Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR107C | 7.94 | 1.02E-15 | 1.47 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YDR362C | 7.64 | 1.10E-14 | 1.47 | TFC6 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 |
YGL068W | 6.17 | 3.36E-10 | 0.53 | MNP1 | Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth |
YOR260W | 5.64 | 8.56E-9 | 0.56 | GCD1 | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YKL013C | 5.08 | 1.88E-7 | 0.37 | ARC19 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YJR042W | 4.71 | 1.23E-6 | 0.03 | NUP85 | Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 |
YNL189W | 4.68 | 1.41E-6 | 0.23 | SRP1 | Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation |
YHR007C | 4.45 | 4.21E-6 | 0.03 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YAL038W | 4.42 | 4.90E-6 | 0.17 | CDC19 | Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication |
YPL007C | 4.25 | 1.06E-5 | 0.03 | TFC8 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 |
YBR110W | 4.22 | 1.20E-5 | 0.17 | ALG1 | Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog |
YDR361C | 4.06 | 2.47E-5 | 0.01 | BCP1 | Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport |
YGL093W | 4.05 | 2.59E-5 | 0.09 | SPC105 | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |
YDR172W | 3.96 | 3.75E-5 | 0.10 | SUP35 | Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype |
YKL173W | 3.85 | 5.79E-5 | 0.14 | SNU114 | GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 |