1309-0633

N-[1-(3-acetamidophenoxy)-2,2,2-trichloroethyl]furan-2-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_968
Screen concentration 340.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 3761976
SMILES CC(=O)NC1=CC(=CC=C1)OC(C(Cl)(Cl)Cl)NC(=O)C2=CC=CO2
Standardized SMILES CC(=O)Nc1cccc(OC(NC(=O)c2occc2)C(Cl)(Cl)Cl)c1
Molecular weight 391.6337
ALogP 2.98
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0
% growth inhibition (Hom. pool) 2.25


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3761976
Download HIP data (tab-delimited text)  (excel)
Gene:CAB2(YIL083C)|FD-Score:3.13|P-value:8.77E-4|Clearance:0.14||SGD DESC:Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) Gene:GPI12(YMR281W)|FD-Score:3.14|P-value:8.53E-4|Clearance:0.01||SGD DESC:ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp Gene:HRP1(YOL123W)|FD-Score:4.68|P-value:1.43E-6|Clearance:0.35||SGD DESC:Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences Gene:MET4(YNL103W)|FD-Score:4.33|P-value:7.31E-6|Clearance:0.02||SGD DESC:Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p Gene:NMT1(YLR195C)|FD-Score:3.88|P-value:5.33E-5|Clearance:0.2||SGD DESC:N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction Gene:PRO3(YER023W)|FD-Score:4.13|P-value:1.84E-5|Clearance:0.25||SGD DESC:Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis Gene:PRP21(YJL203W)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.07||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PRP5(YBR237W)|FD-Score:3.61|P-value:1.54E-4|Clearance:0.26||SGD DESC:RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Gene:RSP5(YER125W)|FD-Score:3.24|P-value:5.93E-4|Clearance:0.11||SGD DESC:E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p Gene:SEC26(YDR238C)|FD-Score:-4.18|P-value:1.45E-5|Clearance:0||SGD DESC:Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) Gene:SRP101(YDR292C)|FD-Score:4.32|P-value:7.91E-6|Clearance:0.19||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:TRS130(YMR218C)|FD-Score:3.26|P-value:5.51E-4|Clearance:0.02||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy Gene:YFH1(YDL120W)|FD-Score:3.35|P-value:4.11E-4|Clearance:0.08||SGD DESC:Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia Gene:YPD1(YDL235C)|FD-Score:-3.99|P-value:3.36E-5|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:CAB2(YIL083C)|FD-Score:3.13|P-value:8.77E-4|Clearance:0.14||SGD DESC:Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) Gene:GPI12(YMR281W)|FD-Score:3.14|P-value:8.53E-4|Clearance:0.01||SGD DESC:ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp Gene:HRP1(YOL123W)|FD-Score:4.68|P-value:1.43E-6|Clearance:0.35||SGD DESC:Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences Gene:MET4(YNL103W)|FD-Score:4.33|P-value:7.31E-6|Clearance:0.02||SGD DESC:Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p Gene:NMT1(YLR195C)|FD-Score:3.88|P-value:5.33E-5|Clearance:0.2||SGD DESC:N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction Gene:PRO3(YER023W)|FD-Score:4.13|P-value:1.84E-5|Clearance:0.25||SGD DESC:Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis Gene:PRP21(YJL203W)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.07||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PRP5(YBR237W)|FD-Score:3.61|P-value:1.54E-4|Clearance:0.26||SGD DESC:RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Gene:RSP5(YER125W)|FD-Score:3.24|P-value:5.93E-4|Clearance:0.11||SGD DESC:E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p Gene:SEC26(YDR238C)|FD-Score:-4.18|P-value:1.45E-5|Clearance:0||SGD DESC:Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) Gene:SRP101(YDR292C)|FD-Score:4.32|P-value:7.91E-6|Clearance:0.19||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:TRS130(YMR218C)|FD-Score:3.26|P-value:5.51E-4|Clearance:0.02||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy Gene:YFH1(YDL120W)|FD-Score:3.35|P-value:4.11E-4|Clearance:0.08||SGD DESC:Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia Gene:YPD1(YDL235C)|FD-Score:-3.99|P-value:3.36E-5|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3761976
Download HOP data (tab-delimited text)  (excel)
Gene:AIM39(YOL053W)|FD-Score:3.19|P-value:7.10E-4||SGD DESC:Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss Gene:ARG8(YOL140W)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine Gene:ATP10(YLR393W)|FD-Score:3.26|P-value:5.67E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Gene:AVT1(YJR001W)|FD-Score:3.86|P-value:5.56E-5||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:AYT1(YLL063C)|FD-Score:4.89|P-value:5.16E-7||SGD DESC:Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis Gene:CEX1(YOR112W)|FD-Score:3.96|P-value:3.78E-5||SGD DESC:Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p Gene:CYC2(YOR037W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) Gene:DAS1(YJL149W)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:DFG5(YMR238W)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:ECM13(YBL043W)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication Gene:FKS3(YMR306W)|FD-Score:-3.18|P-value:7.41E-4||SGD DESC:Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FPS1(YLL043W)|FD-Score:3.11|P-value:9.21E-4||SGD DESC:Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress Gene:GIS2(YNL255C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 Gene:GPH1(YPR160W)|FD-Score:4.83|P-value:6.74E-7||SGD DESC:Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Gene:IBA57(YJR122W)|FD-Score:3.26|P-value:5.57E-4||SGD DESC:Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system Gene:IES4(YOR189W)|FD-Score:3.91|P-value:4.70E-5||SGD DESC:Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses Gene:IRC2(YDR112W_d)|FD-Score:4.06|P-value:2.47E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:KSS1(YGR040W)|FD-Score:-6.55|P-value:2.95E-11||SGD DESC:Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains Gene:LCB3(YJL134W)|FD-Score:-3.21|P-value:6.56E-4||SGD DESC:Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication Gene:MCH4(YOL119C)|FD-Score:-3.41|P-value:3.22E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MDH1(YKL085W)|FD-Score:-3.11|P-value:9.27E-4||SGD DESC:Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated Gene:MDM20(YOL076W)|FD-Score:3.73|P-value:9.53E-5||SGD DESC:Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly Gene:MGM101(YJR144W)|FD-Score:3.42|P-value:3.18E-4||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MHF2(YDL160C-A)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MMT2(YPL224C)|FD-Score:6.69|P-value:1.12E-11||SGD DESC:Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p Gene:MRPL7(YDR237W)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein Gene:MVP1(YMR004W)|FD-Score:-5.49|P-value:1.98E-8||SGD DESC:Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress Gene:NOT3(YIL038C)|FD-Score:3.11|P-value:9.36E-4||SGD DESC:Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation Gene:OPI11(YPR044C_d)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Gene:PRM3(YPL192C)|FD-Score:4.78|P-value:8.73E-7||SGD DESC:Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body Gene:QDR1(YIL120W)|FD-Score:5.81|P-value:3.13E-9||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication Gene:RPS21B(YJL136C)|FD-Score:4.65|P-value:1.66E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RTC5(YOR118W)|FD-Score:-3.16|P-value:8.00E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SKN1(YGR143W)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p Gene:TAT1(YBR069C)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TED1(YIL039W)|FD-Score:3.46|P-value:2.69E-4||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:TPS2(YDR074W)|FD-Score:3.8|P-value:7.21E-5||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:VBA2(YBR293W)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:VPS52(YDR484W)|FD-Score:-5.38|P-value:3.68E-8||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YDR102C(YDR102C_d)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YDR209C(YDR209C_d)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Gene:YDR246W-A(YDR246W-A_p)|FD-Score:3.39|P-value:3.54E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL211C(YJL211C_d)|FD-Score:-3.9|P-value:4.79E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 Gene:YKR104W(YKR104W)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLL007C(YLL007C_p)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Gene:YLR012C(YLR012C_p)|FD-Score:4.34|P-value:7.15E-6||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YMR147W(YMR147W_p)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Putative protein of unknown function Gene:YMR175W-A(YMR175W-A_p)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Putative protein of unknown function Gene:YMR315W(YMR315W)|FD-Score:6.13|P-value:4.34E-10||SGD DESC:Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress Gene:YNK1(YKL067W)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress Gene:YNL205C(YNL205C_d)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL119C-A(YPL119C-A_p)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YTA7(YGR270W)|FD-Score:-8.64|P-value:2.93E-18||SGD DESC:Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p Gene:AIM39(YOL053W)|FD-Score:3.19|P-value:7.10E-4||SGD DESC:Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss Gene:ARG8(YOL140W)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine Gene:ATP10(YLR393W)|FD-Score:3.26|P-value:5.67E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Gene:AVT1(YJR001W)|FD-Score:3.86|P-value:5.56E-5||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:AYT1(YLL063C)|FD-Score:4.89|P-value:5.16E-7||SGD DESC:Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis Gene:CEX1(YOR112W)|FD-Score:3.96|P-value:3.78E-5||SGD DESC:Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p Gene:CYC2(YOR037W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) Gene:DAS1(YJL149W)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:DFG5(YMR238W)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:ECM13(YBL043W)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication Gene:FKS3(YMR306W)|FD-Score:-3.18|P-value:7.41E-4||SGD DESC:Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FPS1(YLL043W)|FD-Score:3.11|P-value:9.21E-4||SGD DESC:Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress Gene:GIS2(YNL255C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 Gene:GPH1(YPR160W)|FD-Score:4.83|P-value:6.74E-7||SGD DESC:Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Gene:IBA57(YJR122W)|FD-Score:3.26|P-value:5.57E-4||SGD DESC:Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system Gene:IES4(YOR189W)|FD-Score:3.91|P-value:4.70E-5||SGD DESC:Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses Gene:IRC2(YDR112W_d)|FD-Score:4.06|P-value:2.47E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:KSS1(YGR040W)|FD-Score:-6.55|P-value:2.95E-11||SGD DESC:Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains Gene:LCB3(YJL134W)|FD-Score:-3.21|P-value:6.56E-4||SGD DESC:Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication Gene:MCH4(YOL119C)|FD-Score:-3.41|P-value:3.22E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MDH1(YKL085W)|FD-Score:-3.11|P-value:9.27E-4||SGD DESC:Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated Gene:MDM20(YOL076W)|FD-Score:3.73|P-value:9.53E-5||SGD DESC:Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly Gene:MGM101(YJR144W)|FD-Score:3.42|P-value:3.18E-4||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MHF2(YDL160C-A)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MMT2(YPL224C)|FD-Score:6.69|P-value:1.12E-11||SGD DESC:Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p Gene:MRPL7(YDR237W)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein Gene:MVP1(YMR004W)|FD-Score:-5.49|P-value:1.98E-8||SGD DESC:Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress Gene:NOT3(YIL038C)|FD-Score:3.11|P-value:9.36E-4||SGD DESC:Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation Gene:OPI11(YPR044C_d)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Gene:PRM3(YPL192C)|FD-Score:4.78|P-value:8.73E-7||SGD DESC:Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body Gene:QDR1(YIL120W)|FD-Score:5.81|P-value:3.13E-9||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication Gene:RPS21B(YJL136C)|FD-Score:4.65|P-value:1.66E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RTC5(YOR118W)|FD-Score:-3.16|P-value:8.00E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SKN1(YGR143W)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p Gene:TAT1(YBR069C)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TED1(YIL039W)|FD-Score:3.46|P-value:2.69E-4||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:TPS2(YDR074W)|FD-Score:3.8|P-value:7.21E-5||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:VBA2(YBR293W)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:VPS52(YDR484W)|FD-Score:-5.38|P-value:3.68E-8||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YDR102C(YDR102C_d)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YDR209C(YDR209C_d)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Gene:YDR246W-A(YDR246W-A_p)|FD-Score:3.39|P-value:3.54E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL211C(YJL211C_d)|FD-Score:-3.9|P-value:4.79E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 Gene:YKR104W(YKR104W)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLL007C(YLL007C_p)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Gene:YLR012C(YLR012C_p)|FD-Score:4.34|P-value:7.15E-6||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YMR147W(YMR147W_p)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Putative protein of unknown function Gene:YMR175W-A(YMR175W-A_p)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Putative protein of unknown function Gene:YMR315W(YMR315W)|FD-Score:6.13|P-value:4.34E-10||SGD DESC:Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress Gene:YNK1(YKL067W)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress Gene:YNL205C(YNL205C_d)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL119C-A(YPL119C-A_p)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YTA7(YGR270W)|FD-Score:-8.64|P-value:2.93E-18||SGD DESC:Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOL123W4.681.43E-60.35HRP1Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YNL103W4.337.31E-60.02MET4Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YDR292C4.327.91E-60.19SRP101Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
YER023W4.131.84E-50.25PRO3Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
YLR195C3.885.33E-50.20NMT1N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YJL203W3.671.19E-40.07PRP21Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YBR237W3.611.54E-40.26PRP5RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
YDL120W3.354.11E-40.08YFH1Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
YMR218C3.265.51E-40.02TRS130One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
YER125W3.245.93E-40.10RSP5E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p
YMR281W3.148.53E-40.01GPI12ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YIL083C3.138.77E-40.14CAB2Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
YJL074C2.990.001400.02SMC3Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
YCR035C2.970.001470.09RRP43Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress
YLR317W_d2.890.001940.03YLR317W_dDubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL224C6.691.12E-11MMT2Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YMR315W6.134.34E-10YMR315WProtein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
YIL120W5.813.13E-9QDR1Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
YLL063C4.895.16E-7AYT1Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
YPR160W4.836.74E-7GPH1Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YPL192C4.788.73E-7PRM3Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
YJL136C4.651.66E-6RPS21BProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
YLR012C_p4.347.15E-6YLR012C_pPutative protein of unknown function; YLR012C is not an essential gene
YDL160C-A4.201.31E-5MHF2Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
YDR112W_d4.062.47E-5IRC2_dDubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YMR147W_p4.022.86E-5YMR147W_pPutative protein of unknown function
YOR112W3.963.78E-5CEX1Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
YOR189W3.914.70E-5IES4Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
YJR001W3.865.56E-5AVT1Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YDR074W3.807.21E-5TPS2Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_968
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0872.51E-11SGTC_9671306-0166 352.0 μMChemDiv (Drug-like library)44376070.0909091
0.0731.74E-8SGTC_9531188-0045 9.7 μMChemDiv (Drug-like library)61444260.08450760S ribosome export
0.0681.49E-7SGTC_1918oxolan-2-ylmethyl 3-bromobenzoate 70.1 μMTimTec (Natural product derivative library)5514690.146667
0.0681.78E-7SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.0958904
0.0673.13E-7SGTC_28869058944 52.0 μMChembridge (Drug-like library)49499290.202899
0.0663.91E-7SGTC_1607st000305 50.6 μMTimTec (Natural product derivative library)54576900.116279
0.0552.30E-5SGTC_31849108758 49.5 μMChembridge (Drug-like library)9028850.327869
0.0534.28E-5SGTC_840443-0269 128.8 μMChemDiv (Drug-like library)61500580.103896
0.0534.41E-5SGTC_23829035899 200.0 μMChembridge (Fragment library)64626790.090909160S ribosome export
0.0535.18E-5SGTC_14884013-0813 75.9 μMChemDiv (Drug-like library)29100570.097561RPP1 & pyrimidine depletion
0.0526.36E-5SGTC_1994063-0024 41.6 μMChemDiv (Drug-like library)3062150.142857
0.0518.76E-5SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.25641
0.0511.02E-4SGTC_2641levomentholum 100.0 μMMicrosource (Natural product library)166660.030303
0.0501.11E-4SGTC_32049114183 49.5 μMChembridge (Drug-like library)170272480.31746
0.0491.44E-4SGTC_1705st027868 56.3 μMTimTec (Natural product derivative library)2929480.0714286

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_20255147754141 μM0.472727315777Chembridge (Fragment library)229.231341.74913
SGTC_2860902572538.96 μM0.44444440546248Chembridge (Drug-like library)313.327843.39515RPP1 & pyrimidine depletion
SGTC_3071501-122322.3 μM0.4333332830329ChemDiv (Drug-like library)412.49374.43623
SGTC_2865903031351.95 μM0.39062542562754Chembridge (Drug-like library)295.332483.91913
SGTC_22817943571200 μM0.3770491244024Chembridge (Fragment library)231.247222.47913
SGTC_2986902244571.43 μM0.3770496459286Chembridge (Drug-like library)285.337663.30813
SGTC_3077911731949.47 μM0.37704917154678Chembridge (Drug-like library)285.337663.30813
SGTC_2999906976571.43 μM0.3548392097066Chembridge (Drug-like library)285.337663.30813amide catabolism
SGTC_3098911903949.47 μM0.35384617161528Chembridge (Drug-like library)287.3287234.05313Golgi
SGTC_8940960-023855.9 μM0.3521136741907ChemDiv (Drug-like library)340.760422.64724