YAL007C / ERP2

Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL007C / ERP2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.33|P-value:3.81E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.29|P-value:4.43E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.71|P-value:8.83E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.06|P-value:8.86E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.33|P-value:3.81E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.57|P-value:1.35E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.28|P-value:4.59E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:-3.16|P-value:6.14E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.53|P-value:1.77E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.04|P-value:9.57E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.44|P-value:2.56E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.95|P-value:3.15E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.06|P-value:9.84E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.16|P-value:6.28E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.77|P-value:5.93E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.10|P-value:8.58E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.22|P-value:5.07E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.43|P-value:2.64E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.22|P-value:5.59E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.19|P-value:1.09E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.31|P-value:3.62E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_2072|Compound:5231554|FD-Score:4.63|P-value:1.40E-6 ID:SGTC_2120|Compound:5538279|FD-Score:3.34|P-value:3.69E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.70|P-value:8.95E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.41|P-value:4.16E-11 ID:SGTC_2411|Compound:st077133|FD-Score:5.35|P-value:3.07E-8 ID:SGTC_2415|Compound:st077333|FD-Score:3.09|P-value:9.10E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.73|P-value:8.10E-5 ID:SGTC_2477|Compound:5967686|FD-Score:5.53|P-value:1.04E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.36|P-value:3.42E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.07|P-value:1.90E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.33|P-value:3.81E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.29|P-value:4.43E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.71|P-value:8.83E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.06|P-value:8.86E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.33|P-value:3.81E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.57|P-value:1.35E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.28|P-value:4.59E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:-3.16|P-value:6.14E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.53|P-value:1.77E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.04|P-value:9.57E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.44|P-value:2.56E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.95|P-value:3.15E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.06|P-value:9.84E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.16|P-value:6.28E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.77|P-value:5.93E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.10|P-value:8.58E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.22|P-value:5.07E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.43|P-value:2.64E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.22|P-value:5.59E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.19|P-value:1.09E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.31|P-value:3.62E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_2072|Compound:5231554|FD-Score:4.63|P-value:1.40E-6 ID:SGTC_2120|Compound:5538279|FD-Score:3.34|P-value:3.69E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.70|P-value:8.95E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.41|P-value:4.16E-11 ID:SGTC_2411|Compound:st077133|FD-Score:5.35|P-value:3.07E-8 ID:SGTC_2415|Compound:st077333|FD-Score:3.09|P-value:9.10E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.73|P-value:8.10E-5 ID:SGTC_2477|Compound:5967686|FD-Score:5.53|P-value:1.04E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.36|P-value:3.42E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.07|P-value:1.90E-5

Top fitness defect scores for YAL007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2165 5727197 6.41 32.1 µM 4.16E-11 9 7.36E-11
2 SGTC_2477 5967686 5.53 25.2 µM 1.04E-8 10 1.58E-8
3 SGTC_2411 st077133 5.35 39.9 µM 3.07E-8 RNA pol III & RNase P/MRP 11 4.51E-8
4 SGTC_2072 5231554 4.63 129.0 µM 1.40E-6 7 1.86E-6
5 SGTC_1709 st033179 4.19 39.1 µM 1.09E-5 10 1.37E-5
6 SGTC_2607 solasodine 4.13 47.4 µM 1.47E-5 52 1.83E-5
7 SGTC_2833 9001315 4.07 45.5 µM 1.90E-5 amide catabolism 51 2.35E-5
8 SGTC_1080 nisoldipine 3.95 24.4 µM 3.15E-5 TSC3-RPN4 27 3.84E-5
9 SGTC_2426 5582046 3.73 32.2 µM 8.10E-5 35 9.63E-5
10 SGTC_172 1112-0046 3.71 2.6 µM 8.83E-5 NEO1 41 1.05E-4
11 SGTC_2133 5320837 3.70 200.0 µM 8.95E-5 ERG2 32 1.06E-4
12 SGTC_696 1560-0013 3.53 611.0 µM 1.77E-4 36 2.06E-4
13 SGTC_1060 3448-7350 3.44 82.0 µM 2.56E-4 Golgi 49 2.95E-4
14 SGTC_1605 st000082 3.43 49.1 µM 2.64E-4 60S ribosome export 33 3.05E-4
15 SGTC_2596 sinensetin 3.36 100.0 µM 3.42E-4 57 3.92E-4
16 SGTC_2120 5538279 3.34 152.0 µM 3.69E-4 32 4.22E-4
17 SGTC_40 0327-0103 3.33 19.8 µM 3.81E-4 51 4.35E-4
18 SGTC_419 nsc-638432 3.33 893.0 µM 3.81E-4 DNA damage response 30 4.35E-4
19 SGTC_136 0097-0015 3.29 404.5 µM 4.43E-4 60S ribosome export 45 5.05E-4
20 SGTC_536 3852-0578 3.28 10.6 µM 4.59E-4 57 5.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.55E-15 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.123 1.04E-12 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.106 8.41E-10 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.100 5.78E-9 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.094 5.63E-8 YPR049C ATG11 hom Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)
0.088 3.39E-7 YPL141C FRK1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication
0.084 1.26E-6 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.084 1.26E-6 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.083 1.43E-6 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.078 5.96E-6 YGL007W_d BRP1_d hom Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
0.078 6.83E-6 YLR375W STP3 hom Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
0.076 9.25E-6 YCL054W SPB1 het AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
0.076 1.03E-5 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.075 1.54E-5 YGL105W ARC1 hom Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress
0.074 1.74E-5 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication