0720-0963

(3-methylphenyl) 6-chloro-2-sulfanylidene-1,3-benzoxazole-3-carboxylate

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_876
Screen concentration 56.8 μM
Source ChemDiv (Drug-like library)
PubChem CID 765861
SMILES CC1=CC(=CC=C1)OC(=O)N2C3=C(C=C(C=C3)Cl)OC2=S
Standardized SMILES Cc1cccc(OC(=O)N2C(=S)Oc3cc(Cl)ccc23)c1
Molecular weight 319.7628
ALogP 5.6
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.54
% growth inhibition (Hom. pool) 7.71


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 765861
Download HIP data (tab-delimited text)  (excel)
Gene:BRL1(YHR036W)|FD-Score:4.77|P-value:9.18E-7|Clearance:0.4||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:ERG11(YHR007C)|FD-Score:3.85|P-value:5.79E-5|Clearance:0.09||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:NUP116(YMR047C)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.09||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p) Gene:PAM16(YJL104W)|FD-Score:4.05|P-value:2.51E-5|Clearance:0.2||SGD DESC:Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain Gene:PRP40(YKL012W)|FD-Score:4.29|P-value:9.05E-6|Clearance:0.16||SGD DESC:U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex Gene:PRP46(YPL151C)|FD-Score:3.17|P-value:7.63E-4|Clearance:0.23||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:RER2(YBR002C)|FD-Score:4.68|P-value:1.42E-6|Clearance:0.4||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RHO1(YPR165W)|FD-Score:-3.72|P-value:9.95E-5|Clearance:0||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RNT1(YMR239C)|FD-Score:4.12|P-value:1.87E-5|Clearance:0.07||SGD DESC:Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes Gene:RPA43(YOR340C)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.08||SGD DESC:RNA polymerase I subunit A43 Gene:RSA4(YCR072C)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.2||SGD DESC:WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus Gene:SPC25(YER018C)|FD-Score:3.59|P-value:1.63E-4|Clearance:0.05||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:SUB2(YDL084W)|FD-Score:3.76|P-value:8.41E-5|Clearance:0.09||SGD DESC:Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:USB1(YLR132C)|FD-Score:3.45|P-value:2.79E-4|Clearance:0.08||SGD DESC:Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants Gene:BRL1(YHR036W)|FD-Score:4.77|P-value:9.18E-7|Clearance:0.4||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:ERG11(YHR007C)|FD-Score:3.85|P-value:5.79E-5|Clearance:0.09||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:NUP116(YMR047C)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.09||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p) Gene:PAM16(YJL104W)|FD-Score:4.05|P-value:2.51E-5|Clearance:0.2||SGD DESC:Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain Gene:PRP40(YKL012W)|FD-Score:4.29|P-value:9.05E-6|Clearance:0.16||SGD DESC:U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex Gene:PRP46(YPL151C)|FD-Score:3.17|P-value:7.63E-4|Clearance:0.23||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:RER2(YBR002C)|FD-Score:4.68|P-value:1.42E-6|Clearance:0.4||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RHO1(YPR165W)|FD-Score:-3.72|P-value:9.95E-5|Clearance:0||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RNT1(YMR239C)|FD-Score:4.12|P-value:1.87E-5|Clearance:0.07||SGD DESC:Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes Gene:RPA43(YOR340C)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.08||SGD DESC:RNA polymerase I subunit A43 Gene:RSA4(YCR072C)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.2||SGD DESC:WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus Gene:SPC25(YER018C)|FD-Score:3.59|P-value:1.63E-4|Clearance:0.05||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:SUB2(YDL084W)|FD-Score:3.76|P-value:8.41E-5|Clearance:0.09||SGD DESC:Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:USB1(YLR132C)|FD-Score:3.45|P-value:2.79E-4|Clearance:0.08||SGD DESC:Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 765861
Download HOP data (tab-delimited text)  (excel)
Gene:ADE1(YAR015W)|FD-Score:-4.2|P-value:1.36E-5||SGD DESC:N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress Gene:AIM34(YMR003W)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Gene:ANP1(YEL036C)|FD-Score:-3.13|P-value:8.63E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ARA1(YBR149W)|FD-Score:3.15|P-value:8.03E-4||SGD DESC:NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product Gene:ATP25(YMR098C)|FD-Score:3.9|P-value:4.90E-5||SGD DESC:Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene Gene:BNS1(YGR230W)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Gene:BRP1(YGL007W_d)|FD-Score:3.84|P-value:6.07E-5||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:COG7(YGL005C)|FD-Score:-4.02|P-value:2.92E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ4(YDR204W)|FD-Score:-3.79|P-value:7.41E-5||SGD DESC:Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex Gene:DSS1(YMR287C)|FD-Score:4.13|P-value:1.78E-5||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:ECM25(YJL201W)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p Gene:EGT2(YNL327W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner Gene:ERF2(YLR246W)|FD-Score:3.92|P-value:4.43E-5||SGD DESC:Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole Gene:ESC8(YOL017W)|FD-Score:4.05|P-value:2.55E-5||SGD DESC:Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication Gene:FRE6(YLL051C)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels Gene:GIP1(YBR045C)|FD-Score:-3.27|P-value:5.45E-4||SGD DESC:Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p Gene:GTT3(YEL017W)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery Gene:HMI1(YOL095C)|FD-Score:6.29|P-value:1.60E-10||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HNT1(YDL125C)|FD-Score:3.22|P-value:6.47E-4||SGD DESC:Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress Gene:INP1(YMR204C)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:IRS4(YKR019C)|FD-Score:-4.62|P-value:1.91E-6||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LAC1(YKL008C)|FD-Score:-3.94|P-value:4.15E-5||SGD DESC:Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p Gene:LOA1(YPR139C)|FD-Score:5.1|P-value:1.72E-7||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:MBP1(YDL056W)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MED1(YPR070W)|FD-Score:-3.72|P-value:9.98E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MHR1(YDR296W)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MOD5(YOR274W)|FD-Score:-6.78|P-value:5.94E-12||SGD DESC:Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis Gene:MRL1(YPR079W)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress Gene:MRP7(YNL005C)|FD-Score:3.9|P-value:4.86E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL28(YDR462W)|FD-Score:4.05|P-value:2.51E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:MRPL35(YDR322W)|FD-Score:3.44|P-value:2.86E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL38(YKL170W)|FD-Score:4.5|P-value:3.42E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress Gene:MRPS12(YNR036C)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins Gene:MRPS5(YBR251W)|FD-Score:3.19|P-value:7.18E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NAS2(YIL007C)|FD-Score:3.91|P-value:4.68E-5||SGD DESC:Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress Gene:NFI1(YOR156C)|FD-Score:-3.81|P-value:6.88E-5||SGD DESC:SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length Gene:NUP120(YKL057C)|FD-Score:-3.64|P-value:1.39E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 Gene:OPT2(YPR194C)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles Gene:PKH3(YDR466W)|FD-Score:3.2|P-value:6.86E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:REI1(YBR267W)|FD-Score:-3.47|P-value:2.63E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RSM18(YER050C)|FD-Score:3.89|P-value:4.93E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein Gene:RSM22(YKL155C)|FD-Score:7.61|P-value:1.37E-14||SGD DESC:Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase Gene:RTG1(YOL067C)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SAC6(YDR129C)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SHB17(YKR043C)|FD-Score:5.66|P-value:7.60E-9||SGD DESC:Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus Gene:SKI3(YPR189W)|FD-Score:3.25|P-value:5.79E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SUV3(YPL029W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron Gene:TLG2(YOL018C)|FD-Score:-3.8|P-value:7.13E-5||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:TMA23(YMR269W)|FD-Score:-3.38|P-value:3.65E-4||SGD DESC:Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan Gene:UBP12(YJL197W)|FD-Score:3.63|P-value:1.39E-4||SGD DESC:Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm Gene:YBR141C(YBR141C_p)|FD-Score:3.74|P-value:9.08E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene Gene:YDL032W(YDL032W_d)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YDR131C(YDR131C_p)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex Gene:YEL045C(YEL045C_d)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Gene:YER158C(YER158C_p)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication Gene:YER186C(YER186C_p)|FD-Score:3.68|P-value:1.19E-4||SGD DESC:Putative protein of unknown function Gene:YLR046C(YLR046C_p)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YML007C-A(YML007C-A_p)|FD-Score:5.87|P-value:2.14E-9||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria Gene:YML122C(YML122C_d)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL184C(YNL184C_p)|FD-Score:5.11|P-value:1.61E-7||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YOL014W(YOL014W_p)|FD-Score:3.16|P-value:7.95E-4||SGD DESC:Putative protein of unknown function Gene:YOR121C(YOR121C_d)|FD-Score:3.86|P-value:5.62E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Gene:YPT6(YLR262C)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:ADE1(YAR015W)|FD-Score:-4.2|P-value:1.36E-5||SGD DESC:N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress Gene:AIM34(YMR003W)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Gene:ANP1(YEL036C)|FD-Score:-3.13|P-value:8.63E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ARA1(YBR149W)|FD-Score:3.15|P-value:8.03E-4||SGD DESC:NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product Gene:ATP25(YMR098C)|FD-Score:3.9|P-value:4.90E-5||SGD DESC:Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene Gene:BNS1(YGR230W)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Gene:BRP1(YGL007W_d)|FD-Score:3.84|P-value:6.07E-5||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:COG7(YGL005C)|FD-Score:-4.02|P-value:2.92E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ4(YDR204W)|FD-Score:-3.79|P-value:7.41E-5||SGD DESC:Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex Gene:DSS1(YMR287C)|FD-Score:4.13|P-value:1.78E-5||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:ECM25(YJL201W)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p Gene:EGT2(YNL327W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner Gene:ERF2(YLR246W)|FD-Score:3.92|P-value:4.43E-5||SGD DESC:Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole Gene:ESC8(YOL017W)|FD-Score:4.05|P-value:2.55E-5||SGD DESC:Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication Gene:FRE6(YLL051C)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels Gene:GIP1(YBR045C)|FD-Score:-3.27|P-value:5.45E-4||SGD DESC:Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p Gene:GTT3(YEL017W)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery Gene:HMI1(YOL095C)|FD-Score:6.29|P-value:1.60E-10||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HNT1(YDL125C)|FD-Score:3.22|P-value:6.47E-4||SGD DESC:Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress Gene:INP1(YMR204C)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:IRS4(YKR019C)|FD-Score:-4.62|P-value:1.91E-6||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LAC1(YKL008C)|FD-Score:-3.94|P-value:4.15E-5||SGD DESC:Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p Gene:LOA1(YPR139C)|FD-Score:5.1|P-value:1.72E-7||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:MBP1(YDL056W)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MED1(YPR070W)|FD-Score:-3.72|P-value:9.98E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MHR1(YDR296W)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MOD5(YOR274W)|FD-Score:-6.78|P-value:5.94E-12||SGD DESC:Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis Gene:MRL1(YPR079W)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress Gene:MRP7(YNL005C)|FD-Score:3.9|P-value:4.86E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL28(YDR462W)|FD-Score:4.05|P-value:2.51E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:MRPL35(YDR322W)|FD-Score:3.44|P-value:2.86E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL38(YKL170W)|FD-Score:4.5|P-value:3.42E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress Gene:MRPS12(YNR036C)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins Gene:MRPS5(YBR251W)|FD-Score:3.19|P-value:7.18E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NAS2(YIL007C)|FD-Score:3.91|P-value:4.68E-5||SGD DESC:Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress Gene:NFI1(YOR156C)|FD-Score:-3.81|P-value:6.88E-5||SGD DESC:SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length Gene:NUP120(YKL057C)|FD-Score:-3.64|P-value:1.39E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 Gene:OPT2(YPR194C)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles Gene:PKH3(YDR466W)|FD-Score:3.2|P-value:6.86E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:REI1(YBR267W)|FD-Score:-3.47|P-value:2.63E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RSM18(YER050C)|FD-Score:3.89|P-value:4.93E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein Gene:RSM22(YKL155C)|FD-Score:7.61|P-value:1.37E-14||SGD DESC:Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase Gene:RTG1(YOL067C)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SAC6(YDR129C)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SHB17(YKR043C)|FD-Score:5.66|P-value:7.60E-9||SGD DESC:Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus Gene:SKI3(YPR189W)|FD-Score:3.25|P-value:5.79E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SUV3(YPL029W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron Gene:TLG2(YOL018C)|FD-Score:-3.8|P-value:7.13E-5||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:TMA23(YMR269W)|FD-Score:-3.38|P-value:3.65E-4||SGD DESC:Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan Gene:UBP12(YJL197W)|FD-Score:3.63|P-value:1.39E-4||SGD DESC:Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm Gene:YBR141C(YBR141C_p)|FD-Score:3.74|P-value:9.08E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene Gene:YDL032W(YDL032W_d)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YDR131C(YDR131C_p)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex Gene:YEL045C(YEL045C_d)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Gene:YER158C(YER158C_p)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication Gene:YER186C(YER186C_p)|FD-Score:3.68|P-value:1.19E-4||SGD DESC:Putative protein of unknown function Gene:YLR046C(YLR046C_p)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YML007C-A(YML007C-A_p)|FD-Score:5.87|P-value:2.14E-9||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria Gene:YML122C(YML122C_d)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL184C(YNL184C_p)|FD-Score:5.11|P-value:1.61E-7||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YOL014W(YOL014W_p)|FD-Score:3.16|P-value:7.95E-4||SGD DESC:Putative protein of unknown function Gene:YOR121C(YOR121C_d)|FD-Score:3.86|P-value:5.62E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Gene:YPT6(YLR262C)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR036W4.779.18E-70.40BRL1Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YBR002C4.681.42E-60.40RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YKL012W4.299.05E-60.16PRP40U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YMR239C4.121.87E-50.07RNT1Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
YJL104W4.052.51E-50.20PAM16Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
YHR007C3.855.79E-50.09ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YDL084W3.768.41E-50.09SUB2Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
YOR340C3.671.19E-40.08RPA43RNA polymerase I subunit A43
YER018C3.591.63E-40.05SPC25Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YMR047C3.542.00E-40.09NUP116FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
YLR132C3.452.79E-40.08USB1Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
YCR072C3.373.77E-40.20RSA4WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YPL151C3.177.63E-40.23PRP46Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YMR200W2.940.001660.19ROT1Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
YMR094W2.750.002980.03CTF13Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL155C7.611.37E-14RSM22Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
YOL095C6.291.60E-10HMI1Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
YML007C-A_p5.872.14E-9YML007C-A_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
YKR043C5.667.60E-9SHB17Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
YNL184C_p5.111.61E-7YNL184C_pProtein of unknown function; expressed at both mRNA and protein levels
YPR139C5.101.72E-7LOA1Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA
YKL170W4.503.42E-6MRPL38Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
YMR204C4.221.21E-5INP1Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane
YLR046C_p4.171.53E-5YLR046C_pPutative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YDR296W4.171.54E-5MHR1Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
YMR287C4.131.78E-5DSS13'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
YDR462W4.052.51E-5MRPL28Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
YOL017W4.052.55E-5ESC8Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
YJL201W4.013.04E-5ECM25Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
YLR246W3.924.43E-5ERF2Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole

GO enrichment analysis for SGTC_876
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1504.21E-31SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.0684932mitochondrial stress
0.1462.42E-29SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.15TRP & mitochondrial translation
0.1394.99E-27SGTC_1742st038235 28.9 μMTimTec (Natural product derivative library)5641030.164557mitochondrial stress
0.1248.44E-22SGTC_1622st003707 19.4 μMTimTec (Natural product derivative library)101408990.129032calcium & mitochondrial duress
0.1156.64E-19SGTC_7670929-0023 86.0 μMChemDiv (Drug-like library)12045630.140845TRP & mitochondrial translation
0.1141.87E-18SGTC_204PMA1.184 62.4 μMChemDiv (Drug-like library)22522130.135802TRP & mitochondrial translation
0.1111.43E-17SGTC_190279-0214 38.4 μMChemDiv (Drug-like library)35662740.15TRP & mitochondrial translation
0.1031.69E-15SGTC_19215740136 50.0 μMMiscellaneous17742430.111111TRP & mitochondrial translation
0.1023.80E-15SGTC_1627st003713 25.6 μMTimTec (Natural product derivative library)161950700.105263calcium & mitochondrial duress
0.1017.05E-15SGTC_2513baicalein 25.6 μMMicrosource (Natural product library)52816050.132353calcium & mitochondrial duress
0.1001.12E-14SGTC_275trichlorophene 5.7 μMMiscellaneous626160.152542mitochondrial stress
0.0984.45E-14SGTC_9083448-7491 47.7 μMChemDiv (Drug-like library)12030310.104478mitochondrial stress
0.0986.10E-14SGTC_1623st003709 20.3 μMTimTec (Natural product derivative library)161926180.2calcium & mitochondrial duress
0.0961.38E-13SGTC_2361509-0011 5.3 μMChemDiv (Drug-like library)31072800.0684932
0.0944.09E-13SGTC_6023130-1533 38.1 μMChemDiv (Drug-like library)7209410.0945946

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_12320279-0259161 μM0.3906251560000ChemDiv (Drug-like library)298.27192.63607
SGTC_1741st03813410.23 μM0.3666671272587TimTec (Natural product derivative library)393.17774.13905
SGTC_1976st07060963.5 μM0.333333682556TimTec (Natural product derivative library)314.719844.44204
SGTC_2841900476138.96 μM0.317462991039Chembridge (Drug-like library)289.756744.08412amide catabolism
SGTC_11574092-039427.6 μM0.3088243659885ChemDiv (Drug-like library)358.861823.7703
SGTC_7450469-0705296 μM0.3015873486736ChemDiv (Drug-like library)238.153741.86706mitochondrial processes
SGTC_3049909222349.47 μM0.2878798623917Chembridge (Drug-like library)328.835843.93502
SGTC_13561502-078185.8 μM0.285714567702ChemDiv (Drug-like library)284.761823.53804fatty acid desaturase (OLE1)
SGTC_5651418-000144.5 μM0.2833332862145ChemDiv (Drug-like library)245.704183.63812
SGTC_13321480-065317.5 μM0.2833335749438ChemDiv (Drug-like library)219.259662.79503TSC3-RPN4