Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YKL141W | 4.11 | 1.96E-5 | 0.93 | SDH3 | Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex |
YNL132W | 3.47 | 2.64E-4 | 0.93 | KRE33 | Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
YLR323C | 2.54 | 0.00555 | 0.02 | CWC24 | Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p |
YBR256C | 2.52 | 0.00581 | 0.05 | RIB5 | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway |
YER165W | 2.47 | 0.00673 | 0.10 | PAB1 | Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G |
YPL151C | 2.37 | 0.00879 | 0.04 | PRP46 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs |
YJL035C | 2.34 | 0.00975 | 0.03 | TAD2 | Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs |
YJL069C | 2.30 | 0.01060 | 0.01 | UTP18 | Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data |
YLR317W_d | 2.29 | 0.01090 | 0.05 | YLR317W_d | Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C |
YOR159C | 2.24 | 0.01240 | 0.06 | SME1 | Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E |
YIL046W | 2.18 | 0.01470 | 0.03 | MET30 | F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus |
YOL034W | 2.15 | 0.01570 | 0.01 | SMC5 | Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair |
YFL029C | 2.14 | 0.01630 | 0.10 | CAK1 | Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases |
YPL063W | 2.04 | 0.02080 | 0.01 | TIM50 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel |
YER022W | 2.03 | 0.02130 | 0.02 | SRB4 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination |