Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL217C | 8.36 | 3.18E-17 | 1.59 | TIM22 | Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported |
YPL266W | 7.39 | 7.22E-14 | 1.59 | DIM1 | Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing |
YBR192W | 6.92 | 2.24E-12 | 1.59 | RIM2 | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family |
YJL086C_d | 5.33 | 4.81E-8 | 0.52 | YJL086C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 |
YNL006W | 4.81 | 7.53E-7 | 0.30 | LST8 | Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat |
YGL113W | 4.51 | 3.26E-6 | 0.13 | SLD3 | Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress |
YER022W | 4.38 | 5.97E-6 | 0.29 | SRB4 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination |
YOL144W | 4.09 | 2.15E-5 | 0.04 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YPL231W | 4.05 | 2.58E-5 | 0.31 | FAS2 | Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities |
YDR013W | 3.74 | 9.21E-5 | 0.16 | PSF1 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YOR232W | 3.58 | 1.75E-4 | 0.12 | MGE1 | Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE |
YGL068W | 3.46 | 2.72E-4 | 0.05 | MNP1 | Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth |
YEL034W | 3.40 | 3.32E-4 | 0.06 | HYP2 | Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication |
YBR002C | 3.34 | 4.19E-4 | 0.05 | RER2 | Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting |
YLR002C | 3.29 | 4.93E-4 | 0.09 | NOC3 | Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing |