Deletion Strain | FD score | P-value | Gene | Gene Description |
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YEL017W | 6.17 | 3.32E-10 | GTT3 | Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery |
YLR446W_p | 5.56 | 1.34E-8 | YLR446W_p | Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene |
YMR237W | 5.26 | 7.03E-8 | BCH1 | Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication |
YDL025C | 5.15 | 1.33E-7 | RTK1 | Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress |
YIL110W | 5.06 | 2.04E-7 | HPM1 | AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance |
YNL121C | 5.00 | 2.94E-7 | TOM70 | Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication |
YER047C | 4.89 | 5.15E-7 | SAP1 | Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system |
YHR010W | 4.78 | 8.67E-7 | RPL27A | Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication |
YCL061C | 4.76 | 9.79E-7 | MRC1 | S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres |
YLR370C | 4.63 | 1.87E-6 | ARC18 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YNL293W | 4.56 | 2.54E-6 | MSB3 | Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YJL105W | 4.54 | 2.86E-6 | SET4 | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication |
YOR042W | 4.53 | 2.91E-6 | CUE5 | Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
YOR183W_p | 4.53 | 2.92E-6 | FYV12_p | Protein of unknown function, required for survival upon exposure to K1 killer toxin |
YBR041W | 4.51 | 3.27E-6 | FAT1 | Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids |