1000-0849

3-hydroxy-N'-[(2-oxonaphthalen-1-ylidene)methyl]naphthalene-2-carbohydrazide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_898
Screen concentration 28.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 6751807
SMILES C1=CC=C2C(=C1)C=CC(=O)C2=CNNC(=O)C3=CC4=CC=CC=C4C=C3O
Standardized SMILES Oc1ccc2ccccc2c1C=NNC(=O)c3cc4ccccc4cc3O
Molecular weight 356.374
ALogP 2.72
H-bond donor count 3
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.91
% growth inhibition (Hom. pool) 3.32


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6751807
Download HIP data (tab-delimited text)  (excel)
Gene:ARP7(YPR034W)|FD-Score:3.56|P-value:1.84E-4|Clearance:0.01||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:GPM1(YKL152C)|FD-Score:3.39|P-value:3.50E-4|Clearance:0.01||SGD DESC:Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis Gene:KEI1(YDR367W)|FD-Score:4.3|P-value:8.43E-6|Clearance:0.73||SGD DESC:Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene Gene:NTF2(YER009W)|FD-Score:3.57|P-value:1.79E-4|Clearance:0.01||SGD DESC:Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport Gene:PRP43(YGL120C)|FD-Score:3.25|P-value:5.80E-4|Clearance:0.05||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:RPA43(YOR340C)|FD-Score:3.38|P-value:3.57E-4|Clearance:0.11||SGD DESC:RNA polymerase I subunit A43 Gene:RPC53(YDL150W)|FD-Score:-3.17|P-value:7.66E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C53 Gene:RPP1(YHR062C)|FD-Score:-5.24|P-value:7.85E-8|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RPT5(YOR117W)|FD-Score:3.55|P-value:1.94E-4|Clearance:0.16||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:RSC8(YFR037C)|FD-Score:3.11|P-value:9.30E-4|Clearance:0.1||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SPC110(YDR356W)|FD-Score:-3.17|P-value:7.66E-4|Clearance:0||SGD DESC:Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner Gene:SSS1(YDR086C)|FD-Score:7.47|P-value:4.08E-14|Clearance:3.16||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:TOM40(YMR203W)|FD-Score:3.27|P-value:5.35E-4|Clearance:0.02||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YDL152W(YDL152W_d)|FD-Score:-3.56|P-value:1.87E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome Gene:YGR115C(YGR115C_d)|FD-Score:3.19|P-value:7.01E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C Gene:ARP7(YPR034W)|FD-Score:3.56|P-value:1.84E-4|Clearance:0.01||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:GPM1(YKL152C)|FD-Score:3.39|P-value:3.50E-4|Clearance:0.01||SGD DESC:Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis Gene:KEI1(YDR367W)|FD-Score:4.3|P-value:8.43E-6|Clearance:0.73||SGD DESC:Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene Gene:NTF2(YER009W)|FD-Score:3.57|P-value:1.79E-4|Clearance:0.01||SGD DESC:Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport Gene:PRP43(YGL120C)|FD-Score:3.25|P-value:5.80E-4|Clearance:0.05||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:RPA43(YOR340C)|FD-Score:3.38|P-value:3.57E-4|Clearance:0.11||SGD DESC:RNA polymerase I subunit A43 Gene:RPC53(YDL150W)|FD-Score:-3.17|P-value:7.66E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C53 Gene:RPP1(YHR062C)|FD-Score:-5.24|P-value:7.85E-8|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RPT5(YOR117W)|FD-Score:3.55|P-value:1.94E-4|Clearance:0.16||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:RSC8(YFR037C)|FD-Score:3.11|P-value:9.30E-4|Clearance:0.1||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SPC110(YDR356W)|FD-Score:-3.17|P-value:7.66E-4|Clearance:0||SGD DESC:Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner Gene:SSS1(YDR086C)|FD-Score:7.47|P-value:4.08E-14|Clearance:3.16||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:TOM40(YMR203W)|FD-Score:3.27|P-value:5.35E-4|Clearance:0.02||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YDL152W(YDL152W_d)|FD-Score:-3.56|P-value:1.87E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome Gene:YGR115C(YGR115C_d)|FD-Score:3.19|P-value:7.01E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6751807
Download HOP data (tab-delimited text)  (excel)
Gene:ABP1(YCR088W)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences Gene:ANT1(YPR128C)|FD-Score:-3.54|P-value:1.98E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:BNA2(YJR078W)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp Gene:CHS7(YHR142W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress Gene:COX11(YPL132W)|FD-Score:-3.16|P-value:7.85E-4||SGD DESC:Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p Gene:CWH43(YCR017C)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion Gene:DDP1(YOR163W)|FD-Score:3.18|P-value:7.28E-4||SGD DESC:Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress Gene:DOA1(YKL213C)|FD-Score:3.12|P-value:9.09E-4||SGD DESC:WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress Gene:DSE4(YNR067C)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:ENT4(YLL038C)|FD-Score:3.94|P-value:4.09E-5||SGD DESC:Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome Gene:GIM5(YML094W)|FD-Score:-4.61|P-value:2.04E-6||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:HIM1(YDR317W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Protein of unknown function involved in DNA repair Gene:HIS5(YIL116W)|FD-Score:4.25|P-value:1.05E-5||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:KRE2(YDR483W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication Gene:LPD1(YFL018C)|FD-Score:-3.5|P-value:2.31E-4||SGD DESC:Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes Gene:MIC23(YBL107C_p)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) Gene:MRPL22(YNL177C)|FD-Score:-3.32|P-value:4.46E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSN1(YOL116W)|FD-Score:4|P-value:3.23E-5||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:MSS1(YMR023C)|FD-Score:3.37|P-value:3.69E-4||SGD DESC:Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 Gene:NCE101(YJL205C)|FD-Score:-3.74|P-value:9.24E-5||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:OPI8(YKR035C_d)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Gene:PDH1(YPR002W)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:RCN2(YOR220W_p)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RNH203(YLR154C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:RTF1(YGL244W)|FD-Score:-3.48|P-value:2.50E-4||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SGF11(YPL047W)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SHH4(YLR164W)|FD-Score:-3.44|P-value:2.90E-4||SGD DESC:Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner Gene:SIS2(YKR072C)|FD-Score:-3.9|P-value:4.77E-5||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SPO16(YHR153C)|FD-Score:5.08|P-value:1.88E-7||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:SSN8(YNL025C)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance Gene:TIM11(YDR322C-A)|FD-Score:-3.22|P-value:6.37E-4||SGD DESC:Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase Gene:VIP1(YLR410W)|FD-Score:3.23|P-value:6.23E-4||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 Gene:YBL095W(YBL095W_p)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBR184W(YBR184W_p)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Putative protein of unknown function; YBR184W is not an essential gene Gene:YBR285W(YBR285W_p)|FD-Score:4.28|P-value:9.29E-6||SGD DESC:Putative protein of unknown function; YBR285W is not an essential gene Gene:YEL067C(YEL067C_p)|FD-Score:3.22|P-value:6.30E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YGR042W(YGR042W_p)|FD-Score:3.29|P-value:5.02E-4||SGD DESC:Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress Gene:YGR291C(YGR291C_d)|FD-Score:4.06|P-value:2.48E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNR071C(YNR071C_p)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:Putative aldose 1-epimerase Gene:ABP1(YCR088W)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences Gene:ANT1(YPR128C)|FD-Score:-3.54|P-value:1.98E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:BNA2(YJR078W)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp Gene:CHS7(YHR142W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress Gene:COX11(YPL132W)|FD-Score:-3.16|P-value:7.85E-4||SGD DESC:Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p Gene:CWH43(YCR017C)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion Gene:DDP1(YOR163W)|FD-Score:3.18|P-value:7.28E-4||SGD DESC:Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress Gene:DOA1(YKL213C)|FD-Score:3.12|P-value:9.09E-4||SGD DESC:WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress Gene:DSE4(YNR067C)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:ENT4(YLL038C)|FD-Score:3.94|P-value:4.09E-5||SGD DESC:Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome Gene:GIM5(YML094W)|FD-Score:-4.61|P-value:2.04E-6||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:HIM1(YDR317W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Protein of unknown function involved in DNA repair Gene:HIS5(YIL116W)|FD-Score:4.25|P-value:1.05E-5||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:KRE2(YDR483W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication Gene:LPD1(YFL018C)|FD-Score:-3.5|P-value:2.31E-4||SGD DESC:Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes Gene:MIC23(YBL107C_p)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) Gene:MRPL22(YNL177C)|FD-Score:-3.32|P-value:4.46E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSN1(YOL116W)|FD-Score:4|P-value:3.23E-5||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:MSS1(YMR023C)|FD-Score:3.37|P-value:3.69E-4||SGD DESC:Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 Gene:NCE101(YJL205C)|FD-Score:-3.74|P-value:9.24E-5||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:OPI8(YKR035C_d)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Gene:PDH1(YPR002W)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:RCN2(YOR220W_p)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RNH203(YLR154C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:RTF1(YGL244W)|FD-Score:-3.48|P-value:2.50E-4||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SGF11(YPL047W)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SHH4(YLR164W)|FD-Score:-3.44|P-value:2.90E-4||SGD DESC:Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner Gene:SIS2(YKR072C)|FD-Score:-3.9|P-value:4.77E-5||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SPO16(YHR153C)|FD-Score:5.08|P-value:1.88E-7||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:SSN8(YNL025C)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance Gene:TIM11(YDR322C-A)|FD-Score:-3.22|P-value:6.37E-4||SGD DESC:Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase Gene:VIP1(YLR410W)|FD-Score:3.23|P-value:6.23E-4||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 Gene:YBL095W(YBL095W_p)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBR184W(YBR184W_p)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Putative protein of unknown function; YBR184W is not an essential gene Gene:YBR285W(YBR285W_p)|FD-Score:4.28|P-value:9.29E-6||SGD DESC:Putative protein of unknown function; YBR285W is not an essential gene Gene:YEL067C(YEL067C_p)|FD-Score:3.22|P-value:6.30E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YGR042W(YGR042W_p)|FD-Score:3.29|P-value:5.02E-4||SGD DESC:Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress Gene:YGR291C(YGR291C_d)|FD-Score:4.06|P-value:2.48E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNR071C(YNR071C_p)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:Putative aldose 1-epimerase

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR086C7.474.08E-143.16SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YDR367W4.308.43E-60.73KEI1Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
YER009W3.571.79E-40.01NTF2Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YPR034W3.561.84E-40.01ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YOR117W3.551.94E-40.16RPT5One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YKL152C3.393.50E-40.01GPM1Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YOR340C3.383.57E-40.11RPA43RNA polymerase I subunit A43
YMR203W3.275.35E-40.02TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YGL120C3.255.80E-40.05PRP43RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YGR115C_d3.197.01E-40.08YGR115C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
YFR037C3.119.30E-40.10RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YOL144W3.010.001300.05NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YHR122W2.960.001520.00CIA2Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
YFL005W2.960.001530.11SEC4Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YPL122C2.850.002200.01TFB2Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YHR153C5.081.88E-7SPO16Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
YBR285W_p4.289.29E-6YBR285W_pPutative protein of unknown function; YBR285W is not an essential gene
YIL116W4.251.05E-5HIS5Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YGR291C_d4.062.48E-5YGR291C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL116W4.003.23E-5MSN1Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress
YLL038C3.944.09E-5ENT4Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
YLR154C3.701.08E-4RNH203Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
YDR483W3.621.48E-4KRE2Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
YDR317W3.561.83E-4HIM1Protein of unknown function involved in DNA repair
YBL095W_p3.542.03E-4YBL095W_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL107C_p3.482.52E-4MIC23_pMitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)
YPL047W3.442.95E-4SGF11Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YMR023C3.373.69E-4MSS1Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
YCR017C3.363.96E-4CWH43Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
YBR184W_p3.354.01E-4YBR184W_pPutative protein of unknown function; YBR184W is not an essential gene

GO enrichment analysis for SGTC_898
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1361.23E-25SGTC_1880MG-132 525.0 μMMiscellaneous4623820.136986
0.1016.14E-15SGTC_2420aureobasidin a 50.0 nMMiscellaneous99634300.0598291
0.1017.92E-15SGTC_31759106517 49.5 μMChembridge (Drug-like library)414680730.112676iron homeostasis
0.0944.27E-13SGTC_21695-(ethoxymethyl)quinolin-8-ol 49.5 μMChembridge (Fragment library)2796210.15873
0.0937.12E-13SGTC_31059121040 49.5 μMChembridge (Drug-like library)414489070.112676
0.0863.32E-11SGTC_29309013230 14.9 μMChembridge (Drug-like library)29958570.04heme biosynthesis & mitochondrial translocase
0.0856.56E-11SGTC_22287354201 200.0 μMChembridge (Fragment library)7534510.0724638endomembrane recycling
0.0856.39E-11SGTC_1962st076595 64.5 μMTimTec (Natural product derivative library)2796190.153846redox potentiating
0.0831.65E-10SGTC_24855633444 17.8 μMMiscellaneous57242390.15942redox potentiating
0.0791.14E-9SGTC_1693xanthone 101.9 μMTimTec (Natural product derivative library)70200.115385DNA damage response
0.0782.08E-9SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.0645161RSC complex & mRNA processing
0.0772.74E-9SGTC_14224031-0024 15.5 μMChemDiv (Drug-like library)7824270.164179iron homeostasis
0.0773.84E-9SGTC_2567aureobasidin a 60.0 nMMiscellaneous99634300.0598291
0.0759.83E-9SGTC_2747doxorubicin 7.6 μMMiscellaneous317030.0873786anthracycline transcription coupled DNA repair
0.0751.02E-8SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.0675676RSC complex & mRNA processing

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1280906-298113.37 μM0.646740226ChemDiv (Drug-like library)296.343682.0124
SGTC_3740880-023182.3 μM0.5423736833587ChemDiv (Drug-like library)382.43453.24523iron homeostasis
SGTC_12800880-025310.1 μM0.5423736836607ChemDiv (Drug-like library)410.44462.91724
SGTC_7851270-011165.3 μM0.5192316741994ChemDiv (Drug-like library)307.300122.53735
SGTC_6671498-104459 μM0.5098046739982ChemDiv (Drug-like library)291.300722.77924RPP1 & pyrimidine depletion
SGTC_18233-hydroxy-2-naphthoic acid106 μM0.4318187104TimTec (Natural product derivative library)188.179422.12623
SGTC_8500388-014375.9 μM0.43137367273ChemDiv (Drug-like library)277.31723.76722
SGTC_6541124-027180.9 μM0.4210535403748ChemDiv (Drug-like library)309.115462.58524
SGTC_1090132-003633.7 μM0.40740767274ChemDiv (Drug-like library)293.31663.26423
SGTC_6441498-119763.3 μM0.46741615ChemDiv (Drug-like library)291.343782.86623