0159-0065

ethyl 3-[3-(1,3-dioxoisoindol-2-yl)propyl]-5-methyl-1H-indole-2-carboxylate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_80
Screen concentration 512.2 μM
Source ChemDiv (Drug-like library)
PubChem CID 1548079
SMILES CCOC(=O)C1=C(C2=C(N1)C=CC(=C2)C)CCCN3C(=O)C4=CC=CC=C4C3=O
Standardized SMILES CCOC(=O)c1[nH]c2ccc(C)cc2c1CCCN3C(=O)c4ccccc4C3=O
Molecular weight 390.4318
ALogP 4.5
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.65
% growth inhibition (Hom. pool) 1.21


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1548079
Download HIP data (tab-delimited text)  (excel)
Gene:KRE33(YNL132W)|FD-Score:3.47|P-value:2.64E-4|Clearance:0.93||SGD DESC:Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:SAM35(YHR083W)|FD-Score:-3.41|P-value:3.26E-4|Clearance:0||SGD DESC:Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane Gene:SDH3(YKL141W)|FD-Score:4.11|P-value:1.96E-5|Clearance:0.93||SGD DESC:Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex Gene:TTI1(YKL033W)|FD-Score:-3.36|P-value:3.92E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies Gene:KRE33(YNL132W)|FD-Score:3.47|P-value:2.64E-4|Clearance:0.93||SGD DESC:Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:SAM35(YHR083W)|FD-Score:-3.41|P-value:3.26E-4|Clearance:0||SGD DESC:Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane Gene:SDH3(YKL141W)|FD-Score:4.11|P-value:1.96E-5|Clearance:0.93||SGD DESC:Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex Gene:TTI1(YKL033W)|FD-Score:-3.36|P-value:3.92E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1548079
Download HOP data (tab-delimited text)  (excel)
Gene:ALD2(YMR170C)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p Gene:ATP23(YNR020C)|FD-Score:-3.37|P-value:3.71E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:CAN1(YEL063C)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:COX5B(YIL111W)|FD-Score:4.98|P-value:3.11E-7||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:DCI1(YOR180C)|FD-Score:-3.35|P-value:4.11E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:DSE1(YER124C)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:GPM3(YOL056W)|FD-Score:3.3|P-value:4.75E-4||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:IZH4(YOL101C)|FD-Score:-3.5|P-value:2.36E-4||SGD DESC:Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress Gene:MPC54(YOR177C)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate Gene:MRPL20(YKR085C)|FD-Score:-3.29|P-value:5.10E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSY1(YPL097W)|FD-Score:-3.26|P-value:5.60E-4||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:NIT1(YIL164C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:NTG1(YAL015C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:OXR1(YPL196W)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes Gene:PHO87(YCR037C)|FD-Score:3.81|P-value:6.83E-5||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:PIG2(YIL045W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase Gene:RMT2(YDR465C)|FD-Score:-3.88|P-value:5.24E-5||SGD DESC:Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress Gene:VPS13(YLL040C)|FD-Score:-3.81|P-value:6.94E-5||SGD DESC:Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively Gene:VPS24(YKL041W)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway Gene:YBR226C(YBR226C_d)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Gene:YCL042W(YCL042W_p)|FD-Score:-3.3|P-value:4.80E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDR154C(YDR154C_d)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YGL176C(YGL176C_p)|FD-Score:-3.22|P-value:6.51E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype Gene:YJL147C(YJL147C_p)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene Gene:YLR122C(YLR122C_d)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Gene:YLR363W-A(YLR363W-A_p)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:YML079W(YML079W_p)|FD-Score:-3.17|P-value:7.61E-4||SGD DESC:Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm Gene:YOR292C(YOR292C_p)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene Gene:ALD2(YMR170C)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p Gene:ATP23(YNR020C)|FD-Score:-3.37|P-value:3.71E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:CAN1(YEL063C)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:COX5B(YIL111W)|FD-Score:4.98|P-value:3.11E-7||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:DCI1(YOR180C)|FD-Score:-3.35|P-value:4.11E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:DSE1(YER124C)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:GPM3(YOL056W)|FD-Score:3.3|P-value:4.75E-4||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:IZH4(YOL101C)|FD-Score:-3.5|P-value:2.36E-4||SGD DESC:Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress Gene:MPC54(YOR177C)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate Gene:MRPL20(YKR085C)|FD-Score:-3.29|P-value:5.10E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSY1(YPL097W)|FD-Score:-3.26|P-value:5.60E-4||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:NIT1(YIL164C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:NTG1(YAL015C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:OXR1(YPL196W)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes Gene:PHO87(YCR037C)|FD-Score:3.81|P-value:6.83E-5||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:PIG2(YIL045W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase Gene:RMT2(YDR465C)|FD-Score:-3.88|P-value:5.24E-5||SGD DESC:Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress Gene:VPS13(YLL040C)|FD-Score:-3.81|P-value:6.94E-5||SGD DESC:Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively Gene:VPS24(YKL041W)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway Gene:YBR226C(YBR226C_d)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Gene:YCL042W(YCL042W_p)|FD-Score:-3.3|P-value:4.80E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDR154C(YDR154C_d)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YGL176C(YGL176C_p)|FD-Score:-3.22|P-value:6.51E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype Gene:YJL147C(YJL147C_p)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene Gene:YLR122C(YLR122C_d)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Gene:YLR363W-A(YLR363W-A_p)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:YML079W(YML079W_p)|FD-Score:-3.17|P-value:7.61E-4||SGD DESC:Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm Gene:YOR292C(YOR292C_p)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL141W4.111.96E-50.93SDH3Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
YNL132W3.472.64E-40.93KRE33Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YLR323C2.540.005550.02CWC24Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
YBR256C2.520.005810.05RIB5Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YER165W2.470.006730.10PAB1Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
YPL151C2.370.008790.04PRP46Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YJL035C2.340.009750.03TAD2Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YJL069C2.300.010600.01UTP18Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLR317W_d2.290.010900.05YLR317W_dDubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
YOR159C2.240.012400.06SME1Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
YIL046W2.180.014700.03MET30F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
YOL034W2.150.015700.01SMC5Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YFL029C2.140.016300.10CAK1Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YPL063W2.040.020800.01TIM50Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
YER022W2.030.021300.02SRB4Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL111W4.983.11E-7COX5BSubunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
YDR154C_d4.251.09E-5YDR154C_dDubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YJL147C_p4.151.67E-5YJL147C_pMitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
YCR037C3.816.83E-5PHO87Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication
YAL015C3.551.91E-4NTG1DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
YIL164C3.542.00E-4NIT1Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YLR363W-A_p3.462.68E-4YLR363W-A_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
YMR170C3.353.99E-4ALD2Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YOL056W3.304.75E-4GPM3Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YPL196W3.245.92E-4OXR1Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes
YIL045W3.245.96E-4PIG2Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YEL063C3.236.21E-4CAN1Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
YOR177C3.177.54E-4MPC54Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
YKL041W3.158.10E-4VPS24One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
YER124C3.138.71E-4DSE1Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress

GO enrichment analysis for SGTC_80
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0806.14E-10SGTC_33549151612 71.4 μMChembridge (Drug-like library)272619490.142857
0.0764.48E-9SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.108696
0.0706.97E-8SGTC_14994480-0877 67.3 μMChemDiv (Drug-like library)28619090.136364
0.0691.37E-7SGTC_840443-0269 128.8 μMChemDiv (Drug-like library)61500580.126582
0.0648.33E-7SGTC_22199098279 200.0 μMChembridge (Fragment library)9023490.140845
0.0561.42E-5SGTC_850868-0259 160.1 μMChemDiv (Drug-like library)831730.12162260S ribosome export
0.0543.29E-5SGTC_23296138490 200.0 μMChembridge (Fragment library)7200190.166667
0.0534.66E-5SGTC_2769toremifene 3.7 μMMiscellaneous30055730.1125
0.0527.28E-5SGTC_497capsazepine 133.0 μMICCB bioactive library27334840.0909091
0.0491.89E-4SGTC_31899110682 49.5 μMChembridge (Drug-like library)171224180.134146
0.0481.95E-4SGTC_2697mebhydrolin 72.4 μMTimTec (Natural product derivative library)225300.113924NEO1
0.0472.89E-4SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.113924
0.0463.74E-4SGTC_33159136395 68.5 μMChembridge (Drug-like library)168768440.183908
0.0464.21E-4SGTC_21906049624 200.0 μMChembridge (Fragment library)22655540.105263
0.0455.65E-4SGTC_21846075246 200.0 μMChembridge (Fragment library)22673200.0933333

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_12630774-120864.8 μM0.387097906585ChemDiv (Drug-like library)304.342543.51612
SGTC_1952st07703664.1 μM0.3768122937007TimTec (Natural product derivative library)258.315623.01412
SGTC_2859902864345.46 μM0.32394417151580Chembridge (Drug-like library)328.405462.51503
SGTC_9483448-029575.3 μM0.296875678569ChemDiv (Drug-like library)223.311343.70112
SGTC_1000086-012849.59 μM0.28787993297ChemDiv (Drug-like library)248.234682.08504copper-dependent oxidative stress
SGTC_7313966-0296387 μM0.287671660956ChemDiv (Drug-like library)318.367582.44314
SGTC_22137173844200 μM0.285714892728Chembridge (Fragment library)259.300382.62204
SGTC_1613st00238152.1 μM0.282051551167TimTec (Natural product derivative library)363.45283.83913
SGTC_1957st07703562.4 μM0.28705593TimTec (Natural product derivative library)278.73413.19212
SGTC_13291447-169750.6 μM0.2784812840515ChemDiv (Drug-like library)286.325722.57623