1319-0219

4-[[3-(1H-benzimidazol-2-yl)-7-methoxychromen-2-ylidene]amino]benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_972
Screen concentration 195.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 23903702
SMILES COC1=CC2=C(C=C1)C=C(C(=NC3=CC=C(C=C3)C(=O)N)O2)C4=NC5=CC=CC=C5N4
Standardized SMILES COc1ccc2C=C(C(=Nc3ccc(cc3)C(=O)N)Oc2c1)c4nc5ccccc5[nH]4
Molecular weight 410.4247
ALogP 4.12
H-bond donor count 2
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 13.9
% growth inhibition (Hom. pool) -5.7


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 23903702
Download HIP data (tab-delimited text)  (excel)
Gene:DRE2(YKR071C)|FD-Score:3.29|P-value:5.07E-4|Clearance:0.04||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:DRS1(YLL008W)|FD-Score:-3.13|P-value:8.60E-4|Clearance:0||SGD DESC:Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles Gene:DSN1(YIR010W)|FD-Score:3.2|P-value:6.88E-4|Clearance:0.01||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Gene:FAD1(YDL045C)|FD-Score:3.11|P-value:9.32E-4|Clearance:0.05||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:LSG1(YGL099W)|FD-Score:7.25|P-value:2.07E-13|Clearance:1.51||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NMD3(YHR170W)|FD-Score:3.23|P-value:6.19E-4|Clearance:0.03||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NPA3(YJR072C)|FD-Score:3.4|P-value:3.42E-4|Clearance:0.06||SGD DESC:Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress Gene:NUP49(YGL172W)|FD-Score:3.33|P-value:4.30E-4|Clearance:0.03||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:RFT1(YBL020W)|FD-Score:3.31|P-value:4.75E-4|Clearance:0.02||SGD DESC:Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein Gene:RPC53(YDL150W)|FD-Score:3.92|P-value:4.52E-5|Clearance:0.08||SGD DESC:RNA polymerase III subunit C53 Gene:RPS15(YOL040C)|FD-Score:3.75|P-value:9.01E-5|Clearance:0.04||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 Gene:RRP17(YDR412W)|FD-Score:5.74|P-value:4.67E-9|Clearance:0.2||SGD DESC:Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA Gene:SEC8(YPR055W)|FD-Score:-3.16|P-value:7.78E-4|Clearance:0||SGD DESC:Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Gene:SPC19(YDR201W)|FD-Score:5.54|P-value:1.53E-8|Clearance:0.48||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body Gene:SRB6(YBR253W)|FD-Score:-3.19|P-value:7.08E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:TFA2(YKR062W)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.22||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation Gene:TIF11(YMR260C)|FD-Score:3.19|P-value:7.04E-4|Clearance:0.08||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:TOR2(YKL203C)|FD-Score:3.84|P-value:6.16E-5|Clearance:0.09||SGD DESC:PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication Gene:TRE2(YOR256C)|FD-Score:3.24|P-value:5.93E-4|Clearance:0.01||SGD DESC:Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication Gene:YGR115C(YGR115C_d)|FD-Score:5.06|P-value:2.14E-7|Clearance:1.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C Gene:YLL037W(YLL037W_d)|FD-Score:-3.6|P-value:1.61E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor Gene:YTM1(YOR272W)|FD-Score:3.7|P-value:1.06E-4|Clearance:0.08||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats Gene:DRE2(YKR071C)|FD-Score:3.29|P-value:5.07E-4|Clearance:0.04||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:DRS1(YLL008W)|FD-Score:-3.13|P-value:8.60E-4|Clearance:0||SGD DESC:Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles Gene:DSN1(YIR010W)|FD-Score:3.2|P-value:6.88E-4|Clearance:0.01||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Gene:FAD1(YDL045C)|FD-Score:3.11|P-value:9.32E-4|Clearance:0.05||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:LSG1(YGL099W)|FD-Score:7.25|P-value:2.07E-13|Clearance:1.51||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NMD3(YHR170W)|FD-Score:3.23|P-value:6.19E-4|Clearance:0.03||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NPA3(YJR072C)|FD-Score:3.4|P-value:3.42E-4|Clearance:0.06||SGD DESC:Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress Gene:NUP49(YGL172W)|FD-Score:3.33|P-value:4.30E-4|Clearance:0.03||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:RFT1(YBL020W)|FD-Score:3.31|P-value:4.75E-4|Clearance:0.02||SGD DESC:Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein Gene:RPC53(YDL150W)|FD-Score:3.92|P-value:4.52E-5|Clearance:0.08||SGD DESC:RNA polymerase III subunit C53 Gene:RPS15(YOL040C)|FD-Score:3.75|P-value:9.01E-5|Clearance:0.04||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 Gene:RRP17(YDR412W)|FD-Score:5.74|P-value:4.67E-9|Clearance:0.2||SGD DESC:Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA Gene:SEC8(YPR055W)|FD-Score:-3.16|P-value:7.78E-4|Clearance:0||SGD DESC:Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Gene:SPC19(YDR201W)|FD-Score:5.54|P-value:1.53E-8|Clearance:0.48||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body Gene:SRB6(YBR253W)|FD-Score:-3.19|P-value:7.08E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:TFA2(YKR062W)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.22||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation Gene:TIF11(YMR260C)|FD-Score:3.19|P-value:7.04E-4|Clearance:0.08||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:TOR2(YKL203C)|FD-Score:3.84|P-value:6.16E-5|Clearance:0.09||SGD DESC:PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication Gene:TRE2(YOR256C)|FD-Score:3.24|P-value:5.93E-4|Clearance:0.01||SGD DESC:Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication Gene:YGR115C(YGR115C_d)|FD-Score:5.06|P-value:2.14E-7|Clearance:1.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C Gene:YLL037W(YLL037W_d)|FD-Score:-3.6|P-value:1.61E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor Gene:YTM1(YOR272W)|FD-Score:3.7|P-value:1.06E-4|Clearance:0.08||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 23903702
Download HOP data (tab-delimited text)  (excel)
Gene:ACE2(YLR131C)|FD-Score:16.9|P-value:1.90E-64||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:ADY3(YDL239C)|FD-Score:4.12|P-value:1.93E-5||SGD DESC:Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication Gene:AKR2(YOR034C)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:ALD6(YPL061W)|FD-Score:-3.46|P-value:2.71E-4||SGD DESC:Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Gene:ATG21(YPL100W)|FD-Score:4.16|P-value:1.58E-5||SGD DESC:Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein Gene:ATP3(YBR039W)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:BUD6(YLR319C)|FD-Score:3.8|P-value:7.24E-5||SGD DESC:Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Gene:CAP2(YIL034C)|FD-Score:3.8|P-value:7.10E-5||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:CHS3(YBR023C)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan Gene:CIR1(YGR207C)|FD-Score:-3.19|P-value:7.23E-4||SGD DESC:Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response Gene:COA3(YJL062W-A)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly Gene:COG1(YGL223C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COS1(YNL336W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:COX11(YPL132W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p Gene:CSN9(YDR179C)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling Gene:CWP1(YKL096W)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance Gene:DAL3(YIR032C)|FD-Score:4.54|P-value:2.83E-6||SGD DESC:Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DPH5(YLR172C)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm Gene:ECM30(YLR436C)|FD-Score:3.19|P-value:6.99E-4||SGD DESC:Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm Gene:ELM1(YKL048C)|FD-Score:8.83|P-value:5.29E-19||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:ELP2(YGR200C)|FD-Score:-3.21|P-value:6.73E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin Gene:EXO1(YOR033C)|FD-Score:-3.75|P-value:8.82E-5||SGD DESC:5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress Gene:FIG1(YBR040W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating Gene:FRE5(YOR384W)|FD-Score:4.58|P-value:2.34E-6||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GAS4(YOL132W)|FD-Score:3.85|P-value:6.02E-5||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GTO3(YMR251W)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Omega class glutathione transferase; putative cytosolic localization Gene:HBS1(YKR084C)|FD-Score:3.13|P-value:8.67E-4||SGD DESC:GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay Gene:HES1(YOR237W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication Gene:HSP42(YDR171W)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress Gene:IML3(YBR107C)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 Gene:KRE1(YNL322C)|FD-Score:4.86|P-value:5.96E-7||SGD DESC:Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Gene:LHP1(YDL051W)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:MDH1(YKL085W)|FD-Score:3.74|P-value:9.32E-5||SGD DESC:Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated Gene:MEF2(YJL102W)|FD-Score:4.51|P-value:3.17E-6||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MRI1(YPR118W)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MSY1(YPL097W)|FD-Score:4.23|P-value:1.14E-5||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:NIT2(YJL126W)|FD-Score:3.78|P-value:7.77E-5||SGD DESC:Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member Gene:NUP60(YAR002W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:OCA6(YDR067C_p)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT Gene:PFK1(YGR240C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PXL1(YKR090W)|FD-Score:-3.85|P-value:5.89E-5||SGD DESC:Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RAX2(YLR084C)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p Gene:RPL34A(YER056C-A)|FD-Score:5.82|P-value:2.96E-9||SGD DESC:Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:5.47|P-value:2.23E-8||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:RPS29A(YLR388W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication Gene:RRP8(YDR083W)|FD-Score:4.05|P-value:2.59E-5||SGD DESC:Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1 Gene:SEA4(YBL104C)|FD-Score:4.31|P-value:8.22E-6||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SEY1(YOR165W)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 Gene:SFB3(YHR098C)|FD-Score:-3.82|P-value:6.63E-5||SGD DESC:Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p Gene:SFG1(YOR315W)|FD-Score:4.53|P-value:3.00E-6||SGD DESC:Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate Gene:SIP5(YMR140W)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SLG1(YOR008C)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Gene:SLO1(YER180C-A)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO Gene:SLY41(YOR307C)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SRT1(YMR101C)|FD-Score:3.19|P-value:6.99E-4||SGD DESC:Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase Gene:SSK2(YNR031C)|FD-Score:4.02|P-value:2.91E-5||SGD DESC:MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress Gene:STB5(YHR178W)|FD-Score:3.84|P-value:6.15E-5||SGD DESC:Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gene:STI1(YOR027W)|FD-Score:3.89|P-value:4.99E-5||SGD DESC:Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop Gene:TAT2(YOL020W)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TED1(YIL039W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:TOP1(YOL006C)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:TRI1(YMR233W)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication Gene:UMP1(YBR173C)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly Gene:VAC14(YLR386W)|FD-Score:3.79|P-value:7.46E-5||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:YBL028C(YBL028C)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YCL042W(YCL042W_p)|FD-Score:3.14|P-value:8.47E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDL159W-A(YDL159W-A_p)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YDR274C(YDR274C_d)|FD-Score:4.45|P-value:4.23E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR336W(YDR336W_p)|FD-Score:7.49|P-value:3.58E-14||SGD DESC:Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene Gene:YDR514C(YDR514C)|FD-Score:3.1|P-value:9.72E-4||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YER137C(YER137C_p)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Putative protein of unknown function Gene:YFR056C(YFR056C_d)|FD-Score:4.19|P-value:1.41E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Gene:YGL177W(YGL177W_d)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL118W(YKL118W_d)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLR108C(YLR108C_p)|FD-Score:3.82|P-value:6.72E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication Gene:YMR310C(YMR310C_p)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene Gene:YNL050C(YNL050C_p)|FD-Score:4.78|P-value:8.98E-7||SGD DESC:Putative protein of unknown function; YNL050c is not an essential gene Gene:YOR072W(YOR072W_d)|FD-Score:7.72|P-value:5.75E-15||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YOR214C(YOR214C_p)|FD-Score:4.34|P-value:7.19E-6||SGD DESC:Putative protein of unknown function; YOR214C is not an essential gene Gene:YOR318C(YOR318C_d)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Gene:YPR059C(YPR059C_d)|FD-Score:3.85|P-value:6.02E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Gene:YPR114W(YPR114W_p)|FD-Score:-3.11|P-value:9.33E-4||SGD DESC:Putative protein of unknown function Gene:ACE2(YLR131C)|FD-Score:16.9|P-value:1.90E-64||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:ADY3(YDL239C)|FD-Score:4.12|P-value:1.93E-5||SGD DESC:Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication Gene:AKR2(YOR034C)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:ALD6(YPL061W)|FD-Score:-3.46|P-value:2.71E-4||SGD DESC:Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Gene:ATG21(YPL100W)|FD-Score:4.16|P-value:1.58E-5||SGD DESC:Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein Gene:ATP3(YBR039W)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:BUD6(YLR319C)|FD-Score:3.8|P-value:7.24E-5||SGD DESC:Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Gene:CAP2(YIL034C)|FD-Score:3.8|P-value:7.10E-5||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:CHS3(YBR023C)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan Gene:CIR1(YGR207C)|FD-Score:-3.19|P-value:7.23E-4||SGD DESC:Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response Gene:COA3(YJL062W-A)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly Gene:COG1(YGL223C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COS1(YNL336W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:COX11(YPL132W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p Gene:CSN9(YDR179C)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling Gene:CWP1(YKL096W)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance Gene:DAL3(YIR032C)|FD-Score:4.54|P-value:2.83E-6||SGD DESC:Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DPH5(YLR172C)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm Gene:ECM30(YLR436C)|FD-Score:3.19|P-value:6.99E-4||SGD DESC:Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm Gene:ELM1(YKL048C)|FD-Score:8.83|P-value:5.29E-19||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:ELP2(YGR200C)|FD-Score:-3.21|P-value:6.73E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin Gene:EXO1(YOR033C)|FD-Score:-3.75|P-value:8.82E-5||SGD DESC:5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress Gene:FIG1(YBR040W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating Gene:FRE5(YOR384W)|FD-Score:4.58|P-value:2.34E-6||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GAS4(YOL132W)|FD-Score:3.85|P-value:6.02E-5||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GTO3(YMR251W)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Omega class glutathione transferase; putative cytosolic localization Gene:HBS1(YKR084C)|FD-Score:3.13|P-value:8.67E-4||SGD DESC:GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay Gene:HES1(YOR237W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication Gene:HSP42(YDR171W)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress Gene:IML3(YBR107C)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 Gene:KRE1(YNL322C)|FD-Score:4.86|P-value:5.96E-7||SGD DESC:Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Gene:LHP1(YDL051W)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:MDH1(YKL085W)|FD-Score:3.74|P-value:9.32E-5||SGD DESC:Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated Gene:MEF2(YJL102W)|FD-Score:4.51|P-value:3.17E-6||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MRI1(YPR118W)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MSY1(YPL097W)|FD-Score:4.23|P-value:1.14E-5||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:NIT2(YJL126W)|FD-Score:3.78|P-value:7.77E-5||SGD DESC:Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member Gene:NUP60(YAR002W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:OCA6(YDR067C_p)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT Gene:PFK1(YGR240C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PXL1(YKR090W)|FD-Score:-3.85|P-value:5.89E-5||SGD DESC:Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RAX2(YLR084C)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p Gene:RPL34A(YER056C-A)|FD-Score:5.82|P-value:2.96E-9||SGD DESC:Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:5.47|P-value:2.23E-8||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:RPS29A(YLR388W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication Gene:RRP8(YDR083W)|FD-Score:4.05|P-value:2.59E-5||SGD DESC:Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1 Gene:SEA4(YBL104C)|FD-Score:4.31|P-value:8.22E-6||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SEY1(YOR165W)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 Gene:SFB3(YHR098C)|FD-Score:-3.82|P-value:6.63E-5||SGD DESC:Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p Gene:SFG1(YOR315W)|FD-Score:4.53|P-value:3.00E-6||SGD DESC:Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate Gene:SIP5(YMR140W)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SLG1(YOR008C)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Gene:SLO1(YER180C-A)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO Gene:SLY41(YOR307C)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SRT1(YMR101C)|FD-Score:3.19|P-value:6.99E-4||SGD DESC:Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase Gene:SSK2(YNR031C)|FD-Score:4.02|P-value:2.91E-5||SGD DESC:MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress Gene:STB5(YHR178W)|FD-Score:3.84|P-value:6.15E-5||SGD DESC:Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gene:STI1(YOR027W)|FD-Score:3.89|P-value:4.99E-5||SGD DESC:Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop Gene:TAT2(YOL020W)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TED1(YIL039W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:TOP1(YOL006C)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:TRI1(YMR233W)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication Gene:UMP1(YBR173C)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly Gene:VAC14(YLR386W)|FD-Score:3.79|P-value:7.46E-5||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:YBL028C(YBL028C)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YCL042W(YCL042W_p)|FD-Score:3.14|P-value:8.47E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDL159W-A(YDL159W-A_p)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YDR274C(YDR274C_d)|FD-Score:4.45|P-value:4.23E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR336W(YDR336W_p)|FD-Score:7.49|P-value:3.58E-14||SGD DESC:Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene Gene:YDR514C(YDR514C)|FD-Score:3.1|P-value:9.72E-4||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YER137C(YER137C_p)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Putative protein of unknown function Gene:YFR056C(YFR056C_d)|FD-Score:4.19|P-value:1.41E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Gene:YGL177W(YGL177W_d)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL118W(YKL118W_d)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLR108C(YLR108C_p)|FD-Score:3.82|P-value:6.72E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication Gene:YMR310C(YMR310C_p)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene Gene:YNL050C(YNL050C_p)|FD-Score:4.78|P-value:8.98E-7||SGD DESC:Putative protein of unknown function; YNL050c is not an essential gene Gene:YOR072W(YOR072W_d)|FD-Score:7.72|P-value:5.75E-15||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YOR214C(YOR214C_p)|FD-Score:4.34|P-value:7.19E-6||SGD DESC:Putative protein of unknown function; YOR214C is not an essential gene Gene:YOR318C(YOR318C_d)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Gene:YPR059C(YPR059C_d)|FD-Score:3.85|P-value:6.02E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Gene:YPR114W(YPR114W_p)|FD-Score:-3.11|P-value:9.33E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL099W7.252.07E-131.51LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YDR412W5.744.67E-90.20RRP17Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
YDR201W5.541.53E-80.48SPC19Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YGR115C_d5.062.14E-71.14YGR115C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
YDL150W3.924.52E-50.08RPC53RNA polymerase III subunit C53
YKL203C3.846.16E-50.09TOR2PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
YOL040C3.759.01E-50.04RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YOR272W3.701.06E-40.08YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YKR062W3.621.48E-40.22TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YJR072C3.403.42E-40.06NPA3Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
YGL172W3.334.30E-40.03NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YBL020W3.314.75E-40.02RFT1Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
YKR071C3.295.07E-40.04DRE2Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
YOR256C3.245.93E-40.01TRE2Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
YHR170W3.236.19E-40.03NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR131C16.901.90E-64ACE2Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
YKL048C8.835.29E-19ELM1Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
YOR072W_d7.725.75E-15YOR072W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YDR336W_p7.493.58E-14YDR336W_pPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
YER056C-A5.822.96E-9RPL34ARibosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication
YHL033C5.472.23E-8RPL8ARibosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
YNL322C4.865.96E-7KRE1Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YNL050C_p4.788.98E-7YNL050C_pPutative protein of unknown function; YNL050c is not an essential gene
YIL039W4.631.83E-6TED1Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YOR384W4.582.34E-6FRE5Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIR032C4.542.83E-6DAL3Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YOR315W4.533.00E-6SFG1Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YJL102W4.513.17E-6MEF2Mitochondrial elongation factor involved in translational elongation
YDR274C_d4.454.23E-6YDR274C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR214C_p4.347.19E-6YOR214C_pPutative protein of unknown function; YOR214C is not an essential gene

GO enrichment analysis for SGTC_972
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2495.11E-84SGTC_1603453-0671 289.7 μMChemDiv (Drug-like library)53222680.0849057
0.1526.55E-32SGTC_830170-0301 39.0 μMChemDiv (Drug-like library)30897160.037037endomembrane recycling
0.1241.57E-21SGTC_14033909-7815 62.9 μMChemDiv (Drug-like library)66154830.152174
0.1232.03E-21SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.12790760S ribosome export
0.1201.80E-20SGTC_31739105693 49.5 μMChembridge (Drug-like library)170966580.137931
0.1202.36E-20SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.15384660S ribosome export
0.1187.80E-20SGTC_24625162487 171.8 μMMiscellaneous22599860.0786517
0.1171.29E-19SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.098901160S ribosome export
0.1163.79E-19SGTC_587k089-0003 57.0 μMChemDiv (Drug-like library)96596960.162162
0.1111.03E-17SGTC_11861319-0216 26.0 μMChemDiv (Drug-like library)45651360.765625
0.1111.10E-17SGTC_33169136639 10.5 μMChembridge (Drug-like library)49036650.08
0.1102.18E-17SGTC_3174495-0002 170.0 μMChemDiv (Drug-like library)159916180.1
0.1102.66E-17SGTC_5794491-1009 110.0 μMChemDiv (Drug-like library)12710410.10714360S ribosome export
0.1064.14E-16SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.082352960S ribosome export
0.1054.48E-16SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.69565260S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_11861319-021626 μM0.7656254565136ChemDiv (Drug-like library)385.3904435.32615
SGTC_8171391-071546 μM0.6984131353946ChemDiv (Drug-like library)367.399985.12114
SGTC_7651319-0117244 μM0.6956523487746ChemDiv (Drug-like library)410.424724.1232560S ribosome export
SGTC_11981612-100586.7 μM0.5733336998509ChemDiv (Drug-like library)410.424724.37825
SGTC_7661391-0721126 μM0.5205481020919ChemDiv (Drug-like library)381.426565.60714
SGTC_6861319-0111510 μM0.4935064562600ChemDiv (Drug-like library)392.4094451560S ribosome export
SGTC_6271391-0720175 μM0.486842997839ChemDiv (Drug-like library)381.426565.60714
SGTC_11871391-0724117 μM0.4794526997986ChemDiv (Drug-like library)380.398744.39424amide catabolism
SGTC_11851319-011381.3 μM0.46254672763ChemDiv (Drug-like library)435.397956.06317DNA damage response
SGTC_1958st07651341.9 μM0.41791732122TimTec (Natural product derivative library)262.26283.31360S ribosome export