1325-0077

N-(2-hydroxyphenyl)naphthalene-2-sulfonamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_973
Screen concentration 65.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 2835149
SMILES C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NC3=CC=CC=C3O
Standardized SMILES Oc1ccccc1NS(=O)(=O)c2ccc3ccccc3c2
Molecular weight 299.3443
ALogP 2.98
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 20.7
% growth inhibition (Hom. pool) 0


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2835149
Download HIP data (tab-delimited text)  (excel)
Gene:ECM16(YMR128W)|FD-Score:-3.11|P-value:9.22E-4|Clearance:0||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:NHP2(YDL208W)|FD-Score:-3.42|P-value:3.11E-4|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP8(YOL144W)|FD-Score:3.46|P-value:2.67E-4|Clearance:0.4||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:RNA1(YMR235C)|FD-Score:3.3|P-value:4.87E-4|Clearance:0.4||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:RPS15(YOL040C)|FD-Score:3.59|P-value:1.66E-4|Clearance:0.4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 Gene:SPC98(YNL126W)|FD-Score:3.44|P-value:2.86E-4|Clearance:0.4||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:TAF4(YMR005W)|FD-Score:-3.12|P-value:9.00E-4|Clearance:0||SGD DESC:TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate Gene:TIM50(YPL063W)|FD-Score:3.61|P-value:1.54E-4|Clearance:0.4||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel Gene:UTP6(YDR449C)|FD-Score:3.67|P-value:1.21E-4|Clearance:0.4||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:ECM16(YMR128W)|FD-Score:-3.11|P-value:9.22E-4|Clearance:0||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:NHP2(YDL208W)|FD-Score:-3.42|P-value:3.11E-4|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP8(YOL144W)|FD-Score:3.46|P-value:2.67E-4|Clearance:0.4||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:RNA1(YMR235C)|FD-Score:3.3|P-value:4.87E-4|Clearance:0.4||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:RPS15(YOL040C)|FD-Score:3.59|P-value:1.66E-4|Clearance:0.4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 Gene:SPC98(YNL126W)|FD-Score:3.44|P-value:2.86E-4|Clearance:0.4||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:TAF4(YMR005W)|FD-Score:-3.12|P-value:9.00E-4|Clearance:0||SGD DESC:TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate Gene:TIM50(YPL063W)|FD-Score:3.61|P-value:1.54E-4|Clearance:0.4||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel Gene:UTP6(YDR449C)|FD-Score:3.67|P-value:1.21E-4|Clearance:0.4||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2835149
Download HOP data (tab-delimited text)  (excel)
Gene:ACK1(YDL203C)|FD-Score:3.4|P-value:3.33E-4||SGD DESC:Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria Gene:AIM3(YBR108W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARF2(YDL137W)|FD-Score:-3.41|P-value:3.28E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:BCH1(YMR237W)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Gene:BCK2(YER167W)|FD-Score:3.78|P-value:7.70E-5||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:BMH1(YER177W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:CCC2(YDR270W)|FD-Score:3.37|P-value:3.74E-4||SGD DESC:Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism Gene:CCS1(YMR038C)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:CHA4(YLR098C)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:ECM25(YJL201W)|FD-Score:4.37|P-value:6.10E-6||SGD DESC:Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p Gene:ERG2(YMR202W)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:FCY1(YPR062W)|FD-Score:3.89|P-value:4.91E-5||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FES1(YBR101C)|FD-Score:3.89|P-value:4.93E-5||SGD DESC:Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FMO1(YHR176W)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:FUM1(YPL262W)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria Gene:GLG2(YJL137C)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication Gene:HOP2(YGL033W)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:IRS4(YKR019C)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LDB19(YOR322C)|FD-Score:3.32|P-value:4.56E-4||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:MAC1(YMR021C)|FD-Score:3.35|P-value:4.05E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MFA1(YDR461W)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 Gene:MRI1(YPR118W)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MRPL40(YPL173W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MTH1(YDR277C)|FD-Score:-3.5|P-value:2.35E-4||SGD DESC:Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation Gene:NMA2(YGR010W)|FD-Score:-3.1|P-value:9.55E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication Gene:NTG2(YOL043C)|FD-Score:3.19|P-value:7.18E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OCA1(YNL099C)|FD-Score:4.38|P-value:5.83E-6||SGD DESC:Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA Gene:REC107(YJR021C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation Gene:RTG3(YBL103C)|FD-Score:-3.13|P-value:8.72E-4||SGD DESC:Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Gene:SEC66(YBR171W)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLM6(YBR266C_d)|FD-Score:3.85|P-value:6.01E-5||SGD DESC:Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Gene:SPE1(YKL184W)|FD-Score:-3.31|P-value:4.68E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SPR3(YGR059W)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Gene:SRY1(YKL218C)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity Gene:SUT1(YGL162W)|FD-Score:3.59|P-value:1.67E-4||SGD DESC:Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:THI4(YGR144W)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents Gene:TPK2(YPL203W)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase Gene:TPO1(YLL028W)|FD-Score:3.59|P-value:1.67E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane Gene:YBR074W(YBR074W_p)|FD-Score:-3.79|P-value:7.40E-5||SGD DESC:Putative metalloprotease Gene:YCL042W(YCL042W_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDR336W(YDR336W_p)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene Gene:YGL108C(YGL108C_p)|FD-Score:5.83|P-value:2.78E-9||SGD DESC:Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress Gene:YIL054W(YIL054W_p)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YKL077W(YKL077W_p)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YKL136W(YKL136W_d)|FD-Score:-3.09|P-value:9.89E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Gene:YLR406C-A(YLR406C-A_p)|FD-Score:-3.13|P-value:8.74E-4||SGD DESC:Putative protein of unknown function Gene:YOR041C(YOR041C_d)|FD-Score:3.98|P-value:3.41E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance Gene:YPK9(YOR291W)|FD-Score:4.32|P-value:7.73E-6||SGD DESC:Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome Gene:YPR123C(YPR123C_d)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:YPR174C(YPR174C_p)|FD-Score:-3.22|P-value:6.31E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication Gene:ACK1(YDL203C)|FD-Score:3.4|P-value:3.33E-4||SGD DESC:Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria Gene:AIM3(YBR108W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARF2(YDL137W)|FD-Score:-3.41|P-value:3.28E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:BCH1(YMR237W)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Gene:BCK2(YER167W)|FD-Score:3.78|P-value:7.70E-5||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:BMH1(YER177W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:CCC2(YDR270W)|FD-Score:3.37|P-value:3.74E-4||SGD DESC:Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism Gene:CCS1(YMR038C)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:CHA4(YLR098C)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:ECM25(YJL201W)|FD-Score:4.37|P-value:6.10E-6||SGD DESC:Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p Gene:ERG2(YMR202W)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:FCY1(YPR062W)|FD-Score:3.89|P-value:4.91E-5||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FES1(YBR101C)|FD-Score:3.89|P-value:4.93E-5||SGD DESC:Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FMO1(YHR176W)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:FUM1(YPL262W)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria Gene:GLG2(YJL137C)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication Gene:HOP2(YGL033W)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:IRS4(YKR019C)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LDB19(YOR322C)|FD-Score:3.32|P-value:4.56E-4||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:MAC1(YMR021C)|FD-Score:3.35|P-value:4.05E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MFA1(YDR461W)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 Gene:MRI1(YPR118W)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MRPL40(YPL173W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MTH1(YDR277C)|FD-Score:-3.5|P-value:2.35E-4||SGD DESC:Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation Gene:NMA2(YGR010W)|FD-Score:-3.1|P-value:9.55E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication Gene:NTG2(YOL043C)|FD-Score:3.19|P-value:7.18E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OCA1(YNL099C)|FD-Score:4.38|P-value:5.83E-6||SGD DESC:Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA Gene:REC107(YJR021C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation Gene:RTG3(YBL103C)|FD-Score:-3.13|P-value:8.72E-4||SGD DESC:Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Gene:SEC66(YBR171W)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLM6(YBR266C_d)|FD-Score:3.85|P-value:6.01E-5||SGD DESC:Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Gene:SPE1(YKL184W)|FD-Score:-3.31|P-value:4.68E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SPR3(YGR059W)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Gene:SRY1(YKL218C)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity Gene:SUT1(YGL162W)|FD-Score:3.59|P-value:1.67E-4||SGD DESC:Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:THI4(YGR144W)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents Gene:TPK2(YPL203W)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase Gene:TPO1(YLL028W)|FD-Score:3.59|P-value:1.67E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane Gene:YBR074W(YBR074W_p)|FD-Score:-3.79|P-value:7.40E-5||SGD DESC:Putative metalloprotease Gene:YCL042W(YCL042W_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDR336W(YDR336W_p)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene Gene:YGL108C(YGL108C_p)|FD-Score:5.83|P-value:2.78E-9||SGD DESC:Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress Gene:YIL054W(YIL054W_p)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YKL077W(YKL077W_p)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YKL136W(YKL136W_d)|FD-Score:-3.09|P-value:9.89E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Gene:YLR406C-A(YLR406C-A_p)|FD-Score:-3.13|P-value:8.74E-4||SGD DESC:Putative protein of unknown function Gene:YOR041C(YOR041C_d)|FD-Score:3.98|P-value:3.41E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance Gene:YPK9(YOR291W)|FD-Score:4.32|P-value:7.73E-6||SGD DESC:Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome Gene:YPR123C(YPR123C_d)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:YPR174C(YPR174C_p)|FD-Score:-3.22|P-value:6.31E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR449C3.671.21E-40.40UTP6Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPL063W3.611.54E-40.40TIM50Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
YOL040C3.591.66E-40.40RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YOL144W3.462.67E-40.40NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YNL126W3.442.86E-40.40SPC98Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YMR235C3.304.87E-40.40RNA1GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
YLR076C_d2.900.001880.06YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YOL021C2.840.002259.36E-4DIS3Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
YNL178W2.840.002260.07RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YBR190W_d2.770.002770.08YBR190W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
YDL120W2.690.003550.06YFH1Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
YDL196W_d2.640.004200.05YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YJL081C2.590.004820.05ARP4Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YFL002C2.540.005620.00SPB4Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YKL013C2.530.005660.10ARC19Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL108C_p5.832.78E-9YGL108C_pProtein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress
YNL099C4.385.83E-6OCA1Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
YJL201W4.376.10E-6ECM25Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
YOR291W4.327.73E-6YPK9Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
YBR108W4.221.22E-5AIM3Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
YOR041C_d3.983.41E-5YOR041C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance
YPR062W3.894.91E-5FCY1Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YBR101C3.894.93E-5FES1Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
YBR266C_d3.856.01E-5SLM6_dProtein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase
YER167W3.787.70E-5BCK2Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YJR021C3.787.90E-5REC107Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
YMR202W3.681.15E-4ERG2C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YGL033W3.671.22E-4HOP2Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YCL042W_p3.661.27E-4YCL042W_pPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIL054W_p3.611.56E-4YIL054W_pProtein of unknown function; expressed at both mRNA and protein levels

GO enrichment analysis for SGTC_973
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1102.19E-17SGTC_21966573537 42.7 μMChembridge (Fragment library)29030870.173077copper-dependent oxidative stress
0.0983.96E-14SGTC_4982,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150.0 μMICCB bioactive library23740.15Golgi
0.0921.34E-12SGTC_20805212524 12.4 μMChembridge (Fragment library)2601830.145833copper-dependent oxidative stress
0.0881.38E-11SGTC_21715739187 198.1 μMChembridge (Fragment library)22627610.0851064copper-dependent oxidative stress
0.0872.16E-11SGTC_21445628481 200.0 μMChembridge (Fragment library)28183990.105263ERG2
0.0815.62E-10SGTC_21535569715 200.0 μMChembridge (Fragment library)20547010.103448iron homeostasis
0.0808.39E-10SGTC_31779107506 49.5 μMChembridge (Drug-like library)88971940.119403ERG2
0.0791.25E-9SGTC_6120302-0167 22.4 μMChemDiv (Drug-like library)2358210.111111copper-dependent oxidative stress
0.0791.38E-9SGTC_6341611-4317 11.2 μMChemDiv (Drug-like library)28435220.09375ERG2
0.0782.26E-9SGTC_2130NSC 7 2.5 μMChembridge (Fragment library)214480.122449copper-dependent oxidative stress
0.0764.38E-9SGTC_15324',5'-dihydroxyflavone 78.7 μMTimTec (Pure natural product library)1655210.166667Golgi
0.0764.69E-9SGTC_2617dihydrotanshinone i 20.8 μMMicrosource (Natural product library)53167430.0769231copper-dependent oxidative stress
0.0765.79E-9SGTC_2667digitoxin 100.0 μMMicrosource (Natural product library)57020410.0412371
0.0758.11E-9SGTC_6260214-0009 33.0 μMChemDiv (Drug-like library)34378740.118644copper-dependent oxidative stress
0.0758.27E-9SGTC_21495554786 194.8 μMChembridge (Fragment library)7450630.0833333cell wall signaling

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_12044049-031518.3 μM0.44186588402ChemDiv (Drug-like library)362.240983.97413
SGTC_13631636-006310.4 μM0.4166676072185ChemDiv (Drug-like library)344.815323.95914Golgi
SGTC_2978901178442.97 μM0.4166672994934Chembridge (Drug-like library)309.38223.67423
SGTC_2917797910353.79 μM0.3725492980565Chembridge (Drug-like library)327.783263.07225
SGTC_9443370-0224231 μM0.3541674580514ChemDiv (Drug-like library)253.252742.96723
SGTC_8500388-014375.9 μM0.33333367273ChemDiv (Drug-like library)277.31723.76722
SGTC_13251431-0015227 μM0.3333331103340ChemDiv (Drug-like library)352.620824.06824Golgi
SGTC_18233-hydroxy-2-naphthoic acid106 μM0.3170737104TimTec (Natural product derivative library)188.179422.12623
SGTC_2814797748242.97 μM0.3157896456762Chembridge (Drug-like library)343.8009034.00615
SGTC_1090132-003633.7 μM0.31372667274ChemDiv (Drug-like library)293.31663.26423