growth inhibition (Hom. pool) 11.49


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3591729
Download HIP data (tab-delimited text)  (excel)
Gene:APC5(YOR249C)|FD-Score:3.21|P-value:6.57E-4|Clearance:0.01||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress Gene:BBP1(YPL255W)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.09||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:IRA1(YBR140C)|FD-Score:-3.29|P-value:5.10E-4|Clearance:0||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication Gene:NOP15(YNL110C)|FD-Score:5.49|P-value:1.97E-8|Clearance:1.1||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:NOP53(YPL146C)|FD-Score:3.17|P-value:7.66E-4|Clearance:0.05||SGD DESC:Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired Gene:PDS5(YMR076C)|FD-Score:3.12|P-value:9.19E-4|Clearance:0.03||SGD DESC:Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis Gene:POP3(YNL282W)|FD-Score:4.4|P-value:5.40E-6|Clearance:1.1||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RRP45(YDR280W)|FD-Score:3.18|P-value:7.43E-4|Clearance:0.01||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:TIF6(YPR016C)|FD-Score:6.02|P-value:8.74E-10|Clearance:1.1||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:TOM22(YNL131W)|FD-Score:3.2|P-value:6.88E-4|Clearance:0.02||SGD DESC:Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes Gene:APC5(YOR249C)|FD-Score:3.21|P-value:6.57E-4|Clearance:0.01||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress Gene:BBP1(YPL255W)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.09||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:IRA1(YBR140C)|FD-Score:-3.29|P-value:5.10E-4|Clearance:0||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication Gene:NOP15(YNL110C)|FD-Score:5.49|P-value:1.97E-8|Clearance:1.1||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:NOP53(YPL146C)|FD-Score:3.17|P-value:7.66E-4|Clearance:0.05||SGD DESC:Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired Gene:PDS5(YMR076C)|FD-Score:3.12|P-value:9.19E-4|Clearance:0.03||SGD DESC:Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis Gene:POP3(YNL282W)|FD-Score:4.4|P-value:5.40E-6|Clearance:1.1||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RRP45(YDR280W)|FD-Score:3.18|P-value:7.43E-4|Clearance:0.01||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:TIF6(YPR016C)|FD-Score:6.02|P-value:8.74E-10|Clearance:1.1||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:TOM22(YNL131W)|FD-Score:3.2|P-value:6.88E-4|Clearance:0.02||SGD DESC:Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3591729
Download HOP data (tab-delimited text)  (excel)
Gene:ADE3(YGR204W)|FD-Score:5.18|P-value:1.11E-7||SGD DESC:Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine Gene:ADE4(YMR300C)|FD-Score:3.1|P-value:9.81E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ADE6(YGR061C)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ADK1(YDR226W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress Gene:ALD2(YMR170C)|FD-Score:-3.19|P-value:7.08E-4||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p Gene:BDH2(YAL061W_p)|FD-Score:-5.86|P-value:2.38E-9||SGD DESC:Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 Gene:BFR1(YOR198C)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:CAR1(YPL111W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:CSM4(YPL200W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Gene:DAL82(YNL314W)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain Gene:DSS1(YMR287C)|FD-Score:3.13|P-value:8.77E-4||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:FYV1(YDR024W_d)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Gene:FYV7(YLR068W)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GAD1(YMR250W)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress Gene:GCN4(YEL009C)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GSY1(YFR015C)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:GSY2(YLR258W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:HER2(YMR293C)|FD-Score:4.07|P-value:2.36E-5||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase Gene:HMI1(YOL095C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HSP150(YJL159W)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication Gene:IMG2(YCR071C)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:INP2(YMR163C)|FD-Score:6.41|P-value:7.40E-11||SGD DESC:Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene Gene:IRS4(YKR019C)|FD-Score:-5.02|P-value:2.60E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:ISY1(YJR050W)|FD-Score:5.21|P-value:9.37E-8||SGD DESC:Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles Gene:KAP120(YPL125W)|FD-Score:4.88|P-value:5.33E-7||SGD DESC:Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p Gene:KCS1(YDR017C)|FD-Score:6.24|P-value:2.20E-10||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance Gene:MCM16(YPR046W)|FD-Score:3.93|P-value:4.21E-5||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MRP10(YDL045W-A)|FD-Score:3.51|P-value:2.27E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs Gene:MRPL24(YMR193W)|FD-Score:3.26|P-value:5.65E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene Gene:MRPL49(YJL096W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL6(YHR147C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL8(YJL063C)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS5(YBR251W)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRT4(YKL009W)|FD-Score:5.51|P-value:1.82E-8||SGD DESC:Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus Gene:MSM1(YGR171C)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p Gene:MST27(YGL051W)|FD-Score:4.3|P-value:8.42E-6||SGD DESC:Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles Gene:MSW1(YDR268W)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:MZM1(YDR493W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog Gene:NIP100(YPL174C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) Gene:PAP2(YOL115W)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p Gene:PAT1(YCR077C)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PAU4(YLR461W)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PET117(YER058W)|FD-Score:3.79|P-value:7.41E-5||SGD DESC:Protein required for assembly of cytochrome c oxidase Gene:PIF1(YML061C)|FD-Score:3.86|P-value:5.65E-5||SGD DESC:DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells Gene:PLP1(YDR183W)|FD-Score:-3.11|P-value:9.24E-4||SGD DESC:Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators Gene:PRM7(YDL039C)|FD-Score:-3.18|P-value:7.35E-4||SGD DESC:Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements Gene:PRY2(YKR013W)|FD-Score:-3.45|P-value:2.81E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PTC6(YCR079W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase Gene:RAD52(YML032C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis Gene:RNH203(YLR154C)|FD-Score:-4.05|P-value:2.54E-5||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:RPA14(YDR156W)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:RNA polymerase I subunit A14 Gene:RPA49(YNL248C)|FD-Score:3.13|P-value:8.84E-4||SGD DESC:RNA polymerase I subunit A49 Gene:RPL19B(YBL027W)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL22A(YLR061W)|FD-Score:5.62|P-value:9.30E-9||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPL31B(YLR406C)|FD-Score:3.82|P-value:6.68E-5||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RPL33B(YOR234C)|FD-Score:4.64|P-value:1.77E-6||SGD DESC:Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication Gene:RPL37B(YDR500C)|FD-Score:3.96|P-value:3.73E-5||SGD DESC:Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication Gene:RPP1A(YDL081C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component Gene:RPS10A(YOR293W)|FD-Score:3.86|P-value:5.76E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication Gene:RSM24(YDR175C)|FD-Score:3.12|P-value:9.09E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SBE2(YDR351W)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SHM2(YLR058C)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis Gene:SLM5(YCR024C)|FD-Score:5.91|P-value:1.76E-9||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SPO75(YLL005C)|FD-Score:-3.46|P-value:2.75E-4||SGD DESC:Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Gene:SPT10(YJL127C)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:SPT21(YMR179W)|FD-Score:3.13|P-value:8.72E-4||SGD DESC:Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress Gene:TGS1(YPL157W)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:TIR3(YIL011W)|FD-Score:-3.66|P-value:1.25E-4||SGD DESC:Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth Gene:TRK1(YJL129C)|FD-Score:3.84|P-value:6.05E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:TRM7(YBR061C)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:TRP2(YER090W)|FD-Score:-4.12|P-value:1.93E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:-6.08|P-value:6.06E-10||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VAC17(YCL063W)|FD-Score:3.74|P-value:9.13E-5||SGD DESC:Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p Gene:VFA1(YER128W)|FD-Score:4.56|P-value:2.59E-6||SGD DESC:Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology Gene:YAP1801(YHR161C)|FD-Score:3.98|P-value:3.47E-5||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication Gene:YBR099C(YBR099C_d)|FD-Score:4.66|P-value:1.59E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Gene:YCL022C(YCL022C_d)|FD-Score:-3.97|P-value:3.59E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Gene:YDR008C(YDR008C_d)|FD-Score:-5.26|P-value:7.26E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER156C(YER156C_p)|FD-Score:5.43|P-value:2.88E-8||SGD DESC:Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.88|P-value:5.16E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR219W(YGR219W_d)|FD-Score:5.65|P-value:8.11E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Gene:YGR250C(YGR250C)|FD-Score:3.13|P-value:8.65E-4||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YJL120W(YJL120W_d)|FD-Score:4.7|P-value:1.30E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Gene:YLR257W(YLR257W_p)|FD-Score:-4.09|P-value:2.15E-5||SGD DESC:Protein of unknown function; protein abundance increases in response to DNA replication stress Gene:YLR264C-A(YLR264C-A_p)|FD-Score:3.56|P-value:1.89E-4||SGD DESC:Putative protein of unknown function Gene:YNL184C(YNL184C_p)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNL228W(YNL228W_d)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YOR072W(YOR072W_d)|FD-Score:6.82|P-value:4.64E-12||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YPT32(YGL210W)|FD-Score:-3.24|P-value:6.06E-4||SGD DESC:Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication Gene:ADE3(YGR204W)|FD-Score:5.18|P-value:1.11E-7||SGD DESC:Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine Gene:ADE4(YMR300C)|FD-Score:3.1|P-value:9.81E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ADE6(YGR061C)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ADK1(YDR226W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress Gene:ALD2(YMR170C)|FD-Score:-3.19|P-value:7.08E-4||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p Gene:BDH2(YAL061W_p)|FD-Score:-5.86|P-value:2.38E-9||SGD DESC:Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 Gene:BFR1(YOR198C)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:CAR1(YPL111W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:CSM4(YPL200W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Gene:DAL82(YNL314W)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain Gene:DSS1(YMR287C)|FD-Score:3.13|P-value:8.77E-4||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:FYV1(YDR024W_d)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Gene:FYV7(YLR068W)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GAD1(YMR250W)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress Gene:GCN4(YEL009C)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GSY1(YFR015C)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:GSY2(YLR258W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:HER2(YMR293C)|FD-Score:4.07|P-value:2.36E-5||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase Gene:HMI1(YOL095C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HSP150(YJL159W)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication Gene:IMG2(YCR071C)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:INP2(YMR163C)|FD-Score:6.41|P-value:7.40E-11||SGD DESC:Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene Gene:IRS4(YKR019C)|FD-Score:-5.02|P-value:2.60E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:ISY1(YJR050W)|FD-Score:5.21|P-value:9.37E-8||SGD DESC:Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles Gene:KAP120(YPL125W)|FD-Score:4.88|P-value:5.33E-7||SGD DESC:Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p Gene:KCS1(YDR017C)|FD-Score:6.24|P-value:2.20E-10||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance Gene:MCM16(YPR046W)|FD-Score:3.93|P-value:4.21E-5||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MRP10(YDL045W-A)|FD-Score:3.51|P-value:2.27E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs Gene:MRPL24(YMR193W)|FD-Score:3.26|P-value:5.65E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene Gene:MRPL49(YJL096W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL6(YHR147C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL8(YJL063C)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS5(YBR251W)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRT4(YKL009W)|FD-Score:5.51|P-value:1.82E-8||SGD DESC:Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus Gene:MSM1(YGR171C)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p Gene:MST27(YGL051W)|FD-Score:4.3|P-value:8.42E-6||SGD DESC:Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles Gene:MSW1(YDR268W)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:MZM1(YDR493W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog Gene:NIP100(YPL174C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) Gene:PAP2(YOL115W)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p Gene:PAT1(YCR077C)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PAU4(YLR461W)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PET117(YER058W)|FD-Score:3.79|P-value:7.41E-5||SGD DESC:Protein required for assembly of cytochrome c oxidase Gene:PIF1(YML061C)|FD-Score:3.86|P-value:5.65E-5||SGD DESC:DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells Gene:PLP1(YDR183W)|FD-Score:-3.11|P-value:9.24E-4||SGD DESC:Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators Gene:PRM7(YDL039C)|FD-Score:-3.18|P-value:7.35E-4||SGD DESC:Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements Gene:PRY2(YKR013W)|FD-Score:-3.45|P-value:2.81E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PTC6(YCR079W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase Gene:RAD52(YML032C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis Gene:RNH203(YLR154C)|FD-Score:-4.05|P-value:2.54E-5||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:RPA14(YDR156W)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:RNA polymerase I subunit A14 Gene:RPA49(YNL248C)|FD-Score:3.13|P-value:8.84E-4||SGD DESC:RNA polymerase I subunit A49 Gene:RPL19B(YBL027W)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL22A(YLR061W)|FD-Score:5.62|P-value:9.30E-9||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPL31B(YLR406C)|FD-Score:3.82|P-value:6.68E-5||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RPL33B(YOR234C)|FD-Score:4.64|P-value:1.77E-6||SGD DESC:Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication Gene:RPL37B(YDR500C)|FD-Score:3.96|P-value:3.73E-5||SGD DESC:Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication Gene:RPP1A(YDL081C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component Gene:RPS10A(YOR293W)|FD-Score:3.86|P-value:5.76E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication Gene:RSM24(YDR175C)|FD-Score:3.12|P-value:9.09E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SBE2(YDR351W)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SHM2(YLR058C)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis Gene:SLM5(YCR024C)|FD-Score:5.91|P-value:1.76E-9||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SPO75(YLL005C)|FD-Score:-3.46|P-value:2.75E-4||SGD DESC:Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Gene:SPT10(YJL127C)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:SPT21(YMR179W)|FD-Score:3.13|P-value:8.72E-4||SGD DESC:Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress Gene:TGS1(YPL157W)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:TIR3(YIL011W)|FD-Score:-3.66|P-value:1.25E-4||SGD DESC:Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth Gene:TRK1(YJL129C)|FD-Score:3.84|P-value:6.05E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:TRM7(YBR061C)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:TRP2(YER090W)|FD-Score:-4.12|P-value:1.93E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:-6.08|P-value:6.06E-10||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VAC17(YCL063W)|FD-Score:3.74|P-value:9.13E-5||SGD DESC:Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p Gene:VFA1(YER128W)|FD-Score:4.56|P-value:2.59E-6||SGD DESC:Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology Gene:YAP1801(YHR161C)|FD-Score:3.98|P-value:3.47E-5||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication Gene:YBR099C(YBR099C_d)|FD-Score:4.66|P-value:1.59E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Gene:YCL022C(YCL022C_d)|FD-Score:-3.97|P-value:3.59E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Gene:YDR008C(YDR008C_d)|FD-Score:-5.26|P-value:7.26E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER156C(YER156C_p)|FD-Score:5.43|P-value:2.88E-8||SGD DESC:Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.88|P-value:5.16E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR219W(YGR219W_d)|FD-Score:5.65|P-value:8.11E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Gene:YGR250C(YGR250C)|FD-Score:3.13|P-value:8.65E-4||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YJL120W(YJL120W_d)|FD-Score:4.7|P-value:1.30E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Gene:YLR257W(YLR257W_p)|FD-Score:-4.09|P-value:2.15E-5||SGD DESC:Protein of unknown function; protein abundance increases in response to DNA replication stress Gene:YLR264C-A(YLR264C-A_p)|FD-Score:3.56|P-value:1.89E-4||SGD DESC:Putative protein of unknown function Gene:YNL184C(YNL184C_p)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNL228W(YNL228W_d)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YOR072W(YOR072W_d)|FD-Score:6.82|P-value:4.64E-12||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YPT32(YGL210W)|FD-Score:-3.24|P-value:6.06E-4||SGD DESC:Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR016C6.028.74E-101.10TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YNL110C5.491.97E-81.10NOP15Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YNL282W4.405.40E-61.10POP3Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YPL255W3.304.85E-40.09BBP1Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YOR249C3.216.57E-40.01APC5Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
YNL131W3.206.88E-40.02TOM22Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
YDR280W3.187.43E-40.01RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YPL146C3.177.66E-40.05NOP53Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YMR076C3.129.19E-40.03PDS5Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis
YDL164C3.090.001000.06CDC9DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YAL001C3.030.001230.03TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YNL118C3.000.001360.02DCP2Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
YJL014W2.980.001430.02CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YGL030W2.960.001520.04RPL30Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
YDR091C2.930.001720.14RLI1Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR072W_d6.824.64E-12YOR072W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YMR163C6.417.40E-11INP2Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
YDR017C6.242.20E-10KCS1Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
YCR024C5.911.76E-9SLM5Mitochondrial asparaginyl-tRNA synthetase
YGR219W_d5.658.11E-9YGR219W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
YLR061W5.629.30E-9RPL22ARibosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
YKL009W5.511.82E-8MRT4Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YER156C_p5.432.88E-8YER156C_pPutative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
YJR050W5.219.37E-8ISY1Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
YGR204W5.181.11E-7ADE3Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
YPL125W4.885.33E-7KAP120Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
YLR068W4.721.19E-6FYV7Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
YJL120W_d4.701.30E-6YJL120W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
YBR099C_d4.661.59E-6YBR099C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
YOR234C4.641.77E-6RPL33BRibosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication

GO enrichment analysis for SGTC_782
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1396.93E-27SGTC_8324083-0019 164.0 μMChemDiv (Drug-like library)19907580.105263translation
0.1373.87E-26SGTC_1180083-0097 135.3 μMChemDiv (Drug-like library)52073560.413333translation
0.1323.03E-24SGTC_7911348-1292 225.0 μMChemDiv (Drug-like library)54370540.119565
0.1223.71E-21SGTC_1230083-0120 66.7 μMChemDiv (Drug-like library)160017010.0860215
0.1193.43E-20SGTC_1040074-0074 591.0 μMChemDiv (Drug-like library)39431240.128205
0.1055.20E-16SGTC_3640083-0097 67.7 μMChemDiv (Drug-like library)52073560.413333
0.0961.18E-13SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.0769231mitochondrial stress
0.0961.19E-13SGTC_630099-0242 26.7 μMChemDiv (Drug-like library)38985020.0555556mitochondrial stress
0.0961.36E-13SGTC_32449134489 49.5 μMChembridge (Drug-like library)165842710.101124
0.0912.77E-12SGTC_1663st014140 55.4 μMTimTec (Natural product derivative library)42071200.087912160S ribosome export
0.0898.51E-12SGTC_831k061-1017 217.0 μMChemDiv (Drug-like library)12401530.1625translation
0.0872.14E-11SGTC_30529092717 49.5 μMChembridge (Drug-like library)252375340.0833333
0.0863.59E-11SGTC_13481493-0373 93.8 μMChemDiv (Drug-like library)30101290.0694444
0.0841.30E-10SGTC_14764112-3294 3.3 μMChemDiv (Drug-like library)7043690.089743660S ribosome export
0.0822.75E-10SGTC_2361509-0011 5.3 μMChemDiv (Drug-like library)31072800.105263

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1180083-0097135.34 μM0.4133335207356ChemDiv (Drug-like library)623.373285.56515translation
SGTC_3640083-009767.7 μM0.4133335207356ChemDiv (Drug-like library)623.373285.56515
SGTC_10953-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran15.5 μM0.252333NIH Clinical Collection424.083385.60413
SGTC_1310141-027733.85 μM0.2394371547771ChemDiv (Drug-like library)419.49575.0222
SGTC_185k048-003725.49 μM0.229736827589ChemDiv (Drug-like library)414.04882.30735RSC & ERG11
SGTC_342k048-008823.3 μM0.229736820570ChemDiv (Drug-like library)413.060743.1224RSC & ERG11
SGTC_2681menadione3.18 μM0.2241384055Miscellaneous172.180022.20402superoxide
SGTC_394menadione8.33 μM0.2241384055Miscellaneous172.180022.20402superoxide
SGTC_1556plumbagin1.48 μM0.22222210205TimTec (Pure natural product library)188.179421.96213superoxide
SGTC_2575plumbagin510 nM0.22222210205TimTec (Pure natural product library)188.179421.96213superoxide
SGTC_13883346-4487254 μM0.2173913345614ChemDiv (Drug-like library)288.364742.5713
SGTC_2981901395238.96 μM0.2162162996344Chembridge (Drug-like library)348.234324.39112
SGTC_2231micatex6.85 μM0.21052620737Miscellaneous344.8264.31911