YAL016C-B_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL016C-B / YAL016C-B

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:-3.62|P-value:7.34E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.00|P-value:6.79E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.20|P-value:3.10E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:2.96|P-value:7.79E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.02|P-value:7.70E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.22|P-value:2.85E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.37|P-value:2.01E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.55|P-value:7.63E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.83|P-value:2.15E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.54|P-value:1.75E-12 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.43|P-value:1.24E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.16|P-value:3.64E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.71|P-value:3.74E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:2.94|P-value:8.36E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_1709|Compound:st033179|FD-Score:2.90|P-value:9.52E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.97|P-value:7.46E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.24|P-value:2.64E-4 ID:SGTC_1815|Compound:st051655|FD-Score:2.89|P-value:9.89E-4 ID:SGTC_1816|Compound:st051957|FD-Score:4.38|P-value:1.54E-6 ID:SGTC_1831|Compound:st055328|FD-Score:2.93|P-value:8.51E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-4.40|P-value:1.87E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.88|P-value:2.28E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.83|P-value:2.92E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.01|P-value:6.49E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.09|P-value:5.96E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.11|P-value:4.41E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.70|P-value:2.69E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.68|P-value:5.56E-5 ID:SGTC_2451|Compound:5856223|FD-Score:3.56|P-value:7.13E-5 ID:SGTC_2798|Compound:7813637|FD-Score:7.41|P-value:1.68E-15 ID:SGTC_2799|Compound:7812892|FD-Score:4.49|P-value:8.57E-7 ID:SGTC_2832|Compound:7992762|FD-Score:4.96|P-value:6.51E-8 ID:SGTC_2905|Compound:7799065|FD-Score:3.59|P-value:6.28E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.18|P-value:3.37E-4 ID:SGTC_3141|Compound:9094609|FD-Score:2.93|P-value:8.77E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.08|P-value:5.02E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.91|P-value:1.53E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.37|P-value:1.62E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.06|P-value:5.26E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.62|P-value:7.34E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.00|P-value:6.79E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.20|P-value:3.10E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:2.96|P-value:7.79E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.02|P-value:7.70E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.22|P-value:2.85E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.37|P-value:2.01E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.55|P-value:7.63E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.83|P-value:2.15E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.54|P-value:1.75E-12 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.43|P-value:1.24E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.16|P-value:3.64E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.71|P-value:3.74E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:2.94|P-value:8.36E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_1709|Compound:st033179|FD-Score:2.90|P-value:9.52E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.97|P-value:7.46E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.24|P-value:2.64E-4 ID:SGTC_1815|Compound:st051655|FD-Score:2.89|P-value:9.89E-4 ID:SGTC_1816|Compound:st051957|FD-Score:4.38|P-value:1.54E-6 ID:SGTC_1831|Compound:st055328|FD-Score:2.93|P-value:8.51E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-4.40|P-value:1.87E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.88|P-value:2.28E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.83|P-value:2.92E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.01|P-value:6.49E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.09|P-value:5.96E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.11|P-value:4.41E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.70|P-value:2.69E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.68|P-value:5.56E-5 ID:SGTC_2451|Compound:5856223|FD-Score:3.56|P-value:7.13E-5 ID:SGTC_2798|Compound:7813637|FD-Score:7.41|P-value:1.68E-15 ID:SGTC_2799|Compound:7812892|FD-Score:4.49|P-value:8.57E-7 ID:SGTC_2832|Compound:7992762|FD-Score:4.96|P-value:6.51E-8 ID:SGTC_2905|Compound:7799065|FD-Score:3.59|P-value:6.28E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.18|P-value:3.37E-4 ID:SGTC_3141|Compound:9094609|FD-Score:2.93|P-value:8.77E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.08|P-value:5.02E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.91|P-value:1.53E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.37|P-value:1.62E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.06|P-value:5.26E-4

Top fitness defect scores for YAL016C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2798 7813637 7.41 45.5 µM 1.68E-15 2 6.34E-14
2 SGTC_1277 0873-0036 6.54 22.0 µM 1.75E-12 PDR1 6 3.08E-11
3 SGTC_2832 7992762 4.96 52.0 µM 6.51E-8 13 3.61E-7
4 SGTC_2128 5255449 4.70 168.5 µM 2.69E-7 17 1.28E-6
5 SGTC_2799 7812892 4.49 81.8 µM 8.57E-7 superoxide 21 3.58E-6
6 SGTC_1816 st051957 4.38 91.6 µM 1.54E-6 6 6.05E-6
7 SGTC_3217 9129673 3.91 49.5 µM 1.53E-5 40 4.68E-5
8 SGTC_1218 1348-1416 3.83 30.7 µM 2.15E-5 SWF1 & branched chain AA biosynthesis 17 6.31E-5
9 SGTC_1459 k035-0031 3.71 35.7 µM 3.74E-5 DNA intercalators 28 1.03E-4
10 SGTC_2905 7799065 3.59 20.1 µM 6.28E-5 18 1.64E-4
11 SGTC_2451 5856223 3.56 45.7 µM 7.13E-5 29 1.84E-4
12 SGTC_1056 3448-1962 3.55 115.0 µM 7.63E-5 amide catabolism 29 1.95E-4
13 SGTC_213 1246-0773 3.47 967.0 nM 1.03E-4 36 2.56E-4
14 SGTC_1611 st001856 3.46 99.4 µM 1.09E-4 31 2.67E-4
15 SGTC_1322 1348-1070 3.43 12.0 µM 1.24E-4 16 3.01E-4
16 SGTC_2130 NSC 7 3.37 2.5 µM 1.57E-4 copper-dependent oxidative stress 55 3.71E-4
17 SGTC_3238 9133470 3.37 49.5 µM 1.62E-4 26 3.82E-4
18 SGTC_1813 st051246 3.24 8.6 µM 2.64E-4 TSC3-RPN4 20 5.91E-4
19 SGTC_682 0kpi-0099 3.22 17.0 µM 2.85E-4 104 6.32E-4
20 SGTC_236 1509-0011 3.20 5.3 µM 3.10E-4 445 6.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.46E-15 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.134 6.52E-15 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.119 4.09E-12 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.115 2.23E-11 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.115 2.66E-11 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.115 2.83E-11 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.110 1.85E-10 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.109 2.25E-10 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.107 6.22E-10 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.105 1.27E-9 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.102 3.40E-9 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.099 7.70E-9 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.099 7.86E-9 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.099 9.37E-9 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.098 1.34E-8 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies