Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YIL048W | 23.10 | 1.42E-118 | 10.60 | NEO1 | Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus |
YMR134W_p | 12.60 | 1.84E-36 | 2.42 | ERG29_p | Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes |
YGR060W | 10.10 | 1.90E-24 | 0.38 | ERG25 | C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol |
YHR007C | 9.75 | 9.03E-23 | 3.90 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YHR072W | 5.85 | 2.44E-9 | 0.45 | ERG7 | Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis |
YOL146W | 5.40 | 3.29E-8 | 0.21 | PSF3 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YFL038C | 5.20 | 1.02E-7 | 0.29 | YPT1 | Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) |
YJL086C_d | 4.90 | 4.71E-7 | 0.90 | YJL086C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 |
YJL081C | 4.00 | 3.17E-5 | 0.20 | ARP4 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
YCR093W | 3.80 | 7.09E-5 | 0.23 | CDC39 | Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor |
YCR052W | 3.58 | 1.72E-4 | 0.39 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YNL272C | 3.19 | 7.02E-4 | 0.02 | SEC2 | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles |
YJL143W | 3.17 | 7.57E-4 | 0.04 | TIM17 | Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex |
YDR449C | 3.13 | 8.74E-4 | 0.04 | UTP6 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YDR064W | 3.09 | 9.86E-4 | 0.08 | RPS13 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 |