| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDR169C-A_p | 8.27 | 6.47E-17 | YDR169C-A_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| YGR104C | 7.47 | 4.15E-14 | SRB5 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance |
| YOL051W | 5.63 | 8.88E-9 | GAL11 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator |
| YER153C | 5.44 | 2.73E-8 | PET122 | Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane |
| YMR074C | 5.39 | 3.45E-8 | YMR074C | Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress |
| YGL063W | 5.34 | 4.70E-8 | PUS2 | Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification |
| YPR198W | 5.33 | 4.82E-8 | SGE1 | Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations |
| YDL185W | 5.14 | 1.41E-7 | VMA1 | Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease |
| YDR191W | 5.04 | 2.28E-7 | HST4 | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
| YJR035W | 4.95 | 3.67E-7 | RAD26 | Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein |
| YLR358C_p | 4.94 | 3.82E-7 | YLR358C_p | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W |
| YDR513W | 4.84 | 6.35E-7 | GRX2 | Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication |
| YLR191W | 4.66 | 1.60E-6 | PEX13 | Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p |
| YMR095C | 4.55 | 2.75E-6 | SNO1 | Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase |
| YER140W_p | 4.44 | 4.57E-6 | EMP65_p | ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
