YAL021C / CCR4

Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL021C / CCR4

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-4.73|P-value:3.76E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.90|P-value:6.93E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.13|P-value:2.64E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.24|P-value:2.51E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.68|P-value:4.41E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:11.60|P-value:4.30E-22 ID:SGTC_140|Compound:0062-0056|FD-Score:4.09|P-value:3.91E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.03|P-value:3.66E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.05|P-value:3.20E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:5.83|P-value:7.97E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:4.62|P-value:7.30E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:8.22|P-value:5.96E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.61|P-value:1.05E-10 ID:SGTC_315|Compound:k915-0449|FD-Score:4.96|P-value:2.29E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:6.11|P-value:2.38E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:4.11|P-value:3.72E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.93|P-value:1.85E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.88|P-value:7.26E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.49|P-value:1.12E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:11.10|P-value:1.61E-20 ID:SGTC_528|Compound:3492-0019|FD-Score:5.27|P-value:7.29E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:7.14|P-value:1.98E-9 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.36|P-value:1.30E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-5.99|P-value:2.73E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:4.91|P-value:2.70E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:4.37|P-value:1.64E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.88|P-value:7.35E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.04|P-value:4.56E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.29|P-value:1.62E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:8.20|P-value:6.64E-12 ID:SGTC_706|Compound:4262-0057|FD-Score:4.00|P-value:5.22E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:7.41|P-value:5.00E-10 ID:SGTC_768|Compound:0384-0033|FD-Score:4.18|P-value:3.01E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.95|P-value:2.35E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:9.54|P-value:1.66E-15 ID:SGTC_900|Compound:1112-0045|FD-Score:4.58|P-value:8.29E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.89|P-value:7.13E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.25|P-value:7.80E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.95|P-value:2.32E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.68|P-value:5.98E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:6.52|P-value:3.94E-8 ID:SGTC_1385|Compound:3091-4834|FD-Score:5.67|P-value:1.53E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.14|P-value:3.42E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.21|P-value:9.02E-6 ID:SGTC_1605|Compound:st000082|FD-Score:-4.22|P-value:2.00E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.31|P-value:6.21E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.66|P-value:1.58E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.98|P-value:5.44E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.45|P-value:3.58E-6 ID:SGTC_1732|Compound:st034308|FD-Score:4.40|P-value:1.49E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.36|P-value:5.10E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.48|P-value:3.19E-6 ID:SGTC_1773|Compound:st048542|FD-Score:5.80|P-value:8.81E-7 ID:SGTC_1781|Compound:st038725|FD-Score:4.79|P-value:4.17E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:11.70|P-value:2.55E-22 ID:SGTC_1937|Compound:st074714|FD-Score:3.80|P-value:9.27E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.17|P-value:3.11E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.10|P-value:1.38E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.12|P-value:1.27E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.22|P-value:1.49E-7 ID:SGTC_2006|Compound:4011487|FD-Score:5.13|P-value:1.22E-5 ID:SGTC_2196|Compound:6573537|FD-Score:4.96|P-value:2.25E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.87|P-value:3.08E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.86|P-value:7.82E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.00|P-value:5.16E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.31|P-value:7.61E-15 ID:SGTC_2385|Compound:9074692|FD-Score:5.53|P-value:2.62E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.37|P-value:1.66E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.14|P-value:3.41E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.81|P-value:8.88E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.96|P-value:4.76E-9 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.42|P-value:1.41E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:5.07|P-value:1.55E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.32|P-value:9.49E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.93|P-value:2.49E-5 ID:SGTC_2698|Compound:st077697|FD-Score:6.78|P-value:1.15E-8 ID:SGTC_2699|Compound:st077704|FD-Score:3.78|P-value:9.58E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.75|P-value:1.09E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:4.12|P-value:3.61E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:8.02|P-value:1.84E-11 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.21|P-value:2.08E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.44|P-value:3.75E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.42|P-value:6.19E-8 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.90|P-value:6.91E-4 ID:SGTC_2873|Compound:9040596|FD-Score:8.35|P-value:2.77E-12 ID:SGTC_2918|Compound:7977171|FD-Score:5.55|P-value:2.45E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.15|P-value:3.34E-4 ID:SGTC_2986|Compound:9022445|FD-Score:4.09|P-value:3.98E-4 ID:SGTC_3082|Compound:9117008|FD-Score:5.23|P-value:8.29E-6 ID:SGTC_3098|Compound:9119039|FD-Score:4.84|P-value:3.49E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-4.91|P-value:2.01E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.93|P-value:4.92E-4 ID:SGTC_3197|Compound:9113331|FD-Score:5.16|P-value:1.08E-5 ID:SGTC_3202|Compound:9113761|FD-Score:4.79|P-value:4.18E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.75|P-value:3.46E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-4.73|P-value:3.76E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.90|P-value:6.93E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.13|P-value:2.64E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.24|P-value:2.51E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.68|P-value:4.41E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:11.60|P-value:4.30E-22 ID:SGTC_140|Compound:0062-0056|FD-Score:4.09|P-value:3.91E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.03|P-value:3.66E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.05|P-value:3.20E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:5.83|P-value:7.97E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:4.62|P-value:7.30E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:8.22|P-value:5.96E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.61|P-value:1.05E-10 ID:SGTC_315|Compound:k915-0449|FD-Score:4.96|P-value:2.29E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:6.11|P-value:2.38E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:4.11|P-value:3.72E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.93|P-value:1.85E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.88|P-value:7.26E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.49|P-value:1.12E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:11.10|P-value:1.61E-20 ID:SGTC_528|Compound:3492-0019|FD-Score:5.27|P-value:7.29E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:7.14|P-value:1.98E-9 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.36|P-value:1.30E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-5.99|P-value:2.73E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:4.91|P-value:2.70E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:4.37|P-value:1.64E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.88|P-value:7.35E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.04|P-value:4.56E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.29|P-value:1.62E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:8.20|P-value:6.64E-12 ID:SGTC_706|Compound:4262-0057|FD-Score:4.00|P-value:5.22E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:7.41|P-value:5.00E-10 ID:SGTC_768|Compound:0384-0033|FD-Score:4.18|P-value:3.01E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.95|P-value:2.35E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:9.54|P-value:1.66E-15 ID:SGTC_900|Compound:1112-0045|FD-Score:4.58|P-value:8.29E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.89|P-value:7.13E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.25|P-value:7.80E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.95|P-value:2.32E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.68|P-value:5.98E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:6.52|P-value:3.94E-8 ID:SGTC_1385|Compound:3091-4834|FD-Score:5.67|P-value:1.53E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.14|P-value:3.42E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.21|P-value:9.02E-6 ID:SGTC_1605|Compound:st000082|FD-Score:-4.22|P-value:2.00E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.31|P-value:6.21E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.66|P-value:1.58E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.98|P-value:5.44E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.45|P-value:3.58E-6 ID:SGTC_1732|Compound:st034308|FD-Score:4.40|P-value:1.49E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.36|P-value:5.10E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.48|P-value:3.19E-6 ID:SGTC_1773|Compound:st048542|FD-Score:5.80|P-value:8.81E-7 ID:SGTC_1781|Compound:st038725|FD-Score:4.79|P-value:4.17E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:11.70|P-value:2.55E-22 ID:SGTC_1937|Compound:st074714|FD-Score:3.80|P-value:9.27E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.17|P-value:3.11E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.10|P-value:1.38E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.12|P-value:1.27E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.22|P-value:1.49E-7 ID:SGTC_2006|Compound:4011487|FD-Score:5.13|P-value:1.22E-5 ID:SGTC_2196|Compound:6573537|FD-Score:4.96|P-value:2.25E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.87|P-value:3.08E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.86|P-value:7.82E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.00|P-value:5.16E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.31|P-value:7.61E-15 ID:SGTC_2385|Compound:9074692|FD-Score:5.53|P-value:2.62E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.37|P-value:1.66E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.14|P-value:3.41E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.81|P-value:8.88E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.96|P-value:4.76E-9 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.42|P-value:1.41E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:5.07|P-value:1.55E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.32|P-value:9.49E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.93|P-value:2.49E-5 ID:SGTC_2698|Compound:st077697|FD-Score:6.78|P-value:1.15E-8 ID:SGTC_2699|Compound:st077704|FD-Score:3.78|P-value:9.58E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.75|P-value:1.09E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:4.12|P-value:3.61E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:8.02|P-value:1.84E-11 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.21|P-value:2.08E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.44|P-value:3.75E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.42|P-value:6.19E-8 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.90|P-value:6.91E-4 ID:SGTC_2873|Compound:9040596|FD-Score:8.35|P-value:2.77E-12 ID:SGTC_2918|Compound:7977171|FD-Score:5.55|P-value:2.45E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.15|P-value:3.34E-4 ID:SGTC_2986|Compound:9022445|FD-Score:4.09|P-value:3.98E-4 ID:SGTC_3082|Compound:9117008|FD-Score:5.23|P-value:8.29E-6 ID:SGTC_3098|Compound:9119039|FD-Score:4.84|P-value:3.49E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-4.91|P-value:2.01E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.93|P-value:4.92E-4 ID:SGTC_3197|Compound:9113331|FD-Score:5.16|P-value:1.08E-5 ID:SGTC_3202|Compound:9113761|FD-Score:4.79|P-value:4.18E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.75|P-value:3.46E-5

Top fitness defect scores for YAL021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1873 rapamycin 11.70 2.0 nM 2.55E-22 5 9.00E-32
2 SGTC_138 0850-0259 11.60 40.9 µM 4.30E-22 cell wall 31 1.92E-31
3 SGTC_524 r073-0010 11.10 27.8 µM 1.61E-20 2 3.71E-29
4 SGTC_878 0828-0289 9.54 13.7 µM 1.66E-15 5 7.14E-22
5 SGTC_2322 7413319 9.31 38.2 µM 7.61E-15 ERAD & cell cycle 23 6.54E-21
6 SGTC_2873 9040596 8.35 71.4 µM 2.77E-12 4 3.43E-17
7 SGTC_268 camptothecin 8.22 39.6 µM 5.96E-12 DNA damage response 14 1.04E-16
8 SGTC_699 0375-0592 8.20 111.0 µM 6.64E-12 iron homeostasis 2 1.22E-16
9 SGTC_2743 auranofin 8.02 4.3 µM 1.84E-11 RPP1 & pyrimidine depletion 3 5.35E-16
10 SGTC_733 4069-0007 7.41 56.1 µM 5.00E-10 ERAD & cell cycle 26 6.42E-14
11 SGTC_535 2293-4129 7.14 48.2 µM 1.98E-9 NEO1 18 4.71E-13
12 SGTC_2619 obliquin 6.96 87.9 µM 4.76E-9 cell wall 59 1.68E-12
13 SGTC_2698 st077697 6.78 67.5 µM 1.15E-8 1 6.03E-12
14 SGTC_1244 0416-0015 6.52 52.5 µM 3.94E-8 ERG2 3 3.60E-11
15 SGTC_2753 fluvastatin 6.42 17.1 µM 6.19E-8 azole & statin 7 6.92E-11
16 SGTC_2666 tannic acid 6.32 100.0 µM 9.49E-8 iron homeostasis 10 1.29E-10
17 SGTC_1991 st073000 6.22 8.9 µM 1.49E-7 NEO1 30 2.48E-10
18 SGTC_351 caspofungin 6.11 25.0 nM 2.38E-7 cell wall 38 4.87E-10
19 SGTC_146 3448-8650 6.05 53.1 µM 3.20E-7 NEO1-PIK1 55 7.47E-10
20 SGTC_197 4544-0043 5.83 41.6 µM 7.97E-7 endomembrane recycling 17 2.80E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 1.12E-76 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.271 9.74E-58 YNR052C POP2 hom RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
0.248 2.88E-48 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.219 9.97E-38 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.217 5.89E-37 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.202 3.55E-32 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.201 8.08E-32 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.192 3.56E-29 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.192 4.05E-29 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.188 4.87E-28 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.184 5.12E-27 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.184 7.19E-27 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.181 3.31E-26 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.179 1.64E-25 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.177 4.75E-25 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p