Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR131C | 16.90 | 1.90E-64 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YKL048C | 8.83 | 5.29E-19 | ELM1 | Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring |
YOR072W_d | 7.72 | 5.75E-15 | YOR072W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive |
YDR336W_p | 7.49 | 3.58E-14 | YDR336W_p | Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene |
YER056C-A | 5.82 | 2.96E-9 | RPL34A | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication |
YHL033C | 5.47 | 2.23E-8 | RPL8A | Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication |
YNL322C | 4.86 | 5.96E-7 | KRE1 | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor |
YNL050C_p | 4.78 | 8.98E-7 | YNL050C_p | Putative protein of unknown function; YNL050c is not an essential gene |
YIL039W | 4.63 | 1.83E-6 | TED1 | Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |
YOR384W | 4.58 | 2.34E-6 | FRE5 | Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YIR032C | 4.54 | 2.83E-6 | DAL3 | Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression |
YOR315W | 4.53 | 3.00E-6 | SFG1 | Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
YJL102W | 4.51 | 3.17E-6 | MEF2 | Mitochondrial elongation factor involved in translational elongation |
YDR274C_d | 4.45 | 4.23E-6 | YDR274C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOR214C_p | 4.34 | 7.19E-6 | YOR214C_p | Putative protein of unknown function; YOR214C is not an essential gene |