HIPHOP chemogenomics database

YAL011W / SWC3

Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae

Zygosity: Homozygous strain

fixedexpanded
Profile for YAL011W / SWC3

Click on Significant Values for Screen Details

Top fitness defect scores for YAL011W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_210	3551-0445	16.30	56.8 µM	2.10E-48		6	3.48E-60
2	SGTC_229	benomyl	15.10	22.9 µM	9.91E-42	tubulin folding & SWR complex	6	7.57E-52
3	SGTC_2352	9027995	14.70	87.8 µM	1.35E-39	tubulin folding & SWR complex	2	3.50E-49
4	SGTC_221	trifluoperazine	14.40	10.3 µM	4.61E-38	NEO1-PIK1	26	2.89E-47
5	SGTC_158	k038-0087	13.00	26.4 µM	3.24E-31	ubiquinone biosynthesis & proteasome	17	1.04E-38
6	SGTC_825	1988-2224	12.10	89.6 µM	1.77E-27	cell wall signaling	2	4.85E-34
7	SGTC_2174	5790901	11.80	200.0 µM	5.42E-26	tubulin folding & SWR complex	7	3.50E-32
8	SGTC_2582	agaric acid	11.40	100.0 µM	1.76E-24	redox potentiating	47	2.71E-30
9	SGTC_2319	6033012	11.30	152.6 µM	4.89E-24	tubulin folding & SWR complex	7	9.70E-30
10	SGTC_86	0417-1630	10.50	471.9 µM	4.74E-21	ubiquinone biosynthesis & proteasome	35	5.25E-26
11	SGTC_1643	st009866	9.88	20.2 µM	6.92E-19		9	2.66E-23
12	SGTC_2125	5246583	9.57	200.0 µM	7.63E-18	tubulin folding & SWR complex	4	5.34E-22
13	SGTC_589	1227-0070	9.52	34.1 µM	1.11E-17		7	8.52E-22
14	SGTC_1326	1431-2094	8.97	10.8 µM	6.81E-16	tubulin folding & SWR complex	8	1.47E-19
15	SGTC_200	k038-0079	8.76	37.5 µM	3.03E-15	ubiquinone biosynthesis & proteasome	13	9.46E-19
16	SGTC_36	0335-0881	8.70	14.2 µM	4.70E-15	ubiquinone biosynthesis & proteasome	29	1.64E-18
17	SGTC_2947	9072639	8.53	7.7 µM	1.54E-14	tubulin folding & SWR complex	4	7.23E-18
18	SGTC_2254	7938975	8.53	95.2 µM	1.61E-14		12	7.63E-18
19	SGTC_149	3970-0822	8.47	46.1 µM	2.28E-14	tubulin folding & SWR complex	15	1.18E-17
20	SGTC_514	4466-0038	8.28	2.6 nM	8.50E-14	cell wall	35	6.11E-17

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.686	0	YLR085C	ARP6	hom	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.680	0	YML041C	VPS71	hom	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.617	0	YDR485C	VPS72	hom	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.614	0	YDR334W	SWR1	hom	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.564	7.68E-281	YBR231C	SWC5	hom	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.530	6.43E-243	YER007W	PAC2	hom	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.481	1.85E-193	YML124C	TUB3	hom	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.418	3.10E-142	YOR349W	CIN1	hom	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.415	1.38E-139	YOL012C	HTZ1	hom	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.377	6.02E-114	YPL241C	CIN2	hom	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.355	4.52E-100	YJL168C	SET2	hom	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.343	1.69E-93	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.323	1.43E-82	YJL169W_d	YJL169W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.321	3.25E-81	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.297	2.28E-69	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2