Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL209C | 4.23 | 1.15E-5 | 0.43 | CWC2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 |
YER009W | 3.80 | 7.22E-5 | 0.31 | NTF2 | Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport |
YER082C | 3.49 | 2.37E-4 | 0.05 | UTP7 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YNR017W | 3.45 | 2.83E-4 | 0.23 | TIM23 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel |
YJL076W | 3.21 | 6.55E-4 | 0.10 | NET1 | Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication |
YLR086W | 3.12 | 9.17E-4 | 0.08 | SMC4 | Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate |
YPR086W | 3.04 | 0.00120 | 0.04 | SUA7 | Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II |
YLR459W | 3.00 | 0.00134 | 0.08 | GAB1 | GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI |
YDR189W | 2.92 | 0.00176 | 0.01 | SLY1 | Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex |
YNL026W | 2.90 | 0.00184 | 0.36 | SAM50 | Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 |
YDR376W | 2.54 | 0.00548 | 0.02 | ARH1 | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
YDL163W_d | 2.52 | 0.00582 | 0.02 | YDL163W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase |
YIL115C | 2.50 | 0.00615 | 0.01 | NUP159 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) |
YKR022C | 2.49 | 0.00636 | 0.03 | NTR2 | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly |
YDL235C | 2.46 | 0.00696 | 0.00 | YPD1 | Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus |