0245-0196

cyclohexyl 2-[(4-nitrophenyl)sulfonylamino]acetate

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_840
Screen concentration 390.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 3827528
SMILES C1CCC(CC1)OC(=O)CNS(=O)(=O)C2=CC=C(C=C2)[N+](=O)[O-]
Standardized SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)NCC(=O)OC2CCCCC2
Molecular weight 342.3675
ALogP 2.2
H-bond donor count 1
H-bond acceptor count 7
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 19.8
% growth inhibition (Hom. pool) 9.48


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3827528
Download HIP data (tab-delimited text)  (excel)
Gene:APC4(YDR118W)|FD-Score:3.53|P-value:2.05E-4|Clearance:0.1||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress Gene:CAK1(YFL029C)|FD-Score:3.23|P-value:6.22E-4|Clearance:0.02||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:FAF1(YIL019W)|FD-Score:4.05|P-value:2.60E-5|Clearance:0.51||SGD DESC:Protein required for pre-rRNA processing and 40S ribosomal subunit assembly Gene:GCD11(YER025W)|FD-Score:3.21|P-value:6.64E-4|Clearance:0.18||SGD DESC:Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Gene:IMP3(YHR148W)|FD-Score:3.39|P-value:3.49E-4|Clearance:0.16||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:NOP1(YDL014W)|FD-Score:4.19|P-value:1.39E-5|Clearance:0.51||SGD DESC:Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin Gene:YDR187C(YDR187C_d)|FD-Score:4.66|P-value:1.56E-6|Clearance:0.51||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YLR458W(YLR458W_d)|FD-Score:3.43|P-value:2.96E-4|Clearance:0.04||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Gene:APC4(YDR118W)|FD-Score:3.53|P-value:2.05E-4|Clearance:0.1||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress Gene:CAK1(YFL029C)|FD-Score:3.23|P-value:6.22E-4|Clearance:0.02||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:FAF1(YIL019W)|FD-Score:4.05|P-value:2.60E-5|Clearance:0.51||SGD DESC:Protein required for pre-rRNA processing and 40S ribosomal subunit assembly Gene:GCD11(YER025W)|FD-Score:3.21|P-value:6.64E-4|Clearance:0.18||SGD DESC:Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Gene:IMP3(YHR148W)|FD-Score:3.39|P-value:3.49E-4|Clearance:0.16||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:NOP1(YDL014W)|FD-Score:4.19|P-value:1.39E-5|Clearance:0.51||SGD DESC:Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin Gene:YDR187C(YDR187C_d)|FD-Score:4.66|P-value:1.56E-6|Clearance:0.51||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YLR458W(YLR458W_d)|FD-Score:3.43|P-value:2.96E-4|Clearance:0.04||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3827528
Download HOP data (tab-delimited text)  (excel)
Gene:ACN9(YDR511W)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes Gene:AVT7(YIL088C)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BGL2(YGR282C)|FD-Score:5.44|P-value:2.61E-8||SGD DESC:Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance Gene:BLI1(YKL061W_p)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome Gene:BUD6(YLR319C)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Gene:CAF130(YGR134W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CBF1(YJR060W)|FD-Score:-4.61|P-value:1.97E-6||SGD DESC:Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress Gene:CWH43(YCR017C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion Gene:EDE1(YBL047C)|FD-Score:3.11|P-value:9.21E-4||SGD DESC:Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death Gene:EPT1(YHR123W)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication Gene:EXO5(YBR163W)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 Gene:FMP25(YLR077W)|FD-Score:5.19|P-value:1.08E-7||SGD DESC:Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria Gene:FPR4(YLR449W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones Gene:FRD1(YEL047C)|FD-Score:5.02|P-value:2.62E-7||SGD DESC:Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication Gene:GDB1(YPR184W)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress Gene:GSM1(YJL103C)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis Gene:GUP1(YGL084C)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HTZ1(YOL012C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:HUL4(YJR036C)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex Gene:IES6(YEL044W)|FD-Score:3.23|P-value:6.13E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes Gene:LRE1(YCL051W)|FD-Score:3.96|P-value:3.73E-5||SGD DESC:Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication Gene:LRG1(YDL240W)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis Gene:MAC1(YMR021C)|FD-Score:3.94|P-value:4.11E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MIC17(YMR002W)|FD-Score:-3.46|P-value:2.67E-4||SGD DESC:Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MRM2(YGL136C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ Gene:MRP7(YNL005C)|FD-Score:4.01|P-value:3.02E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NCE102(YPR149W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) Gene:NOP6(YDL213C)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes Gene:RAD51(YER095W)|FD-Score:5.81|P-value:3.09E-9||SGD DESC:Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein Gene:RDS1(YCR106W)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide Gene:RPL19B(YBL027W)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL9A(YGL147C)|FD-Score:3.99|P-value:3.33E-5||SGD DESC:Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 Gene:RPS21B(YJL136C)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RTC5(YOR118W)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SDS3(YIL084C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes Gene:TED1(YIL039W)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:THI2(YBR240C)|FD-Score:4.16|P-value:1.58E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:THI7(YLR237W)|FD-Score:3.19|P-value:7.15E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:THP1(YOL072W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding Gene:UBP6(YFR010W)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance Gene:VPS29(YHR012W)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval Gene:VPS53(YJL029C)|FD-Score:3.12|P-value:9.19E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR056W(YBR056W_p)|FD-Score:3.39|P-value:3.54E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YCR085W(YCR085W_d)|FD-Score:4.71|P-value:1.22E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL159W-A(YDL159W-A_p)|FD-Score:3.77|P-value:8.01E-5||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YIL024C(YIL024C_p)|FD-Score:3.64|P-value:1.38E-4||SGD DESC:Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p Gene:YML089C(YML089C_d)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage Gene:YMR262W(YMR262W_p)|FD-Score:3.16|P-value:7.82E-4||SGD DESC:Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Gene:YOR072W(YOR072W_d)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:ACN9(YDR511W)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes Gene:AVT7(YIL088C)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BGL2(YGR282C)|FD-Score:5.44|P-value:2.61E-8||SGD DESC:Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance Gene:BLI1(YKL061W_p)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome Gene:BUD6(YLR319C)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Gene:CAF130(YGR134W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CBF1(YJR060W)|FD-Score:-4.61|P-value:1.97E-6||SGD DESC:Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress Gene:CWH43(YCR017C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion Gene:EDE1(YBL047C)|FD-Score:3.11|P-value:9.21E-4||SGD DESC:Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death Gene:EPT1(YHR123W)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication Gene:EXO5(YBR163W)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 Gene:FMP25(YLR077W)|FD-Score:5.19|P-value:1.08E-7||SGD DESC:Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria Gene:FPR4(YLR449W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones Gene:FRD1(YEL047C)|FD-Score:5.02|P-value:2.62E-7||SGD DESC:Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication Gene:GDB1(YPR184W)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress Gene:GSM1(YJL103C)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis Gene:GUP1(YGL084C)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HTZ1(YOL012C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:HUL4(YJR036C)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex Gene:IES6(YEL044W)|FD-Score:3.23|P-value:6.13E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes Gene:LRE1(YCL051W)|FD-Score:3.96|P-value:3.73E-5||SGD DESC:Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication Gene:LRG1(YDL240W)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis Gene:MAC1(YMR021C)|FD-Score:3.94|P-value:4.11E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MIC17(YMR002W)|FD-Score:-3.46|P-value:2.67E-4||SGD DESC:Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MRM2(YGL136C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ Gene:MRP7(YNL005C)|FD-Score:4.01|P-value:3.02E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NCE102(YPR149W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) Gene:NOP6(YDL213C)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes Gene:RAD51(YER095W)|FD-Score:5.81|P-value:3.09E-9||SGD DESC:Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein Gene:RDS1(YCR106W)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide Gene:RPL19B(YBL027W)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL9A(YGL147C)|FD-Score:3.99|P-value:3.33E-5||SGD DESC:Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 Gene:RPS21B(YJL136C)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RTC5(YOR118W)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SDS3(YIL084C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes Gene:TED1(YIL039W)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:THI2(YBR240C)|FD-Score:4.16|P-value:1.58E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:THI7(YLR237W)|FD-Score:3.19|P-value:7.15E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:THP1(YOL072W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding Gene:UBP6(YFR010W)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance Gene:VPS29(YHR012W)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval Gene:VPS53(YJL029C)|FD-Score:3.12|P-value:9.19E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR056W(YBR056W_p)|FD-Score:3.39|P-value:3.54E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YCR085W(YCR085W_d)|FD-Score:4.71|P-value:1.22E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL159W-A(YDL159W-A_p)|FD-Score:3.77|P-value:8.01E-5||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YIL024C(YIL024C_p)|FD-Score:3.64|P-value:1.38E-4||SGD DESC:Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p Gene:YML089C(YML089C_d)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage Gene:YMR262W(YMR262W_p)|FD-Score:3.16|P-value:7.82E-4||SGD DESC:Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Gene:YOR072W(YOR072W_d)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR187C_d4.661.56E-60.51YDR187C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YDL014W4.191.39E-50.51NOP1Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YIL019W4.052.60E-50.51FAF1Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YDR118W3.532.05E-40.10APC4Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
YLR458W_d3.432.96E-40.04YLR458W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
YHR148W3.393.49E-40.16IMP3Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YFL029C3.236.22E-40.02CAK1Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YER025W3.216.64E-40.18GCD11Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YGL048C3.030.001220.00RPT6ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
YMR236W3.030.001230.02TAF9Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
YGL091C3.010.001310.13NBP35Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
YGR090W2.880.002000.11UTP22Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
YNL114C_d2.770.002800.14YNL114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YFL039C2.630.004300.02ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YLR222C2.610.004523.46E-4UTP13Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER095W5.813.09E-9RAD51Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YGR282C5.442.61E-8BGL2Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
YLR077W5.191.08E-7FMP25Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
YEL047C5.022.62E-7FRD1Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
YCR085W_d4.711.22E-6YCR085W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR511W4.454.27E-6ACN9Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
YCR017C4.201.35E-5CWH43Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
YBR240C4.161.58E-5THI2Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
YGL084C4.121.91E-5GUP1Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
YDL213C4.072.39E-5NOP6rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YNL005C4.013.02E-5MRP7Mitochondrial ribosomal protein of the large subunit
YGL147C3.993.33E-5RPL9ARibosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6
YCL051W3.963.73E-5LRE1Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication
YMR021C3.944.11E-5MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YIL088C3.875.37E-5AVT7Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

GO enrichment analysis for SGTC_840
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0952.73E-13SGTC_8610443-0273 110.0 μMChemDiv (Drug-like library)61491690.206349
0.0791.19E-9SGTC_13933470-5649 58.2 μMChemDiv (Drug-like library)41083950.076923160S ribosome export
0.0714.20E-8SGTC_32739137859 49.5 μMChembridge (Drug-like library)23772340.056338
0.0681.44E-7SGTC_22047233102 200.0 μMChembridge (Fragment library)21724800.11267660S ribosome export
0.0641.02E-6SGTC_1569carminic acid 40.6 μMTimTec (Pure natural product library)147490.0804598
0.0631.05E-6SGTC_2392N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200.0 μMChembridge (Fragment library)8031090.0985916
0.0622.25E-6SGTC_1360097-0015 404.5 μMChemDiv (Drug-like library)48613370.2280760S ribosome export
0.0604.15E-6SGTC_26373-alpha-acetoxydihydrodeoxygedunin 100.0 μMMicrosource (Natural product library)67085140.120879
0.0552.59E-5SGTC_32319132313 49.5 μMChembridge (Drug-like library)49059670.0547945
0.0543.16E-5SGTC_1676st018489 23.4 μMTimTec (Natural product derivative library)36962350.054054160S ribosome export
0.0543.64E-5SGTC_1079idarubicin 2.4 μMNIH Clinical Collection6363620.0957447DNA damage response
0.0534.29E-5SGTC_20695228469 200.0 μMChembridge (Fragment library)28352100.0714286
0.0526.07E-5SGTC_1910st062352 60.4 μMTimTec (Natural product derivative library)22457300.111111
0.0527.26E-5SGTC_32599138485 49.5 μMChembridge (Drug-like library)176461530.258065
0.0501.16E-4SGTC_20885278280 127.4 μMChembridge (Fragment library)7915020.0694444

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1140364-0001490.3 μM0.4642864003655ChemDiv (Drug-like library)310.368722.515
SGTC_340469-068381.75 μM0.3448283690923ChemDiv (Drug-like library)337.307942.59217SWF1 & branched chain AA biosynthesis
SGTC_10024049-0206172 μM0.3389834662749ChemDiv (Drug-like library)310.3008432.90316
SGTC_2837900847645.46 μM0.3134332992805Chembridge (Drug-like library)328.3841.21226
SGTC_12600700-16177.75 μM0.3090912853078ChemDiv (Drug-like library)235.235922.80914calcium & mitochondrial duress
SGTC_30591327-00343 μM0.30769215998580ChemDiv (Drug-like library)446.14426.02315
SGTC_30631327-00344 μM0.30769215998580ChemDiv (Drug-like library)446.14426.02315
SGTC_6371181-05197.26 μM0.3050856252091ChemDiv (Drug-like library)250.253860.70925fatty acid desaturase (OLE1)
SGTC_850868-0259160.06 μM0.29824683173ChemDiv (Drug-like library)256.256682.5431360S ribosome export
SGTC_750159-0059199.01 μM0.2950825377270ChemDiv (Drug-like library)251.238621.99916fatty acid desaturase (OLE1)
SGTC_13281441-002569.2 μM0.2950824562601ChemDiv (Drug-like library)287.270722.2724