3237-0776

5-methyl-2-[(4-methylbenzoyl)amino]thiophene-3-carboxylic acid

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_941
Screen concentration 460.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 760008
SMILES CC1=CC=C(C=C1)C(=O)NC2=C(C=C(S2)C)C(=O)O
Standardized SMILES Cc1ccc(cc1)C(=O)Nc2sc(C)cc2C(=O)O
Molecular weight 275.3229
ALogP 2.66
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0.07
% growth inhibition (Hom. pool) 1.24


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 760008
Download HIP data (tab-delimited text)  (excel)
Gene:CDS1(YBR029C)|FD-Score:-3.47|P-value:2.65E-4|Clearance:0||SGD DESC:Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids Gene:GPI16(YHR188C)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.5||SGD DESC:Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog Gene:NSE3(YDR288W)|FD-Score:-3.2|P-value:6.93E-4|Clearance:0||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress Gene:PMA1(YGL008C)|FD-Score:3.76|P-value:8.42E-5|Clearance:0.11||SGD DESC:Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+] Gene:PRE6(YOL038W)|FD-Score:3.15|P-value:8.21E-4|Clearance:0.07||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:PRP28(YDR243C)|FD-Score:4.06|P-value:2.43E-5|Clearance:0.3||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:RPL18A(YOL120C)|FD-Score:5.64|P-value:8.31E-9|Clearance:0.93||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:SPB1(YCL054W)|FD-Score:-3.48|P-value:2.52E-4|Clearance:0||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:TAF11(YML015C)|FD-Score:-3.28|P-value:5.23E-4|Clearance:0||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:TFB3(YDR460W)|FD-Score:5.83|P-value:2.75E-9|Clearance:0.93||SGD DESC:Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit Gene:ULP2(YIL031W)|FD-Score:-3.15|P-value:8.30E-4|Clearance:0||SGD DESC:Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate Gene:YJR023C(YJR023C_d)|FD-Score:4.99|P-value:2.96E-7|Clearance:0.93||SGD DESC:Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing Gene:CDS1(YBR029C)|FD-Score:-3.47|P-value:2.65E-4|Clearance:0||SGD DESC:Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids Gene:GPI16(YHR188C)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.5||SGD DESC:Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog Gene:NSE3(YDR288W)|FD-Score:-3.2|P-value:6.93E-4|Clearance:0||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress Gene:PMA1(YGL008C)|FD-Score:3.76|P-value:8.42E-5|Clearance:0.11||SGD DESC:Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+] Gene:PRE6(YOL038W)|FD-Score:3.15|P-value:8.21E-4|Clearance:0.07||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:PRP28(YDR243C)|FD-Score:4.06|P-value:2.43E-5|Clearance:0.3||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:RPL18A(YOL120C)|FD-Score:5.64|P-value:8.31E-9|Clearance:0.93||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:SPB1(YCL054W)|FD-Score:-3.48|P-value:2.52E-4|Clearance:0||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:TAF11(YML015C)|FD-Score:-3.28|P-value:5.23E-4|Clearance:0||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:TFB3(YDR460W)|FD-Score:5.83|P-value:2.75E-9|Clearance:0.93||SGD DESC:Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit Gene:ULP2(YIL031W)|FD-Score:-3.15|P-value:8.30E-4|Clearance:0||SGD DESC:Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate Gene:YJR023C(YJR023C_d)|FD-Score:4.99|P-value:2.96E-7|Clearance:0.93||SGD DESC:Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 760008
Download HOP data (tab-delimited text)  (excel)
Gene:ACB1(YGR037C)|FD-Score:-4.07|P-value:2.35E-5||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:ADA2(YDR448W)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:ADE4(YMR300C)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ADH7(YCR105W)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance Gene:AFG1(YEL052W)|FD-Score:-3.23|P-value:6.21E-4||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AMD1(YML035C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools Gene:ASM4(YDL088C)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication Gene:ATC1(YDR184C)|FD-Score:-3.92|P-value:4.37E-5||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:ATG15(YCR068W)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BBC1(YJL020C)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches Gene:BEM2(YER155C)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Gene:BSD2(YBR290W)|FD-Score:3.98|P-value:3.38E-5||SGD DESC:Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification Gene:DLD2(YDL178W)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:DUN1(YDL101C)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair Gene:EXG2(YDR261C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:FCJ1(YKR016W)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane Gene:GCS1(YDL226C)|FD-Score:4.07|P-value:2.35E-5||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GCV2(YMR189W)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm Gene:HBN1(YCL026C-B_p)|FD-Score:-4.13|P-value:1.79E-5||SGD DESC:Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress Gene:HNT3(YOR258W)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress Gene:HUG1(YML058W-A)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress Gene:IFM1(YOL023W)|FD-Score:-3.96|P-value:3.79E-5||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IKI3(YLR384C)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IMG1(YCR046C)|FD-Score:4.45|P-value:4.21E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:MBP1(YDL056W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MDM34(YGL219C)|FD-Score:-3.75|P-value:8.70E-5||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MDM38(YOL027C)|FD-Score:4.4|P-value:5.49E-6||SGD DESC:Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome Gene:MEF2(YJL102W)|FD-Score:-3.85|P-value:5.89E-5||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MMS2(YGL087C)|FD-Score:3.21|P-value:6.68E-4||SGD DESC:Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress Gene:MRPL9(YGR220C)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MUK1(YPL070W)|FD-Score:6.62|P-value:1.75E-11||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:NCS2(YNL119W)|FD-Score:4.35|P-value:6.66E-6||SGD DESC:Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Gene:NVJ1(YHR195W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:OLA1(YBR025C)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress Gene:OST5(YGL226C-A)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PAC2(YER007W)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PEX31(YGR004W)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p Gene:PKH3(YDR466W)|FD-Score:-3.48|P-value:2.47E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:POC4(YPL144W)|FD-Score:-3.5|P-value:2.30E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:RGT1(YKL038W)|FD-Score:4.34|P-value:7.08E-6||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:RNY1(YPL123C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity Gene:RPL16B(YNL069C)|FD-Score:3.1|P-value:9.68E-4||SGD DESC:Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication Gene:RRI1(YDL216C)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling Gene:RRM3(YHR031C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RRT5(YFR032C_p)|FD-Score:6.63|P-value:1.69E-11||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RSR1(YGR152C)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases Gene:RXT2(YBR095C)|FD-Score:-3.92|P-value:4.49E-5||SGD DESC:Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Gene:SBH2(YER019C-A)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p Gene:SDC1(YDR469W)|FD-Score:-3.74|P-value:9.09E-5||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 Gene:SDP1(YIL113W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock Gene:SKM1(YOL113W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:SKP2(YNL311C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments Gene:SLI15(YBR156C)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly Gene:SLO1(YER180C-A)|FD-Score:3.73|P-value:9.71E-5||SGD DESC:Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO Gene:SMY2(YBR172C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication Gene:SPT10(YJL127C)|FD-Score:4.25|P-value:1.05E-5||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:STR3(YGL184C)|FD-Score:4.2|P-value:1.32E-5||SGD DESC:Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p Gene:SWM1(YDR260C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation Gene:TDA11(YHR159W_p)|FD-Score:4.85|P-value:6.32E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele Gene:TOM71(YHR117W)|FD-Score:-3.63|P-value:1.43E-4||SGD DESC:Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication Gene:UBX7(YBR273C)|FD-Score:5.55|P-value:1.45E-8||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication Gene:URA8(YJR103W)|FD-Score:3.18|P-value:7.38E-4||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:VOA1(YGR106C)|FD-Score:-3.13|P-value:8.85E-4||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS63(YLR261C_d)|FD-Score:3.5|P-value:2.35E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:WTM1(YOR230W)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR509W(YDR509W_d)|FD-Score:-5.03|P-value:2.40E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR514C(YDR514C)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YER039C-A(YER039C-A_p)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Putative protein of unknown function; YER039C-A is not an essential gene Gene:YFL051C(YFL051C_p)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGR079W(YGR079W_p)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Putative protein of unknown function; YGR079W is not an essential gene Gene:YIL060W(YIL060W_p)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene Gene:YLL020C(YLL020C_d)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 Gene:YOL131W(YOL131W_p)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Putative protein of unknown function Gene:YOR097C(YOR097C_p)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YPR039W(YPR039W_d)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:ACB1(YGR037C)|FD-Score:-4.07|P-value:2.35E-5||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:ADA2(YDR448W)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:ADE4(YMR300C)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ADH7(YCR105W)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance Gene:AFG1(YEL052W)|FD-Score:-3.23|P-value:6.21E-4||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AMD1(YML035C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools Gene:ASM4(YDL088C)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication Gene:ATC1(YDR184C)|FD-Score:-3.92|P-value:4.37E-5||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:ATG15(YCR068W)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BBC1(YJL020C)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches Gene:BEM2(YER155C)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Gene:BSD2(YBR290W)|FD-Score:3.98|P-value:3.38E-5||SGD DESC:Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification Gene:DLD2(YDL178W)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:DUN1(YDL101C)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair Gene:EXG2(YDR261C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:FCJ1(YKR016W)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane Gene:GCS1(YDL226C)|FD-Score:4.07|P-value:2.35E-5||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GCV2(YMR189W)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm Gene:HBN1(YCL026C-B_p)|FD-Score:-4.13|P-value:1.79E-5||SGD DESC:Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress Gene:HNT3(YOR258W)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress Gene:HUG1(YML058W-A)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress Gene:IFM1(YOL023W)|FD-Score:-3.96|P-value:3.79E-5||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IKI3(YLR384C)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IMG1(YCR046C)|FD-Score:4.45|P-value:4.21E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:MBP1(YDL056W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MDM34(YGL219C)|FD-Score:-3.75|P-value:8.70E-5||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MDM38(YOL027C)|FD-Score:4.4|P-value:5.49E-6||SGD DESC:Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome Gene:MEF2(YJL102W)|FD-Score:-3.85|P-value:5.89E-5||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MMS2(YGL087C)|FD-Score:3.21|P-value:6.68E-4||SGD DESC:Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress Gene:MRPL9(YGR220C)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MUK1(YPL070W)|FD-Score:6.62|P-value:1.75E-11||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:NCS2(YNL119W)|FD-Score:4.35|P-value:6.66E-6||SGD DESC:Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Gene:NVJ1(YHR195W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:OLA1(YBR025C)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress Gene:OST5(YGL226C-A)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PAC2(YER007W)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PEX31(YGR004W)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p Gene:PKH3(YDR466W)|FD-Score:-3.48|P-value:2.47E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:POC4(YPL144W)|FD-Score:-3.5|P-value:2.30E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:RGT1(YKL038W)|FD-Score:4.34|P-value:7.08E-6||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:RNY1(YPL123C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity Gene:RPL16B(YNL069C)|FD-Score:3.1|P-value:9.68E-4||SGD DESC:Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication Gene:RRI1(YDL216C)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling Gene:RRM3(YHR031C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RRT5(YFR032C_p)|FD-Score:6.63|P-value:1.69E-11||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RSR1(YGR152C)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases Gene:RXT2(YBR095C)|FD-Score:-3.92|P-value:4.49E-5||SGD DESC:Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Gene:SBH2(YER019C-A)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p Gene:SDC1(YDR469W)|FD-Score:-3.74|P-value:9.09E-5||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 Gene:SDP1(YIL113W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock Gene:SKM1(YOL113W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:SKP2(YNL311C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments Gene:SLI15(YBR156C)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly Gene:SLO1(YER180C-A)|FD-Score:3.73|P-value:9.71E-5||SGD DESC:Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO Gene:SMY2(YBR172C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication Gene:SPT10(YJL127C)|FD-Score:4.25|P-value:1.05E-5||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:STR3(YGL184C)|FD-Score:4.2|P-value:1.32E-5||SGD DESC:Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p Gene:SWM1(YDR260C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation Gene:TDA11(YHR159W_p)|FD-Score:4.85|P-value:6.32E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele Gene:TOM71(YHR117W)|FD-Score:-3.63|P-value:1.43E-4||SGD DESC:Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication Gene:UBX7(YBR273C)|FD-Score:5.55|P-value:1.45E-8||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication Gene:URA8(YJR103W)|FD-Score:3.18|P-value:7.38E-4||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:VOA1(YGR106C)|FD-Score:-3.13|P-value:8.85E-4||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS63(YLR261C_d)|FD-Score:3.5|P-value:2.35E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:WTM1(YOR230W)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR509W(YDR509W_d)|FD-Score:-5.03|P-value:2.40E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR514C(YDR514C)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YER039C-A(YER039C-A_p)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Putative protein of unknown function; YER039C-A is not an essential gene Gene:YFL051C(YFL051C_p)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGR079W(YGR079W_p)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Putative protein of unknown function; YGR079W is not an essential gene Gene:YIL060W(YIL060W_p)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene Gene:YLL020C(YLL020C_d)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 Gene:YOL131W(YOL131W_p)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Putative protein of unknown function Gene:YOR097C(YOR097C_p)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YPR039W(YPR039W_d)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR460W5.832.75E-90.93TFB3Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
YOL120C5.648.31E-90.93RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YJR023C_d4.992.96E-70.93YJR023C_dPutative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
YDR243C4.062.43E-50.30PRP28RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YGL008C3.768.42E-50.11PMA1Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
YHR188C3.651.31E-40.50GPI16Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
YOL038W3.158.21E-40.07PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YGL172W3.070.001050.11NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YPL122C2.970.001500.08TFB2Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
YPR168W2.890.001930.09NUT2Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
YOL134C_d2.800.002570.05YOL134C_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
YDL004W2.750.003000.04ATP16Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YER009W2.700.003440.03NTF2Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YOR261C2.680.003730.05RPN8Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
YPR178W2.630.004290.10PRP4Splicing factor, component of the U4/U6-U5 snRNP complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFR032C_p6.631.69E-11RRT5_pPutative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
YPL070W6.621.75E-11MUK1Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
YBR273C5.551.45E-8UBX7UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication
YHR159W_p4.856.32E-7TDA11_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
YCR046C4.454.21E-6IMG1Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
YOL027C4.405.49E-6MDM38Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
YNL119W4.356.66E-6NCS2Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
YKL038W4.347.08E-6RGT1Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication
YJL127C4.251.05E-5SPT10Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
YGL184C4.201.32E-5STR3Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
YLR384C4.181.43E-5IKI3Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YDL178W4.151.64E-5DLD2D-lactate dehydrogenase, located in the mitochondrial matrix
YDL226C4.072.35E-5GCS1ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YER155C4.022.86E-5BEM2Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
YBR290W3.983.38E-5BSD2Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification

GO enrichment analysis for SGTC_941
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0832.01E-10SGTC_9463434-1334 87.4 μMChemDiv (Drug-like library)40479760.140625
0.0722.62E-8SGTC_8750709-0210 25.7 μMChemDiv (Drug-like library)62513640.0769231fatty acid desaturase (OLE1)
0.0707.90E-8SGTC_2721ifenprodil 61.4 μMMiscellaneous36890.0735294plasma membrane duress
0.0656.08E-7SGTC_258haloperidol 50.8 μMMiscellaneous35590.130435fatty acid desaturase (OLE1)
0.0596.67E-6SGTC_229benomyl 22.9 μMMiscellaneous287800.130435tubulin folding & SWR complex
0.0571.38E-5SGTC_21255246583 200.0 μMChembridge (Fragment library)8352670.236364tubulin folding & SWR complex
0.0561.69E-5SGTC_28879044784 58.4 μMChembridge (Drug-like library)64655460.224138fatty acid desaturase (OLE1)
0.0561.71E-5SGTC_28809042983 58.4 μMChembridge (Drug-like library)64647140.184615fatty acid desaturase (OLE1)
0.0535.32E-5SGTC_30959117207 49.5 μMChembridge (Drug-like library)170152290.212121
0.0525.44E-5SGTC_30819117243 49.5 μMChembridge (Drug-like library)455955890.0746269fatty acid desaturase (OLE1)
0.0526.24E-5SGTC_218alverine citrate 93.8 μMMiscellaneous217180.0754717fatty acid desaturase (OLE1)
0.0519.15E-5SGTC_28939048488 26.0 μMChembridge (Drug-like library)64673380.216667fatty acid desaturase (OLE1)
0.0519.24E-5SGTC_254nsc-64875 3.8 μMMiscellaneous569930.0151515ergosterol depletion effects on membrane
0.0519.42E-5SGTC_14224031-0024 15.5 μMChemDiv (Drug-like library)7824270.220339iron homeostasis
0.0501.29E-4SGTC_13521496-0991 99.0 μMChemDiv (Drug-like library)30000390.122807tubulin folding & SWR complex

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_29087930301100 μM0.4285712223178Chembridge (Drug-like library)387.431143.00533
SGTC_22199098279200 μM0.422222902349Chembridge (Fragment library)213.253540.73714
SGTC_8034488-1585147 μM0.392857747204ChemDiv (Drug-like library)315.386783.924
SGTC_9383126-1755342 μM0.3725491777771ChemDiv (Drug-like library)390.388723.01235
SGTC_10553448-067286 μM0.36748378ChemDiv (Drug-like library)302.369723.92412
SGTC_3091911637249.47 μM0.35185217169793Chembridge (Drug-like library)285.337662.95313
SGTC_22067254556146.97 μM0.3461544398905Chembridge (Fragment library)275.326220.8842460S ribosome export
SGTC_12890976-007369.1 μM0.3404263391136ChemDiv (Drug-like library)253.29582.7812
SGTC_3022908799349.47 μM0.33333317173644Chembridge (Drug-like library)351.422182.40224
SGTC_10134112-3890241 μM0.327869705171ChemDiv (Drug-like library)331.386183.39725TSC3-RPN4