1083-0020

N-(4-chloro-3-nitrophenyl)-3-methoxybenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_899
Screen concentration 478.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 767123
SMILES COC1=CC=CC(=C1)C(=O)NC2=CC(=C(C=C2)Cl)[N+](=O)[O-]
Standardized SMILES COc1cccc(c1)C(=O)Nc2ccc(Cl)c(c2)[N+](=O)[O-]
Molecular weight 306.7011
ALogP 3.16
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.42
% growth inhibition (Hom. pool) 8.95


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 767123
Download HIP data (tab-delimited text)  (excel)
Gene:GPM1(YKL152C)|FD-Score:5.15|P-value:1.33E-7|Clearance:1.47||SGD DESC:Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis Gene:IRA1(YBR140C)|FD-Score:3.44|P-value:2.87E-4|Clearance:0.29||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication Gene:ORC4(YPR162C)|FD-Score:5.15|P-value:1.30E-7|Clearance:1.47||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing Gene:RPR2(YIR015W)|FD-Score:3.64|P-value:1.39E-4|Clearance:0.15||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:SEC13(YLR208W)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.04||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SWD2(YKL018W)|FD-Score:3.49|P-value:2.41E-4|Clearance:0.04||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination Gene:TPI1(YDR050C)|FD-Score:3.15|P-value:8.08E-4|Clearance:0.1||SGD DESC:Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease Gene:YDR187C(YDR187C_d)|FD-Score:3.45|P-value:2.77E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:GPM1(YKL152C)|FD-Score:5.15|P-value:1.33E-7|Clearance:1.47||SGD DESC:Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis Gene:IRA1(YBR140C)|FD-Score:3.44|P-value:2.87E-4|Clearance:0.29||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication Gene:ORC4(YPR162C)|FD-Score:5.15|P-value:1.30E-7|Clearance:1.47||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing Gene:RPR2(YIR015W)|FD-Score:3.64|P-value:1.39E-4|Clearance:0.15||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:SEC13(YLR208W)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.04||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SWD2(YKL018W)|FD-Score:3.49|P-value:2.41E-4|Clearance:0.04||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination Gene:TPI1(YDR050C)|FD-Score:3.15|P-value:8.08E-4|Clearance:0.1||SGD DESC:Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease Gene:YDR187C(YDR187C_d)|FD-Score:3.45|P-value:2.77E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 767123
Download HOP data (tab-delimited text)  (excel)
Gene:AIM1(YAL046C)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss Gene:ANT1(YPR128C)|FD-Score:-3.48|P-value:2.50E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ATG26(YLR189C)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy Gene:BNI1(YNL271C)|FD-Score:5.13|P-value:1.43E-7||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BRE2(YLR015W)|FD-Score:4.73|P-value:1.14E-6||SGD DESC:Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L Gene:BUD14(YAR014C)|FD-Score:4.28|P-value:9.25E-6||SGD DESC:Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress Gene:DLS1(YJL065C)|FD-Score:5.11|P-value:1.62E-7||SGD DESC:Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication Gene:DTD1(YDL219W)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene:GEA2(YEL022W)|FD-Score:-3.23|P-value:6.14E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication Gene:GIR2(YDR152W)|FD-Score:4.65|P-value:1.64E-6||SGD DESC:Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein Gene:GRX7(YBR014C)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:HUL5(YGL141W)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD Gene:HXT17(YNR072W)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:IRC3(YDR332W)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:KNS1(YLL019C)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation Gene:LDB7(YBL006C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MAK3(YPR051W)|FD-Score:4.05|P-value:2.59E-5||SGD DESC:Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus Gene:MAL33(YBR297W)|FD-Score:3.88|P-value:5.23E-5||SGD DESC:MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C Gene:MEF2(YJL102W)|FD-Score:5.89|P-value:1.90E-9||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:NDI1(YML120C)|FD-Score:4.07|P-value:2.30E-5||SGD DESC:NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID Gene:NUM1(YDR150W)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:PCL5(YHR071W)|FD-Score:3.64|P-value:1.38E-4||SGD DESC:Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity Gene:PET100(YDR079W)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme Gene:PEX1(YKL197C)|FD-Score:5.31|P-value:5.45E-8||SGD DESC:AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis Gene:PRY3(YJL078C)|FD-Score:5.24|P-value:7.90E-8||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:RIT1(YMR283C)|FD-Score:3.72|P-value:1.00E-4||SGD DESC:2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA Gene:RMD1(YDL001W)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Cytoplasmic protein required for sporulation Gene:RPN10(YHR200W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein Gene:RPS4A(YJR145C)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication Gene:RTC6(YPL183W-A)|FD-Score:4.77|P-value:9.14E-7||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:RXT2(YBR095C)|FD-Score:-3.14|P-value:8.36E-4||SGD DESC:Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Gene:SCT1(YBL011W)|FD-Score:-3.22|P-value:6.32E-4||SGD DESC:Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed Gene:SET3(YKR029C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SGT2(YOR007C)|FD-Score:-3.81|P-value:7.07E-5||SGD DESC:Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress Gene:SLM5(YCR024C)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:STD1(YOR047C)|FD-Score:4.63|P-value:1.80E-6||SGD DESC:Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] Gene:TDA3(YHR009C_p)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 Gene:TEA1(YOR337W)|FD-Score:4.51|P-value:3.24E-6||SGD DESC:Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Gene:TRF5(YNL299W)|FD-Score:4.58|P-value:2.28E-6||SGD DESC:Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p Gene:UBP13(YBL067C)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:ULS1(YOR191W)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:URA1(YKL216W)|FD-Score:4.82|P-value:7.24E-7||SGD DESC:Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid Gene:VBA2(YBR293W)|FD-Score:5.36|P-value:4.11E-8||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:VOA1(YGR106C)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS25(YJR102C)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:YAL004W(YAL004W_d)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Gene:YAP5(YIR018W)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YBL012C(YBL012C_d)|FD-Score:4.74|P-value:1.08E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBP2(YGL060W)|FD-Score:3.86|P-value:5.78E-5||SGD DESC:Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication Gene:YGR130C(YGR130C)|FD-Score:3.72|P-value:9.80E-5||SGD DESC:Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) Gene:YGR250C(YGR250C)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YGR291C(YGR291C_d)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL028W(YIL028W_d)|FD-Score:-3.21|P-value:6.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL118W(YKL118W_d)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YKL162C-A(YKL162C-A_d)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR031W(YLR031W_p)|FD-Score:4.93|P-value:4.22E-7||SGD DESC:Putative protein of unknown function Gene:YNL067W-B(YNL067W-B_p)|FD-Score:3.77|P-value:8.22E-5||SGD DESC:Putative protein of unknown function Gene:YNL217W(YNL217W_p)|FD-Score:-3.1|P-value:9.71E-4||SGD DESC:Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate Gene:YNL226W(YNL226W_d)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Gene:YPL039W(YPL039W_p)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPR123C(YPR123C_d)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:YTA12(YMR089C)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes Gene:AIM1(YAL046C)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss Gene:ANT1(YPR128C)|FD-Score:-3.48|P-value:2.50E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ATG26(YLR189C)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy Gene:BNI1(YNL271C)|FD-Score:5.13|P-value:1.43E-7||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BRE2(YLR015W)|FD-Score:4.73|P-value:1.14E-6||SGD DESC:Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L Gene:BUD14(YAR014C)|FD-Score:4.28|P-value:9.25E-6||SGD DESC:Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress Gene:DLS1(YJL065C)|FD-Score:5.11|P-value:1.62E-7||SGD DESC:Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication Gene:DTD1(YDL219W)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene:GEA2(YEL022W)|FD-Score:-3.23|P-value:6.14E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication Gene:GIR2(YDR152W)|FD-Score:4.65|P-value:1.64E-6||SGD DESC:Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein Gene:GRX7(YBR014C)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:HUL5(YGL141W)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD Gene:HXT17(YNR072W)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:IRC3(YDR332W)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:KNS1(YLL019C)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation Gene:LDB7(YBL006C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MAK3(YPR051W)|FD-Score:4.05|P-value:2.59E-5||SGD DESC:Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus Gene:MAL33(YBR297W)|FD-Score:3.88|P-value:5.23E-5||SGD DESC:MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C Gene:MEF2(YJL102W)|FD-Score:5.89|P-value:1.90E-9||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:NDI1(YML120C)|FD-Score:4.07|P-value:2.30E-5||SGD DESC:NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID Gene:NUM1(YDR150W)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:PCL5(YHR071W)|FD-Score:3.64|P-value:1.38E-4||SGD DESC:Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity Gene:PET100(YDR079W)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme Gene:PEX1(YKL197C)|FD-Score:5.31|P-value:5.45E-8||SGD DESC:AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis Gene:PRY3(YJL078C)|FD-Score:5.24|P-value:7.90E-8||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:RIT1(YMR283C)|FD-Score:3.72|P-value:1.00E-4||SGD DESC:2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA Gene:RMD1(YDL001W)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Cytoplasmic protein required for sporulation Gene:RPN10(YHR200W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein Gene:RPS4A(YJR145C)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication Gene:RTC6(YPL183W-A)|FD-Score:4.77|P-value:9.14E-7||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:RXT2(YBR095C)|FD-Score:-3.14|P-value:8.36E-4||SGD DESC:Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Gene:SCT1(YBL011W)|FD-Score:-3.22|P-value:6.32E-4||SGD DESC:Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed Gene:SET3(YKR029C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SGT2(YOR007C)|FD-Score:-3.81|P-value:7.07E-5||SGD DESC:Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress Gene:SLM5(YCR024C)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:STD1(YOR047C)|FD-Score:4.63|P-value:1.80E-6||SGD DESC:Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] Gene:TDA3(YHR009C_p)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 Gene:TEA1(YOR337W)|FD-Score:4.51|P-value:3.24E-6||SGD DESC:Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Gene:TRF5(YNL299W)|FD-Score:4.58|P-value:2.28E-6||SGD DESC:Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p Gene:UBP13(YBL067C)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:ULS1(YOR191W)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:URA1(YKL216W)|FD-Score:4.82|P-value:7.24E-7||SGD DESC:Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid Gene:VBA2(YBR293W)|FD-Score:5.36|P-value:4.11E-8||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:VOA1(YGR106C)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS25(YJR102C)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:YAL004W(YAL004W_d)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Gene:YAP5(YIR018W)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YBL012C(YBL012C_d)|FD-Score:4.74|P-value:1.08E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBP2(YGL060W)|FD-Score:3.86|P-value:5.78E-5||SGD DESC:Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication Gene:YGR130C(YGR130C)|FD-Score:3.72|P-value:9.80E-5||SGD DESC:Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) Gene:YGR250C(YGR250C)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YGR291C(YGR291C_d)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL028W(YIL028W_d)|FD-Score:-3.21|P-value:6.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL118W(YKL118W_d)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YKL162C-A(YKL162C-A_d)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR031W(YLR031W_p)|FD-Score:4.93|P-value:4.22E-7||SGD DESC:Putative protein of unknown function Gene:YNL067W-B(YNL067W-B_p)|FD-Score:3.77|P-value:8.22E-5||SGD DESC:Putative protein of unknown function Gene:YNL217W(YNL217W_p)|FD-Score:-3.1|P-value:9.71E-4||SGD DESC:Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate Gene:YNL226W(YNL226W_d)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Gene:YPL039W(YPL039W_p)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPR123C(YPR123C_d)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:YTA12(YMR089C)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR162C5.151.30E-71.47ORC4Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YKL152C5.151.33E-71.47GPM1Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YLR208W3.671.19E-40.04SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YIR015W3.641.39E-40.14RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YKL018W3.492.41E-40.04SWD2Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
YDR187C_d3.452.77E-40.01YDR187C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YBR140C3.442.87E-40.29IRA1GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
YDR050C3.158.08E-40.10TPI1Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
YIL106W3.050.001150.07MOB1Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
YNR026C2.980.001460.05SEC12Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
YAL038W2.930.001720.01CDC19Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
YPR143W2.910.001800.02RRP15Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YDR478W2.890.001930.07SNM1Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YMR290W-A_d2.810.002440.01YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YNL221C2.810.002510.04POP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJL102W5.891.90E-9MEF2Mitochondrial elongation factor involved in translational elongation
YBR293W5.364.11E-8VBA2Permease of basic amino acids in the vacuolar membrane
YKL197C5.315.45E-8PEX1AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
YJL078C5.247.90E-8PRY3Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
YNL271C5.131.43E-7BNI1Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YJL065C5.111.62E-7DLS1Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
YLR031W_p4.934.22E-7YLR031W_pPutative protein of unknown function
YKL216W4.827.24E-7URA1Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YPL183W-A4.779.14E-7RTC6Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
YBL012C_d4.741.08E-6YBL012C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR015W4.731.14E-6BRE2Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
YDR152W4.651.64E-6GIR2Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein
YOR047C4.631.80E-6STD1Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
YNL299W4.582.28E-6TRF5Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
YOR337W4.513.24E-6TEA1Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein

GO enrichment analysis for SGTC_899
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0912.58E-12SGTC_20255147754 141.0 μMChembridge (Fragment library)3157770.305085
0.0791.34E-9SGTC_14204'-methoxyflavone 42.0 μMChemDiv (Drug-like library)777930.169231
0.0781.67E-9SGTC_14884013-0813 75.9 μMChemDiv (Drug-like library)29100570.0886076RPP1 & pyrimidine depletion
0.0781.94E-9SGTC_14833453-0561 55.9 μMChemDiv (Drug-like library)45469910.175
0.0773.31E-9SGTC_1743st037606 46.4 μMTimTec (Natural product derivative library)5901420.0641026
0.0756.95E-9SGTC_8960964-0007 44.5 μMChemDiv (Drug-like library)67567580.0941176
0.0656.65E-7SGTC_2902043-6722 48.1 μMChemDiv (Drug-like library)7737580.0933333
0.0648.89E-7SGTC_9933909-8757 62.7 μMChemDiv (Drug-like library)42883240.142857
0.0631.53E-6SGTC_1621st003705 32.4 μMTimTec (Natural product derivative library)242070320.0989011calcium & mitochondrial duress
0.0621.69E-6SGTC_1380850-0259 40.9 μMChemDiv (Drug-like library)68130040.0804598cell wall
0.0603.71E-6SGTC_14163966-0321 25.3 μMChemDiv (Drug-like library)5825300.0757576
0.0586.98E-6SGTC_14083909-7976 48.8 μMChemDiv (Drug-like library)241523740.0731707Golgi
0.0589.58E-6SGTC_397arbidol 50.0 μMMiscellaneous1314100.111111cell wall
0.0571.13E-5SGTC_6191652-1634 108.0 μMChemDiv (Drug-like library)54004540.0897436PDR1
0.0571.17E-5SGTC_11483909-7663 27.7 μMChemDiv (Drug-like library)40845260.111111

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2900532852885.29 μM0.591837795359Chembridge (Drug-like library)261.703583.26212Golgi
SGTC_5544483-2211187 μM0.56747107ChemDiv (Drug-like library)285.29462.45314
SGTC_2986902244571.43 μM0.5384626459286Chembridge (Drug-like library)285.337663.30813
SGTC_2877904072471.43 μM0.5094346463895Chembridge (Drug-like library)285.337663.30813
SGTC_2827799384771.43 μM0.52985692Chembridge (Drug-like library)283.321783.19813
SGTC_3205911348349.47 μM0.48148117018033Chembridge (Drug-like library)271.311083.06813
SGTC_2931901467455.67 μM0.456142996810Chembridge (Drug-like library)326.174624.03323
SGTC_1759st04305970 μM0.454545669426TimTec (Natural product derivative library)285.29462.45314amide catabolism
SGTC_2999906976571.43 μM0.4545452097066Chembridge (Drug-like library)285.337663.30813amide catabolism
SGTC_3188911078949.47 μM0.446429849217Chembridge (Drug-like library)275.730163.61112iron homeostasis