YAL024C / LTE1

Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL024C / LTE1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.32|P-value:3.05E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.62|P-value:8.62E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:7.32|P-value:3.66E-9 ID:SGTC_157|Compound:1348-1695|FD-Score:5.09|P-value:2.95E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.74|P-value:9.20E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.38|P-value:2.67E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:24.70|P-value:2.27E-85 ID:SGTC_212|Compound:3807-4682|FD-Score:4.32|P-value:3.22E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:6.33|P-value:2.87E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:-5.30|P-value:1.41E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:7.03|P-value:1.40E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:8.69|P-value:3.46E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.42|P-value:2.36E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:4.51|P-value:1.83E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:9.14|P-value:2.63E-13 ID:SGTC_550|Compound:4123-0385|FD-Score:4.02|P-value:7.45E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:11.70|P-value:9.71E-21 ID:SGTC_594|Compound:1487-1584|FD-Score:28.10|P-value:1.48E-109 ID:SGTC_638|Compound:3970-0837|FD-Score:7.22|P-value:5.86E-9 ID:SGTC_639|Compound:0833-0042|FD-Score:9.07|P-value:3.87E-13 ID:SGTC_676|Compound:falcarinol|FD-Score:4.36|P-value:2.85E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.34|P-value:3.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.62|P-value:4.58E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:5.87|P-value:1.79E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:5.85|P-value:1.93E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:15.70|P-value:1.34E-35 ID:SGTC_879|Compound:0831-1030|FD-Score:12.80|P-value:2.21E-24 ID:SGTC_897|Compound:1000-0139|FD-Score:16.60|P-value:1.35E-39 ID:SGTC_984|Compound:1492-0255|FD-Score:6.62|P-value:8.50E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.25|P-value:1.68E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.92|P-value:5.18E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.95|P-value:4.69E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.17|P-value:5.45E-7 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.79|P-value:7.85E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.88|P-value:5.83E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.03|P-value:3.57E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.99|P-value:8.15E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.06|P-value:8.44E-7 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.65|P-value:1.22E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:5.25|P-value:1.72E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.62|P-value:1.31E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:7.14|P-value:8.72E-9 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.80|P-value:7.60E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.95|P-value:9.06E-4 ID:SGTC_1643|Compound:st009866|FD-Score:18.40|P-value:5.10E-48 ID:SGTC_1651|Compound:st011928|FD-Score:6.62|P-value:8.41E-8 ID:SGTC_1678|Compound:st019265|FD-Score:4.93|P-value:4.97E-5 ID:SGTC_1716|Compound:st033144|FD-Score:4.76|P-value:8.56E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.60|P-value:1.40E-4 ID:SGTC_1759|Compound:st043059|FD-Score:5.58|P-value:5.23E-6 ID:SGTC_1773|Compound:st048542|FD-Score:7.77|P-value:4.15E-10 ID:SGTC_1775|Compound:st081588|FD-Score:4.34|P-value:3.02E-4 ID:SGTC_1978|Compound:st071761|FD-Score:6.51|P-value:1.38E-7 ID:SGTC_2058|Compound:5236698|FD-Score:7.68|P-value:6.61E-10 ID:SGTC_2089|Compound:5281248|FD-Score:9.05|P-value:4.54E-13 ID:SGTC_2111|Compound:5486399|FD-Score:5.48|P-value:7.53E-6 ID:SGTC_2141|Compound:5621638|FD-Score:4.69|P-value:1.07E-4 ID:SGTC_2173|Compound:5763948|FD-Score:4.15|P-value:5.19E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.91|P-value:5.27E-5 ID:SGTC_2186|Compound:6124449|FD-Score:-4.68|P-value:1.11E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.04|P-value:9.03E-7 ID:SGTC_2214|Compound:7179297|FD-Score:4.90|P-value:5.39E-5 ID:SGTC_2224|Compound:6650123|FD-Score:5.47|P-value:7.75E-6 ID:SGTC_2225|Compound:6654152|FD-Score:8.08|P-value:8.79E-11 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.47|P-value:2.11E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:10.60|P-value:3.68E-17 ID:SGTC_2246|Compound:7293507|FD-Score:9.96|P-value:1.83E-15 ID:SGTC_2323|Compound:6148992|FD-Score:7.49|P-value:1.68E-9 ID:SGTC_2405|Compound:ticlatone|FD-Score:15.90|P-value:1.93E-36 ID:SGTC_2408|Compound:sulbentine|FD-Score:12.00|P-value:1.47E-21 ID:SGTC_2430|Compound:5571206|FD-Score:5.55|P-value:5.91E-6 ID:SGTC_2483|Compound:5729050|FD-Score:4.02|P-value:7.49E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.71|P-value:1.01E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:8.33|P-value:2.43E-11 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.95|P-value:9.03E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.24|P-value:4.06E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:6.03|P-value:9.46E-7 ID:SGTC_3120|Compound:9124077|FD-Score:6.82|P-value:3.68E-8 ID:SGTC_3211|Compound:9128781|FD-Score:4.46|P-value:2.17E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.04|P-value:3.39E-5 ID:SGTC_3288|Compound:9119690|FD-Score:4.11|P-value:5.80E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.54|P-value:1.32E-9 ID:SGTC_3317|Compound:9138495|FD-Score:4.07|P-value:6.59E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.32|P-value:3.05E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.62|P-value:8.62E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:7.32|P-value:3.66E-9 ID:SGTC_157|Compound:1348-1695|FD-Score:5.09|P-value:2.95E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.74|P-value:9.20E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.38|P-value:2.67E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:24.70|P-value:2.27E-85 ID:SGTC_212|Compound:3807-4682|FD-Score:4.32|P-value:3.22E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:6.33|P-value:2.87E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:-5.30|P-value:1.41E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:7.03|P-value:1.40E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:8.69|P-value:3.46E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.42|P-value:2.36E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:4.51|P-value:1.83E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:9.14|P-value:2.63E-13 ID:SGTC_550|Compound:4123-0385|FD-Score:4.02|P-value:7.45E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:11.70|P-value:9.71E-21 ID:SGTC_594|Compound:1487-1584|FD-Score:28.10|P-value:1.48E-109 ID:SGTC_638|Compound:3970-0837|FD-Score:7.22|P-value:5.86E-9 ID:SGTC_639|Compound:0833-0042|FD-Score:9.07|P-value:3.87E-13 ID:SGTC_676|Compound:falcarinol|FD-Score:4.36|P-value:2.85E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.34|P-value:3.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.62|P-value:4.58E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:5.87|P-value:1.79E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:5.85|P-value:1.93E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:15.70|P-value:1.34E-35 ID:SGTC_879|Compound:0831-1030|FD-Score:12.80|P-value:2.21E-24 ID:SGTC_897|Compound:1000-0139|FD-Score:16.60|P-value:1.35E-39 ID:SGTC_984|Compound:1492-0255|FD-Score:6.62|P-value:8.50E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.25|P-value:1.68E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.92|P-value:5.18E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.95|P-value:4.69E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.17|P-value:5.45E-7 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.79|P-value:7.85E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.88|P-value:5.83E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.03|P-value:3.57E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.99|P-value:8.15E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.06|P-value:8.44E-7 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.65|P-value:1.22E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:5.25|P-value:1.72E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.62|P-value:1.31E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:7.14|P-value:8.72E-9 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.80|P-value:7.60E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.95|P-value:9.06E-4 ID:SGTC_1643|Compound:st009866|FD-Score:18.40|P-value:5.10E-48 ID:SGTC_1651|Compound:st011928|FD-Score:6.62|P-value:8.41E-8 ID:SGTC_1678|Compound:st019265|FD-Score:4.93|P-value:4.97E-5 ID:SGTC_1716|Compound:st033144|FD-Score:4.76|P-value:8.56E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.60|P-value:1.40E-4 ID:SGTC_1759|Compound:st043059|FD-Score:5.58|P-value:5.23E-6 ID:SGTC_1773|Compound:st048542|FD-Score:7.77|P-value:4.15E-10 ID:SGTC_1775|Compound:st081588|FD-Score:4.34|P-value:3.02E-4 ID:SGTC_1978|Compound:st071761|FD-Score:6.51|P-value:1.38E-7 ID:SGTC_2058|Compound:5236698|FD-Score:7.68|P-value:6.61E-10 ID:SGTC_2089|Compound:5281248|FD-Score:9.05|P-value:4.54E-13 ID:SGTC_2111|Compound:5486399|FD-Score:5.48|P-value:7.53E-6 ID:SGTC_2141|Compound:5621638|FD-Score:4.69|P-value:1.07E-4 ID:SGTC_2173|Compound:5763948|FD-Score:4.15|P-value:5.19E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.91|P-value:5.27E-5 ID:SGTC_2186|Compound:6124449|FD-Score:-4.68|P-value:1.11E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.04|P-value:9.03E-7 ID:SGTC_2214|Compound:7179297|FD-Score:4.90|P-value:5.39E-5 ID:SGTC_2224|Compound:6650123|FD-Score:5.47|P-value:7.75E-6 ID:SGTC_2225|Compound:6654152|FD-Score:8.08|P-value:8.79E-11 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.47|P-value:2.11E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:10.60|P-value:3.68E-17 ID:SGTC_2246|Compound:7293507|FD-Score:9.96|P-value:1.83E-15 ID:SGTC_2323|Compound:6148992|FD-Score:7.49|P-value:1.68E-9 ID:SGTC_2405|Compound:ticlatone|FD-Score:15.90|P-value:1.93E-36 ID:SGTC_2408|Compound:sulbentine|FD-Score:12.00|P-value:1.47E-21 ID:SGTC_2430|Compound:5571206|FD-Score:5.55|P-value:5.91E-6 ID:SGTC_2483|Compound:5729050|FD-Score:4.02|P-value:7.49E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.71|P-value:1.01E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:8.33|P-value:2.43E-11 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.95|P-value:9.03E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.24|P-value:4.06E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:6.03|P-value:9.46E-7 ID:SGTC_3120|Compound:9124077|FD-Score:6.82|P-value:3.68E-8 ID:SGTC_3211|Compound:9128781|FD-Score:4.46|P-value:2.17E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.04|P-value:3.39E-5 ID:SGTC_3288|Compound:9119690|FD-Score:4.11|P-value:5.80E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.54|P-value:1.32E-9 ID:SGTC_3317|Compound:9138495|FD-Score:4.07|P-value:6.59E-4

Top fitness defect scores for YAL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_594 1487-1584 28.10 10.8 µM 1.48E-109 2 2.83E-174
2 SGTC_210 3551-0445 24.70 56.8 µM 2.27E-85 3 1.58E-135
3 SGTC_1643 st009866 18.40 20.2 µM 5.10E-48 2 1.03E-75
4 SGTC_897 1000-0139 16.60 31.4 µM 1.35E-39 2 3.11E-62
5 SGTC_2405 ticlatone 15.90 3.5 µM 1.93E-36 5 3.48E-57
6 SGTC_871 0574-0004 15.70 149.0 µM 1.34E-35 2 7.66E-56
7 SGTC_879 0831-1030 12.80 162.0 µM 2.21E-24 2 6.59E-38
8 SGTC_2408 sulbentine 12.00 18.4 µM 1.47E-21 2 2.14E-33
9 SGTC_589 1227-0070 11.70 34.1 µM 9.71E-21 4 4.35E-32
10 SGTC_2233 sulbentine 10.60 40.4 µM 3.68E-17 6 2.24E-26
11 SGTC_2246 7293507 9.96 91.6 µM 1.83E-15 3 1.14E-23
12 SGTC_524 r073-0010 9.14 27.8 µM 2.63E-13 5 3.12E-20
13 SGTC_639 0833-0042 9.07 114.0 µM 3.87E-13 5 5.78E-20
14 SGTC_2089 5281248 9.05 129.7 µM 4.54E-13 superoxide 3 7.44E-20
15 SGTC_451 chloral hydrate 8.69 100.0 µM 3.46E-12 4 1.89E-18
16 SGTC_2573 2',4'-dihydroxychalcone 8.33 15.0 µM 2.43E-11 6 4.19E-17
17 SGTC_2225 6654152 8.08 15.4 µM 8.79E-11 2 3.24E-16
18 SGTC_1773 st048542 7.77 73.6 µM 4.15E-10 8 3.82E-15
19 SGTC_2058 5236698 7.68 133.0 µM 6.61E-10 6 7.99E-15
20 SGTC_3304 9125678 7.54 46.1 µM 1.32E-9 7 2.39E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.571 2.55E-288 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.340 2.56E-91 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.338 2.67E-90 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.330 1.03E-85 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.330 1.22E-85 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.319 7.54E-80 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.313 9.26E-77 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.312 2.48E-76 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.307 3.30E-74 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.265 4.93E-55 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.222 1.38E-38 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.214 4.90E-36 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.208 3.78E-34 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.195 3.94E-30 YOR262W GPN2 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
0.184 7.58E-27 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis