0833-0487

4-(4-phenylphenyl)-1,3-thiazol-2-amine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_880
Screen concentration 87.2 μM
Source ChemDiv (Drug-like library)
PubChem CID 76075
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CSC(=N3)N
Standardized SMILES Nc1nc(cs1)c2ccc(cc2)c3ccccc3
Molecular weight 252.3342
ALogP 3.55
H-bond donor count 1
H-bond acceptor count 3
Response signature mitochondrial processes

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.16
% growth inhibition (Hom. pool) 7.92


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 76075
Download HIP data (tab-delimited text)  (excel)
Gene:GPI13(YLL031C)|FD-Score:-3.19|P-value:7.17E-4|Clearance:0||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:GPN3(YLR243W_p)|FD-Score:-3.52|P-value:2.13E-4|Clearance:0||SGD DESC:Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p Gene:NAM9(YNL137C)|FD-Score:-3.27|P-value:5.36E-4|Clearance:0||SGD DESC:Mitochondrial ribosomal component of the small subunit Gene:PRP11(YDL043C)|FD-Score:3.57|P-value:1.76E-4|Clearance:0.15||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PUP2(YGR253C)|FD-Score:4.3|P-value:8.59E-6|Clearance:0.73||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RLP7(YNL002C)|FD-Score:3.43|P-value:3.04E-4|Clearance:0.16||SGD DESC:Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Gene:STU2(YLR045C)|FD-Score:-4.17|P-value:1.49E-5|Clearance:0||SGD DESC:Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p Gene:YIP1(YGR172C)|FD-Score:-3.12|P-value:9.13E-4|Clearance:0||SGD DESC:Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 Gene:YJL195C(YJL195C_d)|FD-Score:3.26|P-value:5.51E-4|Clearance:0.1||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 Gene:YPL142C(YPL142C_d)|FD-Score:3.16|P-value:7.91E-4|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit Gene:GPI13(YLL031C)|FD-Score:-3.19|P-value:7.17E-4|Clearance:0||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:GPN3(YLR243W_p)|FD-Score:-3.52|P-value:2.13E-4|Clearance:0||SGD DESC:Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p Gene:NAM9(YNL137C)|FD-Score:-3.27|P-value:5.36E-4|Clearance:0||SGD DESC:Mitochondrial ribosomal component of the small subunit Gene:PRP11(YDL043C)|FD-Score:3.57|P-value:1.76E-4|Clearance:0.15||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PUP2(YGR253C)|FD-Score:4.3|P-value:8.59E-6|Clearance:0.73||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RLP7(YNL002C)|FD-Score:3.43|P-value:3.04E-4|Clearance:0.16||SGD DESC:Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Gene:STU2(YLR045C)|FD-Score:-4.17|P-value:1.49E-5|Clearance:0||SGD DESC:Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p Gene:YIP1(YGR172C)|FD-Score:-3.12|P-value:9.13E-4|Clearance:0||SGD DESC:Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 Gene:YJL195C(YJL195C_d)|FD-Score:3.26|P-value:5.51E-4|Clearance:0.1||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 Gene:YPL142C(YPL142C_d)|FD-Score:3.16|P-value:7.91E-4|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 76075
Download HOP data (tab-delimited text)  (excel)
Gene:AFT1(YGL071W)|FD-Score:-3.16|P-value:8.00E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:AQR1(YNL065W)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:ATP11(YNL315C)|FD-Score:15.9|P-value:2.00E-57||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:ATP12(YJL180C)|FD-Score:4.79|P-value:8.40E-7||SGD DESC:Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency Gene:ATP2(YJR121W)|FD-Score:7.12|P-value:5.27E-13||SGD DESC:Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BGL2(YGR282C)|FD-Score:4.56|P-value:2.56E-6||SGD DESC:Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance Gene:BRE2(YLR015W)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L Gene:BUD16(YEL029C)|FD-Score:-5.2|P-value:1.02E-7||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:CKI1(YLR133W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication Gene:COX12(YLR038C)|FD-Score:-3.3|P-value:4.81E-4||SGD DESC:Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV Gene:COX17(YLL009C)|FD-Score:-3.65|P-value:1.31E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CWH41(YGL027C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress Gene:DAL81(YIR023W)|FD-Score:4.7|P-value:1.28E-6||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DER1(YBR201W)|FD-Score:3.17|P-value:7.52E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p Gene:EFT1(YOR133W)|FD-Score:3.28|P-value:5.26E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication Gene:ERV41(YML067C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:FMP41(YNL168C_p)|FD-Score:-4.82|P-value:7.03E-7||SGD DESC:Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GEP4(YHR100C)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT Gene:HHT1(YBR010W)|FD-Score:4.43|P-value:4.75E-6||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation Gene:IRC25(YLR021W)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:KSP1(YHR082C)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress Gene:LOC1(YFR001W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:LOH1(YJL038C)|FD-Score:3.13|P-value:8.72E-4||SGD DESC:Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 Gene:LSC1(YOR142W)|FD-Score:-3.96|P-value:3.81E-5||SGD DESC:Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated Gene:MDL2(YPL270W)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis Gene:MDM34(YGL219C)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MMS4(YBR098W)|FD-Score:-3.89|P-value:4.95E-5||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:NMA1(YLR328W)|FD-Score:4.6|P-value:2.12E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:PAC10(YGR078C)|FD-Score:3.73|P-value:9.39E-5||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PCL1(YNL289W)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:REC104(YHR157W)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination Gene:RGA2(YDR379W)|FD-Score:-3.25|P-value:5.82E-4||SGD DESC:GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p Gene:RPL7B(YPL198W)|FD-Score:-3.23|P-value:6.11E-4||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RPL9A(YGL147C)|FD-Score:4.55|P-value:2.73E-6||SGD DESC:Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 Gene:RPS25A(YGR027C)|FD-Score:3.12|P-value:8.97E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication Gene:RPS9B(YBR189W)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication Gene:SIA1(YOR137C)|FD-Score:-3.12|P-value:9.19E-4||SGD DESC:Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose Gene:SKI2(YLR398C)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SNZ2(YNL333W)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p Gene:STP4(YDL048C)|FD-Score:4.55|P-value:2.67E-6||SGD DESC:Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress Gene:TDA7(YNL176C_p)|FD-Score:5.39|P-value:3.61E-8||SGD DESC:Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele Gene:UBP7(YIL156W)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:UBR2(YLR024C)|FD-Score:-3.13|P-value:8.72E-4||SGD DESC:Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex Gene:YAK1(YJL141C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose Gene:YAP3(YHL009C)|FD-Score:3.75|P-value:8.91E-5||SGD DESC:Basic leucine zipper (bZIP) transcription factor Gene:YCR023C(YCR023C)|FD-Score:-3.17|P-value:7.74E-4||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YDL032W(YDL032W_d)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YER130C(YER130C_p)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YER186C(YER186C_p)|FD-Score:5.05|P-value:2.17E-7||SGD DESC:Putative protein of unknown function Gene:YER188W(YER188W_d)|FD-Score:4.84|P-value:6.57E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YKL027W(YKL027W)|FD-Score:4.53|P-value:2.89E-6||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YLR271W(YLR271W_p)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YLR406C-A(YLR406C-A_p)|FD-Score:3.21|P-value:6.52E-4||SGD DESC:Putative protein of unknown function Gene:YND1(YER005W)|FD-Score:-3.29|P-value:5.03E-4||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNL024C(YNL024C_p)|FD-Score:3.24|P-value:6.02E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YNL203C(YNL203C_d)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR071W(YPR071W_p)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:YPR108W-A(YPR108W-A_p)|FD-Score:-3.33|P-value:4.40E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:AFT1(YGL071W)|FD-Score:-3.16|P-value:8.00E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:AQR1(YNL065W)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:ATP11(YNL315C)|FD-Score:15.9|P-value:2.00E-57||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:ATP12(YJL180C)|FD-Score:4.79|P-value:8.40E-7||SGD DESC:Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency Gene:ATP2(YJR121W)|FD-Score:7.12|P-value:5.27E-13||SGD DESC:Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BGL2(YGR282C)|FD-Score:4.56|P-value:2.56E-6||SGD DESC:Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance Gene:BRE2(YLR015W)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L Gene:BUD16(YEL029C)|FD-Score:-5.2|P-value:1.02E-7||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:CKI1(YLR133W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication Gene:COX12(YLR038C)|FD-Score:-3.3|P-value:4.81E-4||SGD DESC:Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV Gene:COX17(YLL009C)|FD-Score:-3.65|P-value:1.31E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CWH41(YGL027C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress Gene:DAL81(YIR023W)|FD-Score:4.7|P-value:1.28E-6||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DER1(YBR201W)|FD-Score:3.17|P-value:7.52E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p Gene:EFT1(YOR133W)|FD-Score:3.28|P-value:5.26E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication Gene:ERV41(YML067C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:FMP41(YNL168C_p)|FD-Score:-4.82|P-value:7.03E-7||SGD DESC:Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GEP4(YHR100C)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT Gene:HHT1(YBR010W)|FD-Score:4.43|P-value:4.75E-6||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation Gene:IRC25(YLR021W)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:KSP1(YHR082C)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress Gene:LOC1(YFR001W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:LOH1(YJL038C)|FD-Score:3.13|P-value:8.72E-4||SGD DESC:Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 Gene:LSC1(YOR142W)|FD-Score:-3.96|P-value:3.81E-5||SGD DESC:Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated Gene:MDL2(YPL270W)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis Gene:MDM34(YGL219C)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MMS4(YBR098W)|FD-Score:-3.89|P-value:4.95E-5||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:NMA1(YLR328W)|FD-Score:4.6|P-value:2.12E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:PAC10(YGR078C)|FD-Score:3.73|P-value:9.39E-5||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PCL1(YNL289W)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:REC104(YHR157W)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination Gene:RGA2(YDR379W)|FD-Score:-3.25|P-value:5.82E-4||SGD DESC:GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p Gene:RPL7B(YPL198W)|FD-Score:-3.23|P-value:6.11E-4||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RPL9A(YGL147C)|FD-Score:4.55|P-value:2.73E-6||SGD DESC:Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 Gene:RPS25A(YGR027C)|FD-Score:3.12|P-value:8.97E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication Gene:RPS9B(YBR189W)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication Gene:SIA1(YOR137C)|FD-Score:-3.12|P-value:9.19E-4||SGD DESC:Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose Gene:SKI2(YLR398C)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SNZ2(YNL333W)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p Gene:STP4(YDL048C)|FD-Score:4.55|P-value:2.67E-6||SGD DESC:Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress Gene:TDA7(YNL176C_p)|FD-Score:5.39|P-value:3.61E-8||SGD DESC:Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele Gene:UBP7(YIL156W)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:UBR2(YLR024C)|FD-Score:-3.13|P-value:8.72E-4||SGD DESC:Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex Gene:YAK1(YJL141C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose Gene:YAP3(YHL009C)|FD-Score:3.75|P-value:8.91E-5||SGD DESC:Basic leucine zipper (bZIP) transcription factor Gene:YCR023C(YCR023C)|FD-Score:-3.17|P-value:7.74E-4||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YDL032W(YDL032W_d)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YER130C(YER130C_p)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YER186C(YER186C_p)|FD-Score:5.05|P-value:2.17E-7||SGD DESC:Putative protein of unknown function Gene:YER188W(YER188W_d)|FD-Score:4.84|P-value:6.57E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YKL027W(YKL027W)|FD-Score:4.53|P-value:2.89E-6||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YLR271W(YLR271W_p)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YLR406C-A(YLR406C-A_p)|FD-Score:3.21|P-value:6.52E-4||SGD DESC:Putative protein of unknown function Gene:YND1(YER005W)|FD-Score:-3.29|P-value:5.03E-4||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNL024C(YNL024C_p)|FD-Score:3.24|P-value:6.02E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YNL203C(YNL203C_d)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR071W(YPR071W_p)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:YPR108W-A(YPR108W-A_p)|FD-Score:-3.33|P-value:4.40E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR253C4.308.59E-60.73PUP2Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YDL043C3.571.76E-40.14PRP11Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YNL002C3.433.04E-40.17RLP7Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YJL195C_d3.265.51E-40.10YJL195C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
YPL142C_d3.167.91E-40.25YPL142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YLR459W2.910.001810.02GAB1GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
YGL018C2.890.001920.09JAC1Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YMR277W2.800.002520.02FCP1Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YBR055C2.780.002690.03PRP6Splicing factor, component of the U4/U6-U5 snRNP complex
YKR062W2.750.002940.01TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YKL182W2.740.003040.01FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YOL040C2.730.003130.12RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YKR081C2.610.004460.02RPF2Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YIR015W2.590.004780.06RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YOL120C2.530.005710.04RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL315C15.902.00E-57ATP11Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YJR121W7.125.27E-13ATP2Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YNL176C_p5.393.61E-8TDA7_pCell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
YER186C_p5.052.17E-7YER186C_pPutative protein of unknown function
YER188W_d4.846.57E-7YER188W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p
YJL180C4.798.40E-7ATP12Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
YIR023W4.701.28E-6DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YPL270W4.671.48E-6MDL2Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
YLR328W4.602.12E-6NMA1Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
YGR282C4.562.56E-6BGL2Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
YDL048C4.552.67E-6STP4Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress
YGL147C4.552.73E-6RPL9ARibosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6
YKL027W4.532.89E-6YKL027WProtein of unknown function, localized to the mitochondrial outer membrane
YBR010W4.434.75E-6HHT1Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
YLR398C4.082.22E-5SKI2Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay

GO enrichment analysis for SGTC_880
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1851.12E-46SGTC_2630antimycin a 100.0 μMMicrosource (Natural product library)57021990.0449438mitochondrial processes
0.1831.82E-45SGTC_11453546-0597 10.2 μMChemDiv (Drug-like library)8753340.0833333mitochondrial processes
0.1775.46E-43SGTC_20114012611 177.0 μMChembridge (Fragment library)20498870.25mitochondrial processes
0.1461.25E-29SGTC_7441594-0068 283.0 μMChemDiv (Drug-like library)6683920.25641amide catabolism
0.1351.90E-25SGTC_23709071495 200.0 μMChembridge (Fragment library)217911030.0888889mitochondrial processes
0.1287.54E-23SGTC_22847945075 39.2 μMChembridge (Fragment library)12454020.163636mitochondrial processes
0.1262.77E-22SGTC_1641st009299 47.1 μMTimTec (Natural product derivative library)40460540.103448mitochondrial processes
0.1211.34E-20SGTC_21765809774 34.0 μMChembridge (Fragment library)28705390.558824mitochondrial processes
0.1018.94E-15SGTC_486niguldipine 82.0 μMMiscellaneous12360.0705882amide catabolism
0.1001.21E-14SGTC_21775811945 192.0 μMChembridge (Fragment library)53434750.115385
0.0903.42E-12SGTC_23107668677 200.0 μMChembridge (Fragment library)21971430.134615
0.0871.66E-11SGTC_12380333-0287 48.8 μMChemDiv (Drug-like library)72260.219512Golgi
0.0854.85E-11SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.0666667amide catabolism
0.0856.05E-11SGTC_24605552655 174.2 μMMiscellaneous54019890.109091amide catabolism
0.0791.08E-9SGTC_23499023730 187.1 μMChembridge (Fragment library)41262870.0576923

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2176580977433.97 μM0.5588242870539Chembridge (Fragment library)240.752323.38123mitochondrial processes
SGTC_1524469-0003551.23 μM0.425697280ChemDiv (Drug-like library)268.333584.08224
SGTC_6281636-025316 μM0.4254456143ChemDiv (Drug-like library)331.230245.07213sphingolipid biosynthesis & PDR1
SGTC_2166593306131.5 μM0.4210532877375Chembridge (Fragment library)240.752323.38123tubulin folding & SWR complex
SGTC_23829035899200 μM0.4090916462679Chembridge (Fragment library)288.368041.9431460S ribosome export
SGTC_20914-phenylthiadiazole200 μM0.393939270010Chembridge (Fragment library)162.211642.32103
SGTC_20084012253172 μM0.388889603940Chembridge (Fragment library)185.225142.05513
SGTC_13501495-0454146 μM0.3777781069057ChemDiv (Drug-like library)350.843043.92615
SGTC_270485-000132.62 μM0.3752054479ChemDiv (Drug-like library)266.360764.32313RPP1 & pyrimidine depletion
SGTC_9521185-0122232 μM0.348837678600ChemDiv (Drug-like library)282.360163.8214