YAL020C / ATS1

Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL020C / ATS1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.42|P-value:4.64E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.25|P-value:8.24E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.02|P-value:4.94E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.30|P-value:6.88E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.36|P-value:1.19E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.97|P-value:6.00E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.43|P-value:4.45E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.33|P-value:6.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.92|P-value:7.08E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.43|P-value:4.44E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.47|P-value:3.85E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.40|P-value:4.96E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.66|P-value:3.18E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:4.53|P-value:5.73E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:4.25|P-value:1.92E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.22|P-value:8.84E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.28|P-value:1.72E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:5.58|P-value:3.27E-8 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.39|P-value:1.07E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.24|P-value:1.98E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.60|P-value:4.28E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.56|P-value:4.98E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.22|P-value:2.21E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.65|P-value:2.05E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.24|P-value:2.02E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.47|P-value:3.78E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.23|P-value:2.10E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.38|P-value:5.41E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.24|P-value:2.00E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.08|P-value:3.83E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.59|P-value:8.68E-11 ID:SGTC_1800|Compound:st050079|FD-Score:3.73|P-value:1.49E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.47|P-value:7.50E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.94|P-value:7.37E-15 ID:SGTC_1850|Compound:st056238|FD-Score:3.58|P-value:2.66E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-4.40|P-value:9.79E-6 ID:SGTC_2022|Compound:5136654|FD-Score:5.35|P-value:1.12E-7 ID:SGTC_2049|Compound:5262831|FD-Score:-3.21|P-value:9.22E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.87|P-value:8.89E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.56|P-value:2.82E-4 ID:SGTC_2401|Compound:5128683|FD-Score:7.39|P-value:3.91E-13 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.82|P-value:1.06E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-4.01|P-value:4.95E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.98|P-value:5.81E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.63|P-value:2.11E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.71|P-value:2.53E-21 ID:SGTC_2761|Compound:levamisole|FD-Score:4.34|P-value:1.30E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.57|P-value:4.75E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-3.31|P-value:6.60E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-7.05|P-value:4.13E-12 ID:SGTC_2834|Compound:9001755|FD-Score:11.40|P-value:9.12E-29 ID:SGTC_2889|Compound:9059656|FD-Score:-3.37|P-value:5.31E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-4.48|P-value:7.00E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.45|P-value:4.13E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.37|P-value:5.47E-4 ID:SGTC_3085|Compound:9117376|FD-Score:4.16|P-value:2.81E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.46|P-value:7.74E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.91|P-value:7.55E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.88|P-value:8.38E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.38|P-value:5.20E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.31|P-value:1.47E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.42|P-value:4.64E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.25|P-value:8.24E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.02|P-value:4.94E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.30|P-value:6.88E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.36|P-value:1.19E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.97|P-value:6.00E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.43|P-value:4.45E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.33|P-value:6.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.92|P-value:7.08E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.43|P-value:4.44E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.47|P-value:3.85E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.40|P-value:4.96E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.66|P-value:3.18E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:4.53|P-value:5.73E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:4.25|P-value:1.92E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.22|P-value:8.84E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.28|P-value:1.72E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:5.58|P-value:3.27E-8 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.39|P-value:1.07E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.24|P-value:1.98E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.60|P-value:4.28E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.56|P-value:4.98E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.22|P-value:2.21E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.65|P-value:2.05E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.24|P-value:2.02E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.47|P-value:3.78E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.23|P-value:2.10E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.38|P-value:5.41E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.24|P-value:2.00E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.08|P-value:3.83E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.59|P-value:8.68E-11 ID:SGTC_1800|Compound:st050079|FD-Score:3.73|P-value:1.49E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.47|P-value:7.50E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.94|P-value:7.37E-15 ID:SGTC_1850|Compound:st056238|FD-Score:3.58|P-value:2.66E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-4.40|P-value:9.79E-6 ID:SGTC_2022|Compound:5136654|FD-Score:5.35|P-value:1.12E-7 ID:SGTC_2049|Compound:5262831|FD-Score:-3.21|P-value:9.22E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.87|P-value:8.89E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.56|P-value:2.82E-4 ID:SGTC_2401|Compound:5128683|FD-Score:7.39|P-value:3.91E-13 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.82|P-value:1.06E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-4.01|P-value:4.95E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.98|P-value:5.81E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.63|P-value:2.11E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.71|P-value:2.53E-21 ID:SGTC_2761|Compound:levamisole|FD-Score:4.34|P-value:1.30E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.57|P-value:4.75E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-3.31|P-value:6.60E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-7.05|P-value:4.13E-12 ID:SGTC_2834|Compound:9001755|FD-Score:11.40|P-value:9.12E-29 ID:SGTC_2889|Compound:9059656|FD-Score:-3.37|P-value:5.31E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-4.48|P-value:7.00E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.45|P-value:4.13E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.37|P-value:5.47E-4 ID:SGTC_3085|Compound:9117376|FD-Score:4.16|P-value:2.81E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.46|P-value:7.74E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.91|P-value:7.55E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.88|P-value:8.38E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.38|P-value:5.20E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.31|P-value:1.47E-5

Top fitness defect scores for YAL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2834 9001755 11.40 58.4 µM 9.12E-29 2 1.65E-30
2 SGTC_2679 rapamycin 9.71 1.0 nM 2.53E-21 29 1.38E-22
3 SGTC_1844 rapamycin 7.94 4.0 nM 7.37E-15 59 1.04E-15
4 SGTC_2401 5128683 7.39 200.0 µM 3.91E-13 4 7.09E-14
5 SGTC_1754 st042065 6.59 16.1 µM 8.68E-11 NEO1-PIK1 82 2.22E-11
6 SGTC_1074 carmofur 5.58 3.8 µM 3.27E-8 exosome 5 1.22E-8
7 SGTC_2022 5136654 5.35 200.0 µM 1.12E-7 10 4.49E-8
8 SGTC_708 3448-5400 4.66 146.0 µM 3.18E-6 24 1.58E-6
9 SGTC_1093 fluphenazine 4.60 8.0 µM 4.28E-6 8 2.16E-6
10 SGTC_2787 5284540 4.57 71.4 µM 4.75E-6 11 2.42E-6
11 SGTC_710 3448-4187 4.53 58.0 µM 5.73E-6 fatty acid desaturase (OLE1) 37 2.95E-6
12 SGTC_1803 st050068 4.47 52.4 µM 7.50E-6 NEO1-PIK1 143 3.93E-6
13 SGTC_3182 9108849 4.46 49.5 µM 7.74E-6 RPP1 & pyrimidine depletion 7 4.06E-6
14 SGTC_1075 aripiprazole 4.39 15.2 µM 1.07E-5 15 5.73E-6
15 SGTC_128 0906-2981 4.36 13.4 µM 1.19E-5 9 6.39E-6
16 SGTC_2761 levamisole 4.34 97.9 µM 1.30E-5 10 7.02E-6
17 SGTC_3354 9151612 4.31 71.4 µM 1.47E-5 3 8.01E-6
18 SGTC_1052 3253-3998 4.28 198.0 µM 1.72E-5 8 9.51E-6
19 SGTC_954 1189-0853 4.25 2.9 µM 1.92E-5 endomembrane recycling 33 1.06E-5
20 SGTC_1237 0330-0133 4.24 46.1 µM 2.00E-5 ergosterol biosynthesis 19 1.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 7.87E-48 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.244 7.87E-47 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.228 1.16E-40 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.224 1.96E-39 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.203 1.63E-32 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.202 3.00E-32 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.198 4.29E-31 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.196 2.36E-30 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.188 4.23E-28 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.184 6.94E-27 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.183 1.37E-26 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.176 1.07E-24 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.166 3.93E-22 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.165 5.87E-22 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.165 7.33E-22 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4