Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YFL029C | 7.77 | 3.80E-15 | 3.43 | CAK1 | Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases |
YMR268C | 4.35 | 6.92E-6 | 0.33 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YER021W | 4.02 | 2.97E-5 | 0.14 | RPN3 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control |
YIL046W | 3.88 | 5.21E-5 | 0.32 | MET30 | F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus |
YJR023C_d | 3.56 | 1.86E-4 | 0.33 | YJR023C_d | Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing |
YJL005W | 3.23 | 6.16E-4 | 0.01 | CYR1 | Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation |
YIL022W | 3.22 | 6.47E-4 | 0.05 | TIM44 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) |
YGL172W | 3.17 | 7.61E-4 | 0.06 | NUP49 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) |
YOL026C | 3.11 | 9.29E-4 | 0.23 | MIM1 | Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex |
YEL032W | 2.88 | 0.00196 | 0.05 | MCM3 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex |
YKL173W | 2.84 | 0.00228 | 0.02 | SNU114 | GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 |
YGR190C_d | 2.82 | 0.00244 | 0.06 | YGR190C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W |
YNL110C | 2.76 | 0.00291 | 0.06 | NOP15 | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm |
YDR243C | 2.70 | 0.00346 | 0.02 | PRP28 | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
YJL203W | 2.68 | 0.00372 | 0.05 | PRP21 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |