YAL008W / FUN14

Mitochondrial protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL008W / FUN14

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:-3.46|P-value:6.67E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.62|P-value:3.89E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.94|P-value:1.38E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.56|P-value:5.09E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.40|P-value:2.35E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:4.31|P-value:3.35E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.38|P-value:8.84E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.85|P-value:1.87E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.28|P-value:3.81E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:-5.33|P-value:3.89E-7 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.46|P-value:6.95E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.67|P-value:3.36E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.02|P-value:9.49E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.89|P-value:1.61E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.57|P-value:1.29E-7 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.06|P-value:8.76E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.67|P-value:3.42E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.59|P-value:4.51E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.40|P-value:2.34E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.52|P-value:5.66E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.72|P-value:2.83E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.76|P-value:2.53E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.06|P-value:8.75E-5 ID:SGTC_1979|Compound:st071809|FD-Score:-3.56|P-value:4.87E-4 ID:SGTC_2029|Compound:5175081|FD-Score:4.12|P-value:6.98E-5 ID:SGTC_2037|Compound:5169046|FD-Score:5.85|P-value:3.17E-8 ID:SGTC_2047|Compound:4141938|FD-Score:4.19|P-value:5.46E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.52|P-value:5.77E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.88|P-value:2.71E-8 ID:SGTC_2395|Compound:5646831|FD-Score:-4.12|P-value:6.57E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.59|P-value:1.11E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.11|P-value:7.18E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.44|P-value:7.45E-4 ID:SGTC_2903|Compound:5923464|FD-Score:4.03|P-value:9.90E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.74|P-value:5.85E-6 ID:SGTC_3124|Compound:9127567|FD-Score:-4.66|P-value:7.65E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-3.93|P-value:1.35E-4 ID:SGTC_3129|Compound:9127257|FD-Score:6.12|P-value:7.54E-9 ID:SGTC_3245|Compound:9134821|FD-Score:3.54|P-value:5.38E-4 ID:SGTC_3316|Compound:9136639|FD-Score:6.23|P-value:4.19E-9 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.46|P-value:6.67E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.62|P-value:3.89E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.94|P-value:1.38E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.56|P-value:5.09E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.40|P-value:2.35E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:4.31|P-value:3.35E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.38|P-value:8.84E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.85|P-value:1.87E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.28|P-value:3.81E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:-5.33|P-value:3.89E-7 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.46|P-value:6.95E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.67|P-value:3.36E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.02|P-value:9.49E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.89|P-value:1.61E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.57|P-value:1.29E-7 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.06|P-value:8.76E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.67|P-value:3.42E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.59|P-value:4.51E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.40|P-value:2.34E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.52|P-value:5.66E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.72|P-value:2.83E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.76|P-value:2.53E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.06|P-value:8.75E-5 ID:SGTC_1979|Compound:st071809|FD-Score:-3.56|P-value:4.87E-4 ID:SGTC_2029|Compound:5175081|FD-Score:4.12|P-value:6.98E-5 ID:SGTC_2037|Compound:5169046|FD-Score:5.85|P-value:3.17E-8 ID:SGTC_2047|Compound:4141938|FD-Score:4.19|P-value:5.46E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.52|P-value:5.77E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.88|P-value:2.71E-8 ID:SGTC_2395|Compound:5646831|FD-Score:-4.12|P-value:6.57E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.59|P-value:1.11E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.11|P-value:7.18E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.44|P-value:7.45E-4 ID:SGTC_2903|Compound:5923464|FD-Score:4.03|P-value:9.90E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.74|P-value:5.85E-6 ID:SGTC_3124|Compound:9127567|FD-Score:-4.66|P-value:7.65E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-3.93|P-value:1.35E-4 ID:SGTC_3129|Compound:9127257|FD-Score:6.12|P-value:7.54E-9 ID:SGTC_3245|Compound:9134821|FD-Score:3.54|P-value:5.38E-4 ID:SGTC_3316|Compound:9136639|FD-Score:6.23|P-value:4.19E-9

Top fitness defect scores for YAL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3316 9136639 6.23 10.6 µM 4.19E-9 3 2.34E-10
2 SGTC_3129 9127257 6.12 49.5 µM 7.54E-9 3 4.64E-10
3 SGTC_2393 9031399 5.88 185.9 µM 2.71E-8 RNA processing & uracil transport 6 2.06E-9
4 SGTC_2037 5169046 5.85 200.0 µM 3.17E-8 60S ribosome export 2 2.46E-9
5 SGTC_967 1306-0166 5.57 352.0 µM 1.29E-7 7 1.26E-8
6 SGTC_2998 9066762 4.74 71.4 µM 5.85E-6 RPP1 & pyrimidine depletion 11 1.06E-6
7 SGTC_2418 pentamidine 4.59 31.7 µM 1.11E-5 mitochondrial processes 28 2.24E-6
8 SGTC_1190 1486-1332 4.40 13.0 µM 2.34E-5 10 5.32E-6
9 SGTC_337 1315-0038 4.40 354.0 µM 2.35E-5 amide catabolism 21 5.32E-6
10 SGTC_341 1486-1430 4.31 230.0 µM 3.35E-5 17 8.04E-6
11 SGTC_427 1354-0053 4.28 47.3 µM 3.81E-5 12 9.35E-6
12 SGTC_2047 4141938 4.19 200.0 µM 5.46E-5 5 1.42E-5
13 SGTC_2029 5175081 4.12 200.0 µM 6.98E-5 13 1.88E-5
14 SGTC_2823 7987624 4.11 58.4 µM 7.18E-5 25 1.95E-5
15 SGTC_1369 1866-0067 4.06 208.0 µM 8.75E-5 RPP1 & pyrimidine depletion 33 2.45E-5
16 SGTC_1075 aripiprazole 4.06 15.2 µM 8.76E-5 26 2.46E-5
17 SGTC_2903 5923464 4.03 63.9 µM 9.90E-5 6 2.83E-5
18 SGTC_173 1273-0061 3.94 2.7 µM 1.38E-4 mitochondrial stress 187 4.14E-5
19 SGTC_924 2046-0044 3.89 21.3 µM 1.61E-4 16 4.97E-5
20 SGTC_382 3229-0966 3.85 23.2 µM 1.87E-4 24 5.92E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 7.82E-8 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.091 1.36E-7 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.087 4.26E-7 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.085 7.22E-7 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.080 3.24E-6 YLR219W MSC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress
0.080 3.35E-6 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.079 4.70E-6 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.075 1.40E-5 YMR284W YKU70 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.074 1.65E-5 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.073 2.42E-5 YMR158W MRPS8 hom Mitochondrial ribosomal protein of the small subunit
0.072 3.38E-5 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.070 5.58E-5 YBR093C PHO5 hom Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
0.069 7.11E-5 YLR005W SSL1 het Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
0.067 1.05E-4 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.067 1.14E-4 YDR182W-A_p YDR182W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR