Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR010C | 3.43 | 3.01E-4 | 0.14 | RPA135 | RNA polymerase I second largest subunit A135 |
YOR210W | 3.38 | 3.56E-4 | 0.14 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YOR103C | 3.27 | 5.33E-4 | 0.14 | OST2 | Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins |
YNL240C | 3.27 | 5.39E-4 | 0.14 | NAR1 | Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf |
YKL122C | 3.13 | 8.82E-4 | 0.04 | SRP21 | Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm |
YDR037W | 3.09 | 0.00102 | 0.06 | KRS1 | Lysyl-tRNA synthetase |
YER006W | 3.03 | 0.00123 | 0.04 | NUG1 | GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus |
YJL026W | 2.99 | 0.00139 | 0.11 | RNR2 | Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits |
YGR251W | 2.88 | 0.00199 | 0.03 | NOP19 | Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes |
YOR206W | 2.85 | 0.00218 | 0.02 | NOC2 | Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors |
YOL120C | 2.83 | 0.00235 | 0.03 | RPL18A | Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication |
YOL146W | 2.80 | 0.00255 | 0.01 | PSF3 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YKL193C | 2.79 | 0.00266 | 0.13 | SDS22 | Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function |
YOR207C | 2.66 | 0.00396 | 0.02 | RET1 | Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs |
YHR042W | 2.64 | 0.00420 | 0.01 | NCP1 | NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p |