Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR062C | 7.00 | 1.26E-12 | 1.42 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YNL178W | 6.34 | 1.12E-10 | 1.42 | RPS3 | Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 |
YMR185W_p | 5.88 | 2.09E-9 | 1.42 | RTP1_p | Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene |
YER038C | 4.46 | 4.17E-6 | 0.28 | KRE29 | Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
YDR427W | 4.18 | 1.45E-5 | 0.05 | RPN9 | Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress |
YOR340C | 4.13 | 1.78E-5 | 0.07 | RPA43 | RNA polymerase I subunit A43 |
YDR050C | 4.06 | 2.45E-5 | 0.03 | TPI1 | Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease |
YMR268C | 4.03 | 2.80E-5 | 0.29 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YDL195W | 3.74 | 9.14E-5 | 0.03 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YKL145W | 3.71 | 1.03E-4 | 0.01 | RPT1 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance |
YJL015C_d | 3.70 | 1.06E-4 | 0.00 | YJL015C_d | Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W |
YLR208W | 3.70 | 1.07E-4 | 0.11 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YPL143W | 3.59 | 1.65E-4 | 0.05 | RPL33A | Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication |
YBR152W | 3.54 | 2.01E-4 | 0.01 | SPP381 | mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p |
YIL078W | 3.53 | 2.06E-4 | 0.21 | THS1 | Threonyl-tRNA synthetase, essential cytoplasmic protein |