Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDL020C | 8.21 | 1.11E-16 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YOR137C | 7.19 | 3.25E-13 | SIA1 | Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose |
YKL037W | 6.21 | 2.64E-10 | AIM26 | Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT |
YER151C | 5.51 | 1.81E-8 | UBP3 | Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress |
YDR203W_d | 5.46 | 2.37E-8 | YDR203W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDR450W | 5.37 | 4.02E-8 | RPS18A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress |
YNR012W | 5.16 | 1.24E-7 | URK1 | Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP |
YGL054C | 5.11 | 1.63E-7 | ERV14 | COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication |
YGL076C | 4.98 | 3.25E-7 | RPL7A | Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication |
YNL111C | 4.65 | 1.70E-6 | CYB5 | Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation |
YPL051W | 4.52 | 3.14E-6 | ARL3 | GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor |
YBL071W-A | 4.44 | 4.41E-6 | KTI11 | Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs |
YFR038W | 4.33 | 7.29E-6 | IRC5 | Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci |
YDR202C | 4.29 | 8.75E-6 | RAV2 | Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme |
YBR139W | 4.20 | 1.33E-5 | YBR139W | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |