YAL011W / SWC3

Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL011W / SWC3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:8.70|P-value:4.70E-15 ID:SGTC_64|Compound:000l-0018|FD-Score:6.72|P-value:1.15E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:7.81|P-value:1.82E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:10.50|P-value:4.74E-21 ID:SGTC_137|Compound:0438-0332|FD-Score:7.12|P-value:1.23E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:8.25|P-value:1.07E-13 ID:SGTC_149|Compound:3970-0822|FD-Score:8.47|P-value:2.28E-14 ID:SGTC_158|Compound:k038-0087|FD-Score:13.00|P-value:3.24E-31 ID:SGTC_161|Compound:4065-0411|FD-Score:3.79|P-value:4.12E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.81|P-value:1.27E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.32|P-value:6.53E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:8.76|P-value:3.03E-15 ID:SGTC_210|Compound:3551-0445|FD-Score:16.30|P-value:2.10E-48 ID:SGTC_212|Compound:3807-4682|FD-Score:8.21|P-value:1.36E-13 ID:SGTC_216|Compound:k038-0035|FD-Score:7.41|P-value:2.17E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:14.40|P-value:4.61E-38 ID:SGTC_229|Compound:benomyl|FD-Score:15.10|P-value:9.91E-42 ID:SGTC_286|Compound:k060-0067|FD-Score:7.33|P-value:3.60E-11 ID:SGTC_313|Compound:3474-0040|FD-Score:5.36|P-value:1.00E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:6.70|P-value:1.33E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:5.34|P-value:1.09E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.76|P-value:4.53E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.58|P-value:2.52E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.22|P-value:1.85E-6 ID:SGTC_447|Compound:ml7|FD-Score:4.24|P-value:8.85E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.84|P-value:6.04E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:8.28|P-value:8.50E-14 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.56|P-value:8.53E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.74|P-value:4.71E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:9.52|P-value:1.11E-17 ID:SGTC_599|Compound:1935-0052|FD-Score:4.16|P-value:1.15E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.56|P-value:8.38E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.59|P-value:2.42E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:6.37|P-value:7.50E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:8.05|P-value:3.88E-13 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.45|P-value:8.53E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:12.10|P-value:1.77E-27 ID:SGTC_871|Compound:0574-0004|FD-Score:5.57|P-value:3.84E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:5.11|P-value:2.89E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.57|P-value:2.56E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.29|P-value:7.24E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.88|P-value:1.21E-12 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.09|P-value:1.52E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.55|P-value:8.76E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-5.27|P-value:9.32E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:6.26|P-value:1.33E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.60|P-value:2.32E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.39|P-value:8.89E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:8.97|P-value:6.81E-16 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.69|P-value:1.65E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.38|P-value:8.93E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:7.07|P-value:1.59E-10 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.08|P-value:1.54E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.72|P-value:1.47E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.14|P-value:1.25E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.93|P-value:6.13E-6 ID:SGTC_1643|Compound:st009866|FD-Score:9.88|P-value:6.92E-19 ID:SGTC_1652|Compound:st011932|FD-Score:4.97|P-value:5.30E-6 ID:SGTC_1702|Compound:st027038|FD-Score:3.83|P-value:3.58E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.52|P-value:4.96E-7 ID:SGTC_1754|Compound:st042065|FD-Score:5.33|P-value:1.14E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.36|P-value:1.01E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.42|P-value:7.47E-7 ID:SGTC_1831|Compound:st055328|FD-Score:3.91|P-value:2.72E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.22|P-value:6.74E-11 ID:SGTC_1896|Compound:st058441|FD-Score:3.77|P-value:4.28E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.82|P-value:3.67E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.08|P-value:1.54E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.57|P-value:5.92E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.75|P-value:1.30E-5 ID:SGTC_2125|Compound:5246583|FD-Score:9.57|P-value:7.63E-18 ID:SGTC_2141|Compound:5621638|FD-Score:5.04|P-value:3.99E-6 ID:SGTC_2174|Compound:5790901|FD-Score:11.80|P-value:5.42E-26 ID:SGTC_2176|Compound:5809774|FD-Score:3.53|P-value:9.18E-4 ID:SGTC_2200|Compound:6600604|FD-Score:8.08|P-value:3.19E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.03|P-value:1.84E-4 ID:SGTC_2254|Compound:7938975|FD-Score:8.53|P-value:1.61E-14 ID:SGTC_2269|Compound:7935389|FD-Score:6.47|P-value:4.62E-9 ID:SGTC_2277|Compound:7947813|FD-Score:7.42|P-value:2.05E-11 ID:SGTC_2300|Compound:7976697|FD-Score:-3.70|P-value:3.82E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.26|P-value:1.35E-8 ID:SGTC_2309|Compound:7664088|FD-Score:3.63|P-value:6.70E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.28|P-value:7.55E-5 ID:SGTC_2319|Compound:6033012|FD-Score:11.30|P-value:4.89E-24 ID:SGTC_2342|Compound:7990637|FD-Score:7.07|P-value:1.65E-10 ID:SGTC_2346|Compound:9031566|FD-Score:3.73|P-value:4.94E-4 ID:SGTC_2352|Compound:9027995|FD-Score:14.70|P-value:1.35E-39 ID:SGTC_2378|Compound:9074213|FD-Score:4.84|P-value:8.97E-6 ID:SGTC_2381|Compound:9035592|FD-Score:3.83|P-value:3.63E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.16|P-value:1.17E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.45|P-value:5.09E-9 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.35|P-value:5.90E-5 ID:SGTC_2556|Compound:citropten|FD-Score:4.90|P-value:6.92E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.40|P-value:1.76E-24 ID:SGTC_2584|Compound:androsterone|FD-Score:6.29|P-value:1.18E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.69|P-value:1.09E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.51|P-value:7.08E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.14|P-value:1.26E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.51|P-value:9.83E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.50|P-value:9.96E-4 ID:SGTC_2861|Compound:9024595|FD-Score:4.05|P-value:1.71E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.05|P-value:1.74E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.53|P-value:6.71E-4 ID:SGTC_2947|Compound:9072639|FD-Score:8.53|P-value:1.54E-14 ID:SGTC_2958|Compound:9077254|FD-Score:3.99|P-value:2.07E-4 ID:SGTC_2997|Compound:9067075|FD-Score:7.44|P-value:1.83E-11 ID:SGTC_3101|Compound:9120531|FD-Score:4.11|P-value:1.37E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.63|P-value:6.73E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.69|P-value:1.64E-5 ID:SGTC_3253|Compound:9135987|FD-Score:3.95|P-value:2.37E-4 ID:SGTC_3294|Compound:9122953|FD-Score:5.84|P-value:1.11E-7 ID:SGTC_3311|Compound:9131146|FD-Score:4.41|P-value:4.82E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.81|P-value:1.03E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.49|P-value:5.46E-7 ID:SGTC_3344|Compound:9148862|FD-Score:3.67|P-value:6.00E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:8.70|P-value:4.70E-15 ID:SGTC_64|Compound:000l-0018|FD-Score:6.72|P-value:1.15E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:7.81|P-value:1.82E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:10.50|P-value:4.74E-21 ID:SGTC_137|Compound:0438-0332|FD-Score:7.12|P-value:1.23E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:8.25|P-value:1.07E-13 ID:SGTC_149|Compound:3970-0822|FD-Score:8.47|P-value:2.28E-14 ID:SGTC_158|Compound:k038-0087|FD-Score:13.00|P-value:3.24E-31 ID:SGTC_161|Compound:4065-0411|FD-Score:3.79|P-value:4.12E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.81|P-value:1.27E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.32|P-value:6.53E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:8.76|P-value:3.03E-15 ID:SGTC_210|Compound:3551-0445|FD-Score:16.30|P-value:2.10E-48 ID:SGTC_212|Compound:3807-4682|FD-Score:8.21|P-value:1.36E-13 ID:SGTC_216|Compound:k038-0035|FD-Score:7.41|P-value:2.17E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:14.40|P-value:4.61E-38 ID:SGTC_229|Compound:benomyl|FD-Score:15.10|P-value:9.91E-42 ID:SGTC_286|Compound:k060-0067|FD-Score:7.33|P-value:3.60E-11 ID:SGTC_313|Compound:3474-0040|FD-Score:5.36|P-value:1.00E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:6.70|P-value:1.33E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:5.34|P-value:1.09E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.76|P-value:4.53E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.58|P-value:2.52E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.22|P-value:1.85E-6 ID:SGTC_447|Compound:ml7|FD-Score:4.24|P-value:8.85E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.84|P-value:6.04E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:8.28|P-value:8.50E-14 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.56|P-value:8.53E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.74|P-value:4.71E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:9.52|P-value:1.11E-17 ID:SGTC_599|Compound:1935-0052|FD-Score:4.16|P-value:1.15E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.56|P-value:8.38E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.59|P-value:2.42E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:6.37|P-value:7.50E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:8.05|P-value:3.88E-13 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.45|P-value:8.53E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:12.10|P-value:1.77E-27 ID:SGTC_871|Compound:0574-0004|FD-Score:5.57|P-value:3.84E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:5.11|P-value:2.89E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.57|P-value:2.56E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.29|P-value:7.24E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.88|P-value:1.21E-12 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.09|P-value:1.52E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.55|P-value:8.76E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-5.27|P-value:9.32E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:6.26|P-value:1.33E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.60|P-value:2.32E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.39|P-value:8.89E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:8.97|P-value:6.81E-16 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.69|P-value:1.65E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.38|P-value:8.93E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:7.07|P-value:1.59E-10 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.08|P-value:1.54E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.72|P-value:1.47E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.14|P-value:1.25E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.93|P-value:6.13E-6 ID:SGTC_1643|Compound:st009866|FD-Score:9.88|P-value:6.92E-19 ID:SGTC_1652|Compound:st011932|FD-Score:4.97|P-value:5.30E-6 ID:SGTC_1702|Compound:st027038|FD-Score:3.83|P-value:3.58E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.52|P-value:4.96E-7 ID:SGTC_1754|Compound:st042065|FD-Score:5.33|P-value:1.14E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.36|P-value:1.01E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.42|P-value:7.47E-7 ID:SGTC_1831|Compound:st055328|FD-Score:3.91|P-value:2.72E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.22|P-value:6.74E-11 ID:SGTC_1896|Compound:st058441|FD-Score:3.77|P-value:4.28E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.82|P-value:3.67E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.08|P-value:1.54E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.57|P-value:5.92E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.75|P-value:1.30E-5 ID:SGTC_2125|Compound:5246583|FD-Score:9.57|P-value:7.63E-18 ID:SGTC_2141|Compound:5621638|FD-Score:5.04|P-value:3.99E-6 ID:SGTC_2174|Compound:5790901|FD-Score:11.80|P-value:5.42E-26 ID:SGTC_2176|Compound:5809774|FD-Score:3.53|P-value:9.18E-4 ID:SGTC_2200|Compound:6600604|FD-Score:8.08|P-value:3.19E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.03|P-value:1.84E-4 ID:SGTC_2254|Compound:7938975|FD-Score:8.53|P-value:1.61E-14 ID:SGTC_2269|Compound:7935389|FD-Score:6.47|P-value:4.62E-9 ID:SGTC_2277|Compound:7947813|FD-Score:7.42|P-value:2.05E-11 ID:SGTC_2300|Compound:7976697|FD-Score:-3.70|P-value:3.82E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.26|P-value:1.35E-8 ID:SGTC_2309|Compound:7664088|FD-Score:3.63|P-value:6.70E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.28|P-value:7.55E-5 ID:SGTC_2319|Compound:6033012|FD-Score:11.30|P-value:4.89E-24 ID:SGTC_2342|Compound:7990637|FD-Score:7.07|P-value:1.65E-10 ID:SGTC_2346|Compound:9031566|FD-Score:3.73|P-value:4.94E-4 ID:SGTC_2352|Compound:9027995|FD-Score:14.70|P-value:1.35E-39 ID:SGTC_2378|Compound:9074213|FD-Score:4.84|P-value:8.97E-6 ID:SGTC_2381|Compound:9035592|FD-Score:3.83|P-value:3.63E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.16|P-value:1.17E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.45|P-value:5.09E-9 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.35|P-value:5.90E-5 ID:SGTC_2556|Compound:citropten|FD-Score:4.90|P-value:6.92E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.40|P-value:1.76E-24 ID:SGTC_2584|Compound:androsterone|FD-Score:6.29|P-value:1.18E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.69|P-value:1.09E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.51|P-value:7.08E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.14|P-value:1.26E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.51|P-value:9.83E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.50|P-value:9.96E-4 ID:SGTC_2861|Compound:9024595|FD-Score:4.05|P-value:1.71E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.05|P-value:1.74E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.53|P-value:6.71E-4 ID:SGTC_2947|Compound:9072639|FD-Score:8.53|P-value:1.54E-14 ID:SGTC_2958|Compound:9077254|FD-Score:3.99|P-value:2.07E-4 ID:SGTC_2997|Compound:9067075|FD-Score:7.44|P-value:1.83E-11 ID:SGTC_3101|Compound:9120531|FD-Score:4.11|P-value:1.37E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.63|P-value:6.73E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.69|P-value:1.64E-5 ID:SGTC_3253|Compound:9135987|FD-Score:3.95|P-value:2.37E-4 ID:SGTC_3294|Compound:9122953|FD-Score:5.84|P-value:1.11E-7 ID:SGTC_3311|Compound:9131146|FD-Score:4.41|P-value:4.82E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.81|P-value:1.03E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.49|P-value:5.46E-7 ID:SGTC_3344|Compound:9148862|FD-Score:3.67|P-value:6.00E-4

Top fitness defect scores for YAL011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_210 3551-0445 16.30 56.8 µM 2.10E-48 6 3.48E-60
2 SGTC_229 benomyl 15.10 22.9 µM 9.91E-42 tubulin folding & SWR complex 6 7.57E-52
3 SGTC_2352 9027995 14.70 87.8 µM 1.35E-39 tubulin folding & SWR complex 2 3.50E-49
4 SGTC_221 trifluoperazine 14.40 10.3 µM 4.61E-38 NEO1-PIK1 26 2.89E-47
5 SGTC_158 k038-0087 13.00 26.4 µM 3.24E-31 ubiquinone biosynthesis & proteasome 17 1.04E-38
6 SGTC_825 1988-2224 12.10 89.6 µM 1.77E-27 cell wall signaling 2 4.85E-34
7 SGTC_2174 5790901 11.80 200.0 µM 5.42E-26 tubulin folding & SWR complex 7 3.50E-32
8 SGTC_2582 agaric acid 11.40 100.0 µM 1.76E-24 redox potentiating 47 2.71E-30
9 SGTC_2319 6033012 11.30 152.6 µM 4.89E-24 tubulin folding & SWR complex 7 9.70E-30
10 SGTC_86 0417-1630 10.50 471.9 µM 4.74E-21 ubiquinone biosynthesis & proteasome 35 5.25E-26
11 SGTC_1643 st009866 9.88 20.2 µM 6.92E-19 9 2.66E-23
12 SGTC_2125 5246583 9.57 200.0 µM 7.63E-18 tubulin folding & SWR complex 4 5.34E-22
13 SGTC_589 1227-0070 9.52 34.1 µM 1.11E-17 7 8.52E-22
14 SGTC_1326 1431-2094 8.97 10.8 µM 6.81E-16 tubulin folding & SWR complex 8 1.47E-19
15 SGTC_200 k038-0079 8.76 37.5 µM 3.03E-15 ubiquinone biosynthesis & proteasome 13 9.46E-19
16 SGTC_36 0335-0881 8.70 14.2 µM 4.70E-15 ubiquinone biosynthesis & proteasome 29 1.64E-18
17 SGTC_2947 9072639 8.53 7.7 µM 1.54E-14 tubulin folding & SWR complex 4 7.23E-18
18 SGTC_2254 7938975 8.53 95.2 µM 1.61E-14 12 7.63E-18
19 SGTC_149 3970-0822 8.47 46.1 µM 2.28E-14 tubulin folding & SWR complex 15 1.18E-17
20 SGTC_514 4466-0038 8.28 2.6 nM 8.50E-14 cell wall 35 6.11E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.686 0 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.680 0 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.617 0 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.614 0 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.564 7.68E-281 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.530 6.43E-243 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.481 1.85E-193 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.418 3.10E-142 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.415 1.38E-139 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.377 6.02E-114 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.355 4.52E-100 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.343 1.69E-93 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.323 1.43E-82 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.321 3.25E-81 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.297 2.28E-69 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2