0419-0306

4-[1-(3-methoxyphenyl)cyclopentyl]phenol

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_853
Screen concentration 21.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 762713
SMILES COC1=CC=CC(=C1)C2(CCCC2)C3=CC=C(C=C3)O
Standardized SMILES COc1cccc(c1)C2(CCCC2)c3ccc(O)cc3
Molecular weight 268.3502
ALogP 4.55
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 29.45
% growth inhibition (Hom. pool) 5.71


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 762713
Download HIP data (tab-delimited text)  (excel)
Gene:ACT1(YFL039C)|FD-Score:3.16|P-value:7.82E-4|Clearance:0.01||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:HYP2(YEL034W)|FD-Score:6.83|P-value:4.24E-12|Clearance:1.93||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:MIA40(YKL195W)|FD-Score:4.01|P-value:3.07E-5|Clearance:0.02||SGD DESC:Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p Gene:MNP1(YGL068W)|FD-Score:3.18|P-value:7.36E-4|Clearance:0.02||SGD DESC:Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth Gene:NMD3(YHR170W)|FD-Score:4.9|P-value:4.73E-7|Clearance:0.39||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:RFC3(YNL290W)|FD-Score:3.98|P-value:3.39E-5|Clearance:0.33||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPC11(YDR045C)|FD-Score:3.25|P-value:5.73E-4|Clearance:0.01||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RPR2(YIR015W)|FD-Score:3.36|P-value:3.90E-4|Clearance:0.11||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:RPT1(YKL145W)|FD-Score:3.66|P-value:1.28E-4|Clearance:0.06||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance Gene:RSC6(YCR052W)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.02||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SMD2(YLR275W)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.13||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:SPN1(YPR133C)|FD-Score:3.59|P-value:1.65E-4|Clearance:0.02||SGD DESC:Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype Gene:SUI2(YJR007W)|FD-Score:3.16|P-value:8.02E-4|Clearance:0.07||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:TAF12(YDR145W)|FD-Score:3.21|P-value:6.68E-4|Clearance:0.03||SGD DESC:Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A Gene:TAF5(YBR198C)|FD-Score:3.24|P-value:6.03E-4|Clearance:0.03||SGD DESC:Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification Gene:TRS120(YDR407C)|FD-Score:3.42|P-value:3.11E-4|Clearance:0.06||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:UTR5(YEL035C_p)|FD-Score:4.23|P-value:1.19E-5|Clearance:0.22||SGD DESC:Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions Gene:YGR114C(YGR114C_d)|FD-Score:4.51|P-value:3.20E-6|Clearance:0.29||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:6.99|P-value:1.41E-12|Clearance:1.93||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:ACT1(YFL039C)|FD-Score:3.16|P-value:7.82E-4|Clearance:0.01||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:HYP2(YEL034W)|FD-Score:6.83|P-value:4.24E-12|Clearance:1.93||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:MIA40(YKL195W)|FD-Score:4.01|P-value:3.07E-5|Clearance:0.02||SGD DESC:Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p Gene:MNP1(YGL068W)|FD-Score:3.18|P-value:7.36E-4|Clearance:0.02||SGD DESC:Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth Gene:NMD3(YHR170W)|FD-Score:4.9|P-value:4.73E-7|Clearance:0.39||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:RFC3(YNL290W)|FD-Score:3.98|P-value:3.39E-5|Clearance:0.33||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPC11(YDR045C)|FD-Score:3.25|P-value:5.73E-4|Clearance:0.01||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RPR2(YIR015W)|FD-Score:3.36|P-value:3.90E-4|Clearance:0.11||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:RPT1(YKL145W)|FD-Score:3.66|P-value:1.28E-4|Clearance:0.06||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance Gene:RSC6(YCR052W)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.02||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SMD2(YLR275W)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.13||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:SPN1(YPR133C)|FD-Score:3.59|P-value:1.65E-4|Clearance:0.02||SGD DESC:Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype Gene:SUI2(YJR007W)|FD-Score:3.16|P-value:8.02E-4|Clearance:0.07||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:TAF12(YDR145W)|FD-Score:3.21|P-value:6.68E-4|Clearance:0.03||SGD DESC:Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A Gene:TAF5(YBR198C)|FD-Score:3.24|P-value:6.03E-4|Clearance:0.03||SGD DESC:Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification Gene:TRS120(YDR407C)|FD-Score:3.42|P-value:3.11E-4|Clearance:0.06||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:UTR5(YEL035C_p)|FD-Score:4.23|P-value:1.19E-5|Clearance:0.22||SGD DESC:Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions Gene:YGR114C(YGR114C_d)|FD-Score:4.51|P-value:3.20E-6|Clearance:0.29||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:6.99|P-value:1.41E-12|Clearance:1.93||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 762713
Download HOP data (tab-delimited text)  (excel)
Gene:ADE6(YGR061C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ALG5(YPL227C)|FD-Score:4.33|P-value:7.54E-6||SGD DESC:UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Gene:APL3(YBL037W)|FD-Score:4.16|P-value:1.60E-5||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:AVT7(YIL088C)|FD-Score:3.61|P-value:1.54E-4||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BUD26(YDR241W_d)|FD-Score:3.79|P-value:7.45E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:FAA4(YMR246W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication Gene:FKS3(YMR306W)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FPS1(YLL043W)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress Gene:FRD1(YEL047C)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication Gene:GCN4(YEL009C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GIS2(YNL255C)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 Gene:GLG1(YKR058W)|FD-Score:-3.24|P-value:5.94E-4||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication Gene:GLY1(YEL046C)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis Gene:GRX7(YBR014C)|FD-Score:-9.94|P-value:1.41E-23||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:GSF2(YML048W)|FD-Score:4.35|P-value:6.92E-6||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:GYL1(YMR192W)|FD-Score:-5.26|P-value:7.28E-8||SGD DESC:Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:HHT2(YNL031C)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation Gene:IES2(YNL215W)|FD-Score:5.09|P-value:1.82E-7||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:MRPL23(YOR150W)|FD-Score:4.93|P-value:4.17E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NHP10(YDL002C)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:PEX13(YLR191W)|FD-Score:3.26|P-value:5.54E-4||SGD DESC:Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p Gene:PHO88(YBR106W)|FD-Score:3.77|P-value:8.19E-5||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:PUS1(YPL212C)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA Gene:RAM1(YDL090C)|FD-Score:4.18|P-value:1.45E-5||SGD DESC:Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Gene:RPL37B(YDR500C)|FD-Score:3.85|P-value:5.88E-5||SGD DESC:Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication Gene:RPS18A(YDR450W)|FD-Score:3.73|P-value:9.67E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress Gene:RTC1(YOL138C)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SAC7(YDR389W)|FD-Score:5.19|P-value:1.04E-7||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SEH1(YGL100W)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 Gene:SFP1(YLR403W)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion Gene:THI22(YPR121W)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Gene:TOP1(YOL006C)|FD-Score:3.96|P-value:3.77E-5||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBL029C-A(YBL029C-A_p)|FD-Score:4.95|P-value:3.63E-7||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica Gene:YBL070C(YBL070C_d)|FD-Score:3.82|P-value:6.70E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR182C-A(YBR182C-A_p)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBR206W(YBR206W_d)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YCR043C(YCR043C_p)|FD-Score:5.67|P-value:6.98E-9||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Gene:YDR157W(YDR157W_d)|FD-Score:-3.18|P-value:7.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR203W(YDR203W_d)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER091C-A(YER091C-A_d)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YFR045W(YFR045W_p)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YGR051C(YGR051C_d)|FD-Score:3.34|P-value:4.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Gene:YLL044W(YLL044W_d)|FD-Score:4.46|P-value:4.05E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YMR245W(YMR245W_d)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YND1(YER005W)|FD-Score:-7.51|P-value:3.04E-14||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNR061C(YNR061C_p)|FD-Score:4.49|P-value:3.55E-6||SGD DESC:Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:YOL163W(YOL163W_p)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YPR099C(YPR099C_d)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Gene:YPR130C(YPR130C_d)|FD-Score:-4.13|P-value:1.78E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ADE6(YGR061C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ALG5(YPL227C)|FD-Score:4.33|P-value:7.54E-6||SGD DESC:UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Gene:APL3(YBL037W)|FD-Score:4.16|P-value:1.60E-5||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:AVT7(YIL088C)|FD-Score:3.61|P-value:1.54E-4||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BUD26(YDR241W_d)|FD-Score:3.79|P-value:7.45E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:FAA4(YMR246W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication Gene:FKS3(YMR306W)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FPS1(YLL043W)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress Gene:FRD1(YEL047C)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication Gene:GCN4(YEL009C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GIS2(YNL255C)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 Gene:GLG1(YKR058W)|FD-Score:-3.24|P-value:5.94E-4||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication Gene:GLY1(YEL046C)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis Gene:GRX7(YBR014C)|FD-Score:-9.94|P-value:1.41E-23||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:GSF2(YML048W)|FD-Score:4.35|P-value:6.92E-6||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:GYL1(YMR192W)|FD-Score:-5.26|P-value:7.28E-8||SGD DESC:Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:HHT2(YNL031C)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation Gene:IES2(YNL215W)|FD-Score:5.09|P-value:1.82E-7||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:MRPL23(YOR150W)|FD-Score:4.93|P-value:4.17E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NHP10(YDL002C)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:PEX13(YLR191W)|FD-Score:3.26|P-value:5.54E-4||SGD DESC:Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p Gene:PHO88(YBR106W)|FD-Score:3.77|P-value:8.19E-5||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:PUS1(YPL212C)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA Gene:RAM1(YDL090C)|FD-Score:4.18|P-value:1.45E-5||SGD DESC:Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Gene:RPL37B(YDR500C)|FD-Score:3.85|P-value:5.88E-5||SGD DESC:Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication Gene:RPS18A(YDR450W)|FD-Score:3.73|P-value:9.67E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress Gene:RTC1(YOL138C)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SAC7(YDR389W)|FD-Score:5.19|P-value:1.04E-7||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SEH1(YGL100W)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 Gene:SFP1(YLR403W)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion Gene:THI22(YPR121W)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Gene:TOP1(YOL006C)|FD-Score:3.96|P-value:3.77E-5||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBL029C-A(YBL029C-A_p)|FD-Score:4.95|P-value:3.63E-7||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica Gene:YBL070C(YBL070C_d)|FD-Score:3.82|P-value:6.70E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR182C-A(YBR182C-A_p)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBR206W(YBR206W_d)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YCR043C(YCR043C_p)|FD-Score:5.67|P-value:6.98E-9||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Gene:YDR157W(YDR157W_d)|FD-Score:-3.18|P-value:7.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR203W(YDR203W_d)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER091C-A(YER091C-A_d)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YFR045W(YFR045W_p)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YGR051C(YGR051C_d)|FD-Score:3.34|P-value:4.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Gene:YLL044W(YLL044W_d)|FD-Score:4.46|P-value:4.05E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YMR245W(YMR245W_d)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YND1(YER005W)|FD-Score:-7.51|P-value:3.04E-14||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNR061C(YNR061C_p)|FD-Score:4.49|P-value:3.55E-6||SGD DESC:Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:YOL163W(YOL163W_p)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YPR099C(YPR099C_d)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Gene:YPR130C(YPR130C_d)|FD-Score:-4.13|P-value:1.78E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR290W-A_d6.991.41E-121.93YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YEL034W6.834.24E-121.93HYP2Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
YHR170W4.904.73E-70.39NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YGR114C_d4.513.20E-60.29YGR114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YEL035C_p4.231.19E-50.22UTR5_pProtein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
YKL195W4.013.07E-50.02MIA40Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
YNL290W3.983.39E-50.33RFC3Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YKL145W3.661.28E-40.06RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
YPR133C3.591.65E-40.02SPN1Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
YCR052W3.571.78E-40.02RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YLR275W3.551.90E-40.13SMD2Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YDR407C3.423.11E-40.06TRS120One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YIR015W3.363.90E-40.11RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YDR045C3.255.73E-40.01RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YBR198C3.246.03E-40.03TAF5Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR043C_p5.676.98E-9YCR043C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
YDR389W5.191.04E-7SAC7GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YNL215W5.091.82E-7IES2Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
YBL029C-A_p4.953.63E-7YBL029C-A_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YOR150W4.934.17E-7MRPL23Mitochondrial ribosomal protein of the large subunit
YNR061C_p4.493.55E-6YNR061C_pProtein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress
YLL044W_d4.464.05E-6YLL044W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YML048W4.356.92E-6GSF2ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YPL227C4.337.54E-6ALG5UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YDL090C4.181.45E-5RAM1Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YBL037W4.161.60E-5APL3Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
YOL006C3.963.77E-5TOP1Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YMR245W_d3.894.98E-5YMR245W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR500C3.855.88E-5RPL37BRibosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
YPR099C_d3.846.22E-5YPR099C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W

GO enrichment analysis for SGTC_853
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1647.82E-37SGTC_1098clofazimine 15.1 μMNIH Clinical Collection27940.0641026heme biosynthesis & mitochondrial translocase
0.1172.19E-19SGTC_690096-0274 206.7 μMChemDiv (Drug-like library)67413920.0793651mitochondrial processes
0.1158.56E-19SGTC_8510394-0702 453.0 μMChemDiv (Drug-like library)7626460.118644mitochondrial processes
0.1016.09E-15SGTC_7450469-0705 296.0 μMChemDiv (Drug-like library)34867360.109375mitochondrial processes
0.1016.93E-15SGTC_32729137413 49.5 μMChembridge (Drug-like library)176148700.155172
0.1001.19E-14SGTC_14813346-2004 36.0 μMChemDiv (Drug-like library)27705220.131579
0.1001.62E-14SGTC_1113artemisinin 1.2 μMTimTec (Natural product library)22400.0757576heme biosynthesis & mitochondrial translocase
0.0961.08E-13SGTC_1103duloxetine 36.1 μMNIH Clinical Collection608350.106061
0.0921.28E-12SGTC_2727riluzole 51.8 μMMiscellaneous50700.103448mitochondrial processes
0.0903.57E-12SGTC_260302-0163 425.2 μMChemDiv (Drug-like library)31009150.118644heme biosynthesis & mitochondrial translocase
0.0905.48E-12SGTC_13712421-0008 32.7 μMChemDiv (Drug-like library)28275520.0746269mitochondrial processes
0.0841.07E-10SGTC_1647st011722 22.4 μMTimTec (Natural product derivative library)28547830.129032
0.0782.23E-9SGTC_10034049-0218 100.0 μMChemDiv (Drug-like library)2951610.0862069
0.0764.12E-9SGTC_1831st055328 12.0 μMTimTec (Natural product derivative library)11030680.0806452heme biosynthesis & mitochondrial translocase
0.0731.57E-8SGTC_2129girgensonine 121.1 μMChembridge (Fragment library)4426380.196078heme biosynthesis & mitochondrial translocase

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_9571187-156114.1 μM0.5833331538454ChemDiv (Drug-like library)252.35085.01711
SGTC_12440416-001552.5 μM0.57575896201ChemDiv (Drug-like library)254.323624.31922ERG2
SGTC_13071187-159912.2 μM0.523811538471ChemDiv (Drug-like library)296.403365.3512PDR1
SGTC_12430416-00035.65 μM0.4871792141977ChemDiv (Drug-like library)286.795865.68111PDR1
SGTC_23839036125200 μM0.41666779580Chembridge (Fragment library)230.305522.10303
SGTC_1087pterostilbene9.05 μM0.3488375281727NIH Clinical Collection256.296443.54113
SGTC_15427-hydroxy-3'-methoxyflavone49.7 μM0.3272735393153TimTec (Pure natural product library)268.264082.87814
SGTC_20214019055173 μM0.32608744827708Chembridge (Fragment library)163.216321.26112endomembrane recycling
SGTC_1111tnp00062510.7 nM0.296296676306TimTec (Natural product library)268.264082.87814
SGTC_11103-hydroxy-3'-methoxyflavone1.24 μM0.290909676296TimTec (Natural product library)268.264082.58214iron homeostasis