YAL013W / DEP1

Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL013W / DEP1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:6.46|P-value:3.49E-11 ID:SGTC_36|Compound:0335-0881|FD-Score:4.14|P-value:1.55E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.76|P-value:8.30E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.17|P-value:1.34E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.15|P-value:7.71E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:7.82|P-value:1.48E-15 ID:SGTC_367|Compound:0335-0881|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.88|P-value:3.73E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.72|P-value:9.11E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.27|P-value:5.48E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:5.81|P-value:2.29E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:4.30|P-value:7.50E-6 ID:SGTC_707|Compound:0865-0008|FD-Score:3.53|P-value:1.93E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.53|P-value:1.25E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.08|P-value:7.99E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:4.47|P-value:3.36E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.14|P-value:6.68E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.56|P-value:2.17E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.84|P-value:4.39E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.43|P-value:2.27E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.75|P-value:8.23E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.65|P-value:1.39E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.21|P-value:6.24E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.83|P-value:5.83E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.11|P-value:9.08E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.10|P-value:9.23E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.46|P-value:2.53E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-3.42|P-value:2.37E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.38|P-value:3.41E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.75|P-value:8.09E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.20|P-value:1.20E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.25|P-value:9.58E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-4.69|P-value:8.41E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.49|P-value:1.79E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.12|P-value:7.16E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.66|P-value:1.19E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.96|P-value:2.90E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.45|P-value:2.08E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.50|P-value:2.21E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.87|P-value:3.86E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.17|P-value:7.21E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.05|P-value:2.34E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.34|P-value:3.15E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.34|P-value:4.02E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.45|P-value:2.67E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.34|P-value:6.32E-6 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:2.50E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.16|P-value:7.41E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.09|P-value:9.69E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.15|P-value:7.77E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.34|P-value:3.13E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.94|P-value:2.81E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.46|P-value:3.49E-11 ID:SGTC_36|Compound:0335-0881|FD-Score:4.14|P-value:1.55E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.76|P-value:8.30E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.17|P-value:1.34E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.15|P-value:7.71E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:7.82|P-value:1.48E-15 ID:SGTC_367|Compound:0335-0881|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.88|P-value:3.73E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.72|P-value:9.11E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.27|P-value:5.48E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:5.81|P-value:2.29E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:4.30|P-value:7.50E-6 ID:SGTC_707|Compound:0865-0008|FD-Score:3.53|P-value:1.93E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.53|P-value:1.25E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.08|P-value:7.99E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:4.47|P-value:3.36E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.14|P-value:6.68E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.56|P-value:2.17E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.84|P-value:4.39E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.43|P-value:2.27E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.75|P-value:8.23E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.65|P-value:1.39E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.21|P-value:6.24E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.83|P-value:5.83E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.11|P-value:9.08E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.10|P-value:9.23E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.46|P-value:2.53E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-3.42|P-value:2.37E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.38|P-value:3.41E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.75|P-value:8.09E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.20|P-value:1.20E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.25|P-value:9.58E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-4.69|P-value:8.41E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.49|P-value:1.79E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.12|P-value:7.16E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.66|P-value:1.19E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.96|P-value:2.90E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.45|P-value:2.08E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.50|P-value:2.21E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.87|P-value:3.86E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.17|P-value:7.21E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.05|P-value:2.34E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.34|P-value:3.15E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.34|P-value:4.02E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.45|P-value:2.67E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.34|P-value:6.32E-6 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:2.50E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.16|P-value:7.41E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.09|P-value:9.69E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.15|P-value:7.77E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.34|P-value:3.13E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.94|P-value:2.81E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.23|P-value:5.80E-4

Top fitness defect scores for YAL013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 7.82 9.4 µM 1.48E-15 5 2.72E-15
2 SGTC_22 0964-0034 6.46 14.5 µM 3.49E-11 unfolded protein response 14 5.14E-11
3 SGTC_577 r071-0003 5.81 38.6 µM 2.29E-9 fatty acid desaturase (OLE1) 18 3.08E-9
4 SGTC_710 3448-4187 5.53 58.0 µM 1.25E-8 fatty acid desaturase (OLE1) 21 1.62E-8
5 SGTC_513 4245-1575 5.27 41.7 µM 5.48E-8 unfolded protein response 66 6.89E-8
6 SGTC_2399 5884133 4.96 200.0 µM 2.90E-7 cell wall signaling 42 3.52E-7
7 SGTC_142 0335-0849 4.76 62.7 µM 8.30E-7 ubiquinone biosynthesis & proteasome 93 9.87E-7
8 SGTC_1132 3456-3614 4.65 2.5 µM 1.39E-6 tubulin folding & SWR complex 22 1.64E-6
9 SGTC_959 1222-0044 4.56 107.0 µM 2.17E-6 10 2.53E-6
10 SGTC_938 3126-1755 4.47 342.0 µM 3.36E-6 7 3.88E-6
11 SGTC_2924 9010168 4.34 62.8 µM 6.32E-6 cell wall signaling 27 7.21E-6
12 SGTC_663 1486-0733 4.30 13.9 µM 7.50E-6 cell wall signaling 43 8.54E-6
13 SGTC_2009 4012297 4.25 12.1 µM 9.58E-6 cell wall signaling 53 1.09E-5
14 SGTC_2007 4011539 4.20 71.8 µM 1.20E-5 cell wall signaling 49 1.35E-5
15 SGTC_367 0335-0881 4.19 7.1 µM 1.26E-5 ubiquinone biosynthesis & proteasome 67 1.42E-5
16 SGTC_158 k038-0087 4.17 26.4 µM 1.34E-5 ubiquinone biosynthesis & proteasome 127 1.51E-5
17 SGTC_36 0335-0881 4.14 14.2 µM 1.55E-5 ubiquinone biosynthesis & proteasome 113 1.74E-5
18 SGTC_2613 3',4'-dimethoxydalbergione 4.05 24.6 µM 2.34E-5 21 2.60E-5
19 SGTC_1228 0124-0032 3.83 52.5 µM 5.83E-5 20 6.38E-5
20 SGTC_1996 st072960 3.75 66.8 µM 8.09E-5 19 8.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.14E-35 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.182 1.84E-26 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.179 1.20E-25 YMR263W SAP30 hom Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
0.166 4.82E-22 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.166 5.31E-22 YBR095C RXT2 hom Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
0.164 1.36E-21 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.163 1.86E-21 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.162 4.22E-21 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.157 5.39E-20 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.148 8.06E-18 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.145 2.61E-17 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.143 1.03E-16 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.141 2.91E-16 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.139 5.40E-16 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.139 5.43E-16 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication