YAL005C / SSA1

ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL005C / SSA1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-6.47|P-value:6.83E-13 ID:SGTC_90|Compound:0870-0863|FD-Score:-2.89|P-value:8.36E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.18|P-value:1.86E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.90|P-value:5.84E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.85|P-value:9.81E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.27|P-value:9.46E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.65|P-value:2.28E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.38|P-value:5.34E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.30|P-value:1.11E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.06|P-value:3.03E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.81|P-value:8.19E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.50|P-value:6.81E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.00|P-value:5.63E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.77|P-value:9.44E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.50|P-value:4.68E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.48|P-value:5.00E-7 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.38|P-value:5.34E-7 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.86|P-value:6.71E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.33|P-value:9.95E-5 ID:SGTC_1710|Compound:st031758|FD-Score:2.83|P-value:7.46E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.04|P-value:4.67E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.05|P-value:4.50E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.69|P-value:2.91E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-3.11|P-value:3.58E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.02|P-value:5.22E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.14|P-value:2.19E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.13|P-value:3.27E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.53|P-value:3.99E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.10|P-value:3.78E-4 ID:SGTC_2166|Compound:5933061|FD-Score:2.98|P-value:4.28E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.62|P-value:3.96E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.35|P-value:9.05E-5 ID:SGTC_2414|Compound:st077232|FD-Score:7.28|P-value:3.22E-16 ID:SGTC_2443|Compound:5493264|FD-Score:-2.95|P-value:6.81E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.14|P-value:2.23E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.87|P-value:6.44E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.61|P-value:2.70E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.90|P-value:6.59E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.85|P-value:9.74E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.80|P-value:1.13E-5 ID:SGTC_3005|Compound:9076496|FD-Score:4.00|P-value:3.99E-6 ID:SGTC_3307|Compound:9126885|FD-Score:2.77|P-value:9.36E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-6.47|P-value:6.83E-13 ID:SGTC_90|Compound:0870-0863|FD-Score:-2.89|P-value:8.36E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.18|P-value:1.86E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.90|P-value:5.84E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.85|P-value:9.81E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.27|P-value:9.46E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.65|P-value:2.28E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.38|P-value:5.34E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.30|P-value:1.11E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.06|P-value:3.03E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.81|P-value:8.19E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.50|P-value:6.81E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.00|P-value:5.63E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.77|P-value:9.44E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.50|P-value:4.68E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.48|P-value:5.00E-7 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.38|P-value:5.34E-7 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.86|P-value:6.71E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.33|P-value:9.95E-5 ID:SGTC_1710|Compound:st031758|FD-Score:2.83|P-value:7.46E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.04|P-value:4.67E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.05|P-value:4.50E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.69|P-value:2.91E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-3.11|P-value:3.58E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.02|P-value:5.22E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.14|P-value:2.19E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.13|P-value:3.27E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.53|P-value:3.99E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.10|P-value:3.78E-4 ID:SGTC_2166|Compound:5933061|FD-Score:2.98|P-value:4.28E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.62|P-value:3.96E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.35|P-value:9.05E-5 ID:SGTC_2414|Compound:st077232|FD-Score:7.28|P-value:3.22E-16 ID:SGTC_2443|Compound:5493264|FD-Score:-2.95|P-value:6.81E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.14|P-value:2.23E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.87|P-value:6.44E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.61|P-value:2.70E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.90|P-value:6.59E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.85|P-value:9.74E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.80|P-value:1.13E-5 ID:SGTC_3005|Compound:9076496|FD-Score:4.00|P-value:3.99E-6 ID:SGTC_3307|Compound:9126885|FD-Score:2.77|P-value:9.36E-4

Top fitness defect scores for YAL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2414 st077232 7.28 92.9 µM 3.22E-16 1 1.70E-13
2 SGTC_1207 2099-0101 4.38 141.0 µM 5.34E-7 8 6.04E-6
3 SGTC_1428 4049-0204 4.38 61.7 µM 5.34E-7 5 6.04E-6
4 SGTC_656 4090-1979 4.27 187.0 µM 9.46E-7 9 9.66E-6
5 SGTC_3005 9076496 4.00 71.4 µM 3.99E-6 6 3.14E-5
6 SGTC_2760 etidronate 3.90 98.0 µM 6.59E-6 30 4.74E-5
7 SGTC_3000 9075062 3.80 71.4 µM 1.13E-5 22 7.36E-5
8 SGTC_1175 0741-0056 3.65 27.6 µM 2.28E-5 27 1.31E-4
9 SGTC_2754 granisetron 3.61 64.0 µM 2.70E-5 43 1.51E-4
10 SGTC_2039 Aminomethylbenzodioxan 3.53 200.0 µM 3.99E-5 9 2.08E-4
11 SGTC_1412 3909-8563 3.50 178.0 µM 4.68E-5 17 2.37E-4
12 SGTC_2413 inermin 3.35 26.1 µM 9.05E-5 87 4.07E-4
13 SGTC_1690 st023502 3.33 41.2 µM 9.95E-5 calcium & mitochondrial duress 23 4.40E-4
14 SGTC_1243 0416-0003 3.30 5.7 µM 1.11E-4 PDR1 62 4.80E-4
15 SGTC_643 k048-0106 3.28 28.4 µM 1.19E-4 RSC & ERG11 23 5.11E-4
16 SGTC_423 5-fluorouracil 3.18 457.0 µM 1.86E-4 exosome 55 7.35E-4
17 SGTC_2031 5180455 3.14 200.0 µM 2.19E-4 38 8.42E-4
18 SGTC_2484 5809818 3.14 12.0 µM 2.23E-4 42 8.54E-4
19 SGTC_2409 alverine citrate 3.09 64.0 µM 2.68E-4 100 9.91E-4
20 SGTC_2812 7970281 3.09 58.4 µM 2.68E-4 77 9.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.73E-20 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.155 1.64E-19 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.151 1.32E-18 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.150 2.13E-18 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.145 2.97E-17 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.124 4.98E-13 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 8.16E-12 YKL111C_d YKL111C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.114 3.45E-11 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.113 6.46E-11 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.112 6.51E-11 YEL072W RMD6 hom Protein required for sporulation
0.112 7.37E-11 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.30E-9 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.102 3.78E-9 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.100 6.12E-9 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.100 6.44E-9 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c