1473-0395

(4-quinoxalin-2-ylphenyl) propanoate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_980
Screen concentration 201.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 768876
SMILES CCC(=O)OC1=CC=C(C=C1)C2=NC3=CC=CC=C3N=C2
Standardized SMILES CCC(=O)Oc1ccc(cc1)c2cnc3ccccc3n2
Molecular weight 278.3053
ALogP 3.68
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.52
% growth inhibition (Hom. pool) 7.81


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 768876
Download HIP data (tab-delimited text)  (excel)
Gene:ACT1(YFL039C)|FD-Score:3.41|P-value:3.23E-4|Clearance:0.08||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:APC11(YDL008W)|FD-Score:-3.09|P-value:9.95E-4|Clearance:0||SGD DESC:Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity Gene:CCT6(YDR188W)|FD-Score:3.9|P-value:4.75E-5|Clearance:0.11||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:CDC28(YBR160W)|FD-Score:3.15|P-value:8.09E-4|Clearance:0.03||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:EXO70(YJL085W)|FD-Score:4.15|P-value:1.67E-5|Clearance:0.18||SGD DESC:Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:GCD14(YJL125C)|FD-Score:-3.16|P-value:7.93E-4|Clearance:0||SGD DESC:Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression Gene:HTS1(YPR033C)|FD-Score:-3.09|P-value:9.95E-4|Clearance:0||SGD DESC:Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome Gene:IRR1(YIL026C)|FD-Score:3.12|P-value:9.11E-4|Clearance:0.05||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:PDC2(YDR081C)|FD-Score:3.79|P-value:7.52E-5|Clearance:0.09||SGD DESC:Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions Gene:PIS1(YPR113W)|FD-Score:4.32|P-value:7.72E-6|Clearance:0.17||SGD DESC:Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins Gene:PUP2(YGR253C)|FD-Score:3.7|P-value:1.09E-4|Clearance:0.04||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RER2(YBR002C)|FD-Score:3.97|P-value:3.66E-5|Clearance:0.06||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPC40(YPR110C)|FD-Score:3.42|P-value:3.16E-4|Clearance:0.01||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPL15A(YLR029C)|FD-Score:3.19|P-value:7.22E-4|Clearance:0.03||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:RPL17A(YKL180W)|FD-Score:4.51|P-value:3.21E-6|Clearance:0.19||SGD DESC:Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPL25(YOL127W)|FD-Score:3.65|P-value:1.29E-4|Clearance:0.07||SGD DESC:Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 Gene:SRB6(YBR253W)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.16||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:TIM50(YPL063W)|FD-Score:-3.63|P-value:1.44E-4|Clearance:0||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel Gene:YLL037W(YLL037W_d)|FD-Score:3.34|P-value:4.26E-4|Clearance:0.15||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor Gene:ACT1(YFL039C)|FD-Score:3.41|P-value:3.23E-4|Clearance:0.08||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:APC11(YDL008W)|FD-Score:-3.09|P-value:9.95E-4|Clearance:0||SGD DESC:Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity Gene:CCT6(YDR188W)|FD-Score:3.9|P-value:4.75E-5|Clearance:0.11||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:CDC28(YBR160W)|FD-Score:3.15|P-value:8.09E-4|Clearance:0.03||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:EXO70(YJL085W)|FD-Score:4.15|P-value:1.67E-5|Clearance:0.18||SGD DESC:Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:GCD14(YJL125C)|FD-Score:-3.16|P-value:7.93E-4|Clearance:0||SGD DESC:Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression Gene:HTS1(YPR033C)|FD-Score:-3.09|P-value:9.95E-4|Clearance:0||SGD DESC:Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome Gene:IRR1(YIL026C)|FD-Score:3.12|P-value:9.11E-4|Clearance:0.05||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:PDC2(YDR081C)|FD-Score:3.79|P-value:7.52E-5|Clearance:0.09||SGD DESC:Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions Gene:PIS1(YPR113W)|FD-Score:4.32|P-value:7.72E-6|Clearance:0.17||SGD DESC:Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins Gene:PUP2(YGR253C)|FD-Score:3.7|P-value:1.09E-4|Clearance:0.04||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RER2(YBR002C)|FD-Score:3.97|P-value:3.66E-5|Clearance:0.06||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPC40(YPR110C)|FD-Score:3.42|P-value:3.16E-4|Clearance:0.01||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPL15A(YLR029C)|FD-Score:3.19|P-value:7.22E-4|Clearance:0.03||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:RPL17A(YKL180W)|FD-Score:4.51|P-value:3.21E-6|Clearance:0.19||SGD DESC:Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPL25(YOL127W)|FD-Score:3.65|P-value:1.29E-4|Clearance:0.07||SGD DESC:Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 Gene:SRB6(YBR253W)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.16||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:TIM50(YPL063W)|FD-Score:-3.63|P-value:1.44E-4|Clearance:0||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel Gene:YLL037W(YLL037W_d)|FD-Score:3.34|P-value:4.26E-4|Clearance:0.15||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 768876
Download HOP data (tab-delimited text)  (excel)
Gene:AHC1(YOR023C)|FD-Score:-4.42|P-value:5.04E-6||SGD DESC:Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex Gene:AIR1(YIL079C)|FD-Score:3.24|P-value:6.07E-4||SGD DESC:Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication Gene:ART5(YGR068C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:ATG1(YGL180W)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Gene:ATG11(YPR049C)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Gene:BEM3(YPL115C)|FD-Score:-3.44|P-value:2.90E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BIK1(YCL029C)|FD-Score:-3.79|P-value:7.51E-5||SGD DESC:Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Gene:CEM1(YER061C)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CEX1(YOR112W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p Gene:COG6(YNL041C)|FD-Score:4.34|P-value:7.15E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX7(YMR256C)|FD-Score:4.29|P-value:8.80E-6||SGD DESC:Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CYS4(YGR155W)|FD-Score:-3.21|P-value:6.62E-4||SGD DESC:Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria Gene:DAL81(YIR023W)|FD-Score:4.92|P-value:4.33E-7||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:FCY22(YER060W-A)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:FMP27(YLR454W_p)|FD-Score:5.29|P-value:5.99E-8||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GIC1(YHR061C)|FD-Score:-3.62|P-value:1.46E-4||SGD DESC:Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress Gene:HER1(YOR227W)|FD-Score:4.31|P-value:8.27E-6||SGD DESC:Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication Gene:HOM6(YJR139C)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions Gene:IKI3(YLR384C)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:LEO1(YOR123C)|FD-Score:3.37|P-value:3.79E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:MAF1(YDR005C)|FD-Score:3.1|P-value:9.53E-4||SGD DESC:Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions Gene:MDM31(YHR194W)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 Gene:MET6(YER091C)|FD-Score:-3.23|P-value:6.25E-4||SGD DESC:Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs Gene:MFA1(YDR461W)|FD-Score:-4.82|P-value:7.13E-7||SGD DESC:Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 Gene:MRP21(YBL090W)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Gene:MSA2(YKR077W)|FD-Score:3.77|P-value:8.12E-5||SGD DESC:Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation Gene:MSY1(YPL097W)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:NHA1(YLR138W)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH Gene:NNK1(YKL171W)|FD-Score:-3.2|P-value:6.95E-4||SGD DESC:Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm Gene:NTG2(YOL043C)|FD-Score:-3.84|P-value:6.04E-5||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OM14(YBR230C)|FD-Score:5.55|P-value:1.43E-8||SGD DESC:Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron Gene:PAM1(YDR251W)|FD-Score:-4.03|P-value:2.74E-5||SGD DESC:Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype Gene:PAU2(YEL049W)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PCL5(YHR071W)|FD-Score:-3.24|P-value:5.88E-4||SGD DESC:Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity Gene:PFD1(YJL179W)|FD-Score:4.27|P-value:9.80E-6||SGD DESC:Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin Gene:PIR3(YKL163W)|FD-Score:-4.45|P-value:4.25E-6||SGD DESC:O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication Gene:PLB1(YMR008C)|FD-Score:-3.13|P-value:8.81E-4||SGD DESC:Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol Gene:PMD1(YER132C)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions Gene:RAD23(YEL037C)|FD-Score:-4.53|P-value:3.01E-6||SGD DESC:Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover Gene:RBG1(YAL036C)|FD-Score:3.39|P-value:3.56E-4||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:ROT2(YBR229C)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations Gene:RPL37A(YLR185W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:SCP160(YJL080C)|FD-Score:3.17|P-value:7.55E-4||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SMK1(YPR054W)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p Gene:SMY1(YKL079W)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins Gene:STB4(YMR019W)|FD-Score:-3.81|P-value:6.82E-5||SGD DESC:Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; Gene:STP2(YHR006W)|FD-Score:-3.25|P-value:5.74E-4||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:SUR7(YML052W)|FD-Score:-4.47|P-value:3.96E-6||SGD DESC:Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants Gene:SYH1(YPL105C)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication Gene:TAT2(YOL020W)|FD-Score:3.81|P-value:6.84E-5||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TDA10(YGR205W)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele Gene:THI12(YNL332W)|FD-Score:4.41|P-value:5.21E-6||SGD DESC:Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 Gene:THI6(YPL214C)|FD-Score:-3.33|P-value:4.36E-4||SGD DESC:Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:THP1(YOL072W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding Gene:TIM18(YOR297C)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex Gene:YAR023C(YAR023C_p)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family Gene:YCR051W(YCR051W_p)|FD-Score:4|P-value:3.13E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Gene:YDL026W(YDL026W_d)|FD-Score:-3.34|P-value:4.16E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL241W(YDL241W_p)|FD-Score:-4.49|P-value:3.64E-6||SGD DESC:Putative protein of unknown function; YDL241W is not an essential gene Gene:YER152C(YER152C)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Gene:YHR182W(YHR182W_p)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:YIL001W(YIL001W_p)|FD-Score:4.03|P-value:2.73E-5||SGD DESC:Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm Gene:YLL053C(YLL053C_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin Gene:YLR434C(YLR434C_d)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YNL011C(YNL011C_p)|FD-Score:-4.23|P-value:1.18E-5||SGD DESC:Putative protein of unknown function; YNL011C is not an essential gene Gene:YOL159C-A(YOL159C-A)|FD-Score:-3.37|P-value:3.74E-4||SGD DESC:Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species Gene:YOR238W(YOR238W_p)|FD-Score:-3.26|P-value:5.65E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YPK9(YOR291W)|FD-Score:-3.34|P-value:4.20E-4||SGD DESC:Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome Gene:AHC1(YOR023C)|FD-Score:-4.42|P-value:5.04E-6||SGD DESC:Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex Gene:AIR1(YIL079C)|FD-Score:3.24|P-value:6.07E-4||SGD DESC:Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication Gene:ART5(YGR068C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:ATG1(YGL180W)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Gene:ATG11(YPR049C)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Gene:BEM3(YPL115C)|FD-Score:-3.44|P-value:2.90E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BIK1(YCL029C)|FD-Score:-3.79|P-value:7.51E-5||SGD DESC:Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Gene:CEM1(YER061C)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CEX1(YOR112W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p Gene:COG6(YNL041C)|FD-Score:4.34|P-value:7.15E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX7(YMR256C)|FD-Score:4.29|P-value:8.80E-6||SGD DESC:Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CYS4(YGR155W)|FD-Score:-3.21|P-value:6.62E-4||SGD DESC:Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria Gene:DAL81(YIR023W)|FD-Score:4.92|P-value:4.33E-7||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:FCY22(YER060W-A)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:FMP27(YLR454W_p)|FD-Score:5.29|P-value:5.99E-8||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GIC1(YHR061C)|FD-Score:-3.62|P-value:1.46E-4||SGD DESC:Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress Gene:HER1(YOR227W)|FD-Score:4.31|P-value:8.27E-6||SGD DESC:Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication Gene:HOM6(YJR139C)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions Gene:IKI3(YLR384C)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:LEO1(YOR123C)|FD-Score:3.37|P-value:3.79E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:MAF1(YDR005C)|FD-Score:3.1|P-value:9.53E-4||SGD DESC:Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions Gene:MDM31(YHR194W)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 Gene:MET6(YER091C)|FD-Score:-3.23|P-value:6.25E-4||SGD DESC:Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs Gene:MFA1(YDR461W)|FD-Score:-4.82|P-value:7.13E-7||SGD DESC:Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 Gene:MRP21(YBL090W)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Gene:MSA2(YKR077W)|FD-Score:3.77|P-value:8.12E-5||SGD DESC:Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation Gene:MSY1(YPL097W)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:NHA1(YLR138W)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH Gene:NNK1(YKL171W)|FD-Score:-3.2|P-value:6.95E-4||SGD DESC:Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm Gene:NTG2(YOL043C)|FD-Score:-3.84|P-value:6.04E-5||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OM14(YBR230C)|FD-Score:5.55|P-value:1.43E-8||SGD DESC:Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron Gene:PAM1(YDR251W)|FD-Score:-4.03|P-value:2.74E-5||SGD DESC:Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype Gene:PAU2(YEL049W)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PCL5(YHR071W)|FD-Score:-3.24|P-value:5.88E-4||SGD DESC:Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity Gene:PFD1(YJL179W)|FD-Score:4.27|P-value:9.80E-6||SGD DESC:Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin Gene:PIR3(YKL163W)|FD-Score:-4.45|P-value:4.25E-6||SGD DESC:O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication Gene:PLB1(YMR008C)|FD-Score:-3.13|P-value:8.81E-4||SGD DESC:Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol Gene:PMD1(YER132C)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions Gene:RAD23(YEL037C)|FD-Score:-4.53|P-value:3.01E-6||SGD DESC:Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover Gene:RBG1(YAL036C)|FD-Score:3.39|P-value:3.56E-4||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:ROT2(YBR229C)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations Gene:RPL37A(YLR185W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:SCP160(YJL080C)|FD-Score:3.17|P-value:7.55E-4||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SMK1(YPR054W)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p Gene:SMY1(YKL079W)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins Gene:STB4(YMR019W)|FD-Score:-3.81|P-value:6.82E-5||SGD DESC:Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; Gene:STP2(YHR006W)|FD-Score:-3.25|P-value:5.74E-4||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:SUR7(YML052W)|FD-Score:-4.47|P-value:3.96E-6||SGD DESC:Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants Gene:SYH1(YPL105C)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication Gene:TAT2(YOL020W)|FD-Score:3.81|P-value:6.84E-5||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TDA10(YGR205W)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele Gene:THI12(YNL332W)|FD-Score:4.41|P-value:5.21E-6||SGD DESC:Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 Gene:THI6(YPL214C)|FD-Score:-3.33|P-value:4.36E-4||SGD DESC:Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:THP1(YOL072W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding Gene:TIM18(YOR297C)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex Gene:YAR023C(YAR023C_p)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family Gene:YCR051W(YCR051W_p)|FD-Score:4|P-value:3.13E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Gene:YDL026W(YDL026W_d)|FD-Score:-3.34|P-value:4.16E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL241W(YDL241W_p)|FD-Score:-4.49|P-value:3.64E-6||SGD DESC:Putative protein of unknown function; YDL241W is not an essential gene Gene:YER152C(YER152C)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Gene:YHR182W(YHR182W_p)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:YIL001W(YIL001W_p)|FD-Score:4.03|P-value:2.73E-5||SGD DESC:Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm Gene:YLL053C(YLL053C_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin Gene:YLR434C(YLR434C_d)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YNL011C(YNL011C_p)|FD-Score:-4.23|P-value:1.18E-5||SGD DESC:Putative protein of unknown function; YNL011C is not an essential gene Gene:YOL159C-A(YOL159C-A)|FD-Score:-3.37|P-value:3.74E-4||SGD DESC:Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species Gene:YOR238W(YOR238W_p)|FD-Score:-3.26|P-value:5.65E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YPK9(YOR291W)|FD-Score:-3.34|P-value:4.20E-4||SGD DESC:Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL180W4.513.21E-60.19RPL17ARibosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YPR113W4.327.72E-60.17PIS1Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YJL085W4.151.67E-50.18EXO70Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
YBR002C3.973.66E-50.06RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YDR188W3.904.75E-50.11CCT6Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YDR081C3.797.52E-50.09PDC2Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
YGR253C3.701.09E-40.04PUP2Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YOL127W3.651.29E-40.07RPL25Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
YBR253W3.581.71E-40.16SRB6Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YPR110C3.423.16E-40.01RPC40RNA polymerase subunit AC40, common to RNA polymerase I and III
YFL039C3.413.23E-40.08ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YLL037W_d3.344.26E-40.15YLL037W_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
YLR029C3.197.22E-40.03RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YBR160W3.158.09E-40.03CDC28Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress
YIL026C3.129.11E-40.05IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR230C5.551.43E-8OM14Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YLR454W_p5.295.99E-8FMP27_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIR023W4.924.33E-7DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YNL332W4.415.21E-6THI12Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YNL041C4.347.15E-6COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YOR227W4.318.27E-6HER1Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
YMR256C4.298.80E-6COX7Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YJL179W4.279.80E-6PFD1Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YLR434C_d4.171.52E-5YLR434C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
YBL090W4.082.25E-5MRP21Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YIL001W_p4.032.73E-5YIL001W_pPutative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm
YCR051W_p4.003.13E-5YCR051W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YOL020W3.816.84E-5TAT2High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YKR077W3.778.12E-5MSA2Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
YOR112W3.721.01E-4CEX1Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p

GO enrichment analysis for SGTC_980
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1202.89E-20SGTC_24605552655 174.2 μMMiscellaneous54019890.15873amide catabolism
0.0992.70E-14SGTC_9821491-0518 27.5 μMChemDiv (Drug-like library)30912560.0684932
0.0983.80E-14SGTC_486niguldipine 82.0 μMMiscellaneous12360.119565amide catabolism
0.0913.16E-12SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.151515amide catabolism
0.0856.70E-11SGTC_5694130-2812 160.0 μMChemDiv (Drug-like library)7435520.0983607amide catabolism
0.0857.51E-11SGTC_32289131799 49.5 μMChembridge (Drug-like library)170158180.140845amide catabolism
0.0848.48E-11SGTC_2680butyl paraben 22.2 μMMicrosource (Natural product library)71840.181818amide catabolism
0.0831.63E-10SGTC_3371315-0038 354.0 μMChemDiv (Drug-like library)16264370.115385amide catabolism
0.0822.83E-10SGTC_3252810-4341 181.0 μMChemDiv (Drug-like library)7749700.171875amide catabolism
0.0791.28E-9SGTC_6140462-0418 107.0 μMChemDiv (Drug-like library)51883030.114754
0.0764.85E-9SGTC_9903985-0011 41.3 μMChemDiv (Drug-like library)53995650.209677amide catabolism
0.0732.17E-8SGTC_7003453-2283 142.0 μMChemDiv (Drug-like library)5656640.125amide catabolism
0.0732.28E-8SGTC_8490386-0493 241.0 μMChemDiv (Drug-like library)7261190.12963
0.0715.53E-8SGTC_28339001315 45.5 μMChembridge (Drug-like library)29893780.150685amide catabolism
0.0707.60E-8SGTC_33469158254 43.6 μMChembridge (Drug-like library)176395000.15625

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_6721441-001853.7 μM0.361702251141ChemDiv (Drug-like library)212.270323.19403
SGTC_3206911435049.47 μM0.30357117087243Chembridge (Drug-like library)283.321783.53513
SGTC_980074-0023107.66 μM0.3018873563821ChemDiv (Drug-like library)278.343484.63114Golgi
SGTC_1705st02786856.33 μM0.3292948TimTec (Natural product derivative library)256.301284.14902
SGTC_3193911193149.47 μM0.29824617087244Chembridge (Drug-like library)348.191263.79713
SGTC_3194911190349.47 μM0.29824617087251Chembridge (Drug-like library)303.740263.71313
SGTC_2933902679432.47 μM0.2812517586027Chembridge (Drug-like library)359.421044.00505
SGTC_13621611-0397101 μM0.2745127816ChemDiv (Drug-like library)227.258523.65612
SGTC_2817799534271.43 μM0.27419418879975Chembridge (Drug-like library)361.20053.63606
SGTC_2904722513542.03 μM0.2727274446116Chembridge (Drug-like library)364.437564.06914