Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBL007C | 8.88 | 3.46E-19 | SLA1 | Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains |
YOR085W | 8.83 | 5.18E-19 | OST3 | Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins |
YBR229C | 8.26 | 7.12E-17 | ROT2 | Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations |
YDR447C | 8.21 | 1.07E-16 | RPS17B | Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YLR061W | 8.20 | 1.21E-16 | RPL22A | Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication |
YJR032W | 7.80 | 3.02E-15 | CPR7 | Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity |
YBR016W | 6.50 | 4.10E-11 | YBR016W | Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication |
YGR061C | 6.33 | 1.25E-10 | ADE6 | Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway |
YJL056C | 6.08 | 6.12E-10 | ZAP1 | Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains |
YER122C | 5.90 | 1.77E-9 | GLO3 | ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p |
YFR007W | 5.47 | 2.31E-8 | YFH7 | Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases |
YKL096C-B_p | 5.41 | 3.16E-8 | YKL096C-B_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YLR068W | 5.38 | 3.71E-8 | FYV7 | Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin |
YLR048W | 5.36 | 4.05E-8 | RPS0B | Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2 |
YOR216C | 5.12 | 1.50E-7 | RUD3 | Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 |