Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR208W | 7.84 | 2.17E-15 | 3.44 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YDR362C | 4.40 | 5.29E-6 | 0.23 | TFC6 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 |
YDL164C | 4.18 | 1.46E-5 | 0.12 | CDC9 | DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination |
YLL036C | 4.06 | 2.48E-5 | 0.24 | PRP19 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain |
YBL040C | 3.82 | 6.66E-5 | 0.14 | ERD2 | HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins |
YNR035C | 3.68 | 1.15E-4 | 0.08 | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
YJL014W | 3.60 | 1.59E-4 | 0.04 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YOR272W | 3.56 | 1.87E-4 | 0.03 | YTM1 | Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats |
YDR037W | 3.53 | 2.09E-4 | 0.08 | KRS1 | Lysyl-tRNA synthetase |
YJR045C | 3.45 | 2.82E-4 | 0.02 | SSC1 | Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication |
YLR076C_d | 3.43 | 3.07E-4 | 0.12 | YLR076C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 |
YMR314W | 3.31 | 4.69E-4 | 0.02 | PRE5 | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
YER048W-A | 3.29 | 5.07E-4 | 3.89E-4 | ISD11 | Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis |
YDR170C | 3.29 | 5.08E-4 | 0.00 | SEC7 | Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles |
YDR182W | 3.28 | 5.12E-4 | 1.46E-4 | CDC1 | Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution |