| Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
|---|
| YKL173W | 2.88 | 0.00202 | 0.30 | SNU114 | GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 |
| YKL141W | 2.86 | 0.00209 | 0.30 | SDH3 | Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex |
| YBL020W | 2.86 | 0.00213 | 0.30 | RFT1 | Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein |
| YBR256C | 2.56 | 0.00529 | 0.00 | RIB5 | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway |
| YLR347C | 2.55 | 0.00533 | 0.10 | KAP95 | Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p |
| YLR229C | 2.46 | 0.00700 | 0.01 | CDC42 | Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins |
| YFL017C | 2.45 | 0.00714 | 0.19 | GNA1 | Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA |
| YGL044C | 2.26 | 0.01200 | 0.05 | RNA15 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping |
| YNR038W | 2.21 | 0.01370 | 0.03 | DBP6 | Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family |
| YPL151C | 2.18 | 0.01480 | 0.01 | PRP46 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs |
| YGL111W | 2.17 | 0.01520 | 0.01 | NSA1 | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis |
| YGL074C_d | 2.15 | 0.01560 | 0.02 | YGL074C_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor |
| YJR067C | 2.14 | 0.01630 | 0.04 | YAE1 | Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
| YDR412W | 2.10 | 0.01800 | 0.00 | RRP17 | Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA |
| YDR341C | 2.09 | 0.01810 | 0.02 | YDR341C | Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
