Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR018C | 6.21 | 2.67E-10 | GAL7 | Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism |
YGR224W | 5.29 | 6.11E-8 | AZR1 | Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole |
YLR164W | 5.21 | 9.32E-8 | SHH4 | Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
YBR293W | 4.93 | 4.01E-7 | VBA2 | Permease of basic amino acids in the vacuolar membrane |
YKR093W | 4.91 | 4.55E-7 | PTR2 | Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p |
YIL029C_p | 4.81 | 7.39E-7 | YIL029C_p | Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W |
YMR164C | 4.63 | 1.84E-6 | MSS11 | Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals |
YLR370C | 4.58 | 2.32E-6 | ARC18 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YCR009C | 4.41 | 5.20E-6 | RVS161 | Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress |
YGR247W | 4.37 | 6.30E-6 | CPD1 | Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress |
YOR275C | 4.35 | 6.85E-6 | RIM20 | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation |
YHR011W | 4.33 | 7.49E-6 | DIA4 | Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth |
YCL038C | 4.12 | 1.90E-5 | ATG22 | Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation |
YOL035C_d | 4.09 | 2.18E-5 | YOL035C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YCR034W | 4.08 | 2.26E-5 | FEN1 | Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication |