HIPHOP chemogenomics database
YAL005C / SSA1 
ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YAL005C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.159 | 1.73E-20 | YLR414C | PUN1 | hom | Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress |
| 0.155 | 1.64E-19 | YLR405W | DUS4 | hom | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p |
| 0.151 | 1.32E-18 | YGL004C | RPN14 | hom | Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p |
| 0.150 | 2.13E-18 | YDR101C | ARX1 | hom | Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex |
| 0.145 | 2.97E-17 | YCL041C_d | YCL041C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W |
| 0.124 | 4.98E-13 | YKL131W_d | YKL131W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.118 | 8.16E-12 | YKL111C_d | YKL111C_d | het | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 |
| 0.114 | 3.45E-11 | YFL042C_p | YFL042C_p | hom | Putative protein of unknown function; YFL042C is not an essential gene |
| 0.113 | 6.46E-11 | YER060W-A | FCY22 | hom | Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function |
| 0.112 | 6.51E-11 | YEL072W | RMD6 | hom | Protein required for sporulation |
| 0.112 | 7.37E-11 | YGR139W_d | YGR139W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.103 | 2.30E-9 | YKL024C | URA6 | het | Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |
| 0.102 | 3.78E-9 | YLR263W | RED1 | hom | Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p |
| 0.100 | 6.12E-9 | YJL058C | BIT61 | hom | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication |
| 0.100 | 6.44E-9 | YPR151C | SUE1 | hom | Mitochondrial protein required for degradation of unstable forms of cytochrome c |