YAL018C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL018C / YAL018C

Click on Significant Values for Screen Details ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.72|P-value:1.22E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.06|P-value:3.57E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.29|P-value:6.34E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.69|P-value:2.18E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.17|P-value:8.92E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.40|P-value:4.34E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.26|P-value:7.05E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.46|P-value:3.60E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.40|P-value:4.37E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.55|P-value:2.54E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.43|P-value:7.28E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.22|P-value:8.15E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.26|P-value:7.20E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.20|P-value:8.07E-4 ID:SGTC_1746|Compound:st038117|FD-Score:6.64|P-value:3.64E-11 ID:SGTC_1749|Compound:st037932|FD-Score:6.20|P-value:6.23E-10 ID:SGTC_1790|Compound:st045711|FD-Score:-3.19|P-value:8.22E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.18|P-value:1.86E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.64|P-value:1.82E-4 ID:SGTC_2256|Compound:7954252|FD-Score:4.57|P-value:3.80E-6 ID:SGTC_2349|Compound:9023730|FD-Score:4.72|P-value:1.85E-6 ID:SGTC_2440|Compound:5628896|FD-Score:3.33|P-value:5.52E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.51|P-value:2.65E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.57|P-value:3.82E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.19|P-value:8.17E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.92|P-value:5.60E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.30|P-value:5.76E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.37|P-value:4.41E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:4.26|P-value:1.50E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-4.14|P-value:2.25E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.58|P-value:2.08E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.41|P-value:3.86E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.56|P-value:2.43E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.07|P-value:3.31E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.30|P-value:6.26E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.72|P-value:1.22E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.06|P-value:3.57E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.29|P-value:6.34E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.69|P-value:2.18E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.17|P-value:8.92E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.40|P-value:4.34E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.26|P-value:7.05E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.46|P-value:3.60E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.40|P-value:4.37E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.55|P-value:2.54E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.43|P-value:7.28E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.22|P-value:8.15E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.26|P-value:7.20E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.20|P-value:8.07E-4 ID:SGTC_1746|Compound:st038117|FD-Score:6.64|P-value:3.64E-11 ID:SGTC_1749|Compound:st037932|FD-Score:6.20|P-value:6.23E-10 ID:SGTC_1790|Compound:st045711|FD-Score:-3.19|P-value:8.22E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.18|P-value:1.86E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.64|P-value:1.82E-4 ID:SGTC_2256|Compound:7954252|FD-Score:4.57|P-value:3.80E-6 ID:SGTC_2349|Compound:9023730|FD-Score:4.72|P-value:1.85E-6 ID:SGTC_2440|Compound:5628896|FD-Score:3.33|P-value:5.52E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.51|P-value:2.65E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.57|P-value:3.82E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.19|P-value:8.17E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.92|P-value:5.60E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.30|P-value:5.76E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.37|P-value:4.41E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:4.26|P-value:1.50E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-4.14|P-value:2.25E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.58|P-value:2.08E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.41|P-value:3.86E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.56|P-value:2.43E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.07|P-value:3.31E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.30|P-value:6.26E-4

Top fitness defect scores for YAL018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1746 st038117 6.64 42.0 µM 3.64E-11 4 1.52E-11
2 SGTC_1749 st037932 6.20 54.2 µM 6.23E-10 7 2.90E-10
3 SGTC_2349 9023730 4.72 187.1 µM 1.85E-6 9 1.16E-6
4 SGTC_422 cantharidin 4.69 155.0 µM 2.18E-6 cell wall signaling 40 1.37E-6
5 SGTC_2256 7954252 4.57 200.0 µM 3.80E-6 mitochondrial processes 4 2.45E-6
6 SGTC_2453 5731132 4.57 22.2 µM 3.82E-6 10 2.46E-6
7 SGTC_756 0508-1999 4.43 28.3 µM 7.28E-6 RPP1 & pyrimidine depletion 13 4.80E-6
8 SGTC_2761 levamisole 4.26 97.9 µM 1.50E-5 11 1.01E-5
9 SGTC_3326 9140064 4.07 16.4 µM 3.31E-5 19 2.31E-5
10 SGTC_274 sirtinol 4.06 40.1 µM 3.57E-5 17 2.50E-5
11 SGTC_2253 7938677 3.64 135.8 µM 1.82E-4 17 1.36E-4
12 SGTC_3244 9134489 3.56 49.5 µM 2.43E-4 29 1.82E-4
13 SGTC_688 0527-0193 3.55 473.0 µM 2.54E-4 fatty acid desaturase (OLE1) 23 1.92E-4
14 SGTC_1846 st056244 3.55 14.8 µM 2.57E-4 46 1.93E-4
15 SGTC_2030 5175110 3.48 200.0 µM 3.31E-4 Golgi 39 2.52E-4
16 SGTC_671 0560-0003 3.46 407.0 µM 3.60E-4 19 2.75E-4
17 SGTC_608 k048-0125 3.40 159.0 µM 4.34E-4 48 3.33E-4
18 SGTC_679 0422-0091 3.40 41.4 µM 4.37E-4 Golgi 57 3.36E-4
19 SGTC_2440 5628896 3.33 157.8 µM 5.52E-4 36 4.28E-4
20 SGTC_3344 9148862 3.30 3.9 µM 6.26E-4 28 4.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 9.89E-20 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.113 5.69E-11 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.091 1.18E-7 YLR090W XDJ1 hom Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089 2.30E-7 YLR303W MET17 hom Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
0.087 4.22E-7 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.087 4.41E-7 YJL070C_p YJL070C_p hom Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication
0.087 4.95E-7 YGL226C-A OST5 hom Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.087 5.16E-7 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.086 6.42E-7 YBR093C PHO5 hom Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
0.083 1.61E-6 YKL054C DEF1 hom RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
0.081 2.64E-6 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.080 3.16E-6 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.079 4.85E-6 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.079 5.15E-6 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.075 1.48E-5 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p