YAL022C / FUN26

Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL022C / FUN26

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.98|P-value:3.34E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:4.12|P-value:1.78E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.20|P-value:6.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.89|P-value:4.55E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:4.36|P-value:6.10E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.13|P-value:8.19E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.17|P-value:7.49E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.58|P-value:1.11E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:4.46|P-value:3.77E-6 ID:SGTC_397|Compound:arbidol|FD-Score:-3.12|P-value:8.27E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.82|P-value:6.39E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.37|P-value:3.64E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.76|P-value:9.00E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.09|P-value:1.94E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-4.48|P-value:3.24E-6 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.45|P-value:3.84E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.24|P-value:5.54E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.13|P-value:8.47E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.35|P-value:3.97E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.09|P-value:9.31E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.28|P-value:5.01E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.20|P-value:6.66E-4 ID:SGTC_2003|Compound:4023581|FD-Score:6.37|P-value:7.95E-11 ID:SGTC_2010|Compound:4012422|FD-Score:-4.80|P-value:7.02E-7 ID:SGTC_2044|Compound:5102272|FD-Score:4.86|P-value:5.53E-7 ID:SGTC_2046|Compound:4110841|FD-Score:4.02|P-value:2.75E-5 ID:SGTC_2072|Compound:5231554|FD-Score:-3.37|P-value:3.40E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.44|P-value:2.78E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.59|P-value:1.54E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.93|P-value:4.12E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.47|P-value:3.41E-6 ID:SGTC_2394|Compound:5221648|FD-Score:3.78|P-value:7.64E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.54|P-value:1.95E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.24|P-value:5.74E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.44|P-value:2.69E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.49|P-value:2.34E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.40|P-value:3.25E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.56|P-value:2.45E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.32|P-value:4.41E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.03|P-value:2.70E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-3.38|P-value:3.35E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.32|P-value:7.34E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.63|P-value:1.35E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.09|P-value:9.29E-4 ID:SGTC_3158|Compound:9100007|FD-Score:5.92|P-value:1.42E-9 ID:SGTC_3193|Compound:9111931|FD-Score:-3.07|P-value:9.92E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.98|P-value:3.34E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:4.12|P-value:1.78E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.20|P-value:6.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.89|P-value:4.55E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:4.36|P-value:6.10E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.13|P-value:8.19E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.17|P-value:7.49E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.58|P-value:1.11E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:4.46|P-value:3.77E-6 ID:SGTC_397|Compound:arbidol|FD-Score:-3.12|P-value:8.27E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.82|P-value:6.39E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.37|P-value:3.64E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.76|P-value:9.00E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.09|P-value:1.94E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-4.48|P-value:3.24E-6 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.45|P-value:3.84E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.24|P-value:5.54E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.13|P-value:8.47E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.35|P-value:3.97E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.09|P-value:9.31E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.28|P-value:5.01E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.20|P-value:6.66E-4 ID:SGTC_2003|Compound:4023581|FD-Score:6.37|P-value:7.95E-11 ID:SGTC_2010|Compound:4012422|FD-Score:-4.80|P-value:7.02E-7 ID:SGTC_2044|Compound:5102272|FD-Score:4.86|P-value:5.53E-7 ID:SGTC_2046|Compound:4110841|FD-Score:4.02|P-value:2.75E-5 ID:SGTC_2072|Compound:5231554|FD-Score:-3.37|P-value:3.40E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.44|P-value:2.78E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.59|P-value:1.54E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.93|P-value:4.12E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.47|P-value:3.41E-6 ID:SGTC_2394|Compound:5221648|FD-Score:3.78|P-value:7.64E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.54|P-value:1.95E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.24|P-value:5.74E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.44|P-value:2.69E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.49|P-value:2.34E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.40|P-value:3.25E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.56|P-value:2.45E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.32|P-value:4.41E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.03|P-value:2.70E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-3.38|P-value:3.35E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.32|P-value:7.34E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.63|P-value:1.35E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.09|P-value:9.29E-4 ID:SGTC_3158|Compound:9100007|FD-Score:5.92|P-value:1.42E-9 ID:SGTC_3193|Compound:9111931|FD-Score:-3.07|P-value:9.92E-4

Top fitness defect scores for YAL022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2003 4023581 6.37 200.0 µM 7.95E-11 cell wall signaling 11 9.16E-11
2 SGTC_3158 9100007 5.92 49.5 µM 1.42E-9 4 1.60E-9
3 SGTC_361 000s-0510 5.58 1.4 µM 1.11E-8 6 1.23E-8
4 SGTC_2044 5102272 4.86 200.0 µM 5.53E-7 2 5.96E-7
5 SGTC_627 1391-0720 4.76 175.0 µM 9.00E-7 4 9.67E-7
6 SGTC_2700 st077718 4.56 96.8 µM 2.45E-6 7 2.62E-6
7 SGTC_372 0155-0182 4.46 15.9 µM 3.77E-6 mitochondrial response to ROS 21 4.01E-6
8 SGTC_132 0417-1715 4.36 25.8 µM 6.10E-6 RPP1 & pyrimidine depletion 14 6.46E-6
9 SGTC_2930 9013230 4.32 14.9 µM 7.34E-6 heme biosynthesis & mitochondrial translocase 24 7.77E-6
10 SGTC_48 0382-0018 4.12 55.0 µM 1.78E-5 5 1.87E-5
11 SGTC_2804 7954240 4.03 19.5 µM 2.70E-5 29 2.83E-5
12 SGTC_2046 4110841 4.02 106.0 µM 2.75E-5 iron homeostasis 27 2.88E-5
13 SGTC_6 0844-0013 3.98 19.8 µM 3.34E-5 86 3.49E-5
14 SGTC_2272 7805186 3.93 180.0 µM 4.12E-5 cell wall signaling 19 4.31E-5
15 SGTC_454 lyso-paf C-16 3.82 6.7 µM 6.39E-5 19 6.66E-5
16 SGTC_2394 5221648 3.78 200.0 µM 7.64E-5 29 7.95E-5
17 SGTC_329 k048-0121 3.69 21.3 µM 1.09E-4 RSC & ERG11 15 1.13E-4
18 SGTC_2931 9014674 3.63 55.7 µM 1.35E-4 31 1.40E-4
19 SGTC_2409 alverine citrate 3.54 64.0 µM 1.95E-4 68 2.01E-4
20 SGTC_2580 diallyl disulphide 3.49 81.4 µM 2.34E-4 31 2.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.51E-10 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.101 4.64E-9 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.100 6.34E-9 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.097 2.16E-8 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.094 4.92E-8 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.094 5.54E-8 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.089 2.61E-7 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.084 1.01E-6 YER085C_p YER085C_p hom Putative protein of unknown function
0.084 1.26E-6 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.083 1.66E-6 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.081 2.30E-6 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.081 2.73E-6 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.080 3.25E-6 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.080 3.58E-6 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.15E-6 YOR053W_d YOR053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C