YAL009W / SPO7

Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL009W / SPO7

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.78|P-value:3.22E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.16|P-value:7.33E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:6.02|P-value:2.57E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:9.27|P-value:2.30E-17 ID:SGTC_157|Compound:1348-1695|FD-Score:3.94|P-value:1.92E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:14.50|P-value:5.51E-40 ID:SGTC_232|Compound:clozapine|FD-Score:6.11|P-value:1.61E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.95|P-value:1.85E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:5.16|P-value:1.56E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:8.24|P-value:4.37E-14 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.53|P-value:6.34E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.94|P-value:1.90E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.46|P-value:8.98E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.26|P-value:7.52E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.18|P-value:1.17E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:7.62|P-value:2.69E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:3.96|P-value:1.76E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:10.90|P-value:3.43E-23 ID:SGTC_576|Compound:1073-0113|FD-Score:4.72|P-value:1.02E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.64|P-value:5.17E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.62|P-value:1.86E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:6.41|P-value:3.36E-9 ID:SGTC_733|Compound:4069-0007|FD-Score:6.79|P-value:4.12E-10 ID:SGTC_792|Compound:4534-1957|FD-Score:3.73|P-value:3.80E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.11|P-value:8.88E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.43|P-value:8.70E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.24|P-value:8.82E-7 ID:SGTC_940|Compound:3232-1287|FD-Score:4.15|P-value:8.92E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.58|P-value:1.78E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.73|P-value:3.80E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.95|P-value:1.84E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.06|P-value:1.26E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.68|P-value:1.16E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.68|P-value:4.49E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.42|P-value:3.26E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.05|P-value:9.08E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.53|P-value:7.23E-4 ID:SGTC_1547|Compound:harmine|FD-Score:8.51|P-value:6.45E-15 ID:SGTC_1581|Compound:himbacine|FD-Score:4.65|P-value:1.32E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.54|P-value:6.96E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.45|P-value:9.34E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.58|P-value:6.14E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.51|P-value:2.35E-5 ID:SGTC_1754|Compound:st042065|FD-Score:7.36|P-value:1.38E-11 ID:SGTC_1760|Compound:st045453|FD-Score:8.49|P-value:7.40E-15 ID:SGTC_1781|Compound:st038725|FD-Score:9.83|P-value:2.83E-19 ID:SGTC_1797|Compound:st048695|FD-Score:7.62|P-value:2.73E-12 ID:SGTC_1803|Compound:st050068|FD-Score:4.07|P-value:1.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.34|P-value:2.19E-14 ID:SGTC_1884|Compound:5633444|FD-Score:5.49|P-value:3.50E-7 ID:SGTC_1908|Compound:st060353|FD-Score:3.89|P-value:2.24E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.83|P-value:2.77E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.82|P-value:2.87E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.90|P-value:2.20E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.94|P-value:1.60E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.90|P-value:4.85E-8 ID:SGTC_2006|Compound:4011487|FD-Score:4.09|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.47|P-value:8.80E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.95|P-value:1.83E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.57|P-value:1.83E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.94|P-value:3.96E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-4.28|P-value:4.60E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.67|P-value:4.70E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.10|P-value:2.04E-6 ID:SGTC_2149|Compound:5554786|FD-Score:3.66|P-value:4.78E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.50|P-value:3.38E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.96|P-value:3.65E-6 ID:SGTC_2257|Compound:7960413|FD-Score:4.45|P-value:2.91E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.89|P-value:2.22E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.03|P-value:1.39E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.51|P-value:7.81E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.53|P-value:7.25E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.58|P-value:6.16E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:-4.07|P-value:1.01E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.15|P-value:1.66E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.55|P-value:5.95E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.96|P-value:1.53E-10 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.13|P-value:9.79E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.36|P-value:4.19E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.35|P-value:4.33E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.52|P-value:2.98E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:9.36|P-value:1.20E-17 ID:SGTC_2736|Compound:butenafine|FD-Score:5.81|P-value:7.59E-8 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.51|P-value:7.81E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:8.50|P-value:6.98E-15 ID:SGTC_2851|Compound:9015922|FD-Score:3.70|P-value:4.21E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-4.25|P-value:5.22E-5 ID:SGTC_2873|Compound:9040596|FD-Score:5.61|P-value:2.01E-7 ID:SGTC_2889|Compound:9059656|FD-Score:-4.22|P-value:5.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.10|P-value:2.05E-6 ID:SGTC_2902|Compound:5787006|FD-Score:3.97|P-value:1.71E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.59|P-value:6.00E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.52|P-value:7.41E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.33|P-value:4.62E-5 ID:SGTC_3142|Compound:9086498|FD-Score:5.71|P-value:1.22E-7 ID:SGTC_3152|Compound:9099253|FD-Score:10.10|P-value:2.38E-20 ID:SGTC_3207|Compound:9114163|FD-Score:-5.14|P-value:1.36E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.67|P-value:4.59E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.78|P-value:3.22E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.16|P-value:7.33E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:6.02|P-value:2.57E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:9.27|P-value:2.30E-17 ID:SGTC_157|Compound:1348-1695|FD-Score:3.94|P-value:1.92E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:14.50|P-value:5.51E-40 ID:SGTC_232|Compound:clozapine|FD-Score:6.11|P-value:1.61E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.95|P-value:1.85E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:5.16|P-value:1.56E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:8.24|P-value:4.37E-14 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.53|P-value:6.34E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.94|P-value:1.90E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.46|P-value:8.98E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.26|P-value:7.52E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.18|P-value:1.17E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:7.62|P-value:2.69E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:3.96|P-value:1.76E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:10.90|P-value:3.43E-23 ID:SGTC_576|Compound:1073-0113|FD-Score:4.72|P-value:1.02E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.64|P-value:5.17E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.62|P-value:1.86E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:6.41|P-value:3.36E-9 ID:SGTC_733|Compound:4069-0007|FD-Score:6.79|P-value:4.12E-10 ID:SGTC_792|Compound:4534-1957|FD-Score:3.73|P-value:3.80E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.11|P-value:8.88E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.43|P-value:8.70E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.24|P-value:8.82E-7 ID:SGTC_940|Compound:3232-1287|FD-Score:4.15|P-value:8.92E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.58|P-value:1.78E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.73|P-value:3.80E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.95|P-value:1.84E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.06|P-value:1.26E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.68|P-value:1.16E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.68|P-value:4.49E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.42|P-value:3.26E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.05|P-value:9.08E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.53|P-value:7.23E-4 ID:SGTC_1547|Compound:harmine|FD-Score:8.51|P-value:6.45E-15 ID:SGTC_1581|Compound:himbacine|FD-Score:4.65|P-value:1.32E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.54|P-value:6.96E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.45|P-value:9.34E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.58|P-value:6.14E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.51|P-value:2.35E-5 ID:SGTC_1754|Compound:st042065|FD-Score:7.36|P-value:1.38E-11 ID:SGTC_1760|Compound:st045453|FD-Score:8.49|P-value:7.40E-15 ID:SGTC_1781|Compound:st038725|FD-Score:9.83|P-value:2.83E-19 ID:SGTC_1797|Compound:st048695|FD-Score:7.62|P-value:2.73E-12 ID:SGTC_1803|Compound:st050068|FD-Score:4.07|P-value:1.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.34|P-value:2.19E-14 ID:SGTC_1884|Compound:5633444|FD-Score:5.49|P-value:3.50E-7 ID:SGTC_1908|Compound:st060353|FD-Score:3.89|P-value:2.24E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.83|P-value:2.77E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.82|P-value:2.87E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.90|P-value:2.20E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.94|P-value:1.60E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.90|P-value:4.85E-8 ID:SGTC_2006|Compound:4011487|FD-Score:4.09|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.47|P-value:8.80E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.95|P-value:1.83E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.57|P-value:1.83E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.94|P-value:3.96E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-4.28|P-value:4.60E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.67|P-value:4.70E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.10|P-value:2.04E-6 ID:SGTC_2149|Compound:5554786|FD-Score:3.66|P-value:4.78E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.50|P-value:3.38E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.96|P-value:3.65E-6 ID:SGTC_2257|Compound:7960413|FD-Score:4.45|P-value:2.91E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.89|P-value:2.22E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.03|P-value:1.39E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.51|P-value:7.81E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.53|P-value:7.25E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.58|P-value:6.16E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:-4.07|P-value:1.01E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.15|P-value:1.66E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.55|P-value:5.95E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.96|P-value:1.53E-10 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.13|P-value:9.79E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.36|P-value:4.19E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.35|P-value:4.33E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.52|P-value:2.98E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:9.36|P-value:1.20E-17 ID:SGTC_2736|Compound:butenafine|FD-Score:5.81|P-value:7.59E-8 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.51|P-value:7.81E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:8.50|P-value:6.98E-15 ID:SGTC_2851|Compound:9015922|FD-Score:3.70|P-value:4.21E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-4.25|P-value:5.22E-5 ID:SGTC_2873|Compound:9040596|FD-Score:5.61|P-value:2.01E-7 ID:SGTC_2889|Compound:9059656|FD-Score:-4.22|P-value:5.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.10|P-value:2.05E-6 ID:SGTC_2902|Compound:5787006|FD-Score:3.97|P-value:1.71E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.59|P-value:6.00E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.52|P-value:7.41E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.33|P-value:4.62E-5 ID:SGTC_3142|Compound:9086498|FD-Score:5.71|P-value:1.22E-7 ID:SGTC_3152|Compound:9099253|FD-Score:10.10|P-value:2.38E-20 ID:SGTC_3207|Compound:9114163|FD-Score:-5.14|P-value:1.36E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.67|P-value:4.59E-4

Top fitness defect scores for YAL009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 14.50 10.3 µM 5.51E-40 NEO1-PIK1 25 3.16E-48
2 SGTC_535 2293-4129 10.90 48.2 µM 3.43E-23 NEO1 7 7.70E-28
3 SGTC_3152 9099253 10.10 49.5 µM 2.38E-20 NEO1-PIK1 22 2.16E-24
4 SGTC_1781 st038725 9.83 66.3 µM 2.83E-19 NEO1 16 4.38E-23
5 SGTC_2697 mebhydrolin 9.36 72.4 µM 1.20E-17 NEO1 17 4.13E-21
6 SGTC_115 0527-0192 9.27 112.0 µM 2.30E-17 6 9.08E-21
7 SGTC_1547 harmine 8.51 94.2 µM 6.45E-15 ergosterol biosynthesis 9 8.49E-18
8 SGTC_2776 terbinafine 8.50 19.9 µM 6.98E-15 cell wall signaling 15 9.34E-18
9 SGTC_1760 st045453 8.49 10.4 µM 7.40E-15 NEO1-PIK1 46 1.00E-17
10 SGTC_1844 rapamycin 8.34 4.0 nM 2.19E-14 53 3.74E-17
11 SGTC_301 4119-0100 8.24 24.5 µM 4.37E-14 NEO1 19 8.66E-17
12 SGTC_525 k781-2675 7.62 26.7 µM 2.69E-12 redox potentiating 14 1.28E-14
13 SGTC_1797 st048695 7.62 56.8 µM 2.73E-12 NEO1 22 1.30E-14
14 SGTC_1754 st042065 7.36 16.1 µM 1.38E-11 NEO1-PIK1 64 9.30E-14
15 SGTC_1161 k007-0610 7.05 110.0 µM 9.08E-11 ERAD & cell cycle 37 9.14E-13
16 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 6.96 70.0 µM 1.53E-10 redox potentiating 17 1.72E-12
17 SGTC_733 4069-0007 6.79 56.1 µM 4.12E-10 ERAD & cell cycle 31 5.71E-12
18 SGTC_660 4031-1742 6.41 102.0 µM 3.36E-9 redox potentiating 9 7.27E-11
19 SGTC_449 xestospongin c 6.26 11.2 µM 7.52E-9 NEO1-PIK1 19 1.93E-10
20 SGTC_232 clozapine 6.11 119.0 µM 1.61E-8 NEO1 30 4.86E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.606 0 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.538 9.47E-251 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.524 2.59E-236 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.506 9.01E-218 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.498 1.47E-209 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.488 3.12E-200 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.450 3.69E-167 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.444 2.46E-161 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.439 1.21E-157 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.417 4.27E-141 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.397 7.51E-127 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.380 1.44E-115 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.380 3.22E-115 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.374 8.16E-112 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.373 5.63E-111 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene