YAL019W / FUN30

Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL019W / FUN30

Click on Significant Values for Screen Details ID:SGTC_155|Compound:k072-0202|FD-Score:-3.76|P-value:5.82E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:4.59|P-value:1.29E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.32|P-value:3.33E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.67|P-value:8.61E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.54|P-value:1.65E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.36|P-value:2.93E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.62|P-value:1.03E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.04|P-value:9.14E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.17|P-value:5.72E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.28|P-value:3.88E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.76|P-value:5.78E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.24|P-value:7.94E-11 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.34|P-value:3.09E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.11|P-value:7.04E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.18|P-value:5.61E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.16|P-value:5.99E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.35|P-value:3.00E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.78|P-value:5.43E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.05|P-value:8.82E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-3.06|P-value:8.48E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.02|P-value:1.32E-7 ID:SGTC_1840|Compound:st055363|FD-Score:-3.55|P-value:1.38E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.94|P-value:2.08E-7 ID:SGTC_1865|Compound:st057639|FD-Score:3.16|P-value:6.00E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.10|P-value:1.36E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.11|P-value:7.22E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.09|P-value:7.65E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.08|P-value:8.03E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.13|P-value:1.17E-5 ID:SGTC_2174|Compound:5790901|FD-Score:4.86|P-value:3.28E-7 ID:SGTC_2279|Compound:7948423|FD-Score:-3.79|P-value:5.16E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-3.06|P-value:8.43E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-8.51|P-value:1.32E-18 ID:SGTC_2369|Compound:9071472|FD-Score:5.20|P-value:5.08E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.08|P-value:1.44E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.69|P-value:7.73E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.60|P-value:1.12E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.49|P-value:1.73E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.76|P-value:5.82E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:4.59|P-value:1.29E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.32|P-value:3.33E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.67|P-value:8.61E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.54|P-value:1.65E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.36|P-value:2.93E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.62|P-value:1.03E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.04|P-value:9.14E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.17|P-value:5.72E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.28|P-value:3.88E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.76|P-value:5.78E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.24|P-value:7.94E-11 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.34|P-value:3.09E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.11|P-value:7.04E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.18|P-value:5.61E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.16|P-value:5.99E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.35|P-value:3.00E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.78|P-value:5.43E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.05|P-value:8.82E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-3.06|P-value:8.48E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.02|P-value:1.32E-7 ID:SGTC_1840|Compound:st055363|FD-Score:-3.55|P-value:1.38E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.94|P-value:2.08E-7 ID:SGTC_1865|Compound:st057639|FD-Score:3.16|P-value:6.00E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.10|P-value:1.36E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.11|P-value:7.22E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.09|P-value:7.65E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.08|P-value:8.03E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.13|P-value:1.17E-5 ID:SGTC_2174|Compound:5790901|FD-Score:4.86|P-value:3.28E-7 ID:SGTC_2279|Compound:7948423|FD-Score:-3.79|P-value:5.16E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-3.06|P-value:8.43E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-8.51|P-value:1.32E-18 ID:SGTC_2369|Compound:9071472|FD-Score:5.20|P-value:5.08E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.08|P-value:1.44E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.69|P-value:7.73E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.60|P-value:1.12E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.49|P-value:1.73E-4

Top fitness defect scores for YAL019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1031 k035-0009 6.24 16.0 µM 7.94E-11 5 2.13E-10
2 SGTC_2369 9071472 5.20 200.0 µM 5.08E-8 6 1.01E-7
3 SGTC_1707 st032323 5.02 6.3 µM 1.32E-7 DNA damage response 34 2.52E-7
4 SGTC_1841 st054148 4.94 70.0 µM 2.08E-7 3 3.88E-7
5 SGTC_2174 5790901 4.86 200.0 µM 3.28E-7 tubulin folding & SWR complex 21 5.99E-7
6 SGTC_325 2810-4341 4.59 181.0 µM 1.29E-6 amide catabolism 5 2.21E-6
7 SGTC_439 amiodarone 4.54 34.4 µM 1.65E-6 NEO1-PIK1 73 2.80E-6
8 SGTC_2112 5488546 4.13 200.0 µM 1.17E-5 TSC3-RPN4 16 1.82E-5
9 SGTC_1871 st057448 4.10 67.3 µM 1.36E-5 24 2.10E-5
10 SGTC_1496 4469-0713 3.78 57.4 µM 5.43E-5 26 7.88E-5
11 SGTC_950 1165-0508 3.76 94.1 µM 5.78E-5 35 8.36E-5
12 SGTC_431 k089-0097 3.67 107.0 µM 8.61E-5 iron homeostasis 57 1.22E-4
13 SGTC_675 1309-0189 3.62 238.0 µM 1.03E-4 17 1.45E-4
14 SGTC_3174 9107204 3.60 49.5 µM 1.12E-4 ERG2 44 1.57E-4
15 SGTC_333 3486-0131 3.45 40.1 µM 2.04E-4 amide catabolism 18 2.78E-4
16 SGTC_621 3584-0052 3.43 32.1 µM 2.18E-4 35 2.97E-4
17 SGTC_514 4466-0038 3.36 2.6 nM 2.93E-4 cell wall 194 3.94E-4
18 SGTC_1468 k284-1086 3.35 134.0 µM 3.00E-4 DNA intercalators 71 4.03E-4
19 SGTC_1986 st071812 3.35 45.0 µM 3.04E-4 18 4.09E-4
20 SGTC_1035 k081-0041 3.34 55.2 µM 3.09E-4 Golgi 40 4.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.78E-12 YJL118W YJL118W hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
0.105 1.11E-9 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.103 2.54E-9 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.100 6.88E-9 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.093 7.45E-8 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.090 1.62E-7 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.084 1.03E-6 YOL104C NDJ1 hom Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.084 1.06E-6 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.082 1.88E-6 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.079 5.04E-6 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.078 6.75E-6 YMR187C_p YMR187C_p hom Putative protein of unknown function; YMR187C is not an essential gene
0.077 7.97E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.075 1.27E-5 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.074 1.79E-5 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.073 2.57E-5 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting