YAL001C / TFC3

Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding

Zygosity: Heterozygous strain
fixedexpanded
Profile for YAL001C / TFC3

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:6.64|P-value:5.71E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:4.38|P-value:2.19E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.68|P-value:8.84E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:3.87|P-value:9.44E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.20|P-value:3.73E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-4.21|P-value:5.11E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:9.52|P-value:1.77E-14 ID:SGTC_354|Compound:2783-3500|FD-Score:6.04|P-value:7.04E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:-5.78|P-value:3.06E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.03|P-value:6.08E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.24|P-value:3.34E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.89|P-value:1.91E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:4.90|P-value:4.32E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.55|P-value:1.94E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.46|P-value:1.74E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.83|P-value:5.49E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.00|P-value:6.59E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.98|P-value:6.97E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-5.34|P-value:1.47E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:4.03|P-value:6.07E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.16|P-value:5.72E-9 ID:SGTC_871|Compound:0574-0004|FD-Score:6.36|P-value:1.90E-7 ID:SGTC_984|Compound:1492-0255|FD-Score:5.21|P-value:1.53E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:4.01|P-value:6.35E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.49|P-value:1.59E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-4.73|P-value:1.12E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.31|P-value:1.07E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.83|P-value:5.41E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.90|P-value:6.46E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:10.00|P-value:6.79E-16 ID:SGTC_1082|Compound:camptothecin|FD-Score:13.50|P-value:2.59E-27 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.96|P-value:7.44E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.93|P-value:7.95E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.25|P-value:3.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.99|P-value:8.41E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.51|P-value:5.34E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.37|P-value:1.80E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:-4.14|P-value:6.35E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.38|P-value:8.34E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.25|P-value:3.22E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.01|P-value:3.07E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.96|P-value:7.30E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-8.39|P-value:2.30E-11 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.25|P-value:3.05E-7 ID:SGTC_1652|Compound:st011932|FD-Score:10.30|P-value:1.32E-16 ID:SGTC_1707|Compound:st032323|FD-Score:4.38|P-value:2.23E-4 ID:SGTC_1815|Compound:st051655|FD-Score:5.94|P-value:1.03E-6 ID:SGTC_1884|Compound:5633444|FD-Score:4.57|P-value:1.23E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.24|P-value:3.37E-4 ID:SGTC_2049|Compound:5262831|FD-Score:6.66|P-value:5.33E-8 ID:SGTC_2051|Compound:5263410|FD-Score:4.55|P-value:1.31E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.44|P-value:1.87E-4 ID:SGTC_2180|Compound:6301957|FD-Score:6.37|P-value:1.85E-7 ID:SGTC_2186|Compound:6124449|FD-Score:7.16|P-value:5.50E-9 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.52|P-value:1.45E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.98|P-value:6.93E-4 ID:SGTC_2348|Compound:9022543|FD-Score:7.47|P-value:1.29E-9 ID:SGTC_2361|Compound:9034121|FD-Score:3.86|P-value:9.59E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.97|P-value:7.19E-4 ID:SGTC_2378|Compound:9074213|FD-Score:8.16|P-value:3.93E-11 ID:SGTC_2424|Compound:5537928|FD-Score:-4.96|P-value:5.38E-5 ID:SGTC_2434|Compound:5670830|FD-Score:-4.26|P-value:4.43E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.62|P-value:1.07E-4 ID:SGTC_2534|Compound:helenine|FD-Score:8.85|P-value:9.31E-13 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.09|P-value:5.19E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.07|P-value:5.46E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.18|P-value:4.02E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-6.71|P-value:7.36E-8 ID:SGTC_2912|Compound:7964298|FD-Score:6.98|P-value:1.27E-8 ID:SGTC_2925|Compound:9010536|FD-Score:-4.05|P-value:8.07E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.12|P-value:2.10E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-6.18|P-value:6.60E-7 ID:SGTC_3219|Compound:9131112|FD-Score:5.45|P-value:6.43E-6 ID:SGTC_3284|Compound:9108171|FD-Score:-5.31|P-value:1.67E-5 ID:SGTC_3285|Compound:9112818|FD-Score:9.41|P-value:3.35E-14 ID:SGTC_3286|Compound:9117135|FD-Score:5.54|P-value:4.63E-6 ID:SGTC_3293|Compound:9120939|FD-Score:4.22|P-value:3.59E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-5.16|P-value:2.75E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-4.37|P-value:3.24E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.30|P-value:2.95E-9 ID:SGTC_3322|Compound:9139058|FD-Score:3.94|P-value:7.79E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.64|P-value:5.71E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:4.38|P-value:2.19E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.68|P-value:8.84E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:3.87|P-value:9.44E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.20|P-value:3.73E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-4.21|P-value:5.11E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:9.52|P-value:1.77E-14 ID:SGTC_354|Compound:2783-3500|FD-Score:6.04|P-value:7.04E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:-5.78|P-value:3.06E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.03|P-value:6.08E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.24|P-value:3.34E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.89|P-value:1.91E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:4.90|P-value:4.32E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.55|P-value:1.94E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.46|P-value:1.74E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.83|P-value:5.49E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.00|P-value:6.59E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.98|P-value:6.97E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-5.34|P-value:1.47E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:4.03|P-value:6.07E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.16|P-value:5.72E-9 ID:SGTC_871|Compound:0574-0004|FD-Score:6.36|P-value:1.90E-7 ID:SGTC_984|Compound:1492-0255|FD-Score:5.21|P-value:1.53E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:4.01|P-value:6.35E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.49|P-value:1.59E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-4.73|P-value:1.12E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.31|P-value:1.07E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.83|P-value:5.41E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.90|P-value:6.46E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:10.00|P-value:6.79E-16 ID:SGTC_1082|Compound:camptothecin|FD-Score:13.50|P-value:2.59E-27 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.96|P-value:7.44E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.93|P-value:7.95E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.25|P-value:3.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.99|P-value:8.41E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.51|P-value:5.34E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.37|P-value:1.80E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:-4.14|P-value:6.35E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.38|P-value:8.34E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.25|P-value:3.22E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.01|P-value:3.07E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.96|P-value:7.30E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-8.39|P-value:2.30E-11 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.25|P-value:3.05E-7 ID:SGTC_1652|Compound:st011932|FD-Score:10.30|P-value:1.32E-16 ID:SGTC_1707|Compound:st032323|FD-Score:4.38|P-value:2.23E-4 ID:SGTC_1815|Compound:st051655|FD-Score:5.94|P-value:1.03E-6 ID:SGTC_1884|Compound:5633444|FD-Score:4.57|P-value:1.23E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.24|P-value:3.37E-4 ID:SGTC_2049|Compound:5262831|FD-Score:6.66|P-value:5.33E-8 ID:SGTC_2051|Compound:5263410|FD-Score:4.55|P-value:1.31E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.44|P-value:1.87E-4 ID:SGTC_2180|Compound:6301957|FD-Score:6.37|P-value:1.85E-7 ID:SGTC_2186|Compound:6124449|FD-Score:7.16|P-value:5.50E-9 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.52|P-value:1.45E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.98|P-value:6.93E-4 ID:SGTC_2348|Compound:9022543|FD-Score:7.47|P-value:1.29E-9 ID:SGTC_2361|Compound:9034121|FD-Score:3.86|P-value:9.59E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.97|P-value:7.19E-4 ID:SGTC_2378|Compound:9074213|FD-Score:8.16|P-value:3.93E-11 ID:SGTC_2424|Compound:5537928|FD-Score:-4.96|P-value:5.38E-5 ID:SGTC_2434|Compound:5670830|FD-Score:-4.26|P-value:4.43E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.62|P-value:1.07E-4 ID:SGTC_2534|Compound:helenine|FD-Score:8.85|P-value:9.31E-13 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.09|P-value:5.19E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.07|P-value:5.46E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.18|P-value:4.02E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-6.71|P-value:7.36E-8 ID:SGTC_2912|Compound:7964298|FD-Score:6.98|P-value:1.27E-8 ID:SGTC_2925|Compound:9010536|FD-Score:-4.05|P-value:8.07E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.12|P-value:2.10E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-6.18|P-value:6.60E-7 ID:SGTC_3219|Compound:9131112|FD-Score:5.45|P-value:6.43E-6 ID:SGTC_3284|Compound:9108171|FD-Score:-5.31|P-value:1.67E-5 ID:SGTC_3285|Compound:9112818|FD-Score:9.41|P-value:3.35E-14 ID:SGTC_3286|Compound:9117135|FD-Score:5.54|P-value:4.63E-6 ID:SGTC_3293|Compound:9120939|FD-Score:4.22|P-value:3.59E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-5.16|P-value:2.75E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-4.37|P-value:3.24E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.30|P-value:2.95E-9 ID:SGTC_3322|Compound:9139058|FD-Score:3.94|P-value:7.79E-4

Top fitness defect scores for YAL001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1082 camptothecin 13.50 424.9 nM 2.59E-27 DNA damage response 1 4.15E-42 5.29
2 SGTC_1652 st011932 10.30 78.0 µM 1.32E-16 RSC complex & mRNA processing 11 3.82E-25 0.74
3 SGTC_1026 k007-1105 10.00 30.6 µM 6.79E-16 ERAD & cell cycle 5 5.08E-24 0.16
4 SGTC_351 caspofungin 9.52 25.0 nM 1.77E-14 cell wall 3 8.79E-22 0.04
5 SGTC_3285 9112818 9.41 20.9 µM 3.35E-14 cell wall 2 2.40E-21 2.49
6 SGTC_2534 helenine 8.85 20.1 µM 9.31E-13 RSC complex & mRNA processing 5 4.56E-19 0.98
7 SGTC_2378 9074213 8.16 121.4 µM 3.93E-11 RSC complex & mRNA processing 5 1.66E-16 1.08
8 SGTC_2348 9022543 7.47 33.4 µM 1.29E-9 mitochondrial processes 10 4.00E-14 0.10
9 SGTC_3321 9137793 7.30 26.8 µM 2.95E-9 cell wall 5 1.47E-13 0.46
10 SGTC_2186 6124449 7.16 200.0 µM 5.50E-9 RSC complex & mRNA processing 7 3.92E-13 0.28
11 SGTC_863 0466-0191 7.16 129.0 µM 5.72E-9 cell wall 9 4.16E-13 0.84
12 SGTC_2912 7964298 6.98 10.9 µM 1.27E-8 cell wall 20 1.46E-12 0.59
13 SGTC_637 1181-0519 6.89 7.3 µM 1.91E-8 fatty acid desaturase (OLE1) 5 2.77E-12 1.30
14 SGTC_2049 5262831 6.66 67.2 µM 5.33E-8 1 1.38E-11 1.81
15 SGTC_138 0850-0259 6.64 40.9 µM 5.71E-8 cell wall 26 1.54E-11 0.08
16 SGTC_1274 0865-0114 6.37 173.0 µM 1.80E-7 3 9.29E-11 1.27
17 SGTC_2180 6301957 6.37 200.0 µM 1.85E-7 RSC complex & mRNA processing 2 9.71E-11 0.07
18 SGTC_871 0574-0004 6.36 149.0 µM 1.90E-7 13 1.01E-10 0.02
19 SGTC_1493 4348-0038 6.25 111.0 µM 3.05E-7 RSC complex & mRNA processing 14 2.11E-10 0.10
20 SGTC_354 2783-3500 6.04 4.9 µM 7.04E-7 cell wall 11 7.81E-10 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.423 1.34E-145 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.370 1.92E-109 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.370 2.45E-109 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.352 1.95E-98 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.351 2.05E-97 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.341 7.43E-92 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.302 5.68E-72 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.296 8.43E-69 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.275 2.46E-59 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.265 7.70E-55 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.264 1.11E-54 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.256 3.24E-51 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.248 3.40E-48 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.242 6.13E-46 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.239 8.15E-45 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation