0964-0007

6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydropyrazol-3-ylidene]-4-ethyl-3-methoxycyclohexa-2,4-dien-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_896
Screen concentration 44.5 μM
Source ChemDiv (Drug-like library)
PubChem CID 6756758
SMILES CCC1=CC(=C2C(=CNN2)C3=CC4=C(C=C3)OCCO4)C(=O)C=C1OC
Standardized SMILES CCc1cc(c(O)cc1OC)c2[nH]ncc2c3ccc4OCCOc4c3
Molecular weight 352.3838
ALogP 1.46
H-bond donor count 2
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 23.76
% growth inhibition (Hom. pool) 7.83


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6756758
Download HIP data (tab-delimited text)  (excel)
Gene:CCT3(YJL014W)|FD-Score:4.28|P-value:9.28E-6|Clearance:0.09||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:COF1(YLL050C)|FD-Score:3.45|P-value:2.80E-4|Clearance:0.02||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:COG3(YER157W)|FD-Score:-4.8|P-value:8.00E-7|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CWC25(YNL245C)|FD-Score:-3.67|P-value:1.20E-4|Clearance:0||SGD DESC:Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p Gene:DAM1(YGR113W)|FD-Score:5.6|P-value:1.08E-8|Clearance:0.91||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments Gene:DML1(YMR211W)|FD-Score:3.43|P-value:2.96E-4|Clearance:0.1||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:FCF2(YLR051C)|FD-Score:3.23|P-value:6.29E-4|Clearance:0.06||SGD DESC:Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon Gene:FMN1(YDR236C)|FD-Score:4|P-value:3.17E-5|Clearance:0.04||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:JIP5(YPR169W)|FD-Score:4.63|P-value:1.82E-6|Clearance:0.29||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:KRE5(YOR336W)|FD-Score:4.34|P-value:7.12E-6|Clearance:0.06||SGD DESC:Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Gene:NUP57(YGR119C)|FD-Score:3.34|P-value:4.22E-4|Clearance:0.01||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PAN1(YIR006C)|FD-Score:3.5|P-value:2.29E-4|Clearance:0.05||SGD DESC:Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease Gene:PRP43(YGL120C)|FD-Score:3.16|P-value:7.87E-4|Clearance:0.15||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:RPC31(YNL151C)|FD-Score:4.02|P-value:2.89E-5|Clearance:0.02||SGD DESC:RNA polymerase III subunit C31 Gene:RPO31(YOR116C)|FD-Score:4.69|P-value:1.39E-6|Clearance:0.06||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:SEC23(YPR181C)|FD-Score:4.2|P-value:1.36E-5|Clearance:0.17||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:SNM1(YDR478W)|FD-Score:3.91|P-value:4.59E-5|Clearance:0.41||SGD DESC:Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP Gene:TOM40(YMR203W)|FD-Score:4.34|P-value:7.10E-6|Clearance:0||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:TRS31(YDR472W)|FD-Score:-3.36|P-value:3.90E-4|Clearance:0||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:UBC1(YDR177W)|FD-Score:-3.36|P-value:3.94E-4|Clearance:0||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:YDR187C(YDR187C_d)|FD-Score:3.96|P-value:3.68E-5|Clearance:0.05||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YPR136C(YPR136C_d)|FD-Score:3.32|P-value:4.43E-4|Clearance:0.1||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 Gene:CCT3(YJL014W)|FD-Score:4.28|P-value:9.28E-6|Clearance:0.09||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:COF1(YLL050C)|FD-Score:3.45|P-value:2.80E-4|Clearance:0.02||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:COG3(YER157W)|FD-Score:-4.8|P-value:8.00E-7|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CWC25(YNL245C)|FD-Score:-3.67|P-value:1.20E-4|Clearance:0||SGD DESC:Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p Gene:DAM1(YGR113W)|FD-Score:5.6|P-value:1.08E-8|Clearance:0.91||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments Gene:DML1(YMR211W)|FD-Score:3.43|P-value:2.96E-4|Clearance:0.1||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:FCF2(YLR051C)|FD-Score:3.23|P-value:6.29E-4|Clearance:0.06||SGD DESC:Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon Gene:FMN1(YDR236C)|FD-Score:4|P-value:3.17E-5|Clearance:0.04||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:JIP5(YPR169W)|FD-Score:4.63|P-value:1.82E-6|Clearance:0.29||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:KRE5(YOR336W)|FD-Score:4.34|P-value:7.12E-6|Clearance:0.06||SGD DESC:Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Gene:NUP57(YGR119C)|FD-Score:3.34|P-value:4.22E-4|Clearance:0.01||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PAN1(YIR006C)|FD-Score:3.5|P-value:2.29E-4|Clearance:0.05||SGD DESC:Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease Gene:PRP43(YGL120C)|FD-Score:3.16|P-value:7.87E-4|Clearance:0.15||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:RPC31(YNL151C)|FD-Score:4.02|P-value:2.89E-5|Clearance:0.02||SGD DESC:RNA polymerase III subunit C31 Gene:RPO31(YOR116C)|FD-Score:4.69|P-value:1.39E-6|Clearance:0.06||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:SEC23(YPR181C)|FD-Score:4.2|P-value:1.36E-5|Clearance:0.17||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:SNM1(YDR478W)|FD-Score:3.91|P-value:4.59E-5|Clearance:0.41||SGD DESC:Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP Gene:TOM40(YMR203W)|FD-Score:4.34|P-value:7.10E-6|Clearance:0||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:TRS31(YDR472W)|FD-Score:-3.36|P-value:3.90E-4|Clearance:0||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:UBC1(YDR177W)|FD-Score:-3.36|P-value:3.94E-4|Clearance:0||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:YDR187C(YDR187C_d)|FD-Score:3.96|P-value:3.68E-5|Clearance:0.05||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YPR136C(YPR136C_d)|FD-Score:3.32|P-value:4.43E-4|Clearance:0.1||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6756758
Download HOP data (tab-delimited text)  (excel)
Gene:BNI1(YNL271C)|FD-Score:5.95|P-value:1.34E-9||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BTS1(YPL069C)|FD-Score:4.28|P-value:9.26E-6||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CNB1(YKL190W)|FD-Score:3.78|P-value:7.78E-5||SGD DESC:Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress Gene:DSE4(YNR067C)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:EDS1(YBR033W_p)|FD-Score:3.25|P-value:5.77E-4||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:END3(YNL084C)|FD-Score:4.41|P-value:5.12E-6||SGD DESC:EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p Gene:ENT4(YLL038C)|FD-Score:4.1|P-value:2.05E-5||SGD DESC:Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome Gene:ERG2(YMR202W)|FD-Score:3.15|P-value:8.03E-4||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:ERG5(YMR015C)|FD-Score:3.18|P-value:7.26E-4||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:GUF1(YLR289W)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:HHF1(YBR009C)|FD-Score:-4.45|P-value:4.32E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:LSC1(YOR142W)|FD-Score:-3.6|P-value:1.58E-4||SGD DESC:Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated Gene:MEF2(YJL102W)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MNN2(YBR015C)|FD-Score:4.13|P-value:1.79E-5||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MSE1(YOL033W)|FD-Score:-3.49|P-value:2.41E-4||SGD DESC:Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated Gene:MSN4(YKL062W)|FD-Score:3.17|P-value:7.73E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication Gene:MSN5(YDR335W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:NTH1(YDR001C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication Gene:PDR1(YGL013C)|FD-Score:4.53|P-value:2.97E-6||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PDR12(YPL058C)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity Gene:PMA2(YPL036W)|FD-Score:5.68|P-value:6.90E-9||SGD DESC:Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential Gene:PNS1(YOR161C)|FD-Score:-4.14|P-value:1.74E-5||SGD DESC:Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport Gene:PPH3(YDR075W)|FD-Score:3.36|P-value:3.90E-4||SGD DESC:Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Gene:RRG1(YDR065W)|FD-Score:-3.29|P-value:4.99E-4||SGD DESC:Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SBE2(YDR351W)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SCW10(YMR305C)|FD-Score:5.59|P-value:1.17E-8||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p Gene:SPS18(YNL204C)|FD-Score:4.91|P-value:4.66E-7||SGD DESC:Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation Gene:SYC1(YOR179C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:-3.12|P-value:9.14E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP2(YER090W)|FD-Score:-3.67|P-value:1.22E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TSC3(YBR058C-A)|FD-Score:5.94|P-value:1.45E-9||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBC12(YLR306W)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Gene:UBP2(YOR124C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity Gene:VMA5(YKL080W)|FD-Score:-4.9|P-value:4.71E-7||SGD DESC:Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YAP5(YIR018W)|FD-Score:5.17|P-value:1.18E-7||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YDR008C(YDR008C_d)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGL101W(YGL101W_p)|FD-Score:3.98|P-value:3.49E-5||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YIL028W(YIL028W_d)|FD-Score:-3.76|P-value:8.47E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL029C(YIL029C_p)|FD-Score:3.14|P-value:8.51E-4||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YIL032C(YIL032C_d)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL115C(YKL115C_d)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Gene:YKR075C(YKR075C_p)|FD-Score:-3.2|P-value:6.85E-4||SGD DESC:Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YMR075C-A(YMR075C-A_d)|FD-Score:-4.82|P-value:7.12E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Gene:YMR099C(YMR099C)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YMR114C(YMR114C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene Gene:YMR175W-A(YMR175W-A_p)|FD-Score:-4.88|P-value:5.37E-7||SGD DESC:Putative protein of unknown function Gene:YNL058C(YNL058C_p)|FD-Score:4.81|P-value:7.72E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene Gene:YNR068C(YNR068C_p)|FD-Score:-3.1|P-value:9.65E-4||SGD DESC:Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form Gene:YOL029C(YOL029C_p)|FD-Score:-3.2|P-value:6.95E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YPK1(YKL126W)|FD-Score:8.32|P-value:4.58E-17||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR148C(YPR148C)|FD-Score:-3.31|P-value:4.59E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:BNI1(YNL271C)|FD-Score:5.95|P-value:1.34E-9||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BTS1(YPL069C)|FD-Score:4.28|P-value:9.26E-6||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CNB1(YKL190W)|FD-Score:3.78|P-value:7.78E-5||SGD DESC:Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress Gene:DSE4(YNR067C)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:EDS1(YBR033W_p)|FD-Score:3.25|P-value:5.77E-4||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:END3(YNL084C)|FD-Score:4.41|P-value:5.12E-6||SGD DESC:EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p Gene:ENT4(YLL038C)|FD-Score:4.1|P-value:2.05E-5||SGD DESC:Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome Gene:ERG2(YMR202W)|FD-Score:3.15|P-value:8.03E-4||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:ERG5(YMR015C)|FD-Score:3.18|P-value:7.26E-4||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:GUF1(YLR289W)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:HHF1(YBR009C)|FD-Score:-4.45|P-value:4.32E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:LSC1(YOR142W)|FD-Score:-3.6|P-value:1.58E-4||SGD DESC:Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated Gene:MEF2(YJL102W)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MNN2(YBR015C)|FD-Score:4.13|P-value:1.79E-5||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MSE1(YOL033W)|FD-Score:-3.49|P-value:2.41E-4||SGD DESC:Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated Gene:MSN4(YKL062W)|FD-Score:3.17|P-value:7.73E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication Gene:MSN5(YDR335W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:NTH1(YDR001C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication Gene:PDR1(YGL013C)|FD-Score:4.53|P-value:2.97E-6||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PDR12(YPL058C)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity Gene:PMA2(YPL036W)|FD-Score:5.68|P-value:6.90E-9||SGD DESC:Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential Gene:PNS1(YOR161C)|FD-Score:-4.14|P-value:1.74E-5||SGD DESC:Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport Gene:PPH3(YDR075W)|FD-Score:3.36|P-value:3.90E-4||SGD DESC:Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Gene:RRG1(YDR065W)|FD-Score:-3.29|P-value:4.99E-4||SGD DESC:Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SBE2(YDR351W)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SCW10(YMR305C)|FD-Score:5.59|P-value:1.17E-8||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p Gene:SPS18(YNL204C)|FD-Score:4.91|P-value:4.66E-7||SGD DESC:Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation Gene:SYC1(YOR179C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:-3.12|P-value:9.14E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP2(YER090W)|FD-Score:-3.67|P-value:1.22E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TSC3(YBR058C-A)|FD-Score:5.94|P-value:1.45E-9||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBC12(YLR306W)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Gene:UBP2(YOR124C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity Gene:VMA5(YKL080W)|FD-Score:-4.9|P-value:4.71E-7||SGD DESC:Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YAP5(YIR018W)|FD-Score:5.17|P-value:1.18E-7||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YDR008C(YDR008C_d)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGL101W(YGL101W_p)|FD-Score:3.98|P-value:3.49E-5||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YIL028W(YIL028W_d)|FD-Score:-3.76|P-value:8.47E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL029C(YIL029C_p)|FD-Score:3.14|P-value:8.51E-4||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YIL032C(YIL032C_d)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL115C(YKL115C_d)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Gene:YKR075C(YKR075C_p)|FD-Score:-3.2|P-value:6.85E-4||SGD DESC:Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YMR075C-A(YMR075C-A_d)|FD-Score:-4.82|P-value:7.12E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Gene:YMR099C(YMR099C)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YMR114C(YMR114C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene Gene:YMR175W-A(YMR175W-A_p)|FD-Score:-4.88|P-value:5.37E-7||SGD DESC:Putative protein of unknown function Gene:YNL058C(YNL058C_p)|FD-Score:4.81|P-value:7.72E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene Gene:YNR068C(YNR068C_p)|FD-Score:-3.1|P-value:9.65E-4||SGD DESC:Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form Gene:YOL029C(YOL029C_p)|FD-Score:-3.2|P-value:6.95E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YPK1(YKL126W)|FD-Score:8.32|P-value:4.58E-17||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR148C(YPR148C)|FD-Score:-3.31|P-value:4.59E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR113W5.601.08E-80.91DAM1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
YOR116C4.691.39E-60.06RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YPR169W4.631.82E-60.29JIP5Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein
YMR203W4.347.10E-67.04E-4TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YOR336W4.347.12E-60.06KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YJL014W4.289.28E-60.09CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YPR181C4.201.36E-50.17SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
YNL151C4.022.89E-50.02RPC31RNA polymerase III subunit C31
YDR236C4.003.17E-50.04FMN1Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
YDR187C_d3.963.68E-50.05YDR187C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YDR478W3.914.59E-50.41SNM1Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YIR006C3.502.29E-40.05PAN1Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease
YLL050C3.452.80E-40.02COF1Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YMR211W3.432.96E-40.10DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YGR119C3.344.22E-40.01NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL126W8.324.58E-17YPK1Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
YNL271C5.951.34E-9BNI1Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YBR058C-A5.941.45E-9TSC3Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YPL036W5.686.90E-9PMA2Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YMR305C5.591.17E-8SCW10Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YIR018W5.171.18E-7YAP5Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication
YNL204C4.914.66E-7SPS18Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
YNL058C_p4.817.72E-7YNL058C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YGL013C4.532.97E-6PDR1Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
YNL084C4.415.12E-6END3EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
YPL069C4.289.26E-6BTS1Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YBR015C4.131.79E-5MNN2Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YLL038C4.102.05E-5ENT4Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
YLR289W4.102.06E-5GUF1Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
YGL101W_p3.983.49E-5YGL101W_pPutative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p

GO enrichment analysis for SGTC_896
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1711.08E-39SGTC_2740felodipine 17.1 μMMiscellaneous33330.0941176
0.1695.59E-39SGTC_1700st030840 7.9 μMTimTec (Natural product derivative library)54993070.126316PDR1
0.1611.22E-35SGTC_1826st055655 41.6 μMTimTec (Natural product derivative library)6761680.0930233ERG2
0.1613.38E-35SGTC_1464k208-0027 110.0 μMChemDiv (Drug-like library)X14640.06
0.1584.97E-34SGTC_9851493-0307 8.7 μMChemDiv (Drug-like library)32782740.109589TSC3-RPN4
0.1557.15E-33SGTC_5274476-4215 268.0 μMChemDiv (Drug-like library)44187540.0679612PDR1
0.1521.23E-31SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.0652174TSC3-RPN4
0.1511.70E-31SGTC_234nsc-17383 10.7 μMMiscellaneous4089740.0795455ERG2
0.1504.50E-31SGTC_7243910-0327 137.0 μMChemDiv (Drug-like library)28854830.0952381ERG2
0.1491.17E-30SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.0384615TSC3-RPN4
0.1476.34E-30SGTC_20775212015 200.0 μMChembridge (Fragment library)7809000.038961
0.1434.17E-28SGTC_2230bromochlorosalicylanilide 954.5 nMMiscellaneous772540.0921053
0.1433.82E-28SGTC_7764476-4378 112.0 μMChemDiv (Drug-like library)28920080.0543478ERG2
0.1411.82E-27SGTC_1545lovastatin 49.4 μMTimTec (Pure natural product library)129236120.0891089
0.1395.88E-27SGTC_2627acetyl isogambogic acid 100.0 μMMicrosource (Natural product library)68577890.0645161TSC3-RPN4

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_8950964-000613.7 μM0.4126986738897ChemDiv (Drug-like library)345.190621.51524
SGTC_3333486-013140.1 μM0.2753626744690ChemDiv (Drug-like library)296.320541.31525amide catabolism
SGTC_2557derrustone83.84 μM0.273973629853Microsource (Natural product library)326.300162.60106
SGTC_1593justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one54.9 μM0.27027442882TimTec (Pure natural product library)364.348143.60106redox potentiating
SGTC_2492derrusnin100 μM0.270271715307Microsource (Natural product library)356.326142.80107
SGTC_3305912702753.83 μM0.2702741905295Chembridge (Drug-like library)316.378142.87506
SGTC_11443486-018312.5 μM0.2686576744069ChemDiv (Drug-like library)296.320541.0225
SGTC_11740739-009751.1 μM0.26087728447ChemDiv (Drug-like library)302.278762.32836redox potentiating
SGTC_1916st06760649.2 μM0.25555619590279TimTec (Natural product derivative library)406.391422.78427
SGTC_3164910070549.47 μM0.24657517174235Chembridge (Drug-like library)299.321182.8714