Deletion Strain | FD score | P-value | Gene | Gene Description |
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YFR009W | 6.99 | 1.37E-12 | GCN20 | Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA |
YOR220W_p | 6.32 | 1.32E-10 | RCN2_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress |
YHR076W | 5.30 | 5.69E-8 | PTC7 | Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope |
YLR110C | 4.80 | 8.00E-7 | CCW12 | Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication |
YJR097W | 4.63 | 1.84E-6 | JJJ3 | Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 |
YLR087C | 4.50 | 3.47E-6 | CSF1 | Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YER167W | 4.19 | 1.38E-5 | BCK2 | Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations |
YER131W | 4.08 | 2.24E-5 | RPS26B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication |
YGR288W | 4.05 | 2.53E-5 | MAL13 | MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C |
YDL198C | 4.03 | 2.76E-5 | GGC1 | Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family |
YPR188C | 3.86 | 5.66E-5 | MLC2 | Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring |
YMR233W | 3.75 | 8.76E-5 | TRI1 | Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication |
YER090W | 3.73 | 9.50E-5 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YBR026C | 3.73 | 9.75E-5 | ETR1 | 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis |
YNL199C | 3.72 | 9.79E-5 | GCR2 | Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p |